tylD (gene name);
gerKI (gene name);
chmD (gene name);
mydI (gene name)
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
dTDP-6-deoxy-alpha-D-allose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NAD(P)H + H+ [RN:
The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
EC 18.104.22.1684 created 2013
ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
K13313 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
Bate N, Cundliffe E
The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
ExPASy - ENZYME nomenclature database: 22.214.171.1244