KEGG   ORTHOLOGY: K08857
Entry
K08857                      KO                                     

Symbol
NEK1_4_5
Name
NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
Disease
H00511  Short rib-polydactyly syndrome
H02157  Short-rib thoracic dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
   03400 DNA repair and recombination proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  NEK family
   K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other cilium assembly proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Genes
HSA: 341676(NEK5) 4750(NEK1) 6787(NEK4)
PTR: 460434(NEK4) 471345(NEK1) 745999(NEK5)
PPS: 100973939(NEK5) 100981661(NEK4) 100990642(NEK1)
GGO: 101125530(NEK5) 101139519(NEK4) 101144675(NEK1)
PON: 100173731(NEK4) 100436374(NEK1)
NLE: 100581109(NEK1) 100586441(NEK4) 100605118(NEK5)
MCC: 694345(NEK1) 695646(NEK4) 713960(NEK5)
MCF: 102114802(NEK5) 102115637(NEK1) 102130430(NEK4)
CSAB: 103214473(NEK5) 103227744(NEK4) 103236516(NEK1)
CATY: 105585571(NEK4) 105587727(NEK5) 105597820(NEK1)
PANU: 101008575(NEK4) 101009740(NEK5) 101022312(NEK1)
RRO: 104653858(NEK5) 104662876(NEK1) 104663694(NEK4)
RBB: 108519338(NEK5) 108522327(NEK4) 108522850(NEK1)
TFN: 117063744(NEK5) 117082980(NEK4) 117086115(NEK1)
PTEH: 111523006(NEK5) 111528799(NEK4) 111553813(NEK1)
CJC: 100394078(NEK4) 100394930(NEK1)
SBQ: 101029557(NEK5) 101035398(NEK4) 101037612 101051138(NEK1)
MMUR: 105874623(NEK1) 105875057(NEK4) 105881146(NEK5)
MMU: 18004(Nek1) 23955(Nek4) 330721(Nek5)
MCAL: 110299782(Nek1) 110300147(Nek5) 110309470(Nek4)
MPAH: 110325412(Nek4) 110336318(Nek1) 110336903(Nek5)
RNO: 290705(Nek1) 306252(Nek4) 685440(Nek5)
MCOC: 116068997(Nek5) 116069347(Nek1) 116084635(Nek4)
CGE: 100752822(Nek5) 100759305(Nek1) 100761888(Nek4)
PLEU: 114686274(Nek5) 114701101(Nek1) 114708182(Nek4)
NGI: 103727139(Nek1) 103745482(Nek5) 103749012(Nek4)
HGL: 101696587(Nek4) 101703746(Nek1) 101711997(Nek5)
CCAN: 109676479(Nek5) 109686883(Nek1) 109693725(Nek4)
OCU: 100345120(NEK5) 100346687(NEK1) 100349662(NEK4)
TUP: 102489588 102491616(NEK4) 102491752(NEK5)
CFA: 100683905(NEK5) 476591(NEK4) 486058(NEK1)
VVP: 112910267(NEK4) 112934153(NEK1)
VLG: 121476938(NEK5) 121495686(NEK4) 121497499(NEK1)
AML: 100472594(NEK5) 100482924(NEK4) 100483504(NEK1)
UMR: 103658148(NEK1) 103674753(NEK4) 103677632(NEK5)
ORO: 101363457(NEK4) 101364240(NEK1) 101364387(NEK5)
MPUF: 101681534(NEK1) 101685632(NEK4) 101692516(NEK5)
EJU: 114210174(NEK1) 114212796(NEK5) 114225032(NEK4)
MLX: 118004948(NEK4) 118009471(NEK5) 118022165(NEK1) 118022426
FCA: 101093171(NEK4) 101094016(NEK1) 101097612(NEK5)
PYU: 121012904(NEK5) 121016863(NEK4) 121027395(NEK1)
PTG: 102952900(NEK1) 102956539(NEK5) 102963755(NEK4)
PPAD: 109247910(NEK4) 109262434(NEK1) 109265997(NEK5)
