KEGG   ORTHOLOGY: K11155
Entry
K11155                      KO                                     
Symbol
DGAT1
Name
diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
Pathway
map00561  Glycerolipid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04975  Fat digestion and absorption
Module
M00089  Triacylglycerol biosynthesis
Disease
H01174  Congenital diarrhea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K11155  DGAT1; diacylglycerol O-acyltransferase 1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K11155  DGAT1; diacylglycerol O-acyltransferase 1
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    K11155  DGAT1; diacylglycerol O-acyltransferase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.20  diacylglycerol O-acyltransferase
     K11155  DGAT1; diacylglycerol O-acyltransferase 1
    2.3.1.75  long-chain-alcohol O-fatty-acyltransferase
     K11155  DGAT1; diacylglycerol O-acyltransferase 1
    2.3.1.76  retinol O-fatty-acyltransferase
     K11155  DGAT1; diacylglycerol O-acyltransferase 1
Other DBs
RN: R02251 R02366 R02367 R08381
GO: 0004144 0050252
Genes
HSA: 8694(DGAT1)
PTR: 464460(DGAT1)
PPS: 100994391(DGAT1)
GGO: 101142898(DGAT1)
PON: 100453587(DGAT1)
NLE: 100590733(DGAT1)
MCC: 701489(DGAT1)
MCF: 102121566(DGAT1)
MTHB: 126961006
CSAB: 103237618(DGAT1)
CATY: 105581243(DGAT1)
PANU: 101020467(DGAT1)
TGE: 112629859(DGAT1)
RRO: 104671680(DGAT1)
RBB: 108536546(DGAT1)
TFN: 117079312(DGAT1)
PTEH: 111523542(DGAT1)
CJC: 100402659(DGAT1)
SBQ: 101041407(DGAT1)
CSYR: 103272524(DGAT1)
MMUR: 105868898(DGAT1)
LCAT: 123644864(DGAT1)
OGA: 100961287(DGAT1)
MMU: 13350(Dgat1)
MCAL: 110310326(Dgat1)
MPAH: 110334746(Dgat1)
RNO: 84497(Dgat1)
MCOC: 116074725(Dgat1)
MUN: 110562264(Dgat1)
CGE: 100755985(Dgat1)
MAUA: 101839431(Dgat1)
PLEU: 114694176(Dgat1)
MORG: 121461251(Dgat1)
MFOT: 126503327
AAMP: 119823936(Dgat1)
NGI: 103735255(Dgat1)
HGL: 101723650(Dgat1)
CPOC: 100733854(Dgat1)
CCAN: 109691174(Dgat1)
DORD: 105998990(Dgat1)
DSP: 122098871(Dgat1)
NCAR: 124979633
OCU: 100350630(DGAT1)
OPI: 101525494(DGAT1)
TUP: 102474487(DGAT1)
CFA: 482093(DGAT1)
CLUD: 112662190(DGAT1)
VVP: 112911178(DGAT1)
VLG: 121498689(DGAT1)
AML: 100479095(DGAT1)
UMR: 103656696(DGAT1)
UAH: 113247638(DGAT1)
UAR: 123779353(DGAT1)
ELK: 111146542
LLV: 125097457
MPUF: 101693117(DGAT1)
ORO: 101366779(DGAT1)
EJU: 114201092(DGAT1)
ZCA: 113926178(DGAT1)
MLX: 118015312(DGAT1)
NSU: 110579270(DGAT1)
FCA: 101101615(DGAT1)
PYU: 121043140(DGAT1)
PBG: 122495929(DGAT1)
LRUF: 124507892
PTG: 102952284(DGAT1)
PPAD: 109258372(DGAT1)
AJU: 106979135(DGAT1)
HHV: 120246564(DGAT1)
BTA: 282609(DGAT1)
BOM: 102277779(DGAT1)
BBUB: 102390126(DGAT1)
CHX: 100861225(DGAT1)
OAS: 100126245(DGAT1)
ODA: 120878731(DGAT1)
CCAD: 122451441(DGAT1)
SSC: 397118(DGAT1)
CFR: 102515256(DGAT1)
CBAI: 105073815(DGAT1)
CDK: 105104999(DGAT1)
VPC: 102530551(DGAT1)
BACU: 103001320(DGAT1)
LVE: 103073062(DGAT1)
OOR: 101275488(DGAT1)
DLE: 111165111(DGAT1)
PCAD: 102974279(DGAT1)
PSIU: 116742184(DGAT1)
ECB: 100147359(DGAT1)
EPZ: 103540220(DGAT1)
EAI: 106841896(DGAT1)
MYB: 102263903(DGAT1)
MYD: 102769363(DGAT1)
MMYO: 118653153(DGAT1)
MLF: 102424179(DGAT1)
MNA: 107539955(DGAT1)
PKL: 118710157(DGAT1)
HAI: 109375066(DGAT1)
DRO: 112315624(DGAT1)
SHON: 118988846(DGAT1)
AJM: 119064708(DGAT1)
PDIC: 114514557(DGAT1)
PHAS: 123832960(DGAT1)
MMF: 118643309(DGAT1)
RFQ: 117033867(DGAT1)
PALE: 102889573(DGAT1)
PGIG: 120588872(DGAT1)
PVP: 105301966(DGAT1)
RAY: 107503468(DGAT1)
MJV: 108399471(DGAT1)
TOD: 119231737(DGAT1)
SARA: 101550891(DGAT1)
TMU: 101350605
DNM: 101439107(DGAT1)
MDO: 100018271(DGAT1)
GAS: 123242018(DGAT1)
SHR: 100924635(DGAT1)
PCW: 110214325(DGAT1)
OAA: 103166832(DGAT1)
FPG: 106112364(DGAT1)
FCH: 106631435(DGAT1)
ACHC: 115340488(DGAT1)
DPUB: 104297206(DGAT1)
CVF: 104288096(DGAT1)
AAM: 106485793 106487807(DGAT1)
AROW: 112976662(DGAT1)
NPD: 112943212(DGAT1)
DNE: 112985425 112991945(DGAT1)
SCAM: 104138457(DGAT1)
ASN: 102375256(DGAT1)
AMJ: 102576196(DGAT1)
CPOO: 109310393(DGAT1)
PSS: 102448420(DGAT1)
CMY: 102930647 102932469(DGAT1)
CPIC: 101950960(DGAT1) 101951746
TST: 117871848(DGAT1) 117886576
CABI: 116827482 116828232(DGAT1)
MRV: 120384334 120398746(DGAT1)
ACS: 100551857(dgat1)
PVT: 110084814(DGAT1)
SUND: 121929186(DGAT1)
PBI: 103065772(DGAT1)
PMUR: 107300055(DGAT1)
CTIG: 120298024(DGAT1)
PGUT: 117666944(DGAT1)
VKO: 123035254(DGAT1)
PMUA: 114600142(DGAT1)
ZVI: 118089698(DGAT1)
GJA: 107110672(DGAT1)
STOW: 125425140(DGAT1)
XLA: 100381012(dgat1.L)
XTR: 101730812(dgat1)
NPR: 108799410(DGAT1)
RTEM: 120923031(DGAT1)
BBUF: 121001595(DGAT1)
BGAR: 122938045(DGAT1)
DRE: 325875(dgat1a) 436731(dgat1b)
MAMB: 125243708(dgat1b) 125275831(dgat1a)
IPU: 108257065(dgat1a) 108267870(dgat1b)
SMEO: 124376238(dgat1a) 124384318(dgat1b)
TFD: 113644625(dgat1b) 113648068(dgat1a)
EEE: 113571147 113572060(dgat1)
TRU: 101072465 101079602(dgat1)
NCC: 104952233 104959283(dgat1)
ELY: 117261683 117263703(dgat1a) 117265232(dgat1b)
EFO: 125887813 125893571(dgat1b) 125904804(dgat1a)
SLUC: 116040207 116047377(dgat1a) 116049462(dgat1b)
PPUG: 119195682 119197148(dgat1b) 119219218(dgat1a)
MSAM: 119893607 119897680(dgat1b) 119907078(dgat1a)
CUD: 121514035(dgat1b) 121515487 121523920(dgat1a)
ALAT: 119005764(dgat1b) 119016775(dgat1a) 119023772
OAU: 116322502 116322667(dgat1a) 116331366(dgat1b)
OML: 112138961(dgat1a) 112143225(dgat1b)
XMA: 102220430 102225690(dgat1)
XCO: 114141802 114156467(dgat1)
XHE: 116717507 116731846(dgat1)
PRET: 103472475(dgat1) 103478641
PFOR: 103140880 103146836(dgat1)
PLAI: 106946045 106958546(dgat1)
GAF: 122831501 122843123(dgat1a)
CTUL: 119775181(dgat1b) 119779654
GMU: 124866421(dgat1b) 124877928 124879920(dgat1a)
KMR: 108241110(dgat1b) 108242037(dgat1a)
NWH: 119409426(dgat1b) 119425868(dgat1a)
POV: 109633536 109638866(dgat1)
SSEN: 122774434(dgat1b) 122786169(dgat1a)
HHIP: 117770869(dgat1a) 117777146
HSP: 118114155(dgat1b) 118124390(dgat1a)
LCF: 108879464(dgat1a) 108889635(dgat1b) 108901956
XGL: 120784326(dgat1b) 120786827(dgat1a) 120792803
BSPL: 114842540(dgat1b) 114865407(dgat1a)
OTW: 112218465 112229529(dgat1a) 112243899(dgat1b) 112264326
ELS: 105018848 105022840(dgat1)
LOC: 102683351 102695280(dgat1)
LCM: 102349959(DGAT1) 102358735
RTP: 109935410(dgat1) 109936697
BFO: 118417909
BBEL: 109473705
CIN: 100177672
SPU: 575003
APLC: 110982992
SKO: 100376218
DME: Dmel_CG31991(mdy)
DER: 6547631
DSE: 6614434
DSI: Dsimw501_GD24087(Dsim_GD24087)
DAN: 6498181
DSR: 110184937
DPO: 4817308
DPE: 6589755
DMN: 108161944
DWI: 6643530
DGR: 6566587
DAZ: 108611284
DNV: 115562354
DHE: 111601178
DVI: 6628957
CCAT: 101459788
BOD: 106627593
MDE: 101894841
SCAC: 106086210
LCQ: 111682921
LSQ: 119610931
HIS: 119646821
ACOZ: 120959456
AARA: 120900691
ASTE: 118514160
AAG: 5569069
AALB: 109418063
CPII: 120413867
CNS: 116346459
BCOO: 119076336
AME: 552377
ACER: 107996211
ALAB: 122716172
BIM: 100744121
BBIF: 117216546
BVK: 117231704
BVAN: 117166318
BTER: 100646196
