KEGG   ORTHOLOGY: K13310
Entry
K13310                      KO                                     
Symbol
desV, eryCI
Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [EC:2.6.1.106]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13310  desV, eryCI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
     K13310  desV, eryCI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
Other DBs
RN: R06426
Genes
TFV: IDJ81_02380
SRN: A4G23_00481(fdtB_1)
SPAV: Spa2297_32850
SALJ: SMD11_1659
SHAW: CEB94_04710
SGX: H4W23_25510
SFB: CP974_02505
SEN: SACE_0734(eryCI)
ACTI: UA75_17820
ACAD: UA74_17285
AHG: AHOG_15460(fdtB2)
AG: AAC68680(desV)
 » show all
Reference
  Authors
Burgie ES, Thoden JB, Holden HM
  Title
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
  Journal
Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007
Reference
  Authors
Szu PH, He X, Zhao L, Liu HW
  Title
Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation.
  Journal
Angew Chem Int Ed Engl 44:6742-6 (2005)
DOI:10.1002/anie.200501998
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence

KEGG   ORTHOLOGY: K16436
Entry
K16436                      KO                                     
Symbol
evaB, megDII, angB, staI
Name
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
M00800  dTDP-L-megosamine biosynthesis
M00803  dTDP-D-angolosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
   01055 Biosynthesis of vancomycin group antibiotics
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
     K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
    2.6.1.-
     K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Other DBs
RN: R06426 R06631 R08928
Genes
DTX: ATSB10_36020
PPF: Pput_3928
PVD: CFBP1590__4426(fdtB)
PGY: AWU82_24255
OME: OLMES_5572
BOK: DM82_922
BOC: BG90_13
BUU: WS70_10345
PTRP: DCO17_01695
VEI: Veis_0694
GEM: GM21_0941
GUR: Gura_4276
GEO: Geob_0430
GBM: Gbem_3307
DMA: DMR_07600
DBR: Deba_0354
RPE: RPE_1521
MAGN: WV31_12980
SGR: SGR_631
SLE: sle_09260(sle_09260)
SRN: A4G23_02284(fdtB_3)
NCA: Noca_4220
NDA: Ndas_4709
NAL: B005_1433
STRR: EKD16_15580(fdtB)
TCU: Tcur_2777
NCX: Nocox_25585(fdtB)
SACC: EYD13_16495(fdtB)
AOI: AORI_1500
AJA: AJAP_32020(dnrJ)
AMYY: YIM_11615(fdtB1) YIM_22860(fdtB2)
AORI: SD37_33620
SESP: BN6_58910(sam30)
KAL: KALB_6580(acuN1)
ACTI: UA75_05680
ACAD: UA74_05675
AHG: AHOG_05440(fdtB1)
ALO: CRK56086
SAQ: Sare_2337
MIL: ML5_4433
MCAB: HXZ27_04125(evdS12)
PLS: VT03_24275(fdtB)
AG: AAG13910(megDII) ABV49595(angB) BAC55216(staI)
 » show all
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1500]
Reference
  Authors
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H
  Title
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
  Journal
Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09
  Sequence
Reference
  Authors
Rodriguez E, Peiru S, Carney JR, Gramajo H
  Title
In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.
  Journal
Microbiology 152:667-73 (2006)
DOI:10.1099/mic.0.28680-0
  Sequence
Reference
  Authors
Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S
  Title
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
  Journal
Org Biomol Chem 6:3315-27 (2008)
DOI:10.1039/b807914e
  Sequence
Reference
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
  Sequence

