KEGG   ORTHOLOGY: K10160
Entry
K10160                      KO                                     

Symbol
TLR4, CD284
Name
toll-like receptor 4
Pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04145  Phagosome
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05144  Malaria
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05205  Proteoglycans in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05417  Lipid and atherosclerosis
Disease
H00821  Age-related macular degeneration
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04066 HIF-1 signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04151 PI3K-Akt signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10160  TLR4, CD284; toll-like receptor 4
  09143 Cell growth and death
   04217 Necroptosis
    K10160  TLR4, CD284; toll-like receptor 4
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K10160  TLR4, CD284; toll-like receptor 4
   04620 Toll-like receptor signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04621 NOD-like receptor signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K10160  TLR4, CD284; toll-like receptor 4
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K10160  TLR4, CD284; toll-like receptor 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K10160  TLR4, CD284; toll-like receptor 4
   05161 Hepatitis B
    K10160  TLR4, CD284; toll-like receptor 4
   05171 Coronavirus disease - COVID-19
    K10160  TLR4, CD284; toll-like receptor 4
   05164 Influenza A
    K10160  TLR4, CD284; toll-like receptor 4
   05162 Measles
    K10160  TLR4, CD284; toll-like receptor 4
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K10160  TLR4, CD284; toll-like receptor 4
   05132 Salmonella infection
    K10160  TLR4, CD284; toll-like receptor 4
   05131 Shigellosis
    K10160  TLR4, CD284; toll-like receptor 4
   05135 Yersinia infection
    K10160  TLR4, CD284; toll-like receptor 4
   05133 Pertussis
    K10160  TLR4, CD284; toll-like receptor 4
   05134 Legionellosis
    K10160  TLR4, CD284; toll-like receptor 4
   05152 Tuberculosis
    K10160  TLR4, CD284; toll-like receptor 4
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K10160  TLR4, CD284; toll-like receptor 4
   05144 Malaria
    K10160  TLR4, CD284; toll-like receptor 4
   05145 Toxoplasmosis
    K10160  TLR4, CD284; toll-like receptor 4
   05140 Leishmaniasis
    K10160  TLR4, CD284; toll-like receptor 4
   05142 Chagas disease
    K10160  TLR4, CD284; toll-like receptor 4
  09163 Immune disease
   05323 Rheumatoid arthritis
    K10160  TLR4, CD284; toll-like receptor 4
   05321 Inflammatory bowel disease
    K10160  TLR4, CD284; toll-like receptor 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K10160  TLR4, CD284; toll-like receptor 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K10160  TLR4, CD284; toll-like receptor 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10160  TLR4, CD284; toll-like receptor 4
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K10160  TLR4, CD284; toll-like receptor 4
   04090 CD molecules
    K10160  TLR4, CD284; toll-like receptor 4
   00536 Glycosaminoglycan binding proteins
    K10160  TLR4, CD284; toll-like receptor 4
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    K10160  TLR4, CD284; toll-like receptor 4
Pattern recognition receptors [BR:ko04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   K10160  TLR4, CD284; toll-like receptor 4
CD molecules [BR:ko04090]
 Proteins
  K10160  CD284, TLR4; toll-like receptor 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Hyaluronan
  Cell surface receptors