AJU: 106972660 106976517(NEK1) 106987000(NEK4)
HHV: 120221688(NEK1) 120234285(NEK5) 120239425(NEK4)
BTA: 100138147(NEK5) 511455(NEK4) 534671(NEK1)
BOM: 102271510(NEK1) 102277016(NEK4) 102287387(NEK5)
BIU: 109562754(NEK1) 109566748(NEK5) 109576014(NEK4)
BBUB: 102389575 102391455(NEK1) 102403947(NEK4)
CHX: 102179611(NEK4) 102183800(NEK5) 102189122(NEK1)
OAS: 101107110(NEK5) 101110544(NEK4) 101114757(NEK1)
ODA: 120853470(NEK1) 120868374(NEK4) 120883079(NEK5)
CCAD: 122424578(NEK4) 122447199(NEK5) 122452905(NEK1)
SSC: 100156672(NEK5) 100520589(NEK1) 106504146(NEK4)
CFR: 102510287(NEK5) 102512886(NEK4) 102517527(NEK1)
CBAI: 105066178(NEK5) 105073353(NEK1) 105080165(NEK4)
CDK: 105090995(NEK5) 105093308(NEK4) 105101615(NEK1)
BACU: 103003275(NEK5) 103016859(NEK1) 103020484
LVE: 103077466(NEK1) 103089687(NEK5) 103091092(NEK4)
OOR: 101276787(NEK1) 101284485(NEK4) 101285789(NEK5)
DLE: 111174295(NEK4) 111175280 111185341(NEK1)
PCAD: 102976069(NEK4) 102981544(NEK1)
ECB: 100051545(NEK4) 100052593(NEK5) 100061302(NEK1)
EAI: 106821749(NEK4) 106837700(NEK5) 106848465(NEK1)
MYB: 102249725(NEK4) 102259171(NEK1) 102263040(NEK5)
MYD: 102758129(NEK1) 102764427(NEK5) 102767708(NEK4)
MMYO: 118651864(NEK5) 118658733(NEK1) 118667994(NEK4)
MNA: 107527523(NEK1) 107534940(NEK4) 107537545(NEK5)
HAI: 109373882(NEK4) 109394921(NEK1) 109396765(NEK5)
DRO: 112301182(NEK4) 112312199(NEK5) 112312457(NEK1)
SHON: 118993384(NEK4) 118994815(NEK5) 118996841(NEK1)
AJM: 119039661(NEK5) 119040837(NEK1) 119041417(NEK4) 119045614
MMF: 118615260(NEK1) 118622590(NEK5) 118633441(NEK4)
PALE: 102888550(NEK1) 102893235 102894766(NEK4)
PGIG: 120583882(NEK5) 120606323(NEK4) 120613484(NEK1)
RAY: 107498570(NEK4) 107503293(NEK5) 107512541(NEK1)
MJV: 108408411(NEK4)
TOD: 119257965(NEK1) 119258537 119258869(NEK5) 119261250(NEK4)
LAV: 100661998(NEK4) 100665709(NEK1) 100677745(NEK5)
MDO: 100020318(NEK4) 100021205(NEK1) 100028128(NEK5)
SHR: 100917015(NEK1) 100928958(NEK4)
PCW: 110196651(NEK5) 110197531(NEK4) 110215969(NEK1)
OAA: 100077133(NEK1) 100082611(NEK5) 100092385(NEK4)
GGA: 415900(NEK4) 418881(NEK5) 422433(NEK1)
PCOC: 116226081(NEK1) 116239322(NEK4) 116244145(NEK5)
MGP: 100539213(NEK4) 100540479(NEK1) 100541238
CJO: 107308186(NEK5) 107313003(NEK1) 107319539(NEK4)
NMEL: 110388050(NEK5) 110398892(NEK1) 110404835(NEK4)
APLA: 101795060(NEK5) 101797316(NEK4) 101804085(NEK1)
ACYG: 106032343(NEK1) 106035100 106042839(NEK4)
TGU: 100222015(NEK4) 100222443(NEK5) 100229879(NEK1)
LSR: 110468586(NEK5) 110472340(NEK4) 110483752(NEK1)
SCAN: 103816977(NEK4) 103826217(NEK1) 103827384(NEK5)
PMOA: 120497973(NEK1) 120505811(NEK5) 120514039(NEK4)
GFR: 102034206(NEK1) 102038725(NEK5) 102045571(NEK4)
FAB: 101808886(NEK5) 101814798(NEK1) 101816073(NEK4)
