KEGG   ORTHOLOGY: K09844
Entry
K09844                      KO                                     
Symbol
crtC
Name
carotenoid 1,2-hydratase [EC:4.2.1.131]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K09844  crtC; carotenoid 1,2-hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.131  carotenoid 1,2-hydratase
     K09844  crtC; carotenoid 1,2-hydratase
Other DBs
RN: R07516 R07519 R07522 R07528 R07532 R07536 R07539 R07543 R09790
Genes
ALV: Alvin_2567
ATEP: Atep_25200
TVI: Thivi_2016
TMB: Thimo_3010
MPUR: MARPU_13285
TSY: THSYN_31075
TTP: E6P07_01715
THIP: N838_12470 N838_26735
CJAP: GWK36_12665
THIM: KFB96_13185
HHA: Hhal_1615
LIM: L103DPR2_00984(crtC)
LIH: L63ED372_00639(crtC)
RGE: RGE_33580(crtC)
MXA: MXAN_0898
CCX: COCOR_00783(crtC)
SCL: sce0584(crtC)
BRA: BRADO1613(crtC)
BBT: BBta_6442(crtC)
BRS: S23_19130(crtC)
AOL: S58_59230
BRO: BRAD285_5787(crtC)
RPA: RPA1517(crtC)
RPB: RPB_4006
RPC: RPC_1288
RPD: RPD_3761
RPE: RPE_1320
RPT: Rpal_1705
MDI: METDI3491(crtC)
MEX: Mext_2725
MCH: Mchl_2952
MPO: Mpop_2847
MET: M446_3692
MOR: MOC_3188
META: Y590_13115
MIND: mvi_08930
MSL: Msil_2047
RVA: Rvan_0206
RUT: FIU92_10180(crtC)
JAN: Jann_0184(crtC)
RDE: RD1_0116(crtC)
RLI: RLO149_p940110(crtC)
DSH: Dshi_3512(crtC)
RMM: ROSMUCSMR3_00910(crtC)
ROH: FIU89_14260(crtC)
MARU: FIU81_13885(crtC)
ROT: FIV09_18045(crtC)
MALU: KU6B_16380(crtC)
RSP: RSP_0267(crtC)
RCP: RCAP_rcc00682(crtC)
PTP: RCA23_c29570(crtC)
RSU: NHU_04282
RHC: RGUI_1966
LVS: LOKVESSMR4R_03674(crtC)
SPHI: TS85_22885
SSAN: NX02_18470
BLAS: BSY18_2719
ERF: FIU90_13810(crtC)
AMV: ACMV_18840(crtC)
RAP: RHOA_2423
RRU: Rru_A2985
RRF: F11_15290
RPM: RSPPHO_02322(crtC)
IPA: Isop_1565
CTE: CT0301(crtC)
CPC: Cpar_1736
CCH: Cag_0393
CLI: Clim_0360
PVI: Cvib_1502
PLT: Plut_1720
PPH: Ppha_0465
PAA: Paes_1781
CTS: Ctha_1182
CPRV: CYPRO_1942
AG: AAP59035(crtC)
 » show all
Reference
PMID:7721699
  Authors
Lang HP, Cogdell RJ, Takaichi S, Hunter CN.
  Title
Complete DNA sequence, specific Tn5 insertion map, and gene assignment of the carotenoid biosynthesis pathway of Rhodobacter sphaeroides.
  Journal
J Bacteriol 177:2064-73 (1995)
DOI:10.1128/JB.177.8.2064-2073.1995
  Sequence
[rsp:RSP_0267]

