KEGG   ORTHOLOGY: K11987
Entry
K11987                      KO                                     

Symbol
PTGS2, COX2
Name
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04064  NF-kappa B signaling pathway
map04370  VEGF signaling pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04723  Retrograde endocannabinoid signaling
map04726  Serotonergic synapse
map04913  Ovarian steroidogenesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05140  Leishmaniasis
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05204  Chemical carcinogenesis - DNA adducts
map05206  MicroRNAs in cancer
map05222  Small cell lung cancer
Disease
H00017  Esophageal cancer
H00025  Penile cancer
H00046  Cholangiocarcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04064 NF-kappa B signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04668 TNF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04657 IL-17 signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04913 Ovarian steroidogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04921 Oxytocin signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09156 Nervous system
   04726 Serotonergic synapse
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04723 Retrograde endocannabinoid signaling
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05206 MicroRNAs in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05204 Chemical carcinogenesis - DNA adducts
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05165 Human papillomavirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Other DBs
RN: R00073 R01590
GO: 0004666
Genes
HSA: 5743(PTGS2)
PTR: 469616(PTGS2)
PPS: 100985650(PTGS2)
GGO: 101146681(PTGS2)
PON: 100436566(PTGS2)
NLE: 100591090(PTGS2)
MCC: 716671(PTGS2)
MCF: 102143028(PTGS2)
CSAB: 103230420(PTGS2)
CATY: 105579902(PTGS2)
PANU: 101025796(PTGS2)
RRO: 104664377(PTGS2)
RBB: 108523178(PTGS2)
TFN: 117074573(PTGS2)
PTEH: 111536921(PTGS2)
CJC: 100407639(PTGS2)
SBQ: 101027603(PTGS2)
MMUR: 105855505(PTGS2)
MMU: 19225(Ptgs2)
MPAH: 110315297 110321554(Ptgs2)
RNO: 29527(Ptgs2)
MCOC: 116070506(Ptgs2)
MUN: 110553489(Ptgs2)
CGE: 100751220(Ptgs2)
PLEU: 114696775(Ptgs2)
NGI: 103726651(Ptgs2)
HGL: 101704771(Ptgs2)
CCAN: 109685138(Ptgs2)
OCU: 100009248(PTGS2)
TUP: 102478264(PTGS2)
CFA: 442942(PTGS2)
VVP: 112921830(PTGS2)
VLG: 121497643(PTGS2)
AML: 100481615(PTGS2)
UMR: 103668648(PTGS2)
UAH: 113262761(PTGS2)
ORO: 101375484(PTGS2)
ELK: 111150791
MPUF: 101688096(PTGS2)
EJU: 114222880(PTGS2)
MLX: 118013715(PTGS2)
FCA: 100126581(PTGS2)
PTG: 102948685(PTGS2)
PPAD: 109253602(PTGS2)
AJU: 106967086(PTGS2)
HHV: 120248734(PTGS2)
BTA: 282023(PTGS2)
BOM: 102271174(PTGS2)
BIU: 109570734(PTGS2)
BBUB: 102416528(PTGS2)
CHX: 100860905(PTGS2)
OAS: 443460(PTGS2)
ODA: 120880449(PTGS2)
SSC: 397590(PTGS2)
CFR: 102509586(PTGS2)
CBAI: 105083396(PTGS2)
CDK: 105099289(PTGS2)
BACU: 102999195(PTGS2)
LVE: 103088613(PTGS2)
OOR: 101270299(PTGS2)
DLE: 111184673(PTGS2)
PCAD: 102982708(PTGS2)
ECB: 791253(PTGS2)
EPZ: 103547078(PTGS2)
EAI: 106846783(PTGS2)
MYB: 102259598(PTGS2)
MYD: 102774808(PTGS2)
MMYO: 118673371(PTGS2)
MNA: 107546245(PTGS2)
HAI: 109379092(PTGS2)
DRO: 112296707(PTGS2)
SHON: 118979157(PTGS2)
AJM: 119059729(PTGS2)