KEGG   ENZYME: 2.6.1.106
Entry
EC 2.6.1.106                Enzyme                                 
Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]
Reaction(KEGG)
R06426
Substrate
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.
History
EC 2.6.1.106 created 2014
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13310  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
K16436  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Genes
DTXATSB10_36020
PPFPput_3928
PVDCFBP1590__4426(fdtB)
PGYAWU82_24255
OMEOLMES_5572
BOKDM82_922
BOCBG90_13
BUUWS70_10345
PTRPDCO17_01695
VEIVeis_0694
CSERCCO03_02175
OTOADJ79_07890
HHFE2K99_02740
MALIEYF70_28005
MUMFCL38_21545
GEMGM21_0941
GURGura_4276
GEOGeob_0430
GBMGbem_3307
GBNGEOBRER4_09100
GERKP004_03990
GSUBKP001_11415
GPLM1B72_16735
DMADMR_07600
DCBC3Y92_16655
DMSE8L03_14870
DBRDeba_0354
BGZXH91_11590
BSYMCIT39_18485
RPERPE_1521
TFVIDJ81_02380
AOZHUE56_00815
MAGNWV31_12980
HTQFRZ44_03450
NBRO3I_007490
NIEKV110_35795
DPCA6048_11425
SGRSGR_631
SXISXIM_35740
SAMBSAM23877_7111
SLEsle_09260(sle_09260)
SRNA4G23_00481(fdtB_1) A4G23_02284(fdtB_3)
SPAVSpa2297_32850
SCLFBB341_29650
SGMGCM10017557_01770
SCADDN051_13785
SALFSMD44_08276
SALJSMD11_1659
SFKKY5_0020c KY5_8143
SLKSLUN_13800
STIRDDW44_27825
SKACP970_39865
SHAWCEB94_04710
SFICEIZ62_03940 EIZ62_09600
SGALCP966_29030
SSPODDQ41_30670
SPADDVK44_01725
SAQUEJC51_45555
SRIMCP984_10775
SPHVF9278_28225
SCINCP977_28095
STSUB7R87_21940
SCHACP983_27955
SGXH4W23_25510
SCOECP976_32980
SFEUIM697_37655
SLIAHA039_05665
SFBCP974_02505 CP974_12570
SMOBJ7W19_00830
SPEUCGZ69_24380
SGJIAG43_33085
SMAOCAG99_12110
KABB7C62_31175
CRYB7495_14410
ARUBJ5A65_00470
NCANoca_4220
TALXFOF52_07485 FOF52_14840
NDANdas_4709
NALB005_1433
NGVCDO52_02790
STRREKD16_15580(fdtB)
SAIUJ4H86_24150
TCUTcur_2777
NOWGBF35_40090
NCXNocox_25585(fdtB)
SENSACE_0734(eryCI)
SVISvir_29860
SACCEYD13_16495(fdtB)
AOIAORI_1500
AJAAJAP_32020(dnrJ)
AMYCCU254_17445
AMYBBKN51_41540
AMYYYIM_11615(fdtB1) YIM_22860(fdtB2)
AORISD37_33620
PSEQAD006_30040
PECQAD017_31210
SESPBN6_58910(sam30)
SSYIEKG83_32250
KALKALB_6580(acuN1)
KPHYAOZ06_22490 AOZ06_23370
LEDBBK82_43745
AHMTL08_05640
ACTIUA75_05680 UA75_17820
ACADUA74_05675 UA74_17285
AHGAHOG_05440(fdtB1) AHOG_15460(fdtB2)
ACTAC1701_01555
ALOCRK56086
PMADBAY61_07750
SAQSare_2337
MAUMicau_3988
MILML5_4433
MICBMicB006_4930
MCABHXZ27_04125(evdS12)
MCRAID554_11925 ID554_28075
AMSAMIS_50590 AMIS_56730
PLABC6361_24070
PLATC6W10_35925
PFLAPflav_057110
PSUUPsuf_016700(gnnB) Psuf_058220
VERHUT12_18910
NHYJQS43_06860
AEYCDG81_13130
PVNA7sIIA15_06590
PLSVT03_24275(fdtB)
LKBLPTSP3_g21180
 » show all
Reference
1  [PMID:17456741]
  Authors
Burgie ES, Thoden JB, Holden HM
  Title
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
  Journal
Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.106
IUBMB Enzyme Nomenclature: 2.6.1.106
ExPASy - ENZYME nomenclature database: 2.6.1.106
BRENDA, the Enzyme Database: 2.6.1.106

KEGG   REACTION: R06426
Entry
R06426                      Reaction                               
Name
dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-3-oxo-4,6-dideoxy-D-glucose + L-Glutamate <=> dTDP-3-amino-3,4,6-trideoxy-D-glucose + 2-Oxoglutarate
Equation
Reaction class
RC00006  C00025_C00026
RC01514  C11909_C11910
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Orthology
K13310  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [EC:2.6.1.106]
K16436  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]
Other DBs
RHEA: 39910

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