K11859                      KO                                     

tumor necrosis factor, alpha-induced protein 3 [EC:]
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map05162  Measles
map05169  Epstein-Barr virus infection
H01492  Systemic sclerosis
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04668 TNF signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04657 IL-17 signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   05169 Epstein-Barr virus infection
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases  ubiquitinyl hydrolase 1
     K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C64
   K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Other DBs
GO: 0004843
HSA: 7128(TNFAIP3)
PTR: 472136(TNFAIP3)
PPS: 100994797(TNFAIP3)
GGO: 101149274(TNFAIP3)
PON: 100459145(TNFAIP3)
NLE: 100600197(TNFAIP3)
MCC: 704130(TNFAIP3)
MCF: 101867362(TNFAIP3)
CSAB: 103240296(TNFAIP3)
CATY: 105600386(TNFAIP3)
PANU: 100998710(TNFAIP3)
RRO: 104675026(TNFAIP3)
RBB: 108518253(TNFAIP3)
TFN: 117097467(TNFAIP3)
PTEH: 111525526(TNFAIP3)
CJC: 100397002(TNFAIP3)
SBQ: 101052980(TNFAIP3)
MMUR: 105862062(TNFAIP3)
MMU: 21929(Tnfaip3)
MCAL: 110303143(Tnfaip3)
MPAH: 110338221(Tnfaip3)
RNO: 683206(Tnfaip3)
MCOC: 116097806(Tnfaip3)
CGE: 100771931(Tnfaip3)
PLEU: 114686120(Tnfaip3)
NGI: 103724893(Tnfaip3)
CCAN: 109697032(Tnfaip3)
OCU: 100350259(TNFAIP3)
TUP: 102477224(TNFAIP3)
CFA: 484006(TNFAIP3)
VVP: 112919472(TNFAIP3)
VLG: 121485796(TNFAIP3)
AML: 100474270(TNFAIP3)
UMR: 103663491(TNFAIP3)
UAH: 113259486(TNFAIP3)
ORO: 101377530(TNFAIP3)
ELK: 111147788
MPUF: 101691448(TNFAIP3)
EJU: 114222770(TNFAIP3)
MLX: 118000841(TNFAIP3)
FCA: 101083682(TNFAIP3)
PTG: 102958897(TNFAIP3)
PPAD: 109249867(TNFAIP3)
AJU: 106982026(TNFAIP3)
HHV: 120239375(TNFAIP3)
BTA: 508105(TNFAIP3)
BOM: 102266726(TNFAIP3)
BIU: 109563985(TNFAIP3)
BBUB: 102412133(TNFAIP3)
CHX: 102182977(TNFAIP3)
OAS: 101113156(TNFAIP3)
ODA: 120863082(TNFAIP3)
SSC: 100622156(TNFAIP3)
CFR: 102523266(TNFAIP3)
CBAI: 105077436(TNFAIP3)
CDK: 105092086(TNFAIP3)
BACU: 103001161(TNFAIP3)
LVE: 103081298(TNFAIP3)
OOR: 101275303(TNFAIP3)
DLE: 111166213(TNFAIP3)
PCAD: 102991611(TNFAIP3)
ECB: 100073197(TNFAIP3)
EPZ: 103549048(TNFAIP3)
EAI: 106846056(TNFAIP3)
MYB: 102258379(TNFAIP3)
MYD: 102761078(TNFAIP3)
MMYO: 118659998(TNFAIP3)
MNA: 107530982(TNFAIP3)
HAI: 109385645(TNFAIP3)
DRO: 112297385(TNFAIP3)
SHON: 118986669(TNFAIP3)
AJM: 119051859(TNFAIP3)
MMF: 118621121(TNFAIP3)
PALE: 102887009(TNFAIP3)
PGIG: 120603700 120615771(TNFAIP3)
RAY: 107505426(TNFAIP3)
MJV: 108399269(TNFAIP3)
TOD: 119251021 119252914(TNFAIP3)
LAV: 100670852(TNFAIP3)
TMU: 101345067
MDO: 100025842(TNFAIP3)
SHR: 100919524(TNFAIP3)
PCW: 110199059(TNFAIP3)
OAA: 100075332(TNFAIP3)
GGA: 421684(TNFAIP3)
PCOC: 116240637(TNFAIP3)
MGP: 100550484(TNFAIP3)
CJO: 107311676(TNFAIP3)
NMEL: 110396285(TNFAIP3)
APLA: 101796300(TNFAIP3)
ACYG: 106032519(TNFAIP3)
