KEGG   ORTHOLOGY: K09668
Entry
K09668                      KO                                     

Symbol
LARGE
Name
glycosyltransferase-like protein LARGE [EC:2.4.2.- 2.4.1.-]
Pathway
map00515  Mannose type O-glycan biosynthesis
map01100  Metabolic pathways
Module
M00872  O-glycan biosynthesis, mannose type (core M3)
Disease
H00120  Muscular dystrophy-dystroglycanopathy type A
H01960  Muscular dystrophy-dystroglycanopathy type B
H01962  Congenital muscular dystrophy type 1D
H02307  Muscular dystrophy-dystroglycanopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K09668  LARGE; glycosyltransferase-like protein LARGE
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K09668  LARGE; glycosyltransferase-like protein LARGE
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-  
     K09668  LARGE; glycosyltransferase-like protein LARGE
   2.4.2  Pentosyltransferases
    2.4.2.-  
     K09668  LARGE; glycosyltransferase-like protein LARGE
Glycosyltransferases [BR:ko01003]
 Glycan extension
  O-Glycan
   K09668  LARGE; glycosyltransferase-like protein LARGE
Other DBs
RN: R12297 R12298
CAZy: GT8 GT49
Genes
HSA: 120071(LARGE2) 9215(LARGE1)
PTR: 451151(LARGE2) 470192(LARGE1)
PPS: 100973320(LARGE1) 100983244(LARGE2)
GGO: 101141075(LARGE2) 101149289(LARGE1)
PON: 100174135(LARGE1) 100433054(LARGE2)
NLE: 100592217(LARGE1) 100601921(LARGE2)
MCC: 714846(LARGE2) 717403(LARGE1)
MCF: 101925387(LARGE1) 102144935(LARGE2)
CSAB: 103223221(LARGE1) 103236666(LARGE2)
CATY: 105575775(LARGE) 105592790(GYLTL1B)
PANU: 101010541(LARGE2) 101026349(LARGE1)
RRO: 104668383(LARGE2) 104668644(LARGE1)
RBB: 108519281(LARGE2) 108540863(LARGE1)
TFN: 117080073(LARGE2) 117095928(LARGE1)
PTEH: 111524225(LARGE1) 111544914(LARGE2)
CJC: 100410756(LARGE1) 100414072(LARGE2)
SBQ: 101035397(GYLTL1B) 101040901(LARGE)
MMUR: 105864360(LARGE1) 105885250(LARGE2)
MMU: 16795(Large1) 228366(Large2)
MCAL: 110289267(Large2) 110300024(Large1)
MPAH: 110318373(Large2) 110336349(Large1)
RNO: 311202(Large2) 361368(Large1)
MCOC: 116069567(Large1) 116092239(Large2)
MUN: 110549885(Large2) 110555085(Large1)
CGE: 100750932(Large2) 100765249(Large1)
PLEU: 114699710(Large2) 114710595(Large1)
NGI: 103735061(Large2) 103742109(Large1)
HGL: 101699577(Large2) 101713789(Large1)
CPOC: 100724633(Large2) 100736069(Large1)
CCAN: 109689707 109692001(Large2)
OCU: 100346008(LARGE1) 100349053(LARGE2)
OPI: 101517912(LARGE1) 101529192(LARGE2)
TUP: 102489791(LARGE1) 102490949(LARGE2)
CFA: 474521(LARGE1) 483638(LARGE2)
VVP: 112923988(LARGE2) 112929070(LARGE1)
VLG: 121472180(LARGE2) 121491209(LARGE1)
AML: 100466251(LARGE1) 100471450(LARGE2)
UMR: 103672394(LARGE2) 103676447(LARGE1)
UAH: 113256015(LARGE1) 113264992(LARGE2)
ORO: 101372767(LARGE) 101386584(GYLTL1B)
MPUF: 101682057(LARGE) 101686219(GYLTL1B)
EJU: 114197543(LARGE1) 114215127(LARGE2)
MLX: 117998757(LARGE1) 118015804(LARGE2)
FCA: 101085315(LARGE2) 101091463(LARGE1)
PYU: 121040445(LARGE1) 121043479(LARGE2)
PBG: 122472680(LARGE1) 122483748(LARGE2)
PTG: 102949297(LARGE2) 102949773(LARGE1)
PPAD: 109245094(LARGE2) 109265482(LARGE1)
AJU: 106971889(LARGE1) 106978071(LARGE2)
HHV: 120228432(LARGE2) 120230732(LARGE1)
BTA: 506466(LARGE1) 510504(LARGE2)
BOM: 102270818(LARGE2) 102276375(LARGE1)
BIU: 109559490(LARGE1) 109569527(LARGE2)
BBUB: 102398982(LARGE1) 102403363(LARGE2)
CHX: 102183620(LARGE2) 102191587(LARGE1)
OAS: 101117447(LARGE2) 101120155(LARGE1)
ODA: 120858598(LARGE1) 120876923(LARGE2)