BPYO: 122574321
CCAL: 108630029
MGEN: 117224602
NMEA: 116424872
CGIG: 122400133
SOC: 105194711
MPHA: 105833565
ACEP: 105618616
PBAR: 105422883
VEM: 105564389
HST: 105182283
DQU: 106747317
CFO: 105253928
FEX: 115242388
PGC: 109852637
OBO: 105282087
PCF: 106788280
PFUC: 122515591
VPS: 122635863
NVI: 100116518
CSOL: 105364922
TPRE: 106658702
MDL: 103568794
CGLO: 123268155
FAS: 105271257
DAM: 107036296
AGIF: 122860689
LHT: 122501664
CCIN: 107262759
TCA: 664028
DPA: 109533688
SOY: 115881540
ATD: 109602335
CSET: 123312599
AGB: 108912570
LDC: 111511416
NVL: 108568180
OTU: 111424823
BMOR: 101742497
BMAN: 114242959
MSEX: 115447123
BANY: 112054296
NIQ: 126781439
PMAC: 106710683
PPOT: 106099440
PXU: 106127750
PRAP: 110991401
ZCE: 119830300
HAW: 110371905
HZE: 124645453
TNL: 113506955
SLIU: 111352478
OFU: 114352013
DCI: 103512092
CLEC: 106668819
HHAL: 106689225
NLU: 111054822
CSEC: 111872160
FCD: 110852290
DMK: 116919682
PVM: 113829016
PJA: 122245886
PCHN: 125036882
HAME: 121872706
PCLA: 123759312
PTRU: 123504582
HAZT: 108679309
LSM: 121115075
PPOI: 119089453
TUT: 107362581
PTEP: 107450283
SDM: 118196832
CEL: CELE_H19N07.4(mboa-2)
CBR: CBG_23107
BMY: BM_BM12468(Bma-mboa-2)
TSP: Tsp_02502
PCAN: 112553384
BGT: 106051926
GAE: 121387998
HRF: 124138908
HRJ: 124262929
CRG: 105331361
MYI: 110442476
PMAX: 117337851
MMER: 123549120
OBI: 106869194
OSN: 115221438
LAK: 106165236
SHX: MS3_00003249(DGAT1_1)
EGL: EGR_02006
NVE: 5519524
EPA: 110238682
ATEN: 116299071
ADF: 107351603
AMIL: 114963989
PDAM: 113667048
SPIS: 111335241
DGT: 114516678
XEN: 124436472
HMG: 101238034
ATH: AT2G19450(TAG1)
ALY: 9322105
CRB: 17891447
CPAP: 110817535
CIT: 102619099
PVY: 116113684
TCC: 18588364
GRA: 105793287
GAB: 108466843
DZI: 111286703
EGR: 104438076
GMX: 547982(DGAT) 548005(DGAT1A) 732606(DGAT1b)
LJA: Lj4g3v2172770.1(Lj4g3v2172770.1) Lj4g3v2172770.2(Lj4g3v2172770.2) Lj6g3v1226310.1(Lj6g3v1226310.1)
FVE: 101304125
RCN: 112187921
PPER: 18769247
PMUM: 103340712
PAVI: 110749273
PDUL: 117635026
ZJU: 107424129
MNT: 21409930
CSV: 101213517
CMO: 103498593
BHJ: 120079835
MCHA: 111021903
CMAX: 111493820
CMOS: 111450373
CPEP: 111805863
RCU: 8272569
JCU: 105637897(DGAT1)
QLO: 115976088
VVI: 100266364
VRI: 117925364
SIND: 105173637(DGAT1)
EGT: 105968927
ECAD: 122595669
LSV: 111892564
CSIN: 114276617
BVG: 104909051
SOE: 110797728
NNU: 104586668
MING: 122061644
NCOL: 116260096
DOSA: Os05t0196800-00(Os05g0196800) Os06t0563900-01(Os06g0563900)
PEQ: 110022299
AOF: 109828648
ATR: 18443650
MNG: MNEG_1183
APRO: F751_6502
SLB: AWJ20_4739(ARE2)
NCR: NCU00035
NTE: NEUTE1DRAFT129602(NEUTE1DRAFT_129602)
MGR: MGG_05326
SSCK: SPSK_02335
MAW: MAC_07178
MAJ: MAA_07086
CMT: CCM_05029
MBE: MBM_00351
ANI: AN6159.2
ANG: ANI_1_1688104(An12g03600)
ABE: ARB_04951
TVE: TRV_06710
PTE: PTT_18543
DDI: DDB_G0271342(dgat1)
TAN: TA19620
TPV: TP01_0247
BBO: BBOV_IV004970(23.m06462)
CPV: cgd2_1090
 » show all
Reference
  Authors
Shi Y, Cheng D
  Title
Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.
  Journal
Am J Physiol Endocrinol Metab 297:E10-8 (2009)
DOI:10.1152/ajpendo.90949.2008
Reference
PMID:9756920
  Authors
Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL
  Title
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.
  Journal
J Biol Chem 273:26765-71 (1998)
DOI:10.1074/jbc.273.41.26765
  Sequence
[hsa:8694]

KEGG   ORTHOLOGY: K11156
Entry
K11156                      KO                                     
Symbol
DGAT2L4, MFAT, AWAT2
Name
diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04977  Vitamin digestion and absorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K11156  DGAT2L4, MFAT, AWAT2; diacylglycerol O-acyltransferase 2-like protein 4
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    K11156  DGAT2L4, MFAT, AWAT2; diacylglycerol O-acyltransferase 2-like protein 4
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.75  long-chain-alcohol O-fatty-acyltransferase
     K11156  DGAT2L4, MFAT, AWAT2; diacylglycerol O-acyltransferase 2-like protein 4
    2.3.1.76  retinol O-fatty-acyltransferase
     K11156  DGAT2L4, MFAT, AWAT2; diacylglycerol O-acyltransferase 2-like protein 4
Other DBs
RN: R02366 R02367
GO: 0047196
Genes
HSA: 158835(AWAT2)
PTR: 473654(AWAT2)
PPS: 100969745(AWAT2)
GGO: 101153985(AWAT2)
PON: 100444717(AWAT2)
NLE: 100579751(AWAT2)
MCC: 696451(AWAT2)
MCF: 102128700(AWAT2)
MTHB: 126946200
CSAB: 103232124(AWAT2)
CATY: 105586143(AWAT2)
PANU: 100998508 116271873(AWAT2)
TGE: 112616151(AWAT2)
RRO: 104678778(AWAT2)
RBB: 108526323(AWAT2)
TFN: 117077483(AWAT2)
PTEH: 111536099(AWAT2)
CJC: 100406942(AWAT2)
SBQ: 101035036(AWAT2)
CSYR: 103261200(AWAT2)
MMUR: 105855332(AWAT2)
LCAT: 123628304(AWAT2)
OGA: 100958022(AWAT2)
MMU: 245532(Awat2)
MCAL: 110287264(Awat2)
MPAH: 110313940(Awat2)
RNO: 302425(Awat2)
MCOC: 116093751(Awat2)
MUN: 110541347(Awat2)
CGE: 100768365(Awat2)
MAUA: 101841831(Awat2)
PLEU: 114703153(Awat2)
MORG: 121445371
MFOT: 126487051
AAMP: 119805573(Awat2)
NGI: 103743154(Awat2)
HGL: 101701856(Awat2)
CPOC: 100734162(Awat2)
CCAN: 109675699
DORD: 105997251(Awat2)
DSP: 122120673(Awat2)
NCAR: 124972594
OCU: 100340789(AWAT2)
OPI: 101533444(AWAT2)
TUP: 102502982(AWAT2)
CFA: 491936(AWAT2)
CLUD: 112671936(AWAT2)
VVP: 112907586(AWAT2)
VLG: 121482279(AWAT2)
AML: 100475313(AWAT2)
UMR: 103682604(AWAT2)
UAH: 113245600(AWAT2)
UAR: 123780201(AWAT2)
ELK: 111161046
LLV: 125091482
MPUF: 101671117(AWAT2)
ORO: 101386463(AWAT2)
EJU: 114200104(AWAT2)
ZCA: 113931496(AWAT2)
MLX: 118025921(AWAT2)
NSU: 110572309(AWAT2)
FCA: 101086879(AWAT2)
PYU: 121025268(AWAT2)
PBG: 122477297(AWAT2)
LRUF: 124521536
PTG: 102972443(AWAT2)
PPAD: 109254591(AWAT2)
AJU: 106982379(AWAT2)
HHV: 120246057(AWAT2)
BTA: 521298(AWAT2)
BOM: 102275983(AWAT2)
BBUB: 102390285(AWAT2)
CHX: 102177144(AWAT2)
OAS: 101121241(AWAT2)
ODA: 120882038(AWAT2)
CCAD: 122435975(AWAT2)
SSC: 100151799(AWAT2)
CFR: 102514200(AWAT2)
CBAI: 105083735(AWAT2)
CDK: 105087992(AWAT2)
VPC: 102531353(AWAT2)
BACU: 103009724(AWAT2)
LVE: 103074572(AWAT2)
OOR: 101282586(AWAT2)
PCAD: 102990854(AWAT2)
PSIU: 116747093(AWAT2)
ECB: 100066473(AWAT2)
EPZ: 103541350(AWAT2)
EAI: 106827656(AWAT2)
MYB: 102242085(AWAT2)
MYD: 102760049(AWAT2)
MMYO: 118653504(AWAT2)
MLF: 102435686(AWAT2)
MNA: 107532905(AWAT2)
PKL: 118704101
DRO: 112299986(AWAT2)
SHON: 118996721(AWAT2)
AJM: 119040225(AWAT2)
PDIC: 114505398(AWAT2)
PHAS: 123824367(AWAT2)
MMF: 118636677(AWAT2)
RFQ: 117025069
PALE: 102895732(AWAT2)
PGIG: 120583622
PVP: 105299645(AWAT2)
RAY: 107503822(AWAT2)
TOD: 119246684(AWAT2)
SARA: 101558988
LAV: 100669668(AWAT2)
TMU: 105756481
DNM: 101423860
MDO: 100014456(AWAT2)
GAS: 123253312
SHR: 100931966(AWAT2)
PCW: 110201013(AWAT2)
OAA: 100086109
 » show all
Reference
  Authors
Cheng JB, Russell DW
  Title
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
  Journal
J Biol Chem 279:37798-807 (2004)
DOI:10.1074/jbc.M406226200
  Sequence
[hsa:158835]

KEGG   ORTHOLOGY: K00678
