KEGG   ORTHOLOGY: K13318
Entry
K13318                      KO                                     

Name
eryBIV, tylCIV, tylC2
Definition
dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00798  dTDP-L-mycarose biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13318  eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K13318  eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Other DBs
RN: R06436
Genes
SAMB: SAM23877_5606(srm31)
SNR: SNOUR_10150(eryBIV)
SALJ: SMD11_1676(eryBIV)
SEN: SACE_0720(eryBIV)
AG: AAD41822(tylCIV) AAG13916(megBIV)
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0720]
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
Reference
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
DOI:10.1021/ja051409x

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (7)   
   KEGG GENES (6)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (21)   

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KEGG   REACTION: R06436
Entry
R06436                      Reaction                               

Name
dTDP-L-mycarose:NADP+ 4-oxidoreductase
Definition
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ <=> dTDP-L-mycarose + NADP+
Equation
Comment
4-oxoreductase,EryB4 TylC4
Reaction class
RC00001  C00005_C00006
RC00261  C11915_C11916
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00798  dTDP-L-mycarose biosynthesis
Orthology
K13318  dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG RCLASS (2)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (6)   
All databases (22)   

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