CCAD: 122423097(LARGE1) 122449455(LARGE2)
SSC: 100516442(LARGE1) 100517024(LARGE2)
CFR: 102516871(LARGE2) 102518021(LARGE1)
CBAI: 105066830(LARGE) 105076472(GYLTL1B)
CDK: 105097158(LARGE1) 105106854(LARGE2)
BACU: 103006978(LARGE2) 103020347(LARGE1)
LVE: 103077602(LARGE) 103079304(LARGE2)
OOR: 101278232(LARGE) 101288453(GYLTL1B)
DLE: 111183988(LARGE2) 111187799(LARGE1)
PCAD: 102986436(LARGE2) 102989855(LARGE1)
PSIU: 116757673(LARGE2) 116760267(LARGE1)
ECB: 100056834(LARGE2) 100068935(LARGE1)
EAI: 106825739(LARGE1) 106843987(LARGE2)
MYB: 102244531(LARGE2) 102249914(LARGE1)
MYD: 102766947(LARGE1) 102767528(LARGE2)
MMYO: 118649979(LARGE1) 118665092(LARGE2)
MLF: 102417296(LARGE2) 102423999(LARGE1)
MNA: 107530329(GYLTL1B) 107544967(LARGE)
PKL: 118712566(LARGE2) 118728693(LARGE1)
HAI: 109382821(LARGE1) 109390238(LARGE2)
DRO: 112303177(LARGE2) 112321685(LARGE1)
SHON: 118974559(LARGE2) 119002553(LARGE1)
AJM: 119060180(LARGE1) 119064413(LARGE2)
PDIC: 114500496(LARGE2) 114513405(LARGE1)
MMF: 118624159(LARGE1) 118628150(LARGE2)
RFQ: 117028586(LARGE1) 117030031(LARGE2)
PALE: 102886830(LARGE1) 102893810(LARGE2)
PGIG: 120606535(LARGE2) 120614890(LARGE1)
PVP: 105290010(LARGE2) 105311148(LARGE1)
RAY: 107511869(GYLTL1B) 107519213(LARGE)
MJV: 108399895(LARGE1) 108401284(LARGE2) 108408150
TOD: 119247317(LARGE1) 119255322(LARGE2)
LAV: 100667791(LARGE2) 100677041(LARGE1)
MDO: 100016258(LARGE1) 100618746(LARGE2)
GAS: 123250094(LARGE1) 123251026(LARGE2)
SHR: 100913359(LARGE2) 100924845(LARGE1)
PCW: 110205708(LARGE1) 110224034(LARGE2)
OAA: 100073694(LARGE1) 100076327(LARGE2)
GGA: 418062(LARGE1) 423200(LARGE2)
PCOC: 116229176(LARGE2) 116233283(LARGE1)
MGP: 100539641 100550084(LARGE2)
CJO: 107314396(LARGE1) 107314765(LARGE2)
NMEL: 110393484(LARGE1) 110401074(LARGE2)
APLA: 101789764(LARGE1) 101796285(LARGE2)
ACYG: 106035834(LARGE) 106043387(GYLTL1B)
TGU: 100220577(LARGE1) 100226779(LARGE2)
LSR: 110472082(LARGE2) 110483795(LARGE1)
SCAN: 103813208(LARGE1) 103826677(LARGE2)
PMOA: 120500401(LARGE2) 120509979(LARGE1)
OTC: 121333820(LARGE2) 121342335(LARGE1)
PRUF: 121349426(LARGE2) 121361076(LARGE1)
GFR: 102032262(LARGE2) 102042730(LARGE1)
FAB: 101805791(LARGE2) 101818698(LARGE1)
PHI: 102100984(LARGE1) 102101397(LARGE2)
PMAJ: 107204694(LARGE1) 107206293(LARGE2)
CCW: 104688141(LARGE2) 104696264(LARGE1)
ETL: 114058850(LARGE1) 114059184(LARGE2)
FPG: 101913544(LARGE2) 101914724(LARGE1)
FCH: 102055114(LARGE1) 102057914(LARGE2)
CLV: 102087529(LARGE1) 102095199(LARGE2)
EGZ: 104134114(GYLTL1B) 104134282(LARGE)
NNI: 104020369(GYLTL1B) 104020697(LARGE)
ACUN: 113480715(LARGE2) 113482026(LARGE1)
TALA: 104365426(LARGE1) 116961648(LARGE2)
PADL: 103921738(GYLTL1B) 103924454(LARGE)
AAM: 106488787(LARGE1) 106498307(LARGE2)
AROW: 112966086(LARGE2) 112970328
NPD: 112952897(LARGE2) 112958405(LARGE1)
DNE: 112987571(LARGE2) 112993927(LARGE1)
ASN: 102375549(LARGE2) 102381159(LARGE1)
AMJ: 102563100(LARGE1) 102563254(LARGE2)
CPOO: 109316605(LARGE1) 109320903(LARGE2)
GGN: 109296083(LARGE1) 109298915(LARGE2)
PSS: 102443468(LARGE1) 102452146(LARGE2)
CMY: 102941568(LARGE1) 102947188(LARGE2)
CPIC: 101931035(LARGE2) 101949235(LARGE1)
TST: 117876944(LARGE2) 117881078(LARGE1)
CABI: 116815228 116821710(LARGE2)
MRV: 120374624(LARGE1) 120403538(LARGE2)
ACS: 100557465(large2) 100560778(large1)
PVT: 110081684(LARGE2) 110087769
SUND: 121919812(LARGE2) 121930402(LARGE1)
PMUR: 107284721(LARGE1) 107297684(LARGE2)
TSR: 106544120(GYLTL1B) 106554973