Entry
K00678                      KO                                     
Symbol
LRAT
Name
phosphatidylcholine-retinol O-acyltransferase [EC:2.3.1.135]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04977  Vitamin digestion and absorption
Disease
H00837  Leber congenital amaurosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K00678  LRAT; phosphatidylcholine-retinol O-acyltransferase
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    K00678  LRAT; phosphatidylcholine-retinol O-acyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.135  phosphatidylcholine---retinol O-acyltransferase
     K00678  LRAT; phosphatidylcholine-retinol O-acyltransferase
Other DBs
RN: R08387 R08389
GO: 0047173
Genes
HSA: 9227(LRAT)
PTR: 471328(LRAT)
PPS: 100990532(LRAT)
GGO: 101135395(LRAT)
PON: 100432491(LRAT)
NLE: 100579669(LRAT)
MCC: 698871(LRAT)
MCF: 102123283(LRAT)
MTHB: 126955082
CSAB: 103236423(LRAT)
CATY: 105580675(LRAT)
PANU: 101020435(LRAT)
TGE: 112625128(LRAT)
RRO: 104657120(LRAT)
RBB: 108529031(LRAT)
TFN: 117086058(LRAT)
PTEH: 111552243(LRAT)
CJC: 100414604(LRAT)
SBQ: 101042985(LRAT)
CSYR: 103277419(LRAT)
MMUR: 105881778(LRAT)
LCAT: 123637689(LRAT)
OGA: 100966134(LRAT)
MMU: 79235(Lrat)
MCAL: 110291651(Lrat)
MPAH: 110319715(Lrat)
RNO: 64047(Lrat)
MCOC: 116093034(Lrat)
MUN: 110547199(Lrat)
CGE: 100769559(Lrat)
MAUA: 101832465(Lrat)
PLEU: 114682940(Lrat)
MORG: 121452675(Lrat)
MFOT: 126511608
AAMP: 119826390(Lrat)
NGI: 103751034(Lrat)
HGL: 101722664(Lrat)
CPOC: 100729755(Lrat)
CCAN: 109677811(Lrat)
DORD: 105995864(Lrat)
DSP: 122127237(Lrat)
NCAR: 124994876
OCU: 100354707(LRAT)
OPI: 101527023(LRAT)
TUP: 102476648(LRAT)
CFA: 482660(LRAT)
CLUD: 112654537(LRAT)
VVP: 112933438(LRAT)
VLG: 121481294(LRAT)
AML: 100482038(LRAT)
UMR: 103658037(LRAT)
UAH: 113255775(LRAT)
UAR: 123793200(LRAT)
ELK: 111157810
LLV: 125093118
MPUF: 101686629(LRAT)
ORO: 101384293(LRAT)
EJU: 114210180(LRAT)
ZCA: 113924803(LRAT)
MLX: 118022220(LRAT)
NSU: 110588483(LRAT)
FCA: 101092432(LRAT)
PYU: 121028260(LRAT)
PBG: 122475197(LRAT)
LRUF: 124520620
PTG: 102965792(LRAT)
PPAD: 109262496(LRAT)
AJU: 106982446(LRAT)
HHV: 120221623(LRAT)
BTA: 281285(LRAT)
BOM: 102264381(LRAT)
BIU: 109571479(LRAT)
BBUB: 102389350(LRAT)
CHX: 102183532(LRAT)
OAS: 101104976(LRAT) 114108650
ODA: 120871443(LRAT)
CCAD: 122451286(LRAT)
SSC: 100513994(LRAT)
CFR: 102520637(LRAT)
CBAI: 105079734(LRAT)
CDK: 105089285(LRAT)
VPC: 102527160(LRAT)
BACU: 103000637(LRAT)
LVE: 103091446(LRAT)
OOR: 101278519(LRAT)
DLE: 111187711(LRAT)
PCAD: 102978609(LRAT)
PSIU: 116754708(LRAT)
ECB: 100069704(LRAT)
EPZ: 103553820(LRAT)
EAI: 106832954(LRAT)
MYB: 102261540(LRAT)
MYD: 102758952(LRAT)
MMYO: 118659260(LRAT)
MLF: 102427893(LRAT)
MNA: 107525620(LRAT)
PKL: 118711148(LRAT)
HAI: 109382001(LRAT)
DRO: 112312204(LRAT)
SHON: 118995378(LRAT)
AJM: 119065916(LRAT)
PDIC: 114504003(LRAT)
PHAS: 123813659(LRAT)
MMF: 118615893(LRAT)
RFQ: 117038411(LRAT)
PALE: 102888347(LRAT)
PGIG: 120613425(LRAT)
PVP: 105292190(LRAT)
RAY: 107507545(LRAT)
MJV: 108408878(LRAT)
TOD: 119234844(LRAT)
SARA: 101541430(LRAT)
LAV: 100667142(LRAT)
TMU: 101341410
DNM: 101439300(LRAT)
MDO: 100017333(LRAT)
GAS: 123251508(LRAT)
SHR: 100931949(LRAT)
PCW: 110213622(LRAT)
OAA: 100080154(LRAT)
GGA: 422403(LRAT)
PCOC: 116243136(LRAT)
MGP: 104910504(LRAT)
CJO: 107313043(LRAT)
NMEL: 110398861(LRAT)
APLA: 101795343(LRAT)
AFUL: 116489174(LRAT)
TGU: 100224470(LRAT)
LSR: 110470513(LRAT)
SCAN: 103825960(LRAT)
PMOA: 120498061(LRAT)
OTC: 121331385(LRAT)
PRUF: 121360299(LRAT)
FAB: 101813271(LRAT)
PHI: 102105659(LRAT)
PMAJ: 107202673(LRAT)
CCW: 120409867(LRAT)
CBRC: 103617430(LRAT)
ETL: 114066333(LRAT)
ZAB: 102061781(LRAT)
FPG: 106112170(LRAT)
FCH: 102048889(LRAT)
CLV: 102087929(LRAT)
NNI: 104021236(LRAT)
TALA: 116965187(LRAT)
AFOR: 103902288(LRAT)
ACHC: 115343577(LRAT)
MUI: 104540176(LRAT)
AAM: 106492096(LRAT)
NPD: 112949245(LRAT)
ASN: 102378402(LRAT)
AMJ: 102557704(LRAT)
CPOO: 109309692(LRAT)
GGN: 109300838(LRAT)
PSS: 102463592(LRAT)
CMY: 102938217(LRAT)
CPIC: 101949409(LRAT)
TST: 117877603(LRAT)
CABI: 116824081(LRAT)
MRV: 120406935(LRAT)
ACS: 100552136(lrat)
PVT: 110072772(LRAT)
SUND: 121931889(LRAT)
PBI: 103061458(LRAT)
PMUR: 107287990(LRAT)
CTIG: 120316037(LRAT)
TSR: 106550018(LRAT)
PGUT: 117674727(LRAT)
VKO: 123023801(LRAT)
PMUA: 114604741(LRAT) 114604742
ZVI: 118083689(LRAT)
GJA: 107109450(LRAT)
STOW: 125440301(LRAT)
XLA: 108699284 108706650 443823(lrat.L)
XTR: 394746(lrat)
NPR: 108788202 108788203(LRAT)
DRE: 553239(lrata) 553501(lratb) 556575(lratb.2) 566123(si:dkey-30k22.5)
PPRM: 120462844 120462893(lratb.2) 120487494(si:dkey-30k22.5) 120494742(lrata)
MAMB: 125271444(si:dkey-30k22.5) 125272421(lrata) 125272763 125272764(lratb.2)
IPU: 108258976(lratb.2) 108258977 108261015(lrata)
SMEO: 124378050 124378533(lratb.2) 124381673(lrata)
TFD: 113634831(lrata) 113652968 113652969(lratb.2)
TRU: 101076520 101076751(lrat)
NCC: 104949063 104966386(lrat)
CGOB: 115012347(lrat) 115012675
ELY: 117245752 117255851(si:dkey-30k22.5) 117255891(lrata) 117272810
EFO: 125883429 125884286 125886067(lrata) 125886068(si:dkey-30k22.5)
PLEP: 121941462(si:dkey-30k22.5) 121942700(lrata) 121962221(lratb.1) 121962534(lratb.2) 121963621
ESP: 116704044(lrat)
GAT: 120821314 120825187(lrata)
PPUG: 119218293(lrata) 119223041
MSAM: 119884110 119884111 119898789(lrata) 119898790(si:dkey-30k22.5) 119911806
CUD: 121504089 121504935(lratb.2) 121509047(lrata) 121509055(si:dkey-30k22.5)
ALAT: 119022749(lrata) 119023300 119026604 119027440(lratb.2)
OAU: 116312398(si:dkey-30k22.5) 116312412(lrata) 116326521(lratb.2) 116326574
OML: 112137530(lrata) 112137644(si:dkey-30k22.5) 112156356 112156374(lratb.2)
CTUL: 119797130 119797138 119797181(si:dkey-30k22.5)
KMR: 108228851(lrata) 108248302 108248305(lratb.2) 108249452(si:dkey-30k22.5)
MCEP: 125000078(lrata) 125000083(si:dkey-30k22.5) 125009964(lratb.2) 125010096
CSEM: 103383311 103389580(lrat)
SSEN: 122766322 122771684(si:dkey-30k22.5) 122771685(lrata)
HHIP: 117751915 117760283(lrata) 117762673(si:dkey-30k22.5)
HSP: 118102938 118115361(lrata) 118115874(si:dkey-30k22.5)
XGL: 120797300 120797305(lratb.2) 120800556(si:dkey-30k22.5) 120800617(lrata)
BSPL: 114843882 114850357 114850374 114860244(lrata) 114862030(si:dkey-30k22.5) 121202087
AANG: 118226830(lrata) 118228340(si:dkey-30k22.5) 118231467 118232461(lratb.2)
LCM: 102361576(LRAT)
CMK: 103189387
RTP: 109935078(lrat)
BFO: 118431595
FCD: 110849237
 » show all
Reference
PMID:9920938
  Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
  Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
  Journal
J Biol Chem 274:3834-41 (1999)
DOI:10.1074/jbc.274.6.3834
  Sequence
[hsa:9227] [bta:281285]

KEGG   ORTHOLOGY: K11157
Entry
K11157                      KO                                     
Symbol
PNPLA4
Name
patatin-like phospholipase domain-containing protein 4 [EC:3.1.1.-]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K11157  PNPLA4; patatin-like phospholipase domain-containing protein 4
