KEGG   ORTHOLOGY: K13509
Entry
K13509                      KO                                     

Symbol
AGPAT1_2
Name
lysophosphatidate acyltransferase [EC:2.3.1.51]
Pathway
map00561  Glycerolipid metabolism
map00564  Glycerophospholipid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04072  Phospholipase D signaling pathway
map04975  Fat digestion and absorption
Module
M00089  Triacylglycerol biosynthesis
Disease
H00419  Congenital generalized lipodystrophy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K13509  AGPAT1_2; lysophosphatidate acyltransferase
   00564 Glycerophospholipid metabolism
    K13509  AGPAT1_2; lysophosphatidate acyltransferase
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K13509  AGPAT1_2; lysophosphatidate acyltransferase
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    K13509  AGPAT1_2; lysophosphatidate acyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K13509  AGPAT1_2; lysophosphatidate acyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.51  1-acylglycerol-3-phosphate O-acyltransferase
     K13509  AGPAT1_2; lysophosphatidate acyltransferase
Lipid biosynthesis proteins [BR:ko01004]
 Phospholipid acyltransferase
  LPAAT/LPLAT
   K13509  AGPAT1_2; lysophosphatidate acyltransferase
Other DBs
RN: R02241 R09381
COG: COG0204
GO: 0003841
Genes
HSA: 10554(AGPAT1) 10555(AGPAT2)
PTR: 462582(AGPAT1) 748669(AGPAT2)
PPS: 100977572(AGPAT2) 100991029(AGPAT1)
GGO: 101153839(AGPAT1) 101154487(AGPAT2)
PON: 100432876(AGPAT1) 100449893(AGPAT2)
NLE: 100588358(AGPAT2) 100600403(AGPAT1)
MCC: 709753(AGPAT2) 717174(AGPAT1)
MCF: 101865968(AGPAT1) 102135852(AGPAT2)
CSAB: 103221714(AGPAT1) 103239619(AGPAT2)
CATY: 105574094(AGPAT1) 105580577(AGPAT2)
PANU: 101023337(AGPAT2)
RRO: 104669666(AGPAT2) 104673989(AGPAT1)
RBB: 108519889(AGPAT1) 108542907(AGPAT2)
TFN: 117086995(AGPAT1) 117099149(AGPAT2)
PTEH: 111528960(AGPAT1) 111553058(AGPAT2)
CJC: 100401440(AGPAT2) 100412924(AGPAT1)
SBQ: 101030180(AGPAT2) 101044607(AGPAT1)
MMUR: 105858152(AGPAT1) 105880741(AGPAT2)
MMU: 55979(Agpat1) 67512(Agpat2)
MCAL: 110310160(Agpat2) 110312431(Agpat1)
MPAH: 110319070(Agpat2) 110335367(Agpat1)
RNO: 311821(Agpat2) 406165(Agpat1)
MCOC: 116075332(Agpat1) 116089858(Agpat2)
MUN: 110550853(Agpat2) 110565390(Agpat1)
CGE: 100754963(Agpat2) 100758206(Agpat1)
PLEU: 114692823(Agpat2) 114705796(Agpat1)
NGI: 103724409(Agpat1) 103741218(Agpat2)
HGL: 101706478(Agpat2) 101712016(Agpat1)
CCAN: 109690408(Agpat1) 109698980(Agpat2)
OCU: 100358688(AGPAT1)
OPI: 101516235(AGPAT1) 101530584(AGPAT2)
TUP: 102482776(AGPAT2) 102485189(AGPAT1)