PGUT: 117655928(LARGE1) 117665508(LARGE2)
VKO: 123026682(LARGE2) 123028907(LARGE1)
PMUA: 114596062(LARGE2) 114604821(LARGE1)
ZVI: 118085179(LARGE2) 118090665(LARGE1)
GJA: 107108099(LARGE2) 107118339 107124183(LARGE1)
XLA: 108704366 108712551 398936(large2.S) 734944(large2.L)
XTR: 100125087(large2) 100498555(large1)
NPR: 108785457(LARGE2) 108789958(LARGE1)
DRE: 446213(large1) 446214(large2)
CGOB: 115028361
ELY: 117249167(large1) 117253866(large2)
PLEP: 121942110(large2) 121961558(large1)
SLUC: 116061892(large2) 116062245(large1)
ECRA: 117938526(large1)
GAT: 120809118(large2) 120817297(large1)
PPUG: 119210734(large1) 119230182(large2)
MSAM: 119889988(large2) 119918036(large1) 119918037 119918514
CUD: 121505456(large1) 121511729(large2)
OAU: 116313639(large1) 116329920(large2)
OML: 112140075(large2) 112140372(large1)
GAF: 122824429(large2) 122826069(large1)
CTUL: 119771697(large1) 119779092(large2)
KMR: 108241894(large1) 108249394(large2)
CSEM: 103383043
SSEN: 122767311(large1) 122772394(large2)
HHIP: 117757426(large1) 117779423(large2)
XGL: 120796271(large2) 120802620(large1)
SALP: 112080481
AANG: 118219231(large1) 118228131(large2) 118232328
LCM: 102356883(LARGE2) 102357936(LARGE1)
CMK: 103181844(large1) 103191190
RTP: 109910956
BFO: 118413281
BBEL: 109465598
APLC: 110975888
AME: 551749
ACER: 107993815
ALAB: 122718663
BIM: 100748972
BBIF: 117213550
BVK: 117243178
BVAN: 117163339
BTER: 100648019
BPYO: 122568585
CCAL: 108624117
MGEN: 117219016
NMEA: 116429634
CGIG: 122399369
SOC: 105196467
MPHA: 105837446
AEC: 105151389
ACEP: 105617199
PBAR: 105432001
VEM: 105564902
HST: 105180843
DQU: 106751693
CFO: 105254458
FEX: 115239273
LHU: 105668372
PGC: 109859665
OBO: 105279310
PCF: 106785529
PFUC: 122520839
VPS: 122637823
NVI: 100118066
CSOL: 105363412
TPRE: 106650865
CGLO: 123271217
FAS: 105264500
DAM: 107048378
CCIN: 107272201
TCA: 664300
DPA: 109534951
ATD: 109595851
AGB: 108903264
LDC: 111512119
NVL: 108558162
APLN: 108741494
BMOR: 101744219
BMAN: 114242744
MSEX: 115449682
BANY: 112049143
PMAC: 106720799
PPOT: 106111156
PXU: 106120635
PRAP: 110996713
ZCE: 119837456
HAW: 110374165
TNL: 113500366
PXY: 105383503
API: 100161512
AGS: 114130483
RMD: 113551260
BTAB: 109031020
DCI: 103507155
CLEC: 106663369
HHAL: 106688290
NLU: 111055567
FOC: 113202782
ZNE: 110836403
CSEC: 111874195
FCD: 110851331
DMK: 116919986
PVM: 113824569
PJA: 122257119
HAME: 121861622
HAZT: 108665170
EAF: 111707196
DSV: 119449575
RSAN: 119382541
RMP: 119179882
VDE: 111253361
VJA: 111266673
TUT: 107368729
DPTE: 113791731
CSCU: 111631087
PTEP: 107454759
SDM: 118181003
CEL: CELE_K09C8.4(lge-1)
CBR: CBG_17539(Cbr-lge-1)
BMY: BM_BM4952(Bma-lge-1)
TSP: Tsp_04519
PCAN: 112560166
BGT: 106079952
GAE: 121381022
CRG: 105325011
MYI: 110440895
PMAX: 117336173
OBI: 106874133
OSN: 115213840
NVE: 5520897
EPA: 110238176
ATEN: 116307961
ADF: 107345106
AMIL: 114964647
PDAM: 113667602
SPIS: 111321876
DGT: 114530675
HMG: 100213659
 » show all
Reference
  Authors
Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE
  Title
Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
  Journal
Glycobiology 15:912-23 (2005)
DOI:10.1093/glycob/cwi094
  Sequence
[mmu:228366]
Reference
  Authors
Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F
  Title
Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy.
  Journal
Hum Mol Genet 14:657-65 (2005)
DOI:10.1093/hmg/ddi062

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