KEGG   ORTHOLOGY: K13369
Entry
K13369                      KO                                     
Symbol
HSD17B6
Name
17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     K13369  HSD17B6; 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Other DBs
RN: R01836 R02124 R02352 R02353 R04681 R04682 R08945 R08980
GO: 0004303 0004745 0050327
Genes
HSA: 8630(HSD17B6)
PTR: 452001
PPS: 100996145(HSD17B6)
GGO: 101153072
PON: 100454653 100458219(HSD17B6)
NLE: 100606923
MCC: 713549(HSD17B6)
MCF: 101926544(HSD17B6)
MTHB: 126930391
CSAB: 103238543(HSD17B6)
CATY: 105587281(HSD17B6)
TGE: 112634424
RRO: 104673659(HSD17B6)
RBB: 108516069(HSD17B6)
TFN: 117089914(HSD17B6)
PTEH: 111541833(HSD17B6)
CJC: 100387390(HSD17B6)
SBQ: 101054253(HSD17B6)
CSYR: 103275150(HSD17B6) 103275152
MMUR: 105865568
LCAT: 123639631 123639632(HSD17B6)
OGA: 100947460
MMU: 27400(Hsd17b6)
MCAL: 110303948
MPAH: 110326955(Hsd17b6)
RNO: 286964(Hsd17b6)
MCOC: 116076149
CGE: 100762147
PLEU: 114686923
MORG: 121463305
MFOT: 126492032
AAMP: 119803641
NGI: 103730224(Hsd17b6)
HGL: 101699287(Hsd17b6)
CCAN: 109686095
DORD: 105986857(Hsd17b6)
DSP: 122124416(Hsd17b6)
TUP: 102485005(HSD17B6)
CFA: 481118(HSD17B6)
CLUD: 112678001(HSD17B6)
VVP: 112922366(HSD17B6)
VLG: 121491966(HSD17B6)
AML: 100474694
UMR: 103656323(HSD17B6)
UAH: 113256406(HSD17B6)
UAR: 123787236(HSD17B6)
ELK: 111160200
LLV: 125106172
MPUF: 101672306(HSD17B6)
ORO: 101368715(HSD17B6)
EJU: 114215053(HSD17B6)
ZCA: 113921488(HSD17B6)
MLX: 118008692
NSU: 110577830
LWW: 102743313(HSD17B6)
FCA: 101088341(HSD17B6)
PYU: 121040906(HSD17B6)
PBG: 122473787(HSD17B6)
LRUF: 124502205
PTG: 102971783(HSD17B6)
PPAD: 109270351(HSD17B6)
AJU: 106986922(HSD17B6)
HHV: 120224864(HSD17B6)
BTA: 533086(HSD17B6)
BOM: 102283510(HSD17B6)
BIU: 109559345
BBUB: 102407967
BBIS: 104988095
CHX: 102185066
OAS: 101105400
ODA: 120857465
CCAD: 122427641
SSC: 100620470
CFR: 102508382
CBAI: 105075641
CDK: 105096750
BACU: 103008169(HSD17B6)
LVE: 103076064(HSD17B6)
OOR: 101278484(HSD17B6)
DLE: 111173857(HSD17B6)
PCAD: 102988625
PSIU: 116761374
ECB: 100052840
EPZ: 103565330(HSD17B6)
EAI: 106832977(HSD17B6)
MMF: 118623751
RFQ: 117028833
PALE: 102883634(HSD17B6)
PGIG: 120604931
PVP: 105302561
RAY: 107521200(HSD17B6)
MJV: 108402619
LAV: 100657790
TMU: 101345897
SHR: 100931687
PCW: 110211084
AROW: 112962016
NPD: 112956391
DNE: 112994731
AMJ: 102567845
CMY: 102944543
TST: 117888588(HSD17B6)
CABI: 116827724
MRV: 120391156
ACS: 100564174(hsd17b6)
SUND: 121923187
PBI: 103063622
PMUR: 107293735
CTIG: 120302959
TSR: 106545328(HSD17B6)
PGUT: 117662721
ZVI: 118077226(HSD17B6)
GJA: 107120904(HSD17B6)
XTR: 100498221
DSV: 119464839
RMP: 119179486
BGT: 106069124
HRJ: 124278165
CRG: 105342862
OBI: 106873408
 » show all
Reference
PMID:9188497
  Authors
Biswas MG, Russell DW
  Title
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.
  Journal
J Biol Chem 272:15959-66 (1997)
DOI:10.1074/jbc.272.25.15959
  Sequence
[hsa:8630] [rno:286964]
Reference
  Authors
Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY
  Title
Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.
  Journal
Arch Biochem Biophys 386:1-10 (2001)
DOI:10.1006/abbi.2000.2203
  Sequence
[hsa:8630]

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