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.-
     K11157  PNPLA4; patatin-like phospholipase domain-containing protein 4
Other DBs
RN: R02368
Genes
HSA: 8228(PNPLA4)
PTR: 473881(PNPLA4)
PPS: 100982805(PNPLA4)
GGO: 101135079(PNPLA4)
PON: 100442157(PNPLA4)
NLE: 100603159(PNPLA4)
MCC: 708139(PNPLA4)
MCF: 102118580(PNPLA4)
MTHB: 126946653
CSAB: 103231567(PNPLA4)
CATY: 105574747(PNPLA4)
PANU: 101008623
TGE: 112615644(PNPLA4)
RRO: 104654639(PNPLA4)
RBB: 108523967
TFN: 117078153(PNPLA4)
PTEH: 111530931(PNPLA4)
CJC: 100385928(PNPLA4)
SBQ: 101053359(PNPLA4)
CSYR: 103272374(PNPLA4)
MMUR: 105881024(PNPLA4)
LCAT: 123628001(PNPLA4)
OGA: 100960174(PNPLA4)
MCAL: 110309714
MPAH: 110315852(Pnpla4)
RNO: 363471(Pnpla4)
MCOC: 116082217(Pnpla4)
CGE: 113838852
NGI: 103737039(Pnpla4)
HGL: 101719226(Pnpla4)
CPOC: 100714079 100732720(Pnpla4)
CCAN: 109675534(Pnpla4)
NCAR: 124971790
TUP: 102488503(PNPLA4)
CFA: 491729(PNPLA4)
CLUD: 112652508(PNPLA4)
VVP: 112932354(PNPLA4)
VLG: 121482767(PNPLA4)
AML: 100472464(PNPLA4)
UMR: 103666318(PNPLA4)
UAH: 113240758(PNPLA4)
UAR: 123802735(PNPLA4)
ELK: 111157194
LLV: 125091354
MPUF: 101682537(PNPLA4)
ORO: 101365909(PNPLA4)
EJU: 114218110(PNPLA4)
ZCA: 113930672(PNPLA4)
MLX: 118026691(PNPLA4)
NSU: 110582579(PNPLA4)
FCA: 101083743(PNPLA4)
PYU: 121020172(PNPLA4)
PBG: 122477600(PNPLA4)
LRUF: 124509336
PTG: 102956586(PNPLA4)
PPAD: 109248265(PNPLA4)
AJU: 106969349(PNPLA4)
HHV: 120235974(PNPLA4)
BTA: 785567(PNPLA4)
BOM: 102288097(PNPLA4)
BIU: 109576663(PNPLA4)
BBUB: 102401893(PNPLA4)
CHX: 102168524(PNPLA4)
OAS: 101117303(PNPLA4)
ODA: 120882376(PNPLA4)
CCAD: 122434554(PNPLA4)
SSC: 100294680(PNPLA4)
CFR: 102518395(PNPLA4)
CBAI: 105075976(PNPLA4)
CDK: 105086566(PNPLA4)
VPC: 102539599(PNPLA4)
BACU: 103009583(PNPLA4)
LVE: 103083547(PNPLA4)
OOR: 101285577(PNPLA4)
DLE: 111167218(PNPLA4)
PCAD: 102985390(PNPLA4)
PSIU: 116747913(PNPLA4)
ECB: 100050789(PNPLA4)
EPZ: 103563416(PNPLA4)
EAI: 106821790(PNPLA4)
MYB: 102245288(PNPLA4) 106723822
MYD: 102774568(PNPLA4)
MMYO: 118657323(PNPLA4)
MLF: 102439858(PNPLA4)
MNA: 107533018(PNPLA4)
PKL: 118722264(PNPLA4)
HAI: 109378207(PNPLA4)
DRO: 112313366(PNPLA4)
SHON: 118974327(PNPLA4)
AJM: 119058381(PNPLA4)
PDIC: 114489898(PNPLA4)
PHAS: 123830089(PNPLA4)
MMF: 118636518(PNPLA4)
RFQ: 117020533(PNPLA4)
PALE: 102881268(PNPLA4)
PGIG: 120584070(PNPLA4)
PVP: 105307732(PNPLA4)
RAY: 107503820(PNPLA4)
MJV: 108400348(PNPLA4)
TOD: 119246362(PNPLA4)
LAV: 100659288(PNPLA4)
TMU: 101353180
DNM: 101424779(PNPLA4)
MDO: 100018570(PNPLA4)
GAS: 123242557(PNPLA4)
SHR: 100927925(PNPLA4)
PCW: 110221518(PNPLA4)
OAA: 100084357(PNPLA4)
GGA: 418653(PNPLA4)
PCOC: 116230767(PNPLA4)
MGP: 100544945(PNPLA4)
CJO: 107306095(PNPLA4)
NMEL: 110405528(PNPLA4)
APLA: 101799675(PNPLA4)
ACYG: 106040535(PNPLA4)
AFUL: 116502110(PNPLA4)
TGU: 100231394(PNPLA4)
LSR: 110476185(PNPLA4)
SCAN: 103815796(PNPLA4)
PMOA: 120504653(PNPLA4)
OTC: 121342254(PNPLA4)
PRUF: 121356238(PNPLA4)
GFR: 102041467(PNPLA4)
FAB: 101806922(PNPLA4)
PHI: 102101500(PNPLA4)
PMAJ: 107211355(PNPLA4)
CCAE: 111922791(PNPLA4)
CCW: 104686137(PNPLA4)
CBRC: 103617574(PNPLA4)
ETL: 114068457(PNPLA4)
ZAB: 102074351(PNPLA4)
ACHL: 103802847(PNPLA4)
FPG: 101923974(PNPLA4)
FCH: 102055067(PNPLA4)
CLV: 102092592(PNPLA4)
EGZ: 104127472(PNPLA4)
NNI: 104014007(PNPLA4)
PLET: 104615719(PNPLA4)
PCRI: 104032743(PNPLA4)
ACUN: 113482726(PNPLA4)
TALA: 104357739(PNPLA4)
PADL: 103924793(PNPLA4)
AFOR: 103906011(PNPLA4)
ACHC: 115334661(PNPLA4)
HALD: 104312055(PNPLA4)
CCRI: 104165302(PNPLA4)
CSTI: 104555149(PNPLA4)
EHS: 104504521(PNPLA4)
CMAC: 104484241(PNPLA4)
MUI: 104545414
FGA: 104082419(PNPLA4)
GSTE: 104251973(PNPLA4)
LDI: 104342983(PNPLA4)
MNB: 103774412(PNPLA4)
OHA: 104337529(PNPLA4)
NNT: 104400252(PNPLA4)
DPUB: 104298347(PNPLA4)
PGUU: 104462588(PNPLA4)
ACAR: 104532001(PNPLA4)
CVF: 104287277(PNPLA4)
AAM: 106491516(PNPLA4)
AROW: 112976416(PNPLA4)
NPD: 112948176(PNPLA4)
TGT: 104580422(PNPLA4)
DNE: 112989572(PNPLA4)
SCAM: 104149823(PNPLA4)
ASN: 102388371(PNPLA4)
AMJ: 102561661(PNPLA4)
CPOO: 109306094(PNPLA4)
GGN: 109303197(PNPLA4)
PSS: 102453476(PNPLA4)
CMY: 102945552(PNPLA4)
CPIC: 101952890(PNPLA4)
TST: 117870263(PNPLA4)
CABI: 116830518(PNPLA4)
MRV: 120369700(PNPLA4)
ACS: 100555332(pnpla4)
PVT: 110075591(PNPLA4)
SUND: 121926522(PNPLA4)
PBI: 103052521(PNPLA4)
TSR: 106541943(PNPLA4)
PGUT: 117676361(PNPLA4)
VKO: 123024587(PNPLA4)
PMUA: 114596482(PNPLA4)
ZVI: 118085736(PNPLA4)
GJA: 107120298(PNPLA4)
XLA: 496144(pnpla4.L)
XTR: 100495026(pnpla4)
NPR: 108793970(PNPLA4)
RTEM: 120927459(PNPLA4)
BBUF: 120993287(PNPLA4)
BGAR: 122932746(PNPLA4)
DRE: 100037326(pnpla4)
SRX: 107708662
SANH: 107691610
SGH: 107602743(pnpla4)
CCAR: 109048620(pnpla4)
CAUA: 113106470(pnpla4)
PPRM: 120468837(pnpla4)
MAMB: 125272375(pnpla4)
IPU: 100528834(pnpla4)
PHYP: 113537282(pnpla4)
SMEO: 124377787(pnpla4)
TFD: 113652278(pnpla4)
AMEX: 103021326(pnpla4)
EEE: 113577277(pnpla4)
TRU: 101066753(pnpla4) 115246421
LCO: 104934754(pnpla4)
NCC: 104951993(pnpla4)
CGOB: 115021776(pnpla4)
ELY: 117250137(pnpla4) 117250371
EFO: 125885084(pnpla4)
PLEP: 121966850(pnpla4)
SLUC: 116048607(pnpla4)
ECRA: 117939529(pnpla4)
ESP: 116674055(pnpla4)
PFLV: 114551231(pnpla4)
GAT: 120825419(pnpla4)
PPUG: 119218956(pnpla4)
CUD: 121506217(pnpla4)
ALAT: 119015464(pnpla4)
MZE: 101476362(pnpla4)
ONL: 100696211(pnpla4)
OAU: 116322268(pnpla4)
OML: 112140221(pnpla4)
PRET: 103477238(pnpla4)
PFOR: 103130064(pnpla4)
PLAI: 106964544(pnpla4)
PMEI: 106910081(pnpla4)
GAF: 122827168(pnpla4)
CTUL: 119778717(pnpla4)
GMU: 124861869(pnpla4)
KMR: 108249933(pnpla4)
ALIM: 106531328(pnpla4)
NWH: 119423315(pnpla4)
AOCE: 111566420(pnpla4)
MCEP: 125000929(pnpla4)
CSEM: 103389725(pnpla4)
POV: 109640044(pnpla4)
SSEN: 122765327(pnpla4)
HHIP: 117777862(pnpla4)
HSP: 118103605(pnpla4)
SDU: 111232793(pnpla4)
SLAL: 111670298(pnpla4)
XGL: 120798177(pnpla4)
HCQ: 109507804(pnpla4)
BPEC: 110156622(pnpla4)
BSPL: 114851327(pnpla4)
SASA: 106574372(pnpla4)
STRU: 115196002(pnpla4)
OTW: 112267535(pnpla4)
OMY: 110495891
OGO: 124011644
ONE: 115129684(pnpla4)
SALP: 111953631
SNH: 120051265
ELS: 105022505(pnpla4)
SFM: 108929869(pnpla4)
PKI: 111846846(pnpla4)
AANG: 118214201(pnpla4)
LOC: 102687296(pnpla4)
PSPA: 121327577(pnpla4)
ARUT: 117406177
LCM: 102352799(PNPLA4)
CMK: 103172332(pnpla4)
RTP: 109929273
BFO: 118428314
BBEL: 109477834
CEL: CELE_D1054.1(D1054.1)
CBR: CBG_09699
BMY: BM_BM3017(Bm3017)
PCAN: 112554807
GAE: 121367856
HRF: 124139529
HRJ: 124262196
MYI: 110442960
PMAX: 117342890
MMER: 123554186
OBI: 106877734
OSN: 115222363
NVE: 5505440
EPA: 110242187
ATEN: 116301589
ADF: 107352093
AMIL: 114953891
PDAM: 113676286
SPIS: 111335620
DGT: 114524561
XEN: 124445476
 » show all
Reference
PMID:7806223
  Authors
Lee WC, Salido E, Yen PH
  Title
Isolation of a new gene GS2 (DXS1283E) from a CpG island between STS and KAL1 on Xp22.3.
