KEGG   ORTHOLOGY: K12453
Entry
K12453                      KO                                     
Symbol
rfbS
Name
CDP-paratose synthetase [EC:1.1.1.342]
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K12453  rfbS; CDP-paratose synthetase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K12453  rfbS; CDP-paratose synthetase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.342  CDP-paratose synthase
     K12453  rfbS; CDP-paratose synthetase
Other DBs
RN: R04265
COG: COG0451
Genes
STY: STY2299(rfbS)
STT: t0783(rfbS)
SEX: STBHUCCB_8350
SENT: TY21A_03970
SPT: SPA0777(rfbS)
SEK: SSPA0731
SED: SeD_A2429
SEG: SG2120
SEL: SPUL_0808(rfbS)
SEGA: SPUCDC_0808(rfbS)
SET: SEN2085D(rfbS)
SENA: AU38_10540
SENO: AU37_10550
SENV: AU39_10550
SENQ: AU40_11805
SENL: IY59_10835
SEEP: I137_03630
YPE: YPO3112(prt)
YPK: y1071
YPH: YPC_3391(prt)
YPA: YPA_2604
YPN: YPN_0978
YPM: YP_0818(prt)
YPG: YpAngola_A2900(prt)
YPZ: YPZ3_2741(prt)
YPD: YPD4_2729(prt)
YPX: YPD8_2720(prt)
YPW: CH59_2953
YPJ: CH55_1690
YPV: BZ15_415
YPL: CH46_1987
YPS: YPTB1002(prt)
YPO: BZ17_1546
YPI: YpsIP31758_3048(prt)
YPY: YPK_3188
YPB: YPTS_1045
YPU: BZ21_245
YPC: BZ23_521
YPF: BZ19_359
YEW: CH47_2459
PIN: Ping_0776
HYF: DTO96_101657(rfbJ)
GCA: Galf_2845
SMUL: SMUL_2477
APOC: APORC_0917
AELL: AELL_2674
HEBR: AEBR_0586
GUR: Gura_3787
GEO: Geob_2127(prt)
GBM: Gbem_0858(prt)
DHD: Dhaf_4183
SGY: Sgly_2642
 » show all
Reference
PMID:2793833
  Authors
Verma N, Reeves P
  Title
Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae.
  Journal
J Bacteriol 171:5694-701 (1989)
DOI:10.1128/JB.171.10.5694-5701.1989
  Sequence
[sty:STY2299]

KEGG   ENZYME: 1.1.1.342
Entry
EC 1.1.1.342                Enzyme                                 
Name
CDP-paratose synthase;
rfbS (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
Reaction(IUBMB)
CDP-alpha-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R04265]
Reaction(KEGG)
R04265
Substrate
CDP-alpha-D-paratose [CPD:C03598];
NADP+ [CPD:C00006]
Product
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose [CPD:C04297];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi).
History
EC 1.1.1.342 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K12453  CDP-paratose synthetase
Genes
STYSTY2299(rfbS)
STTt0783(rfbS)
SEXSTBHUCCB_8350
SENTTY21A_03970
SPTSPA0777(rfbS)
SEKSSPA0731
SEDSeD_A2429
SEGSG2120
SELSPUL_0808(rfbS)
SEGASPUCDC_0808(rfbS)
SETSEN2085D(rfbS)
SENAAU38_10540
SENOAU37_10550
SENVAU39_10550
SENQAU40_11805
SENLIY59_10835
SENJCFSAN001992_00980
SEEPI137_03630
KRDA3780_14940
BUFD8682_24050
YPEYPO3112(prt)
YPKy1071
YPHYPC_3391(prt)
YPAYPA_2604
YPNYPN_0978
YPMYP_0818(prt)
YPPYPDSF_2748
YPGYpAngola_A2900(prt)
YPZYPZ3_2741(prt)
YPTA1122_10405
YPDYPD4_2729(prt)
YPXYPD8_2720(prt)
YPWCH59_2953
YPJCH55_1690
YPVBZ15_415
YPLCH46_1987
YPSYPTB1002(prt)
YPOBZ17_1546
YPIYpsIP31758_3048(prt)
YPYYPK_3188
YPBYPTS_1045
YPUBZ21_245
YPCBZ23_521
YPFBZ19_359
YEWCH47_2459
YMOHRD69_10870
XBUHGO23_18930
VGABSQ33_09850
SPOLFH971_05610
SDKKHX94_02875
PINPing_0776
AFRIE3E15_05600
AQSDKK66_10195
HYFDTO96_101657(rfbJ)
JALBZG29_24210
GCAGalf_2845
CCOCCCON33237_0121
SMULSMUL_2477
APOCAPORC_0917
AELLAELL_2674
HEBRAEBR_0586
GEFFO488_01055
GURGura_3787
GEOGeob_2127(prt)
GBMGbem_0858(prt)
BCHSJNE38_09500
DHDDhaf_4183
SGYSgly_2642
AWOAwo_c24770
CKNCalkro_1061
SYNESyn6312_0748
CAPCLDAP_10470
TPITREPR_2377
PFERIRI77_19890
BDOEL88_15090
ARACE0W69_011185
SPSCE2P86_16670
MUPA0256_16620
FKAKM029_05925
FMGHYN48_13950
FCRHYN56_01815
SAFSULAZ_1205
PMXPERMA_1994
NIONITINOP_2256
 » show all
Reference
1  [PMID:2793833]
  Authors
Verma N, Reeves P
  Title
Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae.
  Journal
J Bacteriol 171:5694-701 (1989)
DOI:10.1128/JB.171.10.5694-5701.1989
  Sequence
[sty:STY2299]
Reference
2  [PMID:9538012]
  Authors
Hallis TM, Lei Y, Que NL, Liu H
  Title
Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase.
  Journal
Biochemistry 37:4935-45 (1998)
DOI:10.1021/bi9725529
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.342
IUBMB Enzyme Nomenclature: 1.1.1.342
ExPASy - ENZYME nomenclature database: 1.1.1.342
BRENDA, the Enzyme Database: 1.1.1.342

KEGG   REACTION: R04265
Entry
R04265                      Reaction                               
Name
CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
Definition
CDP-3,6-dideoxy-D-glucose + NADP+ <=> CDP-4-dehydro-3,6-dideoxy-D-glucose + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00154  C03598_C04297
Enzyme
Pathway
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Orthology
K12453  CDP-paratose synthetase [EC:1.1.1.342]
Other DBs
RHEA: 34570

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