KEGG   ORTHOLOGY: K10221
Entry
K10221                      KO                                     
Symbol
ligI
Name
2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57]
Pathway
map00362  Benzoate degradation
map00627  Aminobenzoate degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K10221  ligI; 2-pyrone-4,6-dicarboxylate lactonase
   00627 Aminobenzoate degradation
    K10221  ligI; 2-pyrone-4,6-dicarboxylate lactonase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.57  2-pyrone-4,6-dicarboxylate lactonase
     K10221  ligI; 2-pyrone-4,6-dicarboxylate lactonase
Other DBs
RN: R04277
GO: 0047554
Genes
CAMA: F384_17445
CFAR: CI104_02855
CTEL: GBC03_28060
SFG: AV650_17165
SOD: Sant_P0178
SRH: BAY15_1814
SLM: BIZ42_18450
LRZ: BJI69_03965
LPY: FIV34_03355
VNA: PN96_18540
PPF: Pput_1365
PSIL: PMA3_19000
PAT: Patl_3887
ADI: B5T_01356
AJP: AMJAP_1185(ligI)
SALN: SALB1_0063
AMAH: DLM_2157
CGD: CR3_3624
BMK: DM80_94
BMUL: NP80_1640
BPSL: WS57_24960
BGO: BM43_5655
BXB: DR64_7785
BPH: Bphy_3206
BFN: OI25_113
PSPU: NA29_20840
PAPI: SG18_00020
HYF: DTO96_100891(ligI)
BPAR: BN117_2264
BPA: BPP1284
BBR: BB2349
BHZ: ACR54_02168 ACR54_03619(ligI_2)
PUT: PT7_3226
AFQ: AFA_05525
RFR: Rfer_0332
PNA: Pnap_2029
PVAC: HC248_00682(ligI_1) HC248_01466(ligI_2)
AAV: Aave_4267
AAA: Acav_4169
ACRA: BSY15_1205
DAC: Daci_4447
CTES: O987_16270
RTA: Rta_24780
LIM: L103DPR2_01496(ligI)
LIH: L63ED372_01143(ligI_1)
HYB: Q5W_10750
HPSE: HPF_08075(ligI1)
CBAA: SRAA_1352
CBAB: SMCB_0793
LCH: Lcho_3635
URU: DSM104443_02499(pmdD_2)
ABRE: pbN1_38950
AZO: azo2539(ligI)
AOA: dqs_2696
TCL: Tchl_1060
AVP: AVENP_2168(ligI)
MES: Meso_3726
ARA: Arad_8733
RLE: pRL120277(ligI)
BRA: BRADO2340(ligI) BRADO2391
BBT: BBta_2700(ligI) BBta_2744
BRO: BRAD285_4997(ligI)
RPA: RPA4700(ligI)
RPB: RPB_0874
RPD: RPD_0984
RPE: RPE_0749
RPT: Rpal_5181
MOR: MOC_1297
MMED: Mame_04561
MALG: MALG_02281
AHT: ANTHELSMS3_03529(ligI)
MALU: KU6B_25090
NAR: Saro_2819
SMAZ: LH19_17725
SPHI: TS85_18485
SSAN: NX02_17535
SINB: SIDU_17225
SSY: SLG_12570(ligI) SLG_31300
SPHB: EP837_03485(ligI)
SPHR: BSY17_3453(ligI)
SFLA: SPHFLASMR4Y_02981(ligI)
BLAS: BSY18_3517(ligI)
ALB: AEB_P0191
AAY: WYH_01902(ligI)
ADO: A6F68_01086(ligI)
SHUM: STHU_14070
ABS: AZOBR_p310190(ligI)
MAG: amb0254
MAGX: XM1_1090(ligI)
MAGN: WV31_13610
MAGQ: MGMAQ_2663(ligI)
CCYC: SCMU_02400(pcmC)
SALB: XNR_3393
SMAL: SMALA_3249
SFA: Sfla_0533
STRP: F750_6349
STRD: NI25_00230
SLAU: SLA_7097
SHUN: DWB77_01944(ligI)
KSK: KSE_75150(pcmC)
MOO: BWL13_00075(ligI)
AMIN: AUMI_19400
AUW: AURUGA1_00418(ligI)
ART: Arth_4374
ACH: Achl_3359
SEN: SACE_5048(ligI)
AMQ: AMETH_1375(ligI) AMETH_3608(ligI)
PSEE: FRP1_17600
 » show all
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
  Sequence
[ssy:SLG_12570]

KEGG   ENZYME: 3.1.1.57
Entry
EC 3.1.1.57                 Enzyme                                 
Name
2-pyrone-4,6-dicarboxylate lactonase;
2-pyrone-4,6-dicarboxylate hydrolase;
2-pyrone-4,6-dicarboxylate lactonohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase
Reaction(IUBMB)
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN:R04277]
Reaction(KEGG)
R04277
Substrate
2-oxo-2H-pyran-4,6-dicarboxylate;
H2O [CPD:C00001]
Product
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD:C04434]
Comment
The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].
