K12406                      KO                                     
pyruvate kinase isozymes R/L [EC:]
map00010  Glycolysis / Gluconeogenesis
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
map04910  Insulin signaling pathway
map04930  Type II diabetes mellitus
map04932  Non-alcoholic fatty liver disease
map04950  Maturity onset diabetes of the young
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00002  Glycolysis, core module involving three-carbon compounds
H01096  Pyruvate kinase deficiency
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12406  PKLR; pyruvate kinase isozymes R/L
   00620 Pyruvate metabolism
    K12406  PKLR; pyruvate kinase isozymes R/L
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K12406  PKLR; pyruvate kinase isozymes R/L
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K12406  PKLR; pyruvate kinase isozymes R/L
   04950 Maturity onset diabetes of the young
    K12406  PKLR; pyruvate kinase isozymes R/L
   04932 Non-alcoholic fatty liver disease
    K12406  PKLR; pyruvate kinase isozymes R/L
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K12406  PKLR; pyruvate kinase isozymes R/L
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor  pyruvate kinase
     K12406  PKLR; pyruvate kinase isozymes R/L
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K12406  PKLR; pyruvate kinase isozymes R/L
Other DBs
RN: R00200 R00430 R01138 R01858 R02320
GO: 0004743
HSA: 5313(PKLR)
PTR: 469513(PKLR)
PPS: 100980055(PKLR)
GGO: 101129346(PKLR)
PON: 100435140(PKLR)
NLE: 100579676(PKLR)
MCC: 719152(PKLR)
MCF: 102116429(PKLR)
MTHB: 126933640
CSAB: 103223883(PKLR)
CATY: 105593532(PKLR)
PANU: 101016119(PKLR)
TGE: 112622336(PKLR)
RRO: 104659593(PKLR)
RBB: 108526846(PKLR)
TFN: 117074608(PKLR)
PTEH: 111543761(PKLR)
CJC: 100391903(PKLR)
SBQ: 101040510(PKLR)
CSYR: 103262621(PKLR)
MMUR: 105873168(PKLR)
LCAT: 123634068(PKLR)
OGA: 100955995(PKLR)
MMU: 18770(Pklr)
MCAL: 110290727(Pklr)
MPAH: 110320360(Pklr)
RNO: 24651(Pklr)
MCOC: 116093152(Pklr)
MUN: 110544999(Pklr)
CGE: 100755461(Pklr)
MAUA: 101831687(Pklr)
PLEU: 114707930(Pklr)
MORG: 121450778(Pklr)
MFOT: 126486482
AAMP: 119801202(Pklr)
NGI: 103750858(Pklr)
HGL: 101701016(Pklr)
CPOC: 100716756(Pklr)
CCAN: 109687970(Pklr)
DORD: 105984991(Pklr)
DSP: 122109603(Pklr)
NCAR: 124962400
OCU: 100355056
OPI: 101534803(PKLR)
TUP: 102488414(PKLR)
GVR: 103596182(PKLR)
CFA: 490425(PKLR)
CLUD: 112648931(PKLR)
VVP: 112918921(PKLR)
VLG: 121488418(PKLR)
AML: 100474752(PKLR)
UMR: 103668697(PKLR)
UAH: 113245274(PKLR)
UAR: 123783411(PKLR)
ELK: 111138942
LLV: 125086191
MPUF: 101671035(PKLR)
ORO: 101364399(PKLR)
EJU: 114198647(PKLR)
ZCA: 113932065(PKLR)
MLX: 118013609(PKLR)
NSU: 110573558(PKLR)
LWW: 102741679(PKLR)
FCA: 101088459(PKLR)
PYU: 121015639(PKLR)
PBG: 122476589(PKLR)
LRUF: 124521891
PTG: 102971027(PKLR)
PPAD: 109256357(PKLR)
AJU: 106981518(PKLR)
HHV: 120244657(PKLR)
BTA: 539579(PKLR)
BOM: 102273144(PKLR)
BIU: 109553613(PKLR)
BBUB: 102393826(PKLR)
BBIS: 104987400(PKLR)
CHX: 102187548(PKLR)
OAS: 780515(PKLR)
ODA: 120855736(PKLR)
CCAD: 122432517(PKLR)
SSC: 100738344(PKLR)
CFR: 102522070(PKLR)
CBAI: 105068153(PKLR)
CDK: 105088819(PKLR)
VPC: 102542351(PKLR)
BACU: 103019356(PKLR)
LVE: 103089176(PKLR)
OOR: 101290268(PKLR)
DLE: 111166979(PKLR)
PCAD: 102982777(PKLR)
PSIU: 116754609(PKLR)
ECB: 100063608(PKLR)
EPZ: 103552837(PKLR)
EAI: 106828491(PKLR)
MYB: 102255792(PKLR)
MYD: 102762600(PKLR)
MMYO: 118673208(PKLR)
MLF: 102422910(PKLR)
MNA: 107543786(PKLR)
PKL: 118721629(PKLR)
HAI: 109393365(PKLR)
DRO: 112315575(PKLR)
SHON: 118990152(PKLR)
AJM: 119039718(PKLR)
PDIC: 114488856(PKLR)
PHAS: 123804602(PKLR)
MMF: 118637241(PKLR)
RFQ: 117014390(PKLR)
PALE: 102888780(PKLR)
PGIG: 120592122(PKLR)
PVP: 105296362(PKLR)
RAY: 107521461(PKLR)
MJV: 108407272(PKLR)
TOD: 119235279(PKLR)
SARA: 101558377(PKLR)
LAV: 100659553(PKLR)
TMU: 101350675
ETF: 101638962(PKLR)
DNM: 101436765(PKLR)
MDO: 100022269(PKLR)
GAS: 123247777(PKLR)
SHR: 100930790(PKLR)
PCW: 110211952(PKLR)
OAA: 114808131(PKLR)
ASN: 102373250(PKLR)
AMJ: 102572085(PKLR)
CPOO: 109324807(PKLR)
GGN: 109305098(PKLR)
CMY: 102942996(PKLR)
CPIC: 101940854(PKLR)
CABI: 116817240(PKLR)
MRV: 120390465(PKLR)
PVT: 110081059(PKLR)
PBI: 103060723(PKLR)
CTIG: 120317061(PKLR)
TSR: 106544312
VKO: 123032632(PKLR)
PMUA: 114586554(PKLR)
ZVI: 118075917(PKLR)
GJA: 107119573(PKLR)
STOW: 125436554
XLA: 108700448(pklr.S) 398967(pklr.L)
XTR: 100380137(pklr)
NPR: 108794239(PKLR)
RTEM: 120920890(PKLR)
LCM: 102364735(PKLR)
 » show all
Tani K, Fujii H, Nagata S, Miwa S
Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells.
Proc Natl Acad Sci U S A 85:1792-5 (1988)
Kanno H, Fujii H, Hirono A, Miwa S
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.
Proc Natl Acad Sci U S A 88:8218-21 (1991)

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