KEGG   ORTHOLOGY: K12406
Entry
K12406                      KO                                     

Symbol
PKLR
Name
pyruvate kinase isozymes R/L [EC:2.7.1.40]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00230  Purine metabolism
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map04910  Insulin signaling pathway
map04930  Type II diabetes mellitus
map04932  Non-alcoholic fatty liver disease
map04950  Maturity onset diabetes of the young
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00002  Glycolysis, core module involving three-carbon compounds
M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
Disease
H01096  Pyruvate kinase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12406  PKLR; pyruvate kinase isozymes R/L
   00620 Pyruvate metabolism
    K12406  PKLR; pyruvate kinase isozymes R/L
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12406  PKLR; pyruvate kinase isozymes R/L
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K12406  PKLR; pyruvate kinase isozymes R/L
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K12406  PKLR; pyruvate kinase isozymes R/L
   04950 Maturity onset diabetes of the young
    K12406  PKLR; pyruvate kinase isozymes R/L
   04932 Non-alcoholic fatty liver disease
    K12406  PKLR; pyruvate kinase isozymes R/L
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K12406  PKLR; pyruvate kinase isozymes R/L
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     K12406  PKLR; pyruvate kinase isozymes R/L
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K12406  PKLR; pyruvate kinase isozymes R/L
Other DBs
RN: R00200 R00430 R01138 R01858 R02320
GO: 0004743
Genes
HSA: 5313(PKLR)
PTR: 469513(PKLR)
PPS: 100980055(PKLR)
GGO: 101129346(PKLR)
PON: 100435140(PKLR)
NLE: 100579676(PKLR)
MCC: 719152(PKLR)
MCF: 102116429(PKLR)
CSAB: 103223883(PKLR)
CATY: 105593532(PKLR)
PANU: 101016119(PKLR)
RRO: 104659593(PKLR)
RBB: 108526846(PKLR)
TFN: 117074608(PKLR)
PTEH: 111543761(PKLR)
CJC: 100391903(PKLR)
SBQ: 101040510(PKLR)
MMUR: 105873168(PKLR)
MMU: 18770(Pklr)
MCAL: 110290727(Pklr)
MPAH: 110320360(Pklr)
RNO: 24651(Pklr)
MCOC: 116093152(Pklr)
MUN: 110544999(Pklr)
CGE: 100755461(Pklr)
PLEU: 114707930(Pklr)
NGI: 103750858(Pklr)
HGL: 101701016(Pklr)
CCAN: 109687970(Pklr)
OCU: 100355056(PKLR)
TUP: 102488414(PKLR)
CFA: 490425(PKLR)
VVP: 112918921(PKLR)
VLG: 121488418(PKLR)
AML: 100474752(PKLR)
UMR: 103668697(PKLR)
UAH: 113245274(PKLR)
ORO: 101364399(PKLR)
ELK: 111138942
MPUF: 101671035(PKLR)
EJU: 114198647(PKLR)
MLX: 118013609(PKLR)
FCA: 101088459(PKLR)
PYU: 121015639(PKLR)
PTG: 102971027(PKLR)
PPAD: 109256357(PKLR)
AJU: 106981518(PKLR)
HHV: 120244657(PKLR)
BTA: 539579(PKLR)
BOM: 102273144(PKLR)
BIU: 109553613(PKLR)
BBUB: 102393826(PKLR)
CHX: 102187548(PKLR)
OAS: 780515(PKLR)
ODA: 120855736(PKLR)
CCAD: 122432517(PKLR)
SSC: 100738344(PKLR)
CFR: 102522070(PKLR)
CBAI: 105068153(PKLR)
CDK: 105088819(PKLR)
BACU: 103019356(PKLR)
LVE: 103089176(PKLR)
OOR: 101290268(PKLR)
DLE: 111166979(PKLR)
PCAD: 102982777(PKLR)
ECB: 100063608(PKLR)
EPZ: 103552837(PKLR)
EAI: 106828491(PKLR)
MYB: 102255792(PKLR)
MYD: 102762600(PKLR)
MMYO: 118673208(PKLR)
MNA: 107543786(PKLR)
HAI: 109393365(PKLR)
DRO: 112315575(PKLR)
SHON: 118990152(PKLR)
AJM: 119039718(PKLR)
MMF: 118637241(PKLR)
PALE: 102888780(PKLR)
PGIG: 120592122(PKLR)
RAY: 107521461(PKLR)
MJV: 108407272(PKLR)
TOD: 119235279(PKLR)
LAV: 100659553(PKLR)
TMU: 101350675
MDO: 100022269(PKLR)
SHR: 100930790(PKLR)
PCW: 110211952(PKLR)
OAA: 114808131(PKLR)
ASN: 102373250(PKLR)
AMJ: 102572085(PKLR)
CPOO: 109324807(PKLR)
GGN: 109305098(PKLR)
CMY: 102942996(PKLR)
CPIC: 101940854(PKLR)
CABI: 116817240(PKLR)
PVT: 110081059(PKLR)
PBI: 103060723(PKLR)
TSR: 106544312
PMUA: 114586554(PKLR)
ZVI: 118075917(PKLR)
GJA: 107119573(PKLR)
XLA: 108700448(pklr.S) 398967(pklr.L)
XTR: 100380137(pklr)
NPR: 108794239(PKLR)
LCM: 102364735(PKLR)
 » show all
Reference
PMID:3126495
  Authors
Tani K, Fujii H, Nagata S, Miwa S
  Title
Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells.
  Journal
Proc Natl Acad Sci U S A 85:1792-5 (1988)
DOI:10.1073/pnas.85.6.1792
  Sequence
[hsa:5313]
Reference
PMID:1896471
  Authors
Kanno H, Fujii H, Hirono A, Miwa S
  Title
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.
  Journal
Proc Natl Acad Sci U S A 88:8218-21 (1991)
DOI:10.1073/pnas.88.18.8218
  Sequence
[hsa:5313]

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