KEGG   ENZYME: 4.2.1.131
Entry
EC 4.2.1.131                Enzyme                                 
Name
carotenoid 1,2-hydratase;
CrtC
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming)
Reaction(IUBMB)
(1) 1-hydroxy-1,2-dihydrolycopene = lycopene + H2O [RN:R07519];
(2) 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = 1-hydroxy-1,2-dihydrolycopene + H2O [RN:R09790]
Reaction(KEGG)
Substrate
1-hydroxy-1,2-dihydrolycopene [CPD:C19795];
1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene [CPD:C19894]
Product
lycopene [CPD:C05432];
H2O [CPD:C00001];
1-hydroxy-1,2-dihydrolycopene [CPD:C19795]
Comment
In Rubrivivax gelatinosus [1] and Thiocapsa roseopersicina [2] both products are formed, whereas Rhodobacter capsulatus [1] only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene only with Rubrivivax gelatinosus.
History
EC 4.2.1.131 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09844  carotenoid 1,2-hydratase
Genes
ALVAlvin_2567
ATEPAtep_25200
TVIThivi_2016
TMBThimo_3010
MPURMARPU_13285
TSYTHSYN_31075
TTPE6P07_01715
THIPN838_12470 N838_26735
CJAPGWK36_12665
THIMKFB96_13185
TBOGLT988_08930
HHAHhal_1615
HHKHH1059_06240
HHCM911_10375
EBSECTOBSL9_3051
PDQCL55_00013480
PANIDCO16_03410
PCOSC2747_06900
RACRA876_06055
LIML103DPR2_00984(crtC)
LIHL63ED372_00639(crtC)
HYRBSY239_1369
HCZG9Q37_00105
METPC1M51_03600
RGERGE_33580(crtC)
RBNRBXJA2T_09497
RDPRD2015_1032
ATERMW290_02545
METRBSY238_2444
BEBAEM42_07450
MXAMXAN_0898
MSDMYSTI_00908
MYMA176_006083
MFBMFUL124B02_05140
CCXCOCOR_00783(crtC)
MFULILAB_04220
MMASMYMAC_000922
SURSTAUR_7077
AGEAA314_01870
AVMJQX13_22185
MBDMEBOL_004337
CFUSCYFUS_001184
SCLsce0584(crtC)
SCUSCE1572_04050
CCROCMC5_014480
PAUUE8A73_015955
MRMA7982_08936
BSEDDN745_03195
PCAYFRD00_10885
BBAEFRD01_09570
RPODE0E05_11765
AGCBSY240_3674
RROSD4A92_02610
ABAWD5400_04855
PDESFE840_002300
BRABRADO1613(crtC)
BBTBBta_6442(crtC)
BRSS23_19130(crtC)
AOLS58_59230
BROBRAD285_5787(crtC)
BRQCIT40_23965
BBETF8237_24650
RPARPA1517(crtC)
RPBRPB_4006
RPCRPC_1288
RPDRPD_3761
RPERPE_1320
RPTRpal_1705
RPXRpdx1_4003
BOSBSY19_4061
MEAMex_1p2922
MDIMETDI3491(crtC)
MEXMext_2725
MCHMchl_2952
MPOMpop_2847
MZAB2G69_21165
MRDMrad2831_2823
METM446_3692
MORMOC_3188
METAY590_13115
MAQUMaq22A_1p32520
MPHYMCBMB27_02264
MEEDA075_03935
METDC0214_15280
METXA3862_17675
METSDK389_31460
METIDK427_17920
MMESMMSR116_13590
MTEADK419_04890
MINDmvi_08930
MOGMMB17_23910
MTADM6G65_16650
MSLMsil_2047
BBARRHAL1_03019
RVARvan_0206
MROSEHO51_17010
CMETK6K41_01650
AUZSa4125_27800
AUBLXB15_06400
BSBBresu_3049
BRLBZG35_15475
RUTFIU92_10180(crtC)
JANJann_0184(crtC)
RDERD1_0116(crtC)
RLIRLO149_p940110(crtC)
RPONG3256_18635
DSHDshi_3512(crtC)
REDroselon_01073
SUAMBOO69_19435
TOMBWR18_20215
RMMROSMUCSMR3_00910(crtC)
ROKRAK1035_3779
RIDRIdsm_01750
ROMEI983_05415
ROHFIU89_14260(crtC)
THAACFI11_23525
MARUFIU81_13885(crtC)
ROTFIV09_18045(crtC)
RMHLVO79_17395
MALUKU6B_16380(crtC)
RSPRSP_0267(crtC)
RSHRsph17029_1911
RSQRsph17025_2041
RSKRSKD131_1594
CAZTLV780_09100
RCPRCAP_rcc00682(crtC)
RBLB6K69_00165
PTPRCA23_c29570(crtC)
RSUNHU_04282
RHMB5V46_17510
RHCRGUI_1966
LVSLOKVESSMR4R_03674(crtC)
RBGBG454_03010
GEHHYN69_05500
TAWEI545_18920
POZI0K15_00035
NSMJO391_16440
FAQG5B39_11905
HBCAEM38_14605
NOTC7W88_00460
NGFFRF71_09125
NOGGKE62_08415
SPHITS85_22885
SSANNX02_18470
CIJWG74_05025
BLASBSY18_2719
BFWB5J99_04545
PALGHFP57_06970
PARJJ4G78_07555
SANDH3309_05730
POQKZX46_18725
PMEAKTC28_17035
ALHG6N82_11410
ELQGa0102493_111842
ERKCD351_13850
ERFFIU90_13810(crtC)
PNSA9D12_01270
PORLBG023_112666
PHZCHX26_14480
POTE2E27_07355
AMVACMV_18840(crtC)
SRFLHU95_13835
RAPRHOA_2423
NCBC0V82_18190
SKTIGS68_17140
SMUCJL100_008895
SROEJL101_015320
RRURru_A2985
RRFF11_15290
RPMRSPPHO_02322(crtC)
ELIOKO353_03100
IPAIsop_1565
HBSIPV69_02315
CTMCabther_A0575
CVLJ8C06_08655
CTECT0301(crtC)
CPCCpar_1736
CLZBIU88_01405
CCHCag_0393
CPHCpha266_0428
CPBCphamn1_1988
CLIClim_0360
PVICvib_1502
PLTPlut_1720
PPHPpha_0465
PAAPaes_1781
PROCPtc2401_01879
PRSB9H02_08945
PROSCHL67_02450
CTSCtha_1182
CPRVCYPRO_1942
 » show all
Reference
1  [PMID:12745254]
  Authors
Steiger S, Mazet A, Sandmann G
  Title
Heterologous expression, purification, and enzymatic characterization of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus.
  Journal
Arch Biochem Biophys 414:51-8 (2003)
DOI:10.1016/S0003-9861(03)00099-7
  Sequence
Reference
2  [PMID:21590288]
  Authors
Hiseni A, Arends IW, Otten LG
  Title
Biochemical characterization of the carotenoid 1,2-hydratases (CrtC) from Rubrivivax gelatinosus and Thiocapsa roseopersicina.
  Journal
Appl Microbiol Biotechnol 91:1029-36 (2011)
DOI:10.1007/s00253-011-3324-1
  Sequence
[rge:RGE_33580] [ag:AAP59035]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.131
IUBMB Enzyme Nomenclature: 4.2.1.131
ExPASy - ENZYME nomenclature database: 4.2.1.131
BRENDA, the Enzyme Database: 4.2.1.131

KEGG   REACTION: R07516
Entry
R07516                      Reaction                               
Name
lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming)
Definition
gamma-Carotene + H2O <=> 1'-Hydroxy-gamma-carotene
Equation
Comment
hydroxyneurosporene dehydrogenase(crtC)
Reaction class
RC00966  C05435_C15859
Enzyme
Pathway
rn00906  Carotenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K09844  carotenoid 1,2-hydratase [EC:4.2.1.131]

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