KEGG   ORTHOLOGY: K13318
Entry
K13318                      KO                                     
Symbol
eryBIV, tylCIV, tylC2
Name
dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13318  eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     K13318  eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Other DBs
RN: R06436
Genes
SAMB: SAM23877_5606(srm31)
SNR: SNOUR_10150(eryBIV)
SALJ: SMD11_1676(eryBIV)
SBRO: GQF42_07455
SMOB: J7W19_00840
SMAO: CAG99_12100
SAIU: J4H86_24135
SEN: SACE_0720(eryBIV)
AG: AAD41822(tylCIV) AAG13916(megBIV)
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0720]
Reference
PMID:10658660
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
[ag:AAD41822]
Reference
PMID:15984840
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
DOI:10.1021/ja051409x

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (11)   
   KEGG GENES (10)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (27)   

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KEGG   REACTION: R06436
Entry
R06436                      Reaction                               
Name
dTDP-L-mycarose:NADP+ 4-oxidoreductase
Definition
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ <=> dTDP-L-mycarose + NADP+
Equation
C11915 + C00005 + C00080 <=> C11916 + C00006
Comment
4-oxoreductase,EryB4 TylC4
Reaction class
RC00001  C00005_C00006
RC00261  C11915_C11916
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
Orthology
K13318  dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG RCLASS (2)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10)   
All databases (28)   

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