PHI: 102099195(NEK5) 102101142(NEK1) 102110829(NEK4)
PMAJ: 107202862(NEK1) 107208037(NEK5) 107210212(NEK4)
CCAE: 111927900(NEK1) 111935171(NEK4) 111945569
CCW: 104683227(NEK4) 104689945(NEK5) 104690539(NEK1)
ETL: 114059568 114061292(NEK4) 114064973(NEK1)
FPG: 101911989(NEK1) 101916543(NEK5) 101923813(NEK4)
FCH: 102050035(NEK1) 102051609(NEK4) 102056741(NEK5)
CLV: 102086210(NEK5) 102089264(NEK1) 102093212
EGZ: 104123118(NEK1) 104126685(NEK4) 104129676(NEK5)
NNI: 104008705(NEK4) 104010942(NEK5) 104021367(NEK1)
ACUN: 113479128(NEK1) 113482713(NEK5) 113485038(NEK4)
PADL: 103913475(NEK5) 103915094(NEK4) 103922554(NEK1)
AAM: 106482187(NEK4) 106484010(NEK1) 106489228(NEK5)
NPD: 112953138(NEK4) 112955383(NEK1) 112959299(NEK5)
ASN: 102370320(NEK4) 102386517(NEK1) 102388857
AMJ: 102559950(NEK4) 102561351(NEK1) 102574416(NEK5)
CPOO: 109306555(NEK5) 109309742(NEK1) 109318275(NEK4)
GGN: 109289223(NEK4) 109300891(NEK1) 109302825(NEK5)
PSS: 102444868(NEK1) 102445572(NEK5) 102454391(NEK4)
CMY: 102937442(NEK5) 102942101(NEK1) 102947290(NEK4)
CPIC: 101940071(NEK1) 101944066(NEK5) 101947554(NEK4)
TST: 117871000(NEK5) 117877583(NEK1) 117880712(NEK4)
CABI: 116826915(NEK5) 116838449(NEK1) 116839686(NEK4)
ACS: 100552798(nek1) 100558250(nek5) 100560174(nek4)
PVT: 110076146(NEK5) 110080625(NEK4) 110085374(NEK1)
PBI: 103055048(NEK1) 103062506 103063229(NEK5)
TSR: 106539383(NEK1) 106549050(NEK5) 106551071(NEK4)
PGUT: 117674294(NEK5) 117678257(NEK4) 117680124(NEK1)
PMUA: 114591594(NEK4) 114593599 114603843(NEK1)
ZVI: 118080632(NEK4) 118082555(NEK5) 118083630(NEK1)
GJA: 107114670(NEK1) 107121776(NEK4) 107125619
XLA: 108699026(nek1.L) 108706631(nek1.S) 108708675(nek5.L) 414527(nek4.S)
XTR: 100036653(nek1) 100497645(nek5) 780225(nek4)
NPR: 108787016(NEK5) 108789893(NEK1) 108791872(NEK4)
DRE: 393987(nek4) 556002(nek1)
IPU: 108260678(nek1) 108266669
PHYP: 113524663(nek5) 113529077(nek1) 113539594(nek4)
AMEX: 103028272(nek1) 103028530 103043005(nek4)
EEE: 113583900(nek4) 113588971(nek1) 113592181(nek5)
TRU: 101071067(nek1) 101079247(nek4)
LCO: 104919071(nek1) 104939100(nek5) 104940452(nek4)
NCC: 104943005(nek4)
ELY: 117248555 117253950(nek1) 117256258(nek4)
PLEP: 121940810(nek1) 121949191 121958169(nek4)
SLUC: 116058850(nek1) 116067266(nek4) 116067593
ECRA: 117943317(nek4) 117951137(nek1) 117953260
PFLV: 114554606(nek4) 114561847(nek1) 114563574
GAT: 120824131(nek1) 120834186 120834624(nek4)
MSAM: 119885620(nek4) 119901088(nek1) 119903798
CUD: 121506869(nek4) 121512796(nek1) 121522298
MZE: 101475406 101481225(nek4) 101481667(nek1)
ONL: 100695804(nek1) 100697929(nek4) 100698951(nek5)
OAU: 116325685 116326450(nek4) 116331216(nek1)
OLA: 101160722(nek1) 101162253 101169778(nek4)
OML: 112136910(nek1) 112140793(nek4) 112141206