MMF: 118637857(PTGS2)
PALE: 102886561(PTGS2)
PGIG: 120617547(PTGS2)
RAY: 107521616(PTGS2)
MJV: 108406216(PTGS2)
TOD: 119241194(PTGS2)
LAV: 100666359(PTGS2)
TMU: 101345018
MDO: 100024802(PTGS2)
SHR: 100926756(PTGS2)
PCW: 110206875(PTGS2)
OAA: 100086096(PTGS2)
GGA: 396451(PTGS2)
PCOC: 116238667(PTGS2)
MGP: 100550092(PTGS2)
CJO: 107317330(PTGS2)
NMEL: 110402447(PTGS2)
APLA: 101790135(PTGS2)
ACYG: 106034056(PTGS2)
TGU: 100221909(PTGS2)
LSR: 110467832(PTGS2)
SCAN: 103814802(PTGS2)
PMOA: 120510474(PTGS2)
GFR: 102045242(PTGS2)
FAB: 101816125(PTGS2)
PHI: 102105209(PTGS2)
PMAJ: 107208209(PTGS2)
CCAE: 111932522(PTGS2)
CCW: 104693603(PTGS2)
ETL: 114066906(PTGS2)
FPG: 101918755(PTGS2)
FCH: 102050356(PTGS2)
CLV: 102088650(PTGS2)
EGZ: 104124553(PTGS2)
NNI: 104011302(PTGS2)
ACUN: 113483094(PTGS2)
PADL: 103922182(PTGS2)
AAM: 106486027
ASN: 102369126(PTGS2)
AMJ: 106736995(PTGS2)
CPOO: 109307218(PTGS2)
GGN: 109286913(PTGS2)
PSS: 102459102(PTGS2)
CMY: 102934690(PTGS2)
CPIC: 101941281(PTGS2)
TST: 117882058(PTGS2)
CABI: 116826611(PTGS2)
ACS: 100560130(ptgs2)
PVT: 110079773(PTGS2)
PBI: 103063043(PTGS2)
PMUR: 107285158(PTGS2)
TSR: 106542642(PTGS2)
PGUT: 117661093(PTGS2)
GJA: 107121970(PTGS2)
XLA: 108714508(ptgs2.L) 446781(ptgs2.S)
XTR: 595089(ptgs2)
NPR: 108798706(PTGS2)
DRE: 246227(ptgs2a) 559020(ptgs2b)
CCAR: 109071632(ptgs2) 109081129
TRU: 101064817(ptgs2)
LCO: 104921828(ptgs2)
NCC: 104955130(ptgs2)
CGOB: 115006753(ptgs2)
ELY: 117254034(ptgs2b)
PLEP: 121965412(ptgs2b)
SLUC: 116060361(ptgs2b)
ECRA: 117949850(ptgs2b)
PFLV: 114561193(ptgs2)
GAT: 120823991(ptgs2b)
MSAM: 119900433(ptgs2b)
CUD: 121511973(ptgs2b)
MZE: 101472557(ptgs2)
ONL: 100698573(ptgs2)
OAU: 116335047(ptgs2b)
OLA: 100359365(ptgs2)
OML: 112150839(ptgs2b)
XMA: 102228898(ptgs2)
XCO: 114150821(ptgs2)
XHE: 116726213(ptgs2)
PRET: 103468244(ptgs2)
CVG: 107085952(ptgs2)
CTUL: 119787704(ptgs2b)
NFU: 107392885(ptgs2)
KMR: 108238364(ptgs2b)
ALIM: 106516825(ptgs2)
AOCE: 111585762(ptgs2)
CSEM: 103395284(ptgs2)
POV: 109636696(ptgs2)
LCF: 108896773(ptgs2)
SDU: 111219627(ptgs2)
SLAL: 111645378(ptgs2)
XGL: 120791019(ptgs2b)
HCQ: 109519080(ptgs2)
BPEC: 110167945(ptgs2)
MALB: 109961724(ptgs2)
OMY: 100136025(cox-2) 110508862 110521832 110523034(ptgs2b)
ELS: 105028801 105029082(ptgs2)
SFM: 108935147 108935314(ptgs2)
AANG: 118224852(ptgs2b) 118230093(ptgs2a)
LOC: 102685668(ptgs2)
ARUT: 117413155(ptgs2b) 117416604
LCM: 102352257(PTGS2)
CMK: 103179983(ptgs2)
RTP: 109933769(ptgs2)
RMD: 113560185
DMK: 116931895
PVM: 113810970
HAME: 121854255
HAZT: 108668991
PCAN: 112575294
BGT: 106074919
GAE: 121382972
MYI: 110451344
PMAX: 117321998
DGT: 114537549
NEU: NE1240(Ptgs1)
MET: M446_1624
MNO: Mnod_6498
RDE: RD1_1072
MALU: KU6B_22370
MVA: Mvan_3099
SRO: Sros_8745
GOB: Gobs_1219
 » show all
Reference
PMID:8473346
  Authors
Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM
  Title
Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.
  Journal
J Biol Chem 268:9049-54 (1993)
  Sequence
[hsa:5743]
Reference
  Authors
Kim SF, Huri DA, Snyder SH
  Title
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
  Journal
Science 310:1966-70 (2005)
DOI:10.1126/science.1119407

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