K12473                      KO                                     

low-density lipoprotein receptor
map04144  Endocytosis
map04913  Ovarian steroidogenesis
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
map04976  Bile secretion
map04979  Cholesterol metabolism
map05145  Toxoplasmosis
map05160  Hepatitis C
map05417  Lipid and atherosclerosis
H00155  Familial hypercholesterolemia
H01383  Hyperlipoproteinemia type IIa
H01635  Hyperlipidemia
H02505  Atherosclerosis
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12473  LDLR; low-density lipoprotein receptor
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K12473  LDLR; low-density lipoprotein receptor
   04925 Aldosterone synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
   04927 Cortisol synthesis and secretion
    K12473  LDLR; low-density lipoprotein receptor
  09154 Digestive system
   04976 Bile secretion
    K12473  LDLR; low-density lipoprotein receptor
   04979 Cholesterol metabolism
    K12473  LDLR; low-density lipoprotein receptor
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K12473  LDLR; low-density lipoprotein receptor
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K12473  LDLR; low-density lipoprotein receptor
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K12473  LDLR; low-density lipoprotein receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K12473  LDLR; low-density lipoprotein receptor
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12473  LDLR; low-density lipoprotein receptor
Membrane trafficking [BR:ko04131]
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    K12473  LDLR; low-density lipoprotein receptor
Other DBs
GO: 0005041
HSA: 3949(LDLR)
PTR: 455722(LDLR)
PPS: 100974202(LDLR)
GGO: 101124590(LDLR)
PON: 100447659(LDLR)
NLE: 100591481(LDLR)
MCC: 574283(LDLR)
MCF: 102127361(LDLR)
CSAB: 103234364(LDLR)
CATY: 105571287(LDLR)
PANU: 101016912(LDLR)
RRO: 104670517(LDLR)
RBB: 108527932(LDLR)
TFN: 117076836(LDLR)
PTEH: 111527714(LDLR)
CJC: 100385319(LDLR)
SBQ: 101052112(LDLR)
MMUR: 105885441(LDLR)
MMU: 16835(Ldlr)
MCAL: 110301054(Ldlr)
MPAH: 110327206(Ldlr)
RNO: 300438(Ldlr)
MCOC: 116072569(Ldlr)
MUN: 110552462(Ldlr)
CGE: 100689399(Ldlr)
PLEU: 114695236(Ldlr)
NGI: 103734567(Ldlr)
HGL: 101703463(Ldlr)
CCAN: 109692527(Ldlr)
OCU: 100009086(LDLR)
OPI: 101522903(LDLR)
TUP: 102484417(LDLR)
CFA: 100683160(LDLR)
VVP: 112908094(LDLR)
VLG: 121495036(LDLR)
AML: 100473450(LDLR)
UMR: 103678713(LDLR)
UAH: 113243010(LDLR)
ORO: 101367933(LDLR)
ELK: 111162438
MPUF: 101671487(LDLR)
EJU: 114197654(LDLR)
MLX: 118005983(LDLR)
FCA: 101080362(LDLR)
PYU: 121013997(LDLR)
PBG: 122486884(LDLR)
PTG: 102949981(LDLR)
PPAD: 109254084(LDLR)
AJU: 106983922(LDLR)
HHV: 120244466(LDLR)
BTA: 281276(LDLR)
BOM: 102268224(LDLR)
BIU: 109561609(LDLR)
BBUB: 102391004(LDLR)
CHX: 102186579(LDLR)
OAS: 443535(LDLR)
ODA: 120863950(LDLR)
CCAD: 122440398(LDLR)