  Journal
Genomics 22:372-6 (1994)
DOI:10.1006/geno.1994.1397
  Sequence
[hsa:8228]

KEGG   ENZYME: 2.3.1.76
Entry
EC 2.3.1.76                 Enzyme                                 
Name
retinol O-fatty-acyltransferase;
retinol acyltransferase;
retinol fatty-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:retinol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + retinol = CoA + retinyl ester [RN:R02366]
Reaction(KEGG)
R02366 > R02367;
(other) R08381
Substrate
acyl-CoA [CPD:C00040];
retinol [CPD:C00473]
Product
CoA [CPD:C00010];
retinyl ester [CPD:C02075]
Comment
Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA.
History
EC 2.3.1.76 created 1984
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K11155  diacylglycerol O-acyltransferase 1
K11156  diacylglycerol O-acyltransferase 2-like protein 4
Genes
HSA158835(AWAT2) 8694(DGAT1)
PTR464460(DGAT1) 473654(AWAT2)
PPS100969745(AWAT2) 100994391(DGAT1)
GGO101142898(DGAT1) 101153985(AWAT2)
PON100444717(AWAT2) 100453587(DGAT1)
NLE100579751(AWAT2) 100590733(DGAT1)
MCC696451(AWAT2) 701489(DGAT1)
MCF102121566(DGAT1) 102128700(AWAT2)
MTHB126946200 126961006
CSAB103232124(AWAT2) 103237618(DGAT1)
CATY105581243(DGAT1) 105586143(AWAT2)
PANU100998508 101020467(DGAT1) 116271873(AWAT2)
TGE112616151(AWAT2) 112629859(DGAT1)
RRO104671680(DGAT1) 104678778(AWAT2)
RBB108526323(AWAT2) 108536546(DGAT1)
TFN117077483(AWAT2) 117079312(DGAT1)
PTEH111523542(DGAT1) 111536099(AWAT2)
CJC100402659(DGAT1) 100406942(AWAT2)
SBQ101035036(AWAT2) 101041407(DGAT1)
CSYR103261200(AWAT2) 103272524(DGAT1)
MMUR105855332(AWAT2) 105868898(DGAT1)
LCAT123628304(AWAT2) 123644864(DGAT1)
OGA100958022(AWAT2) 100961287(DGAT1)
MMU13350(Dgat1) 245532(Awat2)
MCAL110287264(Awat2) 110310326(Dgat1)
MPAH110313940(Awat2) 110334746(Dgat1)
RNO302425(Awat2) 84497(Dgat1)
MCOC116074725(Dgat1) 116093751(Awat2)
MUN110541347(Awat2) 110562264(Dgat1)
CGE100755985(Dgat1) 100768365(Awat2)
MAUA101839431(Dgat1) 101841831(Awat2)
PLEU114694176(Dgat1) 114703153(Awat2)
MORG121445371 121461251(Dgat1)
MFOT126487051 126503327
AAMP119805573(Awat2) 119823936(Dgat1)
NGI103735255(Dgat1) 103743154(Awat2)
HGL101701856(Awat2) 101723650(Dgat1)
CPOC100733854(Dgat1) 100734162(Awat2)
CCAN109675699 109691174(Dgat1)
DORD105997251(Awat2) 105998990(Dgat1)
DSP122098871(Dgat1) 122120673(Awat2)
NCAR124972594 124979633
OCU100340789(AWAT2) 100350630(DGAT1)
OPI101525494(DGAT1) 101533444(AWAT2)
TUP102474487(DGAT1) 102502982(AWAT2)
CFA482093(DGAT1) 491936(AWAT2)
CLUD112662190(DGAT1) 112671936(AWAT2)
VVP112907586(AWAT2) 112911178(DGAT1)
VLG121482279(AWAT2) 121498689(DGAT1)
AML100475313(AWAT2) 100479095(DGAT1)
UMR103656696(DGAT1) 103682604(AWAT2)
UAH113245600(AWAT2) 113247638(DGAT1)
UAR123779353(DGAT1) 123780201(AWAT2)
ELK111146542 111161046
LLV125091482 125097457
MPUF101671117(AWAT2) 101693117(DGAT1)
ORO101366779(DGAT1) 101386463(AWAT2)
EJU114200104(AWAT2) 114201092(DGAT1)
ZCA113926178(DGAT1) 113931496(AWAT2)
MLX118015312(DGAT1) 118025921(AWAT2)
NSU110572309(AWAT2) 110579270(DGAT1)
FCA101086879(AWAT2) 101101615(DGAT1)
PYU121025268(AWAT2) 121043140(DGAT1)
PBG122477297(AWAT2) 122495929(DGAT1)
LRUF124507892 124521536
PTG102952284(DGAT1) 102972443(AWAT2)
PPAD109254591(AWAT2) 109258372(DGAT1)
AJU106979135(DGAT1) 106982379(AWAT2)
HHV120246057(AWAT2) 120246564(DGAT1)
BTA282609(DGAT1) 521298(AWAT2)
BOM102275983(AWAT2) 102277779(DGAT1)
BBUB102390126(DGAT1) 102390285(AWAT2)
CHX100861225(DGAT1) 102177144(AWAT2)
OAS100126245(DGAT1) 101121241(AWAT2)
ODA120878731(DGAT1) 120882038(AWAT2)
CCAD122435975(AWAT2) 122451441(DGAT1)
SSC100151799(AWAT2) 397118(DGAT1)
CFR102514200(AWAT2) 102515256(DGAT1)
CBAI105073815(DGAT1) 105083735(AWAT2)
CDK105087992(AWAT2) 105104999(DGAT1)
VPC102530551(DGAT1) 102531353(AWAT2)
BACU103001320(DGAT1) 103009724(AWAT2)
LVE103073062(DGAT1) 103074572(AWAT2)
OOR101275488(DGAT1) 101282586(AWAT2)
DLE111165111(DGAT1)
PCAD102974279(DGAT1) 102990854(AWAT2)
PSIU116742184(DGAT1) 116747093(AWAT2)
ECB100066473(AWAT2) 100147359(DGAT1)
EPZ103540220(DGAT1) 103541350(AWAT2)
EAI106827656(AWAT2) 106841896(DGAT1)
MYB102242085(AWAT2) 102263903(DGAT1)
MYD102760049(AWAT2) 102769363(DGAT1)
MMYO118653153(DGAT1) 118653504(AWAT2)
MLF102424179(DGAT1) 102435686(AWAT2)
MNA107532905(AWAT2) 107539955(DGAT1)
PKL118704101 118710157(DGAT1)
HAI109375066(DGAT1)
DRO112299986(AWAT2) 112315624(DGAT1)
SHON118988846(DGAT1) 118996721(AWAT2)
AJM119040225(AWAT2) 119064708(DGAT1)
PDIC114505398(AWAT2) 114514557(DGAT1)
PHAS123824367(AWAT2) 123832960(DGAT1)
MMF118636677(AWAT2) 118643309(DGAT1)
RFQ117025069 117033867(DGAT1)
PALE102889573(DGAT1) 102895732(AWAT2)
PGIG120583622 120588872(DGAT1)
PVP105299645(AWAT2) 105301966(DGAT1)
RAY107503468(DGAT1) 107503822(AWAT2)
MJV108399471(DGAT1)
TOD119231737(DGAT1) 119246684(AWAT2)
SARA101550891(DGAT1) 101558988
LAV100655991 100669668(AWAT2) 104845744
TMU101350605 105756481
DNM101423860 101439107(DGAT1)
MDO100014456(AWAT2) 100018271(DGAT1)
GAS123242018(DGAT1) 123253312
SHR100924635(DGAT1) 100931966(AWAT2)
PCW110201013(AWAT2) 110214325(DGAT1)
OAA100086109 103166832(DGAT1)
LSR110479459 110483891
FPG106112364(DGAT1)
FCH106631435(DGAT1)
ACHC115340488(DGAT1)
DPUB104297206(DGAT1)
CVF104288096(DGAT1)
AAM106485793 106487807(DGAT1)
AROW112976662(DGAT1)
NPD112943212(DGAT1)
DNE112985425 112991945(DGAT1)
SCAM104138457(DGAT1)
ASN102375256(DGAT1)
AMJ102576196(DGAT1)
CPOO109310393(DGAT1)
PSS102448420(DGAT1)
CMY102930647 102932469(DGAT1)
CPIC101950960(DGAT1) 101951746
TST117871848(DGAT1) 117886576
CABI116827482 116828232(DGAT1)
MRV120384334 120398746(DGAT1)
ACS100551857(dgat1)
PVT110084814(DGAT1)
SUND121929186(DGAT1)
PBI103065772(DGAT1)
PMUR107300055(DGAT1)
CTIG120298024(DGAT1)
PGUT117666944(DGAT1)
VKO123035254(DGAT1)
PMUA114600142(DGAT1)
ZVI118089698(DGAT1)
GJA107110672(DGAT1)
STOW125425140(DGAT1)
XLA100381012(dgat1.L)
XTR101730812(dgat1)
NPR108799410(DGAT1)
RTEM120923031(DGAT1)
BBUF121001595(DGAT1)
BGAR122938045(DGAT1)
DRE325875(dgat1a) 436731(dgat1b)
SRX107706563 107724797 107741726 107751676
SANH107655125 107671724 107694771 107704850
SGH107552801 107557468 107566613 107587805
CCAR109081342 109081349 109092539 109111091
CAUA113062576 113062620 113079406 113090343 113116083 113119828
PPRM120483416(dgat1a) 120484730 120484731
MAMB125243708(dgat1b) 125275831(dgat1a)
IPU108257065(dgat1a) 108267870(dgat1b)
PHYP113534178 113536104
SMEO124376238(dgat1a) 124384318(dgat1b)
TFD113644625(dgat1b) 113648068(dgat1a)
AMEX103031398 103039575
EEE113571147 113572060(dgat1)
TRU101072465 101079602(dgat1)
TNGGSTEN00032560G001 GSTEN00034052G001
LCO104919541(dgat1) 104933582 104940359
NCC104952233 104959283(dgat1)
CGOB115009812 115016117 115021863
ELY117261683 117263703(dgat1a) 117265232(dgat1b)
EFO125887813 125893571(dgat1b) 125904804(dgat1a)
PLEP121945535(dgat1b) 121950149 121958068
SLUC116040207 116047377(dgat1a) 116049462(dgat1b)
ECRA117945791 117949528 117957313(dgat1a)
ESP116691471 116693414 116693415 116701661
PFLV114557920 114560717 114568204(dgat1)
GAT120810957 120826363
PPUG119195682 119197148(dgat1b) 119219218(dgat1a)
MSAM119893607 119897680(dgat1b) 119907078(dgat1a)
CUD121514035(dgat1b) 121515487 121523920(dgat1a)
ALAT119005764(dgat1b) 119016775(dgat1a) 119023772
MZE101469920 101473178 101487504 112435568
ONL100691083 100691118 102081853
OAU116322502 116322667(dgat1a) 116331366(dgat1b)