   K10160  TLR4, CD284; toll-like receptor 4
Genes
HSA: 7099(TLR4)
PTR: 743242(TLR4)
PPS: 100980644(TLR4)
GGO: 101148715(TLR4)
PON: 100457237(TLR4)
NLE: 100601154(TLR4)
MCC: 574360(TLR4)
MCF: 102136906(TLR4)
CSAB: 103218937(TLR4)
CATY: 105600415(TLR4)
PANU: 101009041(TLR4)
RRO: 104658520(TLR4)
RBB: 108530054(TLR4)
TFN: 117098762(TLR4)
PTEH: 111550322(TLR4)
CJC: 100399012(TLR4)
SBQ: 101043935(TLR4)
MMUR: 105873668(TLR4)
MMU: 21898(Tlr4)
MCAL: 110293229(Tlr4)
MPAH: 110323586(Tlr4)
RNO: 29260(Tlr4)
MCOC: 116096145(Tlr4)
MUN: 110565332(Tlr4)
CGE: 100689329(Tlr4)
PLEU: 114705782(Tlr4)
NGI: 103734505(Tlr4)
HGL: 101715916(Tlr4)
CCAN: 109700701(Tlr4)
OCU: 100009497(TLR4)
TUP: 102501464(TLR4)
CFA: 403417(TLR4)
VVP: 112923099(TLR4)
VLG: 121496246(TLR4)
AML: 100472815(TLR4)
UMR: 103670382(TLR4)
UAH: 113266343(TLR4)
ORO: 101371071(TLR4)
ELK: 111146042
MPUF: 101690347(TLR4)
EJU: 114212737(TLR4)
MLX: 118017761(TLR4)
FCA: 493698(TLR4)
PTG: 102959529(TLR4)
PPAD: 109269905(TLR4)
AJU: 106977278(TLR4)
HHV: 120240966(TLR4)
BTA: 281536(TLR4)
BOM: 102288174(TLR4)
BIU: 109563399(TLR4)
BBUB: 102407022(TLR4)
CHX: 100860955(TLR4)
OAS: 554263(TLR4)
ODA: 120864691(TLR4)
SSC: 399541(TLR4)
CFR: 102522349(TLR4)
CBAI: 105070721(TLR4)
CDK: 105104576(TLR4)
BACU: 103015759(TLR4)
LVE: 103074659(TLR4)
OOR: 101282217(TLR4)
DLE: 111177277(TLR4)
PCAD: 102983076(TLR4)
ECB: 100066890(TLR4) 111771935
EPZ: 103562040(TLR4)
EAI: 106824214(TLR4)
MYB: 102253644(TLR4)
MYD: 102756242(TLR4)
MMYO: 118667106(TLR4)
MNA: 107537636(TLR4)
HAI: 109385740(TLR4)
DRO: 112306266(TLR4)
SHON: 118995970(TLR4)
AJM: 119056324(TLR4)
MMF: 118629497(TLR4)
PALE: 102897365(TLR4)
PGIG: 120605781(TLR4)
RAY: 107514466(TLR4)
MJV: 108400680(TLR4)
TOD: 119232116(TLR4)
LAV: 100654493(TLR4)
TMU: 101353470
MDO: 100014467(TLR4)
SHR: 100927125(TLR4)
PCW: 110211357(TLR4)
OAA: 100077751 114811053(TLR4)
GGA: 417241(TLR4)
PCOC: 116234179(TLR4)
MGP: 100540712(TLR4)
CJO: 107321682(TLR4)
NMEL: 110406939(TLR4)
APLA: 101799388(TLR4)
ACYG: 106037141(TLR4)
TGU: 100216357(TLR4)
LSR: 110482234(TLR4)
SCAN: 103819051(TLR4)
PMOA: 120507511(TLR4)
GFR: 102037892(TLR4)
FAB: 101813378(TLR4)
PHI: 102101350(TLR4)
PMAJ: 107211898(TLR4)
CCAE: 111936941(TLR4)
CCW: 104688244(TLR4)
ETL: 114054565(TLR4)
FPG: 101922930(TLR4)
FCH: 102055613(TLR4)
CLV: 102096659(TLR4)
EGZ: 104122702(TLR4)
NNI: 104022122(TLR4)
ACUN: 113486459(TLR4)
PADL: 103912903(TLR4)
AAM: 106499946(TLR4)
ASN: 102383551(TLR4)
AMJ: 102574232(TLR4)
CPOO: 109313858(TLR4)
GGN: 109292881(TLR4)
PSS: 102448887(TLR4)
CMY: 102941701(TLR4)
CPIC: 101954201(TLR4)
TST: 117867273(TLR4)
CABI: 116835169(TLR4)
ACS: 100559216(tlr4)
PVT: 110088887(TLR4)
PBI: 103060306(TLR4)
PMUR: 107285740(TLR4)
TSR: 106546496(TLR4)
PGUT: 117656869(TLR4)
PMUA: 114589367(TLR4)
ZVI: 118083676(TLR4)
GJA: 107106055(TLR4)
XLA: 108700046
NPR: 108794768
DRE: 403131(tlr4ba) 403132(tlr4bb) 795671(tlr4al)
CCAR: 109100795
IPU: 108263518(TLR4-1)
PHYP: 113538004
LOC: 102693850(tlr4)
PSPA: 121303579
ARUT: 117396808
 » show all
Reference
PMID:9237759
  Authors
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr
  Title
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
  Journal
Nature 388:394-7 (1997)
DOI:10.1038/41131
  Sequence
[hsa:7099]
Reference
  Authors
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ
  Title
Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis.
  Journal
J Pediatr Surg 42:927-32; discussion 933 (2007)
DOI:10.1016/j.jpedsurg.2007.01.023
  Sequence
[mmu:21898]
Reference
  Authors
Schmidt M, Raghavan B, Muller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M
  Title
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.