History
EC 3.1.1.57 created 1986, modified 2010
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10221  2-pyrone-4,6-dicarboxylate lactonase
Genes
CAMAF384_17445
CFARCI104_02855
CTELGBC03_28060
SFGAV650_17165
SODSant_P0178
SRHBAY15_1814
SLMBIZ42_18450
LRZBJI69_03965
LPYFIV34_03355
VNAPN96_18540
VEJVEJY3_18106
VFLAL536_10305
VZIG5S32_20200
PPFPput_1365
PORAPT59_12355
PFEPSF113_3475
PMEDE3Z27_14230
PLULFOB45_15885
PSILPMA3_19000
PEZHWQ56_16715
EMODM558_04795
MARAD0851_19030
ASEII8T81_09360
PATPatl_3887
PCARPC2016_2102
AAWAVL56_08870
ALRDS731_01470
NAXHC341_04190
ADIB5T_01356
MMWMmwyl1_3940
MMEMarme_0834
MPCMar181_0382
MPRIMP3633_0450
MARDIBG28_02955
MFOIJSY38_12240
MPRFJ8N69_06135
MGEOCFI10_14880
MARLHH196_02865
AJPAMJAP_1185(ligI)
GSNYC6258_04097
RFOREIFOR_00531
SALNSALB1_0063
NAQD0T90_09315
NBLGJV52_09135
VFFVITFI_CDS3222
VITADP71_27530
VSTLVJ81_00720
VMSLVJ82_10335
AMAHDLM_2157
AQSDKK66_18675
RPJN234_30685
RINACS15_1397
REUReut_C5930
CGDCR3_3624
CPAUEHF44_18960
COXE0W60_28375
BCENDM39_1238 DM39_4038 DM39_4100 DM39_6517
BMKDM80_94
BMULNP80_1640
BPSLWS57_24960
BGFBC1003_5360
BGDbgla_2g19270
BGOBM43_5655
BUQAC233_04830 AC233_29335
BGPBGL_1c25240
BPLAbpln_1g24790
BXBDR64_7785
BPHBphy_3206
BPXBUPH_06640
BFNOI25_113
BCAIK788_0006188
PARABTO02_04400 BTO02_05925 BTO02_23040
PHSC2L64_34390 C2L64_37600
PTERC2L65_33605
PGPCUJ91_26860
PCJCUJ87_23740
PMEGFNZ07_25800
PACSFAZ98_22755 FAZ98_30405 FAZ98_33245 FAZ98_33260
PEWKZJ38_18180 KZJ38_19275
PDQCL55_00003560
PSPUNA29_20840
PAPISG18_00020
POXMB84_11910
PTXABW99_00705 ABW99_15630
PFGAB870_18240
PNRAT302_25990
PFIBPI93_003455 PI93_020295
HYFDTO96_100891(ligI)
BPARBN117_2264
BPABPP1284
BBHBN112_0173
BBRBB2349
BBXBBS798_2187
BHOD560_0873 D560_3710
BHMD558_0859 D558_3685
BHZACR54_02168 ACR54_03619(ligI_2)
BBROBAU06_03665 BAU06_04480 BAU06_06650 BAU06_13430 BAU06_18535
BFZBAU07_03750 BAU07_04035 BAU07_04450 BAU07_07810 BAU07_13120 BAU07_13515 BAU07_16320 BAU07_19595
BPDZBBN53_10960
BOHAKI39_03430 AKI39_06460 AKI39_09600 AKI39_11980 AKI39_12615 AKI39_16390 AKI39_17745 AKI39_20815 AKI39_22565
BGMCAL15_05970 CAL15_12605
BOJCBF45_13160
AXONH44784_001151 NH44784_058711
AXNAX27061_1863
AXXERS451415_01862
ADTAPT56_08855
AISBUW96_00550
ASWCVS48_21110 CVS48_26370
ACHRC2U31_15515
ACHBDVB37_07935 DVB37_11190
ADYHLG70_13200
PUTPT7_3226
PUSCKA81_10530
AKATKWG_14735 TKWG_21325
AMIMMIM_c16210 MIM_c34700
CDNBN940_08546
AFQAFA_05525
AAQUD3M96_07065
PHNPAEH1_07120
OUEI6G29_08380
PIGEGT29_12205 EGT29_16255 EGT29_16550 EGT29_24545 EGT29_25320
KGYEHF36_13180
PARKLSG25_04100
RFRRfer_0332
RSBRS694_12685
RHYRD110_16990 RD110_21830 RD110_24765
RHFEUB48_12935
RHOAHZ993_17895
POLBpro_2147 Bpro_4322
PNAPnap_2029
PVACHC248_00682(ligI_1) HC248_01466(ligI_2)
AAVAave_4267
AAAAcav_4169
ACKC380_22710
ACRABSY15_1205
ACIDCBP33_05240
ACIPCBP36_05690 CBP36_20280
ACINCBP34_05075
ACISCBP35_13250 CBP35_20355