OLA101155899 101166984
OML112138961(dgat1a) 112143225(dgat1b)
XMA102220430 102225690(dgat1)
XCO114141802 114156467(dgat1)
XHE116717507 116731846(dgat1)
PRET103472475(dgat1) 103478641
PFOR103140880 103146836(dgat1)
PLAI106946045 106958546(dgat1)
PMEI106916852 106928476
GAF122831501 122843123(dgat1a)
CVG107096196 107102649
CTUL119775181(dgat1b) 119779654
GMU124866421(dgat1b) 124877928 124879920(dgat1a)
NFU107389273 107394608 107395184
KMR108241110(dgat1b) 108242037(dgat1a)
ALIM106518138(dgat1) 106527102 106536329
NWH119409426(dgat1b) 119425868(dgat1a)
AOCE111567391 111573142
MCEP125015075 125016860 125019819(dgat1a)
CSEM103388561 103394287
POV109633536 109638866(dgat1)
SSEN122774434(dgat1b) 122786169(dgat1a)
HHIP117770869(dgat1a) 117777146
HSP118114155(dgat1b) 118124390(dgat1a)
LCF108879464(dgat1a) 108889635(dgat1b) 108901956
SDU111223509 111236802 111238841
SLAL111647688 111652724 111662381
XGL120784326(dgat1b) 120786827(dgat1a) 120792803
HCQ109512011 109518042
BPEC110160303 110161130 110171646
MALB109958740 109967303
BSPL114842540(dgat1b) 114865407(dgat1a)
SASA106560908 106570407 106588986 106605973 106606064 106606100
STRU115174058 115175571 115185682 115196890
OTW112218465 112229529(dgat1a) 112243899(dgat1b) 112264326
OMY110488052(dgat1a) 110494222 110496672 110506952 110520733
OGO124005906 124008059 124012270 124044333(dgat1a)
ONE115128727 115131337 115134358
SALP111954999 111956178 111962301
SNH120022261 120027397(dgat1a) 120048828 120065825
CCLU121531801 121542655 121543315 121571834(dgat1a) 121586773
ELS105018848 105022840(dgat1)
SFM108922051(dgat1) 108926542 108940649
PKI111843919(dgat1) 111844272 111851826
AANG118215306 118232926(dgat1a) 118237490
LOC102683351 102695280(dgat1)
PSPA121296694 121313708 121315166 121325403
ARUT117399315 117425628 117435281(dgat1a)
LCM102349959(DGAT1) 102358735
CMK103183634 103185953
RTP109935410(dgat1) 109936697
BFO118417909
BBEL109473705
CIN100177672
SCLV120325807 120326316
SPU575003
APLC110982992
SKO100376218
DMEDmel_CG31991(mdy)
DER6547631
DSE6614434
DSIDsimw501_GD24087(Dsim_GD24087)
DYADyak_GE12771
DAN6498181
DSR110184937
DPO4817308
DPE6589755
DMN108161944
DWI6643530
DGR6566587
DMODmoj_GI14192
DAZ108611284
DNV115562354
DHE111601178
DVI6628957
CCAT101459788
BOD106627593
RZE108355272 108366756 108367926
MDE101894841
SCAC106086210
LCQ111682921
LSQ119610931
HIS119646821
AGAAgaP_AGAP007843
ACOZ120959456
AARA120900691
ASTE118514160
AAG5569069
AALB109418063
CQUCpipJ_CPIJ005914
CPII120413867
CNS116346459
BCOO119076336
AME552377
ACER107996211
ALAB122716172
BIM100744121
BBIF117216546
BVK117231704
BVAN117166318
BTER100646196
BPYO122574321
CCAL108630029
OBB114876455 114876458
MGEN117224602
NMEA116424872
CGIG122400133
SOC105194711
MPHA105833565
AEC105150735 105151363 105153905
ACEP105618616
PBAR105422883
VEM105564389
HST105182283
DQU106747317
CFO105253928
FEX115242388
LHU105672373 105676355
PGC109852637
OBO105282087
PCF106788280
PFUC122515591
VPS122635863
NVI100116518
CSOL105364922
TPRE106658702
MDL103568794
CGLO123268155
FAS105271257
DAM107036296
AGIF122860689
LHT122501664
CCIN107262759
TCA664028
DPA109533688
SOY115881540
ATD109602335
CSET123312599
AGB108912570
LDC111511416
NVL108568180
APLN108732978 108738283 108738284
PPYR116158711 116158755 116178074
OTU111424823
BMOR101742497
BMAN114242959
MSEX115447123
DPLKGM_215813
BANY112054296
NIQ126781439
PMAC106710683
PPOT106099440
PXU106127750
PRAP110991401
ZCE119830300
HAW110371905
HZE124645453
TNL113506955
SLIU111352478
OFU114352013
CFEL113372371 113372959
BTAB109033927 109033936
DCI103512092
CLEC106668819
HHAL106689225
NLU111054822
PHUPhum_PHUM464830
FOC113204060 113213267
TPAL117645964 117647150
ZNE110828835 110841191
CSEC111872160
FCD110852290
DPXDAPPUDRAFT_300124
DMK116919682
PVM113829016
PJA122245886
PCHN125036882
HAME121872706
PCLA123759312
PTRU123504582
HAZT108679309
EAF111699456 111713715
LSM121115075
PPOI119089453
DSV119433330 119436275
RSAN119373828 119403260
RMP119176579 119177361
TUT107362581
DPTE113792896 113795426 113797359
DFR124492452 124498430 124498565
CSCU111631623 111639054
PTEP107450283
SDM118196832
CELCELE_H19N07.4(mboa-2)
CBRCBG_23107
BMYBM_BM12468(Bma-mboa-2)
LOALOAG_07245
NAINECAME_15885
TSPTsp_02502
HROHELRODRAFT_193513
LGILOTGIDRAFT_231331
PCAN112553384
BGT106051926
GAE121387998
HRF124138908
HRJ124262929
CRG105331361
MYI110442476
PMAX117337851
MMER123549120
OBI106869194
OSN115221438
LAK106165236
SMMSmp_127280
SHXMS3_00003249(DGAT1_1)
OVIT265_00228
EGLEGR_02006
NVE5519524
EPA110238682
ATEN116299071
ADF107351603
AMIL114963989
PDAM113667048
SPIS111335241
DGT114516678
XEN124436472
HMG101238034
TADTRIADDRAFT_35841
AQU100636603 100637352 100640646
ATHAT2G19450(TAG1)
ALY9322105
CRB17891447
CSAT104701387 104748933 104767141
EUSEUTSA_v10022645mg
BRP103828297 103837958
BNA106352950 106375527 106382435 106402120 106406949 106436339
BOE106301685 106313337
RSZ108806506 108823770 108823781 108823802
THJ104814629 104820018
CPAP110817535
CIT102619099
CICCICLE_v100080481m
PVY116113684
MINC123195156 123199911
TCC18588364
GRA105793287
GHI107932255 121231954
GAB108466843
DZI111286703
EGR104438076
GMX547982(DGAT) 548005(DGAT1A) 732606(DGAT1b)
GSJ114367652 114382302 114394172
PVUPHAVU_003G134900g PHAVU_009G230700g
VRA106759755 106769144
VAR108331823 108338536
VUN114164815 114178989
CCAJ109804420 109807689
APRC113846417 113870784
MTR11443662 25494216
CAM101497785 101507886
LJALj4g3v2172770.1(Lj4g3v2172770.1) Lj4g3v2172770.2(Lj4g3v2172770.2) Lj6g3v1226310.1(Lj6g3v1226310.1)
ADU107478843 107496826
AIP107630508 107643251
AHF112696987 112723654 112738290 112790365
LANG109326199 109328042 109347548
FVE101304125
RCN112187921
PPER18769247
PMUM103340712
PAVI110749273
PDUL117635026
MDM103400825 114819572
PXB103940921 103951884
ZJU107424129
MNT21409930
CSV101213517
CMO103498593
BHJ120079835
MCHA111021903
CMAX111493820
CMOS111450373
CPEP111805863
RCU8272569
JCU105637897(DGAT1)
HBR110633612 110642432
MESC110603913 110611767
POP18107695 7484659
PEU105110113 105112821 105140456
PALZ118047965 118056693
JRE109009388 109009971
QSU111990032 112002203 112011105
QLO115976088
TWL119992963 120005593
VVI100266364
VRI117925364
SLY101245821 101264840
SPEN107005263 107026503
SOT102592250 102593515
SSTN125862419 125875965
CANN107840924 107877877
NTA107784357 107789692 107821867(DAGAT) 107830919
NSY104222136 104228678
NTO104094249 104100752
NAU109219417 109226554
INI109148038 109169022
ITR115998169 116020056
SIND105173637(DGAT1)
OEU111366337 111383725 111399475
EGT105968927
SSPL121746744 121752052 121754242 121754245 121796266 121800031
HAN110886978 110893727 110928453
ECAD122595669
LSV111892564
CCAV112501304 112516398
DCR108197160 108210867
CSIN114276617
BVG104909051
SOE110797728
CQI110683045 110712895
NNU104586668
MING122061644
TSS122653651 122668981
PSOM113295664 113316617 113347770 113350524
NCOL116260096
OSA4338045 4341317
DOSAOs05t0196800-00(Os05g0196800) Os06t0563900-01(Os06g0563900)
OBR102716701 102716784
BDI100827885 100832396
ATS109752785 109765064
TDC119329278 119330647 119340898 119368528
TAES123041784 123115703 123148010 123160017 123166926 123180788
TUA125520309 125551211
SBI8055715 8076727
ZMA100383910 103629820
SITA101759157 101778658
SVS117849906 117853245
PVIR120664349 120670509 120697657 120704879