SSC: 396801(LDLR)
CFR: 102506814(LDLR)
CBAI: 105078333(LDLR)
CDK: 105087617(LDLR)
BACU: 103002602(LDLR)
LVE: 103088391(LDLR)
OOR: 101283356(LDLR)
DLE: 111165995(LDLR)
PCAD: 102984457(LDLR)
ECB: 100057389(LDLR)
EPZ: 103564902(LDLR)
EAI: 106846613(LDLR)
MYB: 102246709(LDLR)
MYD: 102771350(LDLR)
MMYO: 118658815(LDLR)
MNA: 107533280(LDLR)
HAI: 109391592(LDLR)
DRO: 112301407(LDLR)
AJM: 119038836(LDLR)
MMF: 118615655(LDLR)
PALE: 102888790(LDLR)
PGIG: 120610833(LDLR)
RAY: 107515081(LDLR)
MJV: 108398211(LDLR)
TOD: 119240964(LDLR)
LAV: 100669109(LDLR)
TMU: 101342003
MDO: 654363(LDLR)
SHR: 100923750(LDLR)
PCW: 110214144(LDLR)
OAA: 100079454(LDLR)
TGU: 115491721(LDLR)
ASN: 102370878(LDLR)
AMJ: 102574674(LDLR)
CMY: 102937401(LDLR)
CPIC: 101932535(LDLR)
TST: 117888675(LDLR)
CABI: 116824825(LDLR)
ACS: 100554150(ldlr)
PVT: 110077953(LDLR)
PBI: 103053965(LDLR)
PMUR: 107287119(LDLR)
TSR: 106556718(LDLR)
PGUT: 117677541(LDLR)
PMUA: 114587524(LDLR)
ZVI: 118097714(LDLR)
GJA: 107105423(LDLR)
XLA: 373644(ldlr.S) 397757(ldlr.L)
XTR: 100495826(ldlr)
NPR: 108798866(LDLR)
DRE: 387529(ldlra)
SGH: 107568242(ldlr) 107568383
IPU: 108273208 108278865(ldlr)
PHYP: 113527861(ldlr) 113538289
AMEX: 103022705(ldlr) 103043840
TRU: 101072134(ldlr)
NCC: 104943331(ldlr)
CGOB: 115011422 115012519(ldlr)
ELY: 117255578(ldlrb) 117268821(ldlra)
PLEP: 121941881(ldlrb) 121956263(ldlra)
SLUC: 116040497(ldlrb) 116065316(ldlra)
ECRA: 117951346(ldlrb) 117958244(ldlra)
PFLV: 114569597(ldlr) 114569648
GAT: 120825223(ldlrb) 120828278(ldlra)
PPUG: 119218472(ldlrb) 119219920(ldlra)
MSAM: 119883456(ldlra) 119899188(ldlrb)
CUD: 121503365(ldlra) 121508634(ldlrb)
ONL: 100711286(ldlr) 100711575
OAU: 116321393(ldlrb) 116326860(ldlra)
OML: 112146091(ldlra) 112157423(ldlrb)
XMA: 102236051 102238173(ldlr)
XCO: 114143993 114159915(ldlr)
XHE: 116720159 116735825(ldlr)
PRET: 103468275 103468516(ldlr)
CTUL: 119786850(ldlra) 119788236(ldlrb)
NFU: 107376229(ldlr) 107382301
KMR: 108236227(ldlra) 108244362(ldlrb)
AOCE: 111566387(ldlr) 111570157
SDU: 111231510 111238052(ldlr)
SLAL: 111664553 111673794(ldlr)
XGL: 120786685(ldlra) 120800441(ldlrb)
HCQ: 109508411(ldlr) 109511383
BPEC: 110171504(ldlr) 110172564
ELS: 105012136 105013183(ldlr)
SFM: 108926163(ldlr) 108940142
PKI: 111833450 111856344(ldlr)
AANG: 118217039 118221621(ldlrb)
LOC: 102688974(ldlr)
PSPA: 121309152
LCM: 102359035(LDLR)
CMK: 103187554(ldlra)
RTP: 109924140(ldlr)
PPYR: 116161273
PMAX: 117331691
 » show all
Martinez-Olivan J, Arias-Moreno X, Velazquez-Campoy A, Millet O, Sancho J
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
FEBS J 281:1534-46 (2014)
Hoffer MJ, van Eck MM, Petrij F, van der Zee A, de Wit E, Meijer D, Grosveld G, Havekes LM, Hofker MH, Frants RR
The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.
Biochem Biophys Res Commun 191:880-6 (1993)

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