KEGG   ORTHOLOGY: K13779
Entry
K13779                      KO                                     
Symbol
atuE
Name
isohexenylglutaconyl-CoA hydratase [EC:4.2.1.57]
Pathway
map00281  Geraniol degradation
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K13779  atuE; isohexenylglutaconyl-CoA hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.57  isohexenylglutaconyl-CoA hydratase
     K13779  atuE; isohexenylglutaconyl-CoA hydratase
Other DBs
RN: R03493
COG: COG1024
GO: 0050005
Genes
RGL: CS053_05365
PAE: PA2890(atuE)
PAEV: N297_2993
PAEI: N296_2993
PAU: PA14_26690
PAP: PSPA7_2264
PAG: PLES_21741(atuE)
PAF: PAM18_2073(atuE)
PNC: NCGM2_4001
PAEB: NCGM1900_3421
PAEP: PA1S_10960
PAEM: U769_10500
PAEL: T223_10970
PAEU: BN889_03228(atuE)
PAEG: AI22_22910
PAEC: M802_2990
PAEO: M801_2858
PMY: Pmen_2693
PMK: MDS_2025
PPSE: BN5_2437
PCQ: PcP3B5_19980(echA8_1)
PFL: PFL_4198(atuE)
PPRC: PFLCHA0_c42610(echA5)
PPRO: PPC_4295(atuE)
PFS: PFLU_4396
PFC: PflA506_3700(atuE)
PFB: VO64_5140
PMAN: OU5_1499
PFW: PF1751_v1c38910(atuE)
PKC: PKB_3705
PSOS: POS17_4286(atuE)
PANR: A7J50_4074
PSET: THL1_3722
PSIL: PMA3_07215
PALL: UYA_10250
POJ: PtoMrB4_17780(atuE)
PKH: JLK41_10345(atuE)
PSEP: C4K39_6116
PWZ: J7655_12405(atuE)
PTW: TUM18999_18970(atuE)
PHF: NLY38_09540(atuE)
MAQ: Maqu_2806
MHC: MARHY2693
MAD: HP15_2541
MARJ: MARI_02970(echA8_1)
ACB: A1S_3006
ABM: ABSDF2869
ABY: ABAYE0482
ABN: AB57_3457
ABB: ABBFA_00511(echA8_1)
ABX: ABK1_3257
ABH: M3Q_3438
ABAD: ABD1_28950
ABAZ: P795_2375
ABAU: IX87_11725
ABAA: IX88_17970
ACC: BDGL_002470(ech2)
AGU: AS4_37350(liuC)
PAT: Patl_0318
SAGA: M5M_01895
MICC: AUP74_02724(caiD_2)
MICT: FIU95_11175(caiD)
MICZ: GL2_32310(atuE)
CYQ: Q91_1220
HCH: HCH_05751
ABO: ABO_0987(ech2)
ADI: B5T_01798(ech2)
AXE: P40_08545
APAC: S7S_10300
OAI: OLEAN_C05750(ech)
REH: H16_A2138(h16_A2138)
RME: Rmet_1723
BPS: BPSS2033
BPSE: BDL_5456
BPSM: BBQ_4088
BPSU: BBN_5508
BPSD: BBX_4623
BPK: BBK_4784
BPSH: DR55_5688
BPSA: BBU_3965
BPSO: X996_5493
BUT: X994_5050
BTQ: BTQ_3582
BTJ: BTJ_4618
BTZ: BTL_5405
BTD: BTI_4953
BTV: BTHA_4797
BTHE: BTN_5076
BTHM: BTRA_5344
BTHA: DR62_5205
BTHL: BG87_5412
BOK: DM82_6352
BOC: BG90_4322
BSAV: WS86_29380
BUL: BW21_4481
RFR: Rfer_2816
ACRA: BSY15_2085
CTES: O987_10850
LIH: L63ED372_00597(paaF_2)
HYB: Q5W_16945
HPSE: HPF_03620(paaF2)
RGE: RGE_32890
RVA: Rvan_3071
PSF: PSE_4602
PZU: PHZ_p0199
GAK: X907_0621
SECH: B18_27410
SFLA: SPHFLASMR4Y_02318(caiD)
RCE: RC1_3532
TMO: TMO_b0367
 » show all
Reference
  Authors
Forster-Fromme K, Hoschle B, Mack C, Bott M, Armbruster W, Jendrossek D
  Title
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
  Journal
Appl Environ Microbiol 72:4819-28 (2006)
DOI:10.1128/AEM.00853-06
  Sequence
[pae:PA2890]

KEGG   ENZYME: 4.2.1.57
Entry
EC 4.2.1.57                 Enzyme                                 
Name
isohexenylglutaconyl-CoA hydratase;
3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase;
isohexenylglutaconyl coenzyme A hydratase;