  Journal
Nat Immunol 11:814-9 (2010)
DOI:10.1038/ni.1919
  Sequence
[hsa:7099]

KEGG   ORTHOLOGY: K10159
Entry
K10159                      KO                                     

Symbol
TLR2, CD282
Name
toll-like receptor 2
Pathway
map04145  Phagosome
map04151  PI3K-Akt signaling pathway
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map05132  Salmonella infection
map05134  Legionellosis
map05140  Leishmaniasis
map05142  Chagas disease
map05144  Malaria
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05205  Proteoglycans in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05417  Lipid and atherosclerosis
Disease
H00344  Leprosy
H01358  Atopic dermatitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K10159  TLR2, CD282; toll-like receptor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10159  TLR2, CD282; toll-like receptor 2
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K10159  TLR2, CD282; toll-like receptor 2
   04620 Toll-like receptor signaling pathway
    K10159  TLR2, CD282; toll-like receptor 2
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K10159  TLR2, CD282; toll-like receptor 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K10159  TLR2, CD282; toll-like receptor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K10159  TLR2, CD282; toll-like receptor 2
   05161 Hepatitis B
    K10159  TLR2, CD282; toll-like receptor 2
   05171 Coronavirus disease - COVID-19
    K10159  TLR2, CD282; toll-like receptor 2
   05162 Measles
    K10159  TLR2, CD282; toll-like receptor 2
   05168 Herpes simplex virus 1 infection
    K10159  TLR2, CD282; toll-like receptor 2
   05169 Epstein-Barr virus infection
    K10159  TLR2, CD282; toll-like receptor 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K10159  TLR2, CD282; toll-like receptor 2
   05134 Legionellosis
    K10159  TLR2, CD282; toll-like receptor 2
   05152 Tuberculosis
    K10159  TLR2, CD282; toll-like receptor 2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K10159  TLR2, CD282; toll-like receptor 2
   05144 Malaria
    K10159  TLR2, CD282; toll-like receptor 2
   05145 Toxoplasmosis
    K10159  TLR2, CD282; toll-like receptor 2
   05140 Leishmaniasis
    K10159  TLR2, CD282; toll-like receptor 2
   05142 Chagas disease
    K10159  TLR2, CD282; toll-like receptor 2
  09163 Immune disease
   05323 Rheumatoid arthritis
    K10159  TLR2, CD282; toll-like receptor 2
   05321 Inflammatory bowel disease
    K10159  TLR2, CD282; toll-like receptor 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K10159  TLR2, CD282; toll-like receptor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10159  TLR2, CD282; toll-like receptor 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K10159  TLR2, CD282; toll-like receptor 2
   04054 Pattern recognition receptors
    K10159  TLR2, CD282; toll-like receptor 2
   04090 CD molecules
    K10159  TLR2, CD282; toll-like receptor 2
   00536 Glycosaminoglycan binding proteins
    K10159  TLR2, CD282; toll-like receptor 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    K10159  TLR2, CD282; toll-like receptor 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   K10159  TLR2, CD282; toll-like receptor 2
Pattern recognition receptors [BR:ko04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   K10159  TLR2, CD282; toll-like receptor 2
CD molecules [BR:ko04090]
 Proteins
  K10159  CD282, TLR2; toll-like receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Hyaluronan
  Cell surface receptors
   K10159  TLR2, CD282; toll-like receptor 2
Genes
HSA: 7097(TLR2)
PTR: 471325(TLR2)
PPS: 100994768(TLR2)