ACIOEAG14_01250
AMONH9L24_06090
AANTHUK68_10985
ARADKI609_21450
VEIVeis_0169 Veis_2408 Veis_3066
DACDaci_4447
DELDelCs14_1671 DelCs14_2357
DTSBI380_01385 BI380_07820
DHKBO996_20110
DLAI6G47_01640 I6G47_02125 I6G47_02305 I6G47_32015 I6G47_32140 I6G47_33670
VAPVapar_6113
VPDVAPA_2c10340 VAPA_2c11270
CTTCtCNB1_2743
CTESO987_16270
CKEB5M06_09340
COFFOZ74_08480
CODOLAD35_20160
ADNAlide_4174
ADKAlide2_0520 Alide2_4515
RTARta_24780
OTKC6570_16460
LIML103DPR2_01496(ligI)
LIHL63ED372_01143(ligI_1)
HYRBSY239_2224
HYBQ5W_10750
HYLLPB072_16075
HYCE5678_08765
HPSEHPF_08075(ligI1)
HYNF9K07_00745 F9K07_05175 F9K07_12195 F9K07_24190
HTNKI616_18180
DIHG7047_09795 G7047_27830
DRGH9K76_20700
CBAASRAA_1352
CBABSMCB_0793
MIUABE85_07990
SNNEWH46_19135
ATERMW290_13880
HFRG5S34_04765
LCHLcho_3635
RGUA4W93_03355
XYKGT347_11365 GT347_11560 GT347_12600 GT347_26755
SHDSUTH_01240
URUDSM104443_02499(pmdD_2)
ABREpbN1_38950
AZOazo2539(ligI)
AOAdqs_2696
AZRCJ010_16070
THUAC731_016800
TCLTchl_1060
TAKTharo_1101
DDZDSYM_13540
AVPAVENP_2168(ligI)
MAMOA6B35_15240
MESOBSQ44_09540 BSQ44_12990
MESMeso_3726
NIYFQ775_19495
ORMHTY61_00100
SIXBSY16_5482
ARAArad_8733
RLEpRL120277(ligI)
RIIFFM53_025315
RLSHB780_11945
NGLRG1141_CH43630
NGGRG540_CH44040
NEOCYG48_21440
RHTNT26_0603 NT26_1310
RFVRFYW14_01477
BJUBJ6T_13040 BJ6T_60170
BJPRN69_06380 RN69_29150
BRABRADO2340(ligI) BRADO2391
BBTBBta_2700(ligI) BBta_2744
BRSS23_44030 S23_65540
AOLS58_48340 S58_52120 S58_52590
BRCBCCGELA001_04240 BCCGELA001_15980
BRADBF49_1201 BF49_3410
BICLMTR13_15080 LMTR13_21630
BROBRAD285_4997(ligI)
BRKCWS35_19305 CWS35_38395
BOTCIT37_07880 CIT37_34690
BRQCIT40_12005 CIT40_29075
BGQX265_04980 X265_24095 X265_24100
BGZXH91_21300 XH91_21305
BSYMCIT39_11245 CIT39_22795 CIT39_28095
BBETF8237_00740 F8237_03010 F8237_03015 F8237_12095 F8237_35230
BARHWN72_04320 WN72_20635 WN72_20640
BVZBRAD3257_5191 BRAD3257_6825 BRAD3257_8444
BELBE61_68130
BDGLPJ38_08565 LPJ38_21385
RPARPA4700(ligI)
RPBRPB_0874
RPDRPD_0984
RPERPE_0749
RPTRpal_5181
RPXRpdx1_4875
TRBHB776_04630 HB776_05165 HB776_11045 HB776_27395
BVVBHK69_03810
BOIBLM15_10880
AZCAZC_1318 AZC_3355
STARG3545_13620 G3545_16175
MORMOC_1297
MPHYMCBMB27_00669
METXA3862_25200
MMESMMSR116_28295
MOCBB934_00255
RHZRHPLAN_07670 RHPLAN_09550 RHPLAN_19760 RHPLAN_24990 RHPLAN_69890
PHLKKY_2368 KKY_3753
MMEDMame_04561
BRND1F64_00900 D1F64_06545
PSINCAK95_20335 CAK95_22265
PHRC6569_13335
PSTGE8M01_01060 E8M01_07400 E8M01_14330 E8M01_20450 E8M01_22940
BSBBresu_2121
BGOEIFJ75_11210
MALGMALG_02281
YANAYJ57_14085
TOMBWR18_09525
AHTANTHELSMS3_03529(ligI)
OCDFHY55_07535
RMHLVO79_00060
MALUKU6B_25090
TGLHFZ77_17800
SEDIEBB79_03590
PGVSL003B_2852
CMAGCBW24_02315 CBW24_05765
NARSaro_2819
NPPPP1Y_Mpl10379
NPNJI59_20860
NREBES08_14140
NOVTQ38_025055 TQ38_028380
NORFA702_07585
NDRHT578_09000 HT578_09575
SMAZLH19_17725
RDICMV14_06855
SPHITS85_18485