TGU: 100227030(TNFAIP3)
LSR: 110483298(TNFAIP3)
SCAN: 103818470(TNFAIP3)
PMOA: 120501443(TNFAIP3)
GFR: 102041044(TNFAIP3)
FAB: 101817397(TNFAIP3)
PHI: 102102986(TNFAIP3)
PMAJ: 107202524(TNFAIP3)
CCAE: 111945140(TNFAIP3)
CCW: 104689521(TNFAIP3)
ETL: 114059512(TNFAIP3)
FPG: 101911730(TNFAIP3)
FCH: 102046472(TNFAIP3)
CLV: 102097352(TNFAIP3)
EGZ: 104131136(TNFAIP3)
NNI: 104008814(TNFAIP3)
ACUN: 113478855(TNFAIP3)
PADL: 103912709(TNFAIP3)
AAM: 106497913(TNFAIP3)
ASN: 102372488(TNFAIP3)
AMJ: 102558492(TNFAIP3)
CPOO: 109320187(TNFAIP3)
GGN: 109304738(TNFAIP3)
PSS: 102450291(TNFAIP3)
CMY: 102936943(TNFAIP3)
CPIC: 101945596(TNFAIP3)
TST: 117874897(TNFAIP3)
CABI: 116818778(TNFAIP3)
ACS: 100564334(tnfaip3)
PVT: 110071261(TNFAIP3)
PBI: 103068002(TNFAIP3)
PMUR: 107294501(TNFAIP3)
TSR: 106547167(TNFAIP3)
PGUT: 117666303(TNFAIP3)
PMUA: 114594180(TNFAIP3)
ZVI: 118077770 118082066(TNFAIP3)
GJA: 107122065(TNFAIP3)
XLA: 446998(tnfaip3.S)
NPR: 108795154(TNFAIP3)
DRE: 564497(tnfaip3)
SRX: 107720364 107751155(tnfaip3)
IPU: 108263677(tnfaip3)
PHYP: 113542100(tnfaip3)
AMEX: 103035626(tnfaip3)
EEE: 113585834(tnfaip3)
TRU: 101062530(tnfaip3)
LCO: 104928434(tnfaip3)
NCC: 104955588(tnfaip3)
CGOB: 115019818(tnfaip3)
ELY: 117248491(tnfaip3)
PLEP: 121954268(tnfaip3)
SLUC: 116056560(tnfaip3)
ECRA: 117959978(tnfaip3)
PFLV: 114572289(tnfaip3)
GAT: 120820768(tnfaip3)
MSAM: 119917056(tnfaip3)
CUD: 121510853(tnfaip3)
MZE: 101476138(tnfaip3)
ONL: 100692128(tnfaip3)
OAU: 116325737(tnfaip3)
OLA: 101160685(tnfaip3)
OML: 112161989(tnfaip3)
XMA: 102237440(tnfaip3)
XCO: 114138247(tnfaip3)
XHE: 116713474(tnfaip3)
PRET: 103476679(tnfaip3)
CVG: 107099924(tnfaip3)
CTUL: 119790547(tnfaip3)
NFU: 107375829(tnfaip3)
KMR: 108245439(tnfaip3)
ALIM: 106535065(tnfaip3)
AOCE: 111582004(tnfaip3)
CSEM: 103386958(tnfaip3)
POV: 109634788(tnfaip3)
LCF: 108897419(tnfaip3)
SDU: 111235218(tnfaip3)
SLAL: 111645308(tnfaip3)
XGL: 120796570(tnfaip3)
HCQ: 109510035(tnfaip3)
BPEC: 110157241(tnfaip3)
MALB: 109959569(tnfaip3)
SASA: 106589680(tnfaip3) 106610821
SALP: 111968025(tnfaip3) 111978266
SNH: 120029473(tnfaip3) 120046845
ELS: 105021223(tnfaip3)
SFM: 108931280 108932919(tnfaip3)
PKI: 111837608(tnfaip3)
LOC: 102692234(tnfaip3) 107077521
PSPA: 121303322 121316063 121317186(tnfaip3)
LCM: 102362242(TNFAIP3) 106703405
CMK: 103178317(tnfaip3) 103185665
SPU: 590500
APLC: 110974467
SKO: 100369415
PCAN: 112567026
BGT: 106078457
GAE: 121372539
CRG: 105347244
MYI: 110463768
PMAX: 117327794
LAK: 106165950
NVE: 5510450
EPA: 110235961
ATEN: 116303600
ADF: 107344228
AMIL: 114975192
PDAM: 113664510
SPIS: 111325763
DGT: 114537034
HMG: 105848063
AQU: 105316699
 » show all
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Nature 430:694-9 (2004)
Opipari AW Jr, Boguski MS, Dixit VM
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
J Biol Chem 265:14705-8 (1990)

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