GGO: 101128447(TLR2)
PON: 100456464(TLR2)
NLE: 100604724(TLR2)
MCC: 574290(TLR2)
MCF: 102146068(TLR2)
CSAB: 103236415
CATY: 105580685(TLR2)
PANU: 103884712(TLR2)
RRO: 104677747(TLR2)
RBB: 108529041(TLR2)
TFN: 117086043
PTEH: 111553190(TLR2)
CJC: 100404611(TLR2)
SBQ: 101045472(TLR2)
MMUR: 105881794(TLR2)
MMU: 24088(Tlr2)
MCAL: 110291353(Tlr2)
MPAH: 110320724(Tlr2)
RNO: 310553(Tlr2)
MCOC: 116093042(Tlr2)
MUN: 110541773(Tlr2)
CGE: 100771475(Tlr2)
PLEU: 114710188(Tlr2)
NGI: 103750991(Tlr2)
HGL: 101724657(Tlr2)
CCAN: 109701180(Tlr2)
OCU: 100009578(TLR2)
TUP: 102482498(TLR2)
CFA: 448807(TLR2)
VVP: 112933419(TLR2)
VLG: 121480909(TLR2)
AML: 100465129(TLR2)
UMR: 103658031
UAH: 113255769(TLR2)
ORO: 101363280(TLR2) 101367407
ELK: 111154734
MPUF: 101681595(TLR2)
EJU: 114210089(TLR2)
MLX: 118022230(TLR2) 118022538
FCA: 493797(TLR2)
PPAD: 109262509(TLR2)
AJU: 106982476
HHV: 120233209(TLR2)
BTA: 281534(TLR2)
BOM: 102268835(TLR2)
BIU: 109571498(TLR2)
BBUB: 102397791(TLR2)
CHX: 100860747(TLR2)
OAS: 554262(TLR2)
ODA: 120871484(TLR2)
SSC: 396623(TLR2)
CFR: 102523960(TLR2)
CBAI: 105079727(TLR2)
CDK: 105099662(TLR2)
BACU: 102998386(TLR2)
LVE: 103090179
OOR: 101276053
DLE: 111187714(TLR2)
PCAD: 102976342(TLR2)
ECB: 100009701(TLR2)
EPZ: 103553736(TLR2)
EAI: 106821799(TLR2)
MYB: 102256005(TLR2)
MYD: 102761137(TLR2)
MMYO: 118658736(TLR2)
MNA: 107525584(TLR2)
HAI: 109382017(TLR2)
DRO: 112312607(TLR2)
SHON: 118995387(TLR2)
AJM: 119065905(TLR2)
MMF: 118616119(TLR2)
PALE: 102893057(TLR2)
PGIG: 120613273(TLR2)
RAY: 107510758(TLR2)
MJV: 108390634(TLR2)
TOD: 119233466(TLR2)
LAV: 100654442(TLR2)
TMU: 101342847
MDO: 100024558(TLR2)
SHR: 100932981(TLR2)
PCW: 110213633(TLR2)
OAA: 100081248(TLR2)
GGA: 374141(TLR2A) 769014(TLR2B)
NMEL: 110398324(TLR2)
APLA: 101791786(TLR2) 110351185
ACYG: 106032264(TLR2) 106049058
TGU: 100219691(TLR2)
SCAN: 103826229(TLR2)
PMAJ: 107202976(TLR2)
CCW: 104697168(TLR2) 120409612
ETL: 114066323(TLR2)
FCH: 102051584(TLR2) 102058278
CLV: 102084454 102084767(TLR2)
ACUN: 113479805 113479806(TLR2)
AMJ: 102569653 102571171(CD14) 102572093(TLR2) 106740518(TLR2)
CPOO: 109309593(TLR2) 109309681
GGN: 109300368 109300828(TLR2)
PMUR: 107283615(CD14) 107288063 107289574(TLR2)
TSR: 106544777(TLR2) 106553961
PGUT: 117662113(TLR2) 117671348
PMUA: 114586776 114601154(CD14)
ZVI: 118076498 118079342(CD14) 118084395(TLR2)
DRE: 403125(tlr2) 403133(tlr18)
IPU: 108258959(tlr2) 108272691(TLR18)
PHYP: 113533829 113535686(tlr2)
TRU: 101068527 101068557(tlr2)
NCC: 104943968
ECRA: 117945977(tlr18) 117962114
GAT: 120811005(tlr18) 120822770(tlr2)
KMR: 108239773 108243184(tlr18) 108248293(tlr2)
AOCE: 111586854(tlr2)
CSEM: 103388693
POV: 109633418 109646959(tlr2)
XGL: 120784198(tlr18) 120797238(tlr2)
HCQ: 109512204
MALB: 109968926
OMY: 100750259(tlr2) 110487251(tlr18) 110514733
ELS: 105028681 105030906(tlr2)
SFM: 108926796
PKI: 111838449
LOC: 102687114 107077084(tlr2)
PSPA: 121309885(tlr18) 121327847(tlr2) 121331267
OTU: 111421891
BANY: 112052573
CSEC: 111866701
HAME: 121853834
DSV: 119456459
CSCU: 111628016
PCAN: 112561167
BGT: 106067351
CRG: 105324722
AMIL: 114952281
PDAM: 113685912
DGT: 114528769
 » show all
Reference
PMID:9596645
  Authors
Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS
  Title
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
  Journal
Blood 91:4020-7 (1998)
  Sequence
[hsa:7097]
Reference
  Authors
Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO
  Title
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.
  Journal
Immunity 31:873-84 (2009)
DOI:10.1016/j.immuni.2009.09.018
  Sequence
[mmu:24088]

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