PHAI112886216 112890486
PDA103709557 103719431
EGU105040465 105047643 105047997
MUS103968850 103999268
DCT110097309 110107905
PEQ110022299
AOF109828648
ATR18443650
SMOSELMODRAFT_138381(TAG1-2) SELMODRAFT_81638
PPP112287010 112292007
VCNVOLCADRAFT_69078
MNGMNEG_1183
CSLCOCSUDRAFT_54084
CVRCHLNCDRAFT_28812
APROF751_6502
CMECYME_CMQ199C
GSLGasu_29900
CCPCHC_T00009240001
YLIYALI0D07986g
SLBAWJ20_4739(ARE2)
NCRNCU00035
NTENEUTE1DRAFT129602(NEUTE1DRAFT_129602)
SMPSMAC_00123
PANPODANSg5375
TTTTHITE_2119816
MTMMYCTH_2303878
CTHRCTHT_0069450
MGRMGG_05326
PPEIPpBr36_03710
TMNUCRPA7_366
SSCKSPSK_02335
FGRFGSG_06688
FPUFPSE_01558
FVRFVEG_05426
FOXFOXG_02252
NHENECHADRAFT_100228
TRETRIREDRAFT_61705
TRRM419DRAFT_81078
MAWMAC_07178
MAJMAA_07086
CMTCCM_05029
PLJVFPFJ_05773
VALVDBG_08786
VDAVDAG_06444
CFJCFIO01_03366
CLUPCLUP02_03746
CHIGCH63R_02761
SAPOSAPIO_CDS5820
ELAUCREL1_6688
PFYPFICI_11496
SSLSS1G_13567
BFUBCIN_16g01220
MBEMBM_00351
PSCOLY89DRAFT_631653
GLZGLAREA_07814
ANIAN6159.2
AFMAFUA_2G08380
ACTACLA_080210
NFINFIA_084010
AORAO090011000863
ANGANI_1_1688104(An12g03600)
AFVAFLA_008254
ALUCAKAW2_60782A
ACHEACHE_50368A
APUUAPUU_51089A
PCSPc13g04400
PDPPDIP_85010
TMFPMAA_070720
TRGTRUGW13939_06218
CIMCIMG_00860
CPWCPC735_054550
UREUREG_00818
PBLPAAG_07527
PBNPADG_05222
ABEARB_04951
TVETRV_06710
AJEHCAG_07348
BGHBDBG_08114
PNOSNOG_13711
PTEPTT_18543
BZECOCCADRAFT_101346
BSCCOCSADRAFT_91729
BORCOCMIDRAFT_9045
AALTCC77DRAFT_1015346
ZTRMYCGRDRAFT_108832
PFJMYCFIDRAFT_153247
FFUCLAFUR5_06359
BCOMBAUCODRAFT_120378
NPAUCRNP2_5448
TMLGSTUM_00010199001
ECUECU10_0300
EINEint_100250
EHEEHEL_100300
EROEROM_100180
NCENCER_100059
MBRMONBRDRAFT_20830
SREPTSG_02810
DDIDDB_G0271342(dgat1)
DPPDICPUDRAFT_154444
DFADFA_06763 DFA_11930
ACANACA1_112640 ACA1_151370
PFAPF3D7_0322300
PFDPFDG_00612
PFHPFHG_03156
PREIPRSY57_0321600
PGABPGSY75_0322300
PYOPY17X_1219400
PCBPCHAS_1216900
PBEPBANKA_1216200
PVVPVVCY_1201700
PKNPKNH_0818500
PVXPVX_095120
PCYPCYB_082750
TANTA19620
TPVTP01_0247
TOTTOT_010000236
BEQBEWA_032080
BBOBBOV_IV004970(23.m06462)
BMICBMR1_02g00690
BBIGBBBOND_0210010
CPVcgd2_1090
CHOChro.20121
TGOTGME49_232730
TETTTHERM_00046260
PTMGSPATT00008374001 GSPATT00013044001 GSPATT00020321001 GSPATT00021071001 GSPATT00022973001 GSPATT00022974001 GSPATT00023565001
PTIPHATRDRAFT_9794
FCYFRACYDRAFT_276226
TPSTHAPSDRAFT_261279(DGT)
AAFAURANDRAFT_3067
EHXEMIHUDRAFT_64505
GTTGUITHDRAFT_113937
NGRNAEGRDRAFT_57973 NAEGRDRAFT_80131 NAEGRDRAFT_80541
 » show all
Reference
1  [PMID:6826734]
  Authors
Helgerud P, Petersen LB, Norum KR.
  Title
Retinol esterification by microsomes from the mucosa of human small intestine. Evidence for acyl-Coenzyme A retinol acyltransferase activity.
  Journal
J Clin Invest 71:747-53 (1983)
DOI:10.1172/JCI110822
Reference
2  [PMID:7061433]
  Authors
Ross AC.
  Title
Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase.
  Journal
J Biol Chem 257:2453-9 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.76
IUBMB Enzyme Nomenclature: 2.3.1.76
ExPASy - ENZYME nomenclature database: 2.3.1.76
BRENDA, the Enzyme Database: 2.3.1.76
CAS: 81295-48-9

KEGG   ENZYME: 2.3.1.135
Entry
EC 2.3.1.135                Enzyme                                 
Name
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN:R04514]
Reaction(KEGG)
R04514 > R08387 R08389
Substrate
phosphatidylcholine [CPD:C00157];
retinol---[cellular-retinol-binding-protein]
Product
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
EC 2.3.1.135 created 1992, modified 2011
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K00678  phosphatidylcholine-retinol O-acyltransferase
Genes
HSA9227(LRAT)
PTR471328(LRAT)
PPS100990532(LRAT)
GGO101135395(LRAT)
PON100432491(LRAT)
NLE100579669(LRAT)
MCC698871(LRAT)
MCF102123283(LRAT)
MTHB126955082
CSAB103236423(LRAT)
CATY105580675(LRAT)
PANU101020435(LRAT)
TGE112625128(LRAT)
RRO104657120(LRAT)
RBB108529031(LRAT)
TFN117086058(LRAT)
PTEH111552243(LRAT)
CJC100414604(LRAT)
SBQ101042985(LRAT)
CSYR103277419(LRAT)
MMUR105881778(LRAT)
LCAT123637689(LRAT)
OGA100966134(LRAT)
MMU79235(Lrat)
MCAL110291651(Lrat)
MPAH110319715(Lrat)
RNO64047(Lrat)
MCOC116093034(Lrat)
MUN110547199(Lrat)
CGE100769559(Lrat)
MAUA101832465(Lrat)
PLEU114682940(Lrat)
MORG121452675(Lrat)
MFOT126511608
AAMP119826390(Lrat)
NGI103751034(Lrat)
HGL101722664(Lrat)
CPOC100729755(Lrat)
CCAN109677811(Lrat)
DORD105995864(Lrat)
DSP122127237(Lrat)
NCAR124994876
OCU100354707(LRAT)
OPI101527023(LRAT)
TUP102476648(LRAT)
CFA482660(LRAT)
CLUD112654537(LRAT)
VVP112933438(LRAT)
VLG121481294(LRAT)
AML100482038(LRAT)
UMR103658037(LRAT)
UAH113255775(LRAT)
UAR123793200(LRAT)
ELK111157810
LLV125093118
MPUF101686629(LRAT)
ORO101384293(LRAT)
EJU114210180(LRAT)
ZCA113924803(LRAT)
MLX118022220(LRAT)
NSU110588483(LRAT)
FCA101092432(LRAT)
PYU121028260(LRAT)
PBG122475197(LRAT)
LRUF124520620
PTG102965792(LRAT)
PPAD109262496(LRAT)
AJU106982446(LRAT)
HHV120221623(LRAT)
BTA281285(LRAT)
BOM102264381(LRAT)
BIU109571479(LRAT)
BBUB102389350(LRAT)
CHX102183532(LRAT)
OAS101104976(LRAT) 114108650
ODA120871443(LRAT)
CCAD122451286(LRAT)
SSC100513994(LRAT)
CFR102520637(LRAT)
CBAI105079734(LRAT)
CDK105089285(LRAT)
VPC102527160(LRAT)
BACU103000637(LRAT)
LVE103091446(LRAT)
OOR101278519(LRAT)
DLE111187711(LRAT)
PCAD102978609(LRAT)
PSIU116754708(LRAT)
ECB100069704(LRAT)
EPZ103553820(LRAT)
EAI106832954(LRAT)
MYB102261540(LRAT)
MYD102758952(LRAT)
MMYO118659260(LRAT)
MLF102427893(LRAT)
MNA107525620(LRAT)
PKL118711148(LRAT)
HAI109382001(LRAT)
DRO112312204(LRAT)
SHON118995378(LRAT)
AJM119065916(LRAT)
PDIC114504003(LRAT)
PHAS123813659(LRAT)
MMF118615893(LRAT)
RFQ117038411(LRAT)
PALE102888347(LRAT)
PGIG120613425(LRAT)
PVP105292190(LRAT)
RAY107507545(LRAT)
MJV108408878(LRAT)
TOD119234844(LRAT)
SARA101541430(LRAT)
LAV100667142(LRAT)
TMU101341410
DNM101439300(LRAT)
MDO100017333(LRAT)
GAS123251508(LRAT)
SHR100931949(LRAT)
PCW110213622(LRAT)
OAA100080154(LRAT)
GGA422403(LRAT)
PCOC116243136(LRAT)
MGP104910504(LRAT)
CJO107313043(LRAT)
NMEL110398861(LRAT)
APLA101795343(LRAT)
AFUL116489174(LRAT)
TGU100224470(LRAT)
LSR110470513(LRAT)
SCAN103825960(LRAT)
PMOA120498061(LRAT)
OTC121331385(LRAT)
PRUF121360299(LRAT)
FAB101813271(LRAT)
PHI102105659(LRAT)
PMAJ107202673(LRAT)
CCW120409867(LRAT)
CBRC103617430(LRAT)
ETL114066333(LRAT)
ZAB102061781(LRAT)
FPG106112170(LRAT)
FCH102048889(LRAT)
CLV102087929(LRAT)
NNI104021236(LRAT)
TALA116965187(LRAT)
AFOR103902288(LRAT)
ACHC115343577(LRAT)
MUI104540176(LRAT)
AAM106492096(LRAT)
NPD112949245(LRAT)
ASN102378402(LRAT)
AMJ102557704(LRAT)
CPOO109309692(LRAT)
GGN109300838(LRAT)
PSS102463592(LRAT)
CMY102938217(LRAT)
CPIC101949409(LRAT)
TST117877603(LRAT)
CABI116824081(LRAT)
MRV120406935(LRAT)
ACS100552136(lrat)
PVT110072772(LRAT)
SUND121931889(LRAT)
PBI103061458(LRAT)
PMUR107287990(LRAT)
CTIG120316037(LRAT)
TSR106550018(LRAT)
PGUT117674727(LRAT)
VKO123023801(LRAT)
PMUA114604741(LRAT) 114604742
ZVI118083689(LRAT)
GJA107109450(LRAT)
STOW125440301(LRAT)
XLA108699284 108706650 443823(lrat.L)
XTR394746(lrat)
NPR108788202 108788203(LRAT)
RTEM120920155 120920168
BBUF120990059 120990060
BGAR122941866 122942060
DRE553239(lrata) 553501(lratb) 556575(lratb.2) 566123(si:dkey-30k22.5)
SRX107714135 107714151 107714634 107757590 107758847 107758870
SANH107665938 107665945 107692632 107692634 107695853 107695864 107700276