beta-isohexenylglutaconyl-CoA-hydratase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
Reaction(IUBMB)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O [RN:R03493]
Reaction(KEGG)
R03493
Substrate
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]
Product
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291];
H2O [CPD:C00001]
Comment
Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
History
EC 4.2.1.57 created 1972
Pathway
ec00281  Geraniol degradation
ec01110  Biosynthesis of secondary metabolites
Orthology
K13779  isohexenylglutaconyl-CoA hydratase
Genes
RGLCS053_05365
PAEPA2890(atuE)
PAEVN297_2993
PAEIN296_2993
PAUPA14_26690
PAPPSPA7_2264
PAGPLES_21741(atuE)
PAFPAM18_2073(atuE)
PNCNCGM2_4001
PAEBNCGM1900_3421
PDKPADK2_09920
PSGG655_10355
PRPM062_15480
PAEPPA1S_10960
PAERPA1R_gp0722
PAEMU769_10500
PAELT223_10970
PAESSCV20265_2216
PAEUBN889_03228(atuE)
PAEGAI22_22910
PAECM802_2990
PAEOM801_2858
PMYPmen_2693
PMKMDS_2025
PREPCA10_37640
PPSEBN5_2437
PFUWKF707C_19280
PALCA0T30_09825
PCQPcP3B5_19980(echA8_1)
PMUIG4G71_19930
PPAAB7D75_10680
PFLPFL_4198(atuE)
PPRCPFLCHA0_c42610(echA5)
PPROPPC_4295(atuE)
PFNHZ99_27645
PFOPfl01_3949
PFSPFLU_4396
PFCPflA506_3700(atuE)
PFBVO64_5140
PMANOU5_1499
PTVAA957_22840
PVRPverR02_22375
PAZOAYR47_28665
PRXHRH33_19065
PFWPF1751_v1c38910(atuE)
PFFPFLUOLIPICF716745
PFXA7318_18705
PPUUPputUW4_01474
PDRH681_15885
PSKU771_22890
PKCPKB_3705
PCHEY04_21280
PCZPCL1606_19670
PSOSPOS17_4286(atuE)
PKRAYO71_21560
PFKPFAS1_02935
PANRA7J50_4074
PSETTHL1_3722
PSILPMA3_07215
PYMAK972_1689
PKEDLD99_19840
PALLUYA_10250
PUMHGP31_23190
POJPtoMrB4_17780(atuE)
PGYAWU82_00340
PLALFXN65_18465
PSEJHNQ25_14635
PKHJLK41_10345(atuE)
PTYJWV26_20535
PMAOPMYSY11_2044
PATAJWU58_09110
PZEHU754_020990
PMOEHV782_020190
PCAMHNE05_10000
PSEPC4K39_6116
PVWHU752_023690
PTRTHU722_0020660
PSAMHU731_007040
PTZHU718_021185
PSHHHU773_010440
PHVHU739_020395
PASGKSS96_20310
PAZEKSS91_08300
PWZJ7655_12405(atuE)
PTWTUM18999_18970(atuE)
PIEHU724_019815
PGFJ0G10_21215
PCAVD3880_13540
PHFNLY38_09540(atuE)
PIZLAB08_R42970
PPEGKUA23_21415
PSIINF676_18780
PFITKJY40_20405
HPEGEAO82_15110
MAQMaqu_2806
MHCMARHY2693
MADHP15_2541
MSXAU14_06535
MARIACP86_03035
MLQASQ50_05315
MSQBKP64_01775
MARAD0851_06245
MARJMARI_02970(echA8_1)
ACBA1S_3006
ABMABSDF2869
ABYABAYE0482
ABCACICU_03205
ABNAB57_3457
ABBABBFA_00511(echA8_1)
ABXABK1_3257
ABZABZJ_03389
ABRABTJ_00493
ABDABTW07_3421
ABHM3Q_3438
ABADABD1_28950
ABJBJAB07104_03294
ABABBJAB0715_03357
ABAJBJAB0868_03250
ABAZP795_2375
ABKLX00_16130
ABAUIX87_11725
ABAAIX88_17970
ABWBL01_15700
ACCBDGL_002470(ech2)
ANORR32_02585
ALCOTEC02_02500
ACALBUM88_16985
ASEII8T81_02655
ACDAOLE_02445
ACWA0J50_02390
ACVAMD27_02945
AHLAHTJS_02680
AJNBVL33_14910
ADVDJ533_05380
AWUBEN71_15680
AGUAS4_37350(liuC)
ADSFPL17_17120
ABERBSR55_18365
ALJG8D99_12455
ASHAG8E00_03480
AGYLFPL18_09805
AVZHWI77_02525
MBAHHYN46_03590
PATPatl_0318
AMHI633_00605
AMBAMBAS45_14995
GAGGlaag_3942
HMIsoil367_12300
ALKMNKI27_15115
ASEMNNL22_11445
SAGAM5