XMA: 102219862(nek1) 102225044(nek5) 102230022(nek4)
XCO: 114135537(nek4) 114148161(nek5) 114151345(nek1)
XHE: 116710474(nek4) 116723071(nek5) 116726104(nek1)
PRET: 103460208 103463862(nek1) 103464893(nek4)
CVG: 107090125(nek5) 107103657(nek4) 107103729(nek1)
CTUL: 119774235(nek1) 119790189 119791802(nek4)
NFU: 107385574(nek4) 107389589(nek5) 107396568(nek1)
KMR: 108240191(nek1) 108246853(nek4) 108248630
ALIM: 106526070(nek1) 106527757(nek5) 106534017(nek4)
AOCE: 111566405(nek1) 111570835 111587422(nek4)
CSEM: 103386146(nek4) 103391509(nek5) 103398921(nek1)
POV: 109625849(nek1) 109628882(nek4)
LCF: 108878978(nek1) 108889412(nek4) 108896322
SDU: 111221670(nek4) 111226337(nek1) 111237965
SLAL: 111659579 111660165(nek1) 111667883(nek4)
XGL: 120790913(nek1) 120801466 120807302(nek4)
HCQ: 109515100(nek1) 109519337(nek5) 109522630(nek4)
BPEC: 110154880(nek1) 110162963(nek5) 110168405(nek4)
MALB: 109956038(nek4) 109962096(nek1) 109972591(nek5)
ELS: 105011810(nek1) 105016320(nek5) 105028383(nek4)
PKI: 111840532(nek4) 111850158(nek1) 111854114(nek5)
LOC: 102687337(nek1) 102689791(nek4) 102696477(nek5)
LCM: 102347554(NEK5) 102350772(NEK4) 102367432(NEK1)
CMK: 103177169 103186328(nek1) 103188767(nek4)
RTP: 109919878(nek4) 109932445(nek5) 109935032(nek1)
CGIG: 122400254
ZNE: 110833256
CSEC: 111866412
HAZT: 108676353
EAF: 111703648
AQU: 100639181
ATH: AT1G54510(NEK1) AT3G04810(NEK2) AT3G12200(Nek7) AT3G20860(NEK5) AT3G44200(NEK6) AT3G63280(NEK4) AT5G28290(NEK3)
LJA: Lj0g3v0066389.1(Lj0g3v0066389.1) Lj0g3v0066389.2(Lj0g3v0066389.2) Lj0g3v0200839.1(Lj0g3v0200839.1) Lj0g3v0250989.1(Lj0g3v0250989.1) Lj0g3v0250989.2(Lj0g3v0250989.2) Lj1g3v4446980.1(Lj1g3v4446980.1) Lj1g3v4446980.2(Lj1g3v4446980.2) Lj3g3v1339050.1(Lj3g3v1339050.1) Lj3g3v1339050.2(Lj3g3v1339050.2) Lj5g3v1003590.1(Lj5g3v1003590.1)
DOSA: Os02t0590800-00(Os02g0590800) Os03t0636800-01(Os03g0636800) Os05t0440800-01(Os05g0440800) Os07t0176600-01(Os07g0176600) Os12t0604700-01(Os12g0604700)
PPP: 112279091
MNG: MNEG_0630
APRO: F751_4261
MPP: MICPUCDRAFT_48904(NEK1-like)
DDI: DDB_G0275241(nek3) DDB_G0289277(nek4)
DFA: DFA_05352(nek4) DFA_06011(nek3)
CPV: cgd8_2180
SMIN: v1.2.022548.t1(symbB.v1.2.022548.t1) v1.2.031111.t1(symbB.v1.2.031111.t1)
SPAR: SPRG_01495
TCR: 506851.10
 » show all
Reference
  Authors
Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A
  Title
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
  Journal
Am J Hum Genet 88:106-14 (2011)
DOI:10.1016/j.ajhg.2010.12.004
  Sequence
[hsa:4750]
Reference
PMID:8208544
  Authors
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, et al.
  Title
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
  Journal
Oncogene 9:1977-88 (1994)
  Sequence
[hsa:6787]

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