SGH107564312 107564324 107572196 107572197 107590728 107590773 107598257(lrat)
CCAR109053612 109085059 109107035 109107036
CAUA113044499 113044500 113044789 113100968 113107983 113109892
PPRM120462844 120462893(lratb.2) 120487494(si:dkey-30k22.5) 120494742(lrata)
MAMB125271444(si:dkey-30k22.5) 125272421(lrata) 125272763 125272764(lratb.2)
IPU108258976(lratb.2) 108258977 108261015(lrata)
PHYP113524574 113524578
SMEO124378050 124378533(lratb.2) 124381673(lrata)
TFD113634831(lrata) 113652968 113652969(lratb.2)
AMEX103023349 103023667 103037297(lrat)
EEE113574913 113583875
TRU101076520 101076751(lrat)
TNGGSTEN00000329G001 GSTEN00000330G001 GSTEN00013684G001 GSTEN00013685G001
LCO104917826 104917836(lrat) 109137012
NCC104949063 104966386(lrat)
CGOB115012347(lrat) 115012675
ELY117245752 117255851(si:dkey-30k22.5) 117255891(lrata) 117272810
EFO125883429 125884286 125886067(lrata) 125886068(si:dkey-30k22.5)
PLEP121941462(si:dkey-30k22.5) 121942700(lrata) 121962221(lratb.1) 121962534(lratb.2) 121963621
SLUC116051743 116052082 116052147
ECRA117941032 117954676
ESP116704044(lrat)
PFLV114545934 114546175 114557758 114562873
GAT120821314 120825187(lrata)
PPUG119218293(lrata) 119223041
MSAM119884110 119884111 119898789(lrata) 119898790(si:dkey-30k22.5) 119911806
CUD121504089 121504935(lratb.2) 121509047(lrata) 121509055(si:dkey-30k22.5)
ALAT119022749(lrata) 119023300 119026604 119027440(lratb.2)
MZE101468959 101469269 101485910 101486513
ONL100695577 100704704 100712580 109194412
OAU116312398(si:dkey-30k22.5) 116312412(lrata) 116326521(lratb.2) 116326574
OLA101158747 101162811 101172026 105356312
OML112137530(lrata) 112137644(si:dkey-30k22.5) 112156356 112156374(lratb.2)
XMA102217705 102223500 102225752
XCO114144069 114156863 114158010
XHE116719317 116732228 116733392
PRET103461909(lrat) 103480983 103480984
PFOR103149051 103149052 103156491
PLAI106949946 106949947 106953329(lrat)
PMEI106904117(lrat) 106910222 106910223
GAF122821042 122821063(lratb.2) 122830425
CVG107082284 107082299 107094918
CTUL119797130 119797138 119797181(si:dkey-30k22.5)
GMU124867780 124880260 124881075
NFU107396750 107396751
KMR108228851(lrata) 108248302 108248305(lratb.2) 108249452(si:dkey-30k22.5)
ALIM106519616(lrat) 106529231 106529233
NWH119417279 119419524 119422878(lrata)
AOCE111575111 111575125 111582913 111582918
MCEP125000078(lrata) 125000083(si:dkey-30k22.5) 125009964(lratb.2) 125010096
CSEM103383311 103389580(lrat)
POV109634737 109634762 109641900 109641901
SSEN122766322 122771684(si:dkey-30k22.5) 122771685(lrata)
HHIP117751915 117760283(lrata) 117762673(si:dkey-30k22.5)
HSP118102938 118115361(lrata) 118115874(si:dkey-30k22.5)
LCF108874763 108874769 108886657 108901657
SDU111216694 111216699 111237528 111237529
SLAL111649474 111649477 111663255 111663312(lrat)
XGL120797300 120797305(lratb.2) 120800556(si:dkey-30k22.5) 120800617(lrata)
HCQ109506952 109511520 109511521
BPEC110157705 110159451 110166097 110166259(lrat)
MALB109968215 109972941
BSPL114843882 114850357 114850374 114860244(lrata) 114862030(si:dkey-30k22.5) 121202087
SASA100195897(lrat) 106578168 106578182(LRAT) 106602563 106609867
STRU115191893 115193434 115194898 115198039 115201984 115202138
OTW112237687 112241754(lratb.1) 112262267 112262268 121847620
OMY110497453 110497454 110500951 110532986 110534421 118965977
OGO124002061 124002231 124008728 124008746 124013001 124028892
ONE115126778 115127009 115137336 115146554 115146555
SALP111958377 111958474 111971325 111971625
SNH120030189 120030694(lratb.1) 120034718 120035021 120049187 120051975 120052209
CCLU121558040 121558042 121558804 121558808 121572686
ELS105022864 105022865(lrat) 105030634 105030635
SFM108924362 108924447 108930780
PKI111833401 111837433 111837434
AANG118226830(lrata) 118228340(si:dkey-30k22.5) 118231467 118232461(lratb.2)
LOC102689719 102698541
PSPA121295181 121300150
ARUT117409620 117420592 117420657
LCM102361576(LRAT)
CMK103189387
RTP109935078(lrat)
BFO118431595
FCD110849237
PCAN112574694 112576349
BGT106052893 106077869
CRG105325359 105325365 109619122 117681093 117692902
MMER123524717 123562300
ATEN116308361 116308362
 » show all
Reference
1  [PMID:3410848]
  Authors
MacDonald PN, Ong DE.
  Title
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.
  Journal
J Biol Chem 263:12478-82 (1988)
  Sequence
[rno:64047]
Reference
2  [PMID:2722792]
  Authors
Saari JC, Bredberg DL.
  Title
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes.
  Journal
J Biol Chem 264:8636-40 (1989)
  Sequence
[bta:281285]
Reference
3  [PMID:8489497]
  Authors
Saari JC, Bredberg DL, Farrell DF
  Title
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase.
  Journal
Biochem J 291 ( Pt 3):697-700 (1993)
DOI:10.1042/bj2910697
Reference
4  [PMID:9767084]
  Authors
Mata NL, Tsin AT
  Title
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes.
  Journal
Biochim Biophys Acta 1394:16-22 (1998)
DOI:10.1016/S0005-2760(98)00078-2
Reference
5  [PMID:9920938]
  Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
  Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
  Journal
J Biol Chem 274:3834-41 (1999)
DOI:10.1074/jbc.274.6.3834
  Sequence
[hsa:9227] [bta:281285]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.135
IUBMB Enzyme Nomenclature: 2.3.1.135
ExPASy - ENZYME nomenclature database: 2.3.1.135
BRENDA, the Enzyme Database: 2.3.1.135
CAS: 117444-03-8

KEGG   REACTION: R02366
Entry
R02366                      Reaction                               
Name
Acyl-CoA:retinol O-acyltransferase
Definition
Acyl-CoA + Retinol <=> CoA + Retinyl ester
Equation
Reaction class
RC00004  C00010_C00040
RC00041  C00473_C02075
Enzyme
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K11155  diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
K11156  diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]
Other DBs
RHEA: 11491

KEGG   REACTION: R02367
Entry
R02367                      Reaction                               
Name
Palmitoyl-CoA:retinol O-acyltransferase
Definition
Palmitoyl-CoA + Retinol <=> CoA + Retinyl palmitate
Equation
Reaction class
RC00004  C00010_C00154
RC00041  C00473_C02588
Enzyme
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K11155  diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
K11156  diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]

KEGG   REACTION: R02368
Entry
R02368                      Reaction                               
Name
retinyl-palmitate palmitohydrolase
Definition
Retinyl palmitate + H2O <=> Retinol + Hexadecanoic acid
Equation
Reaction class
RC00020  C00249_C02588
RC00041  C00473_C02588
Enzyme
3.1.1.-
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K11157  patatin-like phospholipase domain-containing protein 4 [EC:3.1.1.-]
Other DBs
RHEA: 21511

KEGG   REACTION: R08387
Entry
R08387                      Reaction                               
Name
phosphatidylcholine:retinol O-acyltransferase
Definition
Phosphatidylcholine + Retinol <=> 2-Acyl-sn-glycero-3-phosphocholine + Retinyl ester
Equation
Reaction class
RC00041  C00157_C04233  C00473_C02075
Enzyme
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K00678  phosphatidylcholine-retinol O-acyltransferase [EC:2.3.1.135]

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