CFA: 474857(AGPAT1) 491249(AGPAT2)
VVP: 112906878(AGPAT2) 112913641(AGPAT1)
VLG: 121472674(AGPAT2) 121476193(AGPAT1)
AML: 100469184(AGPAT2) 100476518(AGPAT1)
UMR: 103675286(AGPAT2) 103682278(AGPAT1)
UAH: 113243756(AGPAT1) 113248579 113248634(AGPAT2)
ORO: 101380138(AGPAT2) 101382299(AGPAT1)
MPUF: 101673397(AGPAT2) 101687441(AGPAT1)
EJU: 114201888(AGPAT2) 114222154(AGPAT1)
MLX: 118017515(AGPAT2) 118027307(AGPAT1)
FCA: 101094635(AGPAT2) 101096064(AGPAT1)
PYU: 121022322(AGPAT1) 121022853(AGPAT2)
PBG: 122475070(AGPAT2) 122478244(AGPAT1)
PTG: 102957012(AGPAT2) 102964663(AGPAT1)
PPAD: 109258777(AGPAT2) 109260526(AGPAT1)
AJU: 106983492(AGPAT1) 106989564(AGPAT2)
HHV: 120221860(AGPAT1) 120221961(AGPAT2)
BTA: 282137(AGPAT1) 512112(AGPAT2)
BOM: 102265165(AGPAT1) 102277646(AGPAT2)
BIU: 109566592(AGPAT2) 109576853(AGPAT1)
BBUB: 102394165(AGPAT2) 102398595(AGPAT1)
CHX: 100860912(AGPAT1) 102173200(AGPAT2)
OAS: 101114511(AGPAT2) 443121(AGPAT1)
ODA: 120852156(AGPAT2) 120870589(AGPAT1)
CCAD: 122429910(AGPAT1) 122442348(AGPAT2)
SSC: 100170768(AGPAT2) 613128(AGPAT1)
CFR: 102515113(AGPAT2) 102522717(AGPAT1)
CBAI: 105069742(AGPAT2) 105074028(AGPAT1)
CDK: 105090851(AGPAT1) 105105791(AGPAT2)
BACU: 102997588 103012097(AGPAT1)
OOR: 101277978(AGPAT1) 101283053(AGPAT2)
DLE: 111170954(AGPAT1) 111177021(AGPAT2)
PCAD: 102976926(AGPAT1) 102981564(AGPAT2)
ECB: 100059501(AGPAT1) 100068797(AGPAT2)
EPZ: 103566649(AGPAT1) 103567693(AGPAT2)
EAI: 106831020(AGPAT1) 106845562(AGPAT2)
MYB: 102248796(AGPAT2) 102260060(AGPAT1)
MYD: 102759634(AGPAT2) 102768385(AGPAT1)
MMYO: 118655297(AGPAT2) 118679542(AGPAT1)
MNA: 107535575(AGPAT2) 107538983(AGPAT1)
PKL: 118705122(AGPAT1) 118707053(AGPAT2)
HAI: 109373114(AGPAT1) 109382406(AGPAT2)
DRO: 112302225(AGPAT1) 112306372(AGPAT2)
SHON: 118980181(AGPAT2) 118991457(AGPAT1)
AJM: 119036112(AGPAT2) 119053735(AGPAT1)
MMF: 118620998(AGPAT1) 118629391(AGPAT2)
PALE: 102890008(AGPAT2) 102897143(AGPAT1)
PGIG: 120599791(AGPAT2) 120618883(AGPAT1)
RAY: 107498453(AGPAT1) 107514885(AGPAT2)
MJV: 108393797(AGPAT1) 108407183(AGPAT2)
TOD: 119232451(AGPAT2) 119252242(AGPAT1)
LAV: 100658640(AGPAT2) 100665752(AGPAT1)
MDO: 100019982(AGPAT2) 100025689(AGPAT1)
SHR: 100925097(AGPAT1) 100925750(AGPAT2)
PCW: 110199430(AGPAT1) 110205352(AGPAT2)
OAA: 100081509(AGPAT2) 100089235(AGPAT1)
GGA: 419941(PRR29) 770506(AGPAT1) 772114(AGPAT2)
APLA: 101801127(AGPAT1) 101803978(AGPAT2)
PMOA: 120498395(AGPAT1) 120512362(AGPAT2) 120513461
OTC: 121333022(AGPAT1) 121336877(AGPAT2) 121346889
PRUF: 121350510(AGPAT1) 121362391(AGPAT2) 121362976
FAB: 101809630(AGPAT1) 101813123 101813443(AGPAT2) 101815252
PHI: 102101003 102105871 102106346(AGPAT1) 102114564(AGPAT2)
PMAJ: 107212080(AGPAT2) 107212842 107215046(AGPAT1)
CCAE: 111936866(AGPAT2) 111937618 111940052(AGPAT1) 111945090
ETL: 114059092(AGPAT2) 114063787 114069183(AGPAT1)
EGZ: 104129364(AGPAT2) 104131093(AGPAT1)
ACUN: 113486557(AGPAT2) 113487198(AGPAT1) 113489197
AAM: 106483771(AGPAT2) 106496109 106497448(AGPAT1)
DNE: 112979936(AGPAT2) 112982803(AGPAT1)
ASN: 102375237 102388531(AGPAT2) 106723013(AGPAT1)
AMJ: 102559540 102567189(AGPAT2) 102570924(AGPAT1)
CPOO: 109314010(AGPAT2) 109317650
GGN: 109291025(AGPAT1) 109292749(AGPAT2)
PSS: 102448805(AGPAT2)
CMY: 102936043(AGPAT2)
CPIC: 101943398(AGPAT2) 101944318(AGPAT1)
TST: 117867143(AGPAT2)
CABI: 116817406(AGPAT2)
PVT: 110074910 110079649(AGPAT2) 110088056 110089782(AGPAT1)
PBI: 103052835(AGPAT2) 103058714 103059196 103061591(AGPAT1)
PMUR: 107292850 107295289(AGPAT2) 107296716(AGPAT1) 107303026
PGUT: 117664606 117667824(AGPAT1) 117671308(AGPAT2)
PMUA: 114582288 114589165(AGPAT2) 114592117 114592357(AGPAT1)
GJA: 107107509(AGPAT1) 107107627 107112961 107113010(AGPAT2)
XLA: 108699908(agpat2.S) 108700224(agpat1.S) 447513(agpat1.L)
XTR: 100037898(agpat1) 100170486(agpat2)
NPR: 108786548(AGPAT1) 108790233(AGPAT2) 108795775
DRE: 777624(agpat2)
CCAR: 109105349
IPU: 108278901(agpat2)
PHYP: 113535814
AMEX: 111193896
EEE: 113583951
TRU: 101079283
LCO: 104928171
CGOB: 115017007
ELY: 117270009(agpat2)
PLEP: 121960237(agpat2)
SLUC: 116062941(agpat2)
ECRA: 117959280(agpat2)
PFLV: 114571203
GAT: 120831986(agpat2)
PPUG: 119226798(agpat2)
MSAM: 119914047(agpat2)
CUD: 121525115(agpat2)
MZE: 101480285
ONL: 100701022
OAU: 116316188(agpat2)
OLA: 101159762
OML: 112163352(agpat2)
XMA: 102232433
XCO: 114149962
XHE: 116724862
PRET: 103473378
CVG: 107100728
CTUL: 119796467(agpat2)
NFU: 107374952
KMR: 108244768(agpat2)
ALIM: 106525214
AOCE: 111565148
CSEM: 103390057
POV: 109626522
LCF: 108881030
SDU: 111220809
SLAL: 111666849
XGL: 120806604(agpat2)
HCQ: 109525570
BPEC: 110157445
MALB: 109971322
OTW: 112220202(agpat2) 112230899
ELS: 105015263
AANG: 118212762(agpat2)
LOC: 102688128(agpat2)
LCM: 102345535(AGPAT2) 102367142(AGPAT1)
CMK: 103182976(agpat2)
BFO: 118420785
BBEL: 109482335
DME: Dmel_CG3812(Agpat1)
DER: 6551231
DSE: 6618593
DSI: Dsimw501_GD17087(Dsim_GD17087) Dsimw501_GD22398(Dsim_GD22398)
DAN: 6504072
DPE: 6599212
DWI: 6644554
DGR: 6565468
DVI: 26531300
CCAT: 101459763
BOD: 106615064
SCAC: 106085743
BIM: 100741980
BBIF: 117206145
BVK: 117243647
BVAN: 117154334
BTER: 100650358
CCAL: 108629274
MGEN: 117221178
NMEA: 116432099
CGIG: 122398188
SOC: 105195976
FEX: 115241094
PFUC: 122523030
TPRE: 106650665
CCIN: 107268577
AGB: 108912788
LDC: 111511559
PPYR: 116162661
OTU: 111415846
BMOR: 101737501 101739608 101741213(AGPAT5) 101741440(AGPAT2) 101741580(AGPAT3)
DNX: 107161346
DMK: 116926169
HAME: 121868714
DSV: 119435662
RSAN: 119378335
RMP: 119162061
CSCU: 111614209
PTEP: 107449017
CEL: CELE_F59F4.4(acl-1) CELE_T06E8.1(acl-2)
CBR: CBG04832(Cbr-acl-2) CBG16005(Cbr-acl-1)
BMY: BM_BM4604(Bma-acl-1) BM_BM5620(Bma-acl-2)
PCAN: 112575307
BGT: 106054537
GAE: 121384822
MYI: 110441721
PMAX: 117321831
OBI: 106878776
OSN: 115232561
LAK: 106172962
NVE: 5506127
EPA: 110246326
ATEN: 116305334
ADF: 107339418
AMIL: 114961628
PDAM: 113669095
SPIS: 111329647
HMG: 100209966
CPAP: 110810935
CIT: 102618702
TCC: 18593526
DZI: 111302264
VAR: 108337499
VUN: 114188824
APRC: 113854292
ADU: 107496575
AIP: 107609797
LANG: 109356853
FVE: 101295305
ZJU: 107431891
MNT: 21400819
CSV: 101217317
CMO: 103501589
BHJ: 120090196
MCHA: 111019003
CMAX: 111476710
CMOS: 111447575
RCU: 8282895
JCU: 105632950
MESC: 110600941
PEU: 105130135
QLO: 115954501
VRI: 117908534
BVG: 104891679
MUS: 103971379
DCT: 110099302
AOF: 109844734
ATR: 18448056
SCE: YDL052C(SLC1)
ERC: Ecym_2773
KMX: KLMA_60451(SLC1)
NCS: NCAS_0A02390(NCAS0A02390)
NDI: NDAI_0D04480(NDAI0D04480) NDAI_0F00220(NDAI0F00220)
TPF: TPHA_0B00910(TPHA0B00910) TPHA_0B02370(TPHA0B02370)
TBL: TBLA_0A08150(TBLA0A08150)
TDL: TDEL_0E01460(TDEL0E01460)
KAF: KAFR_0G03120(KAFR0G03120)
CAL: CAALFM_C302600CA(SLC1)
SLB: AWJ20_5112(SLC1)
NCR: NCU00168
NTE: NEUTE1DRAFT63173(NEUTE1DRAFT_63173)
MGR: MGG_11040
SSCK: SPSK_02631
MAW: MAC_00405
MAJ: MAA_06056
CMT: CCM_02787
BFU: BCIN_16g02640(Bcslc1)
MBE: MBM_04438
ANI: AN6139.2
ANG: ANI_1_490104(An12g03960)
ABE: ARB_04925
TVE: TRV_05343
PTE: PTT_08466
SPO: SPAC1851.02(slc1)
CNB: CNBI2930
TASA: A1Q1_00096
LBC: LACBIDRAFT_172108(LPAAT)
ABP: AGABI1DRAFT39220(AGABI1DRAFT_39220)
ABV: AGABI2DRAFT154320(AGABI2DRAFT_154320)
MGL: MGL_3009
MRT: MRET_3617
DFA: DFA_00449
GBA: J421_0084
 » show all
Reference
PMID:9461603
  Authors
Aguado B, Campbell RD
  Title
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex.
  Journal
J Biol Chem 273:4096-105 (1998)
DOI:10.1074/jbc.273.7.4096
Reference
  Authors
Agarwal AK, Sukumaran S, Cortes VA, Tunison K, Mizrachi D, Sankella S, Gerard RD, Horton JD, Garg A
  Title
Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.
  Journal
J Biol Chem 286:37676-91 (2011)
DOI:10.1074/jbc.M111.250449
  Sequence
[hsa:10555]

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