SSANNX02_17535
SPANAWL63_08175
SKRBRX40_12220
SPHCCVN68_17275
SPIIG7077_01545
SSUAFPZ54_06180
SBINSBA_ch2_7350
SINBSIDU_17225
SCHSphch_3897
SSYSLG_12570(ligI) SLG_31300
SPHBEP837_03485(ligI)
SPHRBSY17_3453(ligI)
SHYDCJD35_16790 CJD35_19540
SYAA6768_17510
SPYGYGS_C2P1466
SAMISAMIE_1030480
SPHGAZE99_04470
SFLASPHFLASMR4Y_02981(ligI)
SPHYCHN51_00930
BLASBSY18_3517(ligI)
BFWB5J99_08380
SPHSETR14_07960
POQKZX46_07365
ALBAEB_P0191
AAYWYH_01902(ligI)
ADOA6F68_01086(ligI)
CMANA9D14_17210
POTE2E27_18085
RGIRGI145_21145
ROSCTJ15_00865
RMUCFOB66_01820
SHUMSTHU_14070
SVCSTVA_09650
ABSAZOBR_p310190(ligI)
ABQABAZ39_27970
AZTTSH58p_32560
NCBC0V82_22465
MAGamb0254
MAGXXM1_1090(ligI)
MAGNWV31_13610
HTQFRZ44_30490
HADHFRZ61_17020
MAGQMGMAQ_2663(ligI)
NACINUH88_04090
SNEANBZ79_04470
PARHI5S86_08100
CCYCSCMU_02400(pcmC)
ROAPd630_LPD00182 Pd630_LPD04715
SALBXNR_3393
SSXSACTE_0140
SVLStrvi_8545
SRCM271_28945
SMALSMALA_3249
SSOII1A49_20040
SFASfla_0533
STRPF750_6349
STRFASR50_30550
SKYD0C37_14365
SGMGCM10017557_04190 GCM10017557_43730
STRDNI25_00230
SAUOBV401_19740
SLAUSLA_7097
SGDELQ87_11405
SASTCD934_19155
SFUGCNQ36_19910
SBATG4Z16_15895
SHUNDWB77_01944(ligI)
SVDCP969_30940
SPRACP972_00310
SROIIAG44_39510
SLFJEQ17_24545
KSKKSE_75150(pcmC)
KITCFP65_0441
MAURBOH66_06365
MHOSCXR34_05665
MOOBWL13_00075(ligI)
AMINAUMI_19400
AUMAURMO_01270
AUWAURUGA1_00418(ligI)
ARTArth_4374
ARTPE5206_14130
ACHAchl_3359
APNAsphe3_42370
SATKSA2016_0445
PEIH9L10_00560
SENSACE_5048(ligI)
AMQAMETH_1375(ligI) AMETH_3608(ligI)
AACDLWP59_16015
APRTMUY14_18935
PSEEFRP1_17600
PSEQAD006_02315 AD006_25055
PECQAD017_04645 AD017_10140
PHHAFB00_07640
PMADBAY61_18825
JTLM6D93_14085
GMRGmarT_08140
CAMUCA2015_3712
 » show all
Reference
1  [PMID:7142106]
  Authors
Kersten PJ, Dagley S, Whittaker JW, Arciero DM, Lipscomb JD.
  Title
2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species.
  Journal
J Bacteriol 152:1154-62 (1982)
Reference
2  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J Biochem (Tokyo) 93:557-65 (1983)
DOI:10.1093/oxfordjournals.jbchem.a134210
Reference
3  [PMID:21219457]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.57
IUBMB Enzyme Nomenclature: 3.1.1.57
ExPASy - ENZYME nomenclature database: 3.1.1.57
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.57
BRENDA, the Enzyme Database: 3.1.1.57
CAS: 84177-55-9

KEGG   REACTION: R04277
Entry
R04277                      Reaction                               
Name
2-pyrone-4,6-dicarboxylate lactonohydrolase
Definition
2-Pyrone-4,6-dicarboxylate + H2O <=> (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
Equation
Reaction class
RC03110  C03671_C04434
Enzyme
Pathway
rn00362  Benzoate degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K10221  2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57]
Other DBs
RHEA: 10647

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