KEGG   ORTHOLOGY: K13545
Entry
K13545                      KO                                     
Symbol
RCCR, ACD2
Name
red chlorophyll catabolite reductase [EC:1.3.7.12]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K13545  RCCR, ACD2; red chlorophyll catabolite reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.12  red chlorophyll catabolite reductase
     K13545  RCCR, ACD2; red chlorophyll catabolite reductase
Other DBs
RN: R09032
GO: 0051743
Genes
ATH: AT4G37000(ACD2)
ALY: 9303041
CRB: 111828541
CSAT: 104716415 104721055 104729460
EUS: EUTSA_v10025731mg EUTSA_v10027845mg EUTSA_v10027846mg
BRP: 103862886
BNA: 106426866 106438613 111202026
BOE: 106325027
RSZ: 108819142
THJ: 104807582
CPAP: 110814300
MINC: 123193402
TCC: 18611120
GRA: 105803912
GAB: 108461228
EGR: 104418575
VRA: 106763057
VAR: 108337053
VUN: 114195690
CCAJ: 109806983
APRC: 113847072
MTR: 11442328
CAM: 101488374
LJA: Lj2g3v3246900.1(Lj2g3v3246900.1)
ADU: 107496225
AIP: 107608673
LANG: 109356885
FVE: 101301239
RCN: 112185943
PPER: 18769442
PMUM: 103339882
PAVI: 110765868
PDUL: 117634688
MDM: 103401375
PXB: 103964494
ZJU: 107424775
RCU: 8262890
JCU: 105639704
HBR: 110646846
MESC: 110629083
VVI: 100252439
VRI: 117919356
SLY: 778267
SPEN: 107014711
SOT: 102591737
CANN: 107868112
NSY: 104239946
NTO: 104108838
NAU: 109211050
INI: 109177802
ITR: 116000427
OEU: 111410341
EGT: 105972914
SSPL: 121741847
HAN: 110909121
ECAD: 122603307
LSV: 111876719
CCAV: 112518578
DCR: 108192987
CSIN: 114260490
BVG: 104883759
SOE: 110777086
NNU: 104608870
MING: 122069185
TSS: 122651858
DOSA: Os10t0389100-00(Os10g0389100) Os10t0389200-01(Os10g0389200) Os10t0389300-01(Os10g0389300)
OBR: 102703616
BDI: 100843855
ZMA: 100272914
SITA: 101780665
SVS: 117840638
PDA: 103701815
MUS: 103999342
DCT: 110101222
PEQ: 110027504
AOF: 109827526
ATR: 18421357
PPP: 112292462
AG: CAB77705(RCCR)
 » show all
Reference
  Authors
Wuthrich KL, Bovet L, Hunziker PE, Donnison IS, Hortensteiner S
  Title
Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.
  Journal
Plant J 21:189-98 (2000)
DOI:10.1046/j.1365-313x.2000.00667.x
  Sequence
Reference
  Authors
Mach JM, Castillo AR, Hoogstraten R, Greenberg JT
  Title
The Arabidopsis-accelerated cell death gene ACD2 encodes red chlorophyll catabolite reductase and suppresses the spread of disease symptoms.
  Journal
Proc Natl Acad Sci U S A 98:771-6 (2001)
DOI:10.1073/pnas.021465298
  Sequence
[ath:AT4G37000]

KEGG   ENZYME: 1.3.7.12
Entry
EC 1.3.7.12                 Enzyme                                 
Name
red chlorophyll catabolite reductase;
RCCR;
RCC reductase;
red Chl catabolite reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase
Reaction(IUBMB)
primary fluorescent chlorophyll catabolite + 2 oxidized ferredoxin [iron-sulfur] cluster = red chlorophyll catabolite + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ [RN:R09032]
Reaction(KEGG)
R09032
Substrate
primary fluorescent chlorophyll catabolite [CPD:C18098];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
red chlorophyll catabolite [CPD:C18022];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
The enzyme participates in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The reaction requires reduced ferredoxin, which is generated from NADPH produced either through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place while red chlorophyll catabolite is still bound to EC 1.14.15.17, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2].
History
EC 1.3.7.12 created 2007 as EC 1.3.1.80, transferred 2016 to EC 1.3.7.12
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K13545  red chlorophyll catabolite reductase
Genes
ATHAT4G37000(ACD2)
ALY9303041
CRB111828541
CSAT104716415 104721055 104729460
EUSEUTSA_v10025731mg EUTSA_v10027845mg EUTSA_v10027846mg
BRP103862886
BNA106426866 106438613 111202026
BOE106325027
RSZ108819142
THJ104807582
CPAP110814300
CIT102622999 102623285
CICCICLE_v10026041mg CICLE_v10026248mg
PVY116112407 116116769
MINC123193402
TCC18611120
GRA105803912
GHI107897716 107913254
GAB108461228
DZI111292562 111299984
EGR104418575
GMX100777640 100780934
GSJ114383322 114403224
PVUPHAVU_008G280200g PHAVU_008G280300g
VRA106763057
VAR108337053
VUN114195690
CCAJ109806983
APRC113847072
MTR11442328
CAM101488374
LJALj2g3v3246900.1(Lj2g3v3246900.1)
ADU107496225
AIP107608673
AHF112701797 112764981
LANG109356885
FVE101301239
RCN112185943
PPER18769442
PMUM103339882
PAVI110765868
PDUL117634688
MDM103401375
PXB103964494
ZJU107424775
MNT21384210 21394345 21394346
CSV101202861 101223133
CMO103497431 103497432
BHJ120089204 120089221
MCHA111017870 111017957
CMAX111499492 111499662 111499663
CMOS111451176 111451765
CPEP111785012 111785014 111796165 111796166
RCU8262890
JCU105639704
HBR110646846
MESC110629083
POP7462586 7483116
PEU105138976 105138977 105138985
PALZ118047897 118047898
JRE108983930 108985767
QSU111998865 111998868
QLO115950885 115950924
TWL120011254 120013867 120014953
VVI100252439
VRI117919356
SLY778267
SPEN107014711
SOT102591737
SSTN125859094 125859986
CANN107868112
NTA107810967 107825518
NSY104239946
NTO104108838
NAU109211050
INI109177802
ITR116000427
SIND105177623 105177624
OEU111410341
EGT105972914
SSPL121741847
HAN110909121
ECAD122603307
LSV111876719
CCAV112518578
DCR108192987
CSIN114260490
BVG104883759
SOE110777086
CQI110682303 110718122
NNU104608870
MING122069185
TSS122651858
PSOM113346713 113356881
NCOL116252082 116253048
OSA107277220 4348519
DOSAOs10t0389100-00(Os10g0389100) Os10t0389200-01(Os10g0389200) Os10t0389300-01(Os10g0389300)
OBR102703616
BDI100843855
ATS109745881 109767332
TDC119314655 119326411 119331775 119336169 119357510
TAES123129900 123133085 123138571 123142922 123153767 123156544 123164229
TUA125517190 125517199 125542622
SBI8062831 8068743 8079617
ZMA100272914
SITA101780665
SVS117840638
PVIR120651187 120691151
PHAI112873608 112878352
PDA103701815
EGU105041580 105048691
MUS103999342
DCT110101222
PEQ110027504
AOF109827526
ATR18421357
SMOSELMODRAFT_186296 SELMODRAFT_269565
PPP112292462
 » show all
Reference
1  [PMID:12223835]
  Authors
Rodoni S, Muhlecker W, Anderl M, Krautler B, Moser D, Thomas H, Matile P, Hortensteiner S.
  Title
Chlorophyll Breakdown in Senescent Chloroplasts (Cleavage of Pheophorbide a in Two Enzymic Steps).
  Journal
Plant Physiol 115:669-676 (1997)
DOI:10.1104/pp.115.2.669
Reference
2  [PMID:10743659]
  Authors
Wuthrich KL, Bovet L, Hunziker PE, Donnison IS, Hortensteiner S
  Title
Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.
  Journal
Plant J 21:189-98 (2000)
DOI:10.1046/j.1365-313x.2000.00667.x
  Sequence
Reference
3  [PMID:17237353]
  Authors
Pruzinska A, Anders I, Aubry S, Schenk N, Tapernoux-Luthi E, Muller T, Krautler B, Hortensteiner S.
  Title
In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown.
  Journal
Plant Cell 19:369-87 (2007)
DOI:10.1105/tpc.106.044404
  Sequence
[ath:AT4G37000]
Reference
4  [PMID:16669755]
  Authors
Hortensteiner S.
  Title
Chlorophyll degradation during senescence.
  Journal
Annu Rev Plant Biol 57:55-77 (2006)
DOI:10.1146/annurev.arplant.57.032905.105212
Reference
5  [PMID:12223836]
  Authors
Rodoni S, Vicentini F, Schellenberg M, Matile P, Hortensteiner S.
  Title
Partial Purification and Characterization of Red Chlorophyll Catabolite Reductase, a Stroma Protein Involved in Chlorophyll Breakdown.
  Journal
Plant Physiol 115:677-682 (1997)
DOI:10.1104/pp.115.2.677
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.12
IUBMB Enzyme Nomenclature: 1.3.7.12
ExPASy - ENZYME nomenclature database: 1.3.7.12
BRENDA, the Enzyme Database: 1.3.7.12

KEGG   REACTION: R09032
Entry
R09032                      Reaction                               
Name
primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase
Definition
Primary fluorescent chlorophyll catabolite + 2 Oxidized ferredoxin <=> Red chlorophyll catabolite + 2 Reduced ferredoxin + 2 H+
Equation
C18098 + 2 C00139 <=> C18022 + 2 C00138 + 2 C00080
Reaction class
RC01474  C18022_C18098
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K13545  red chlorophyll catabolite reductase [EC:1.3.7.12]
Other DBs
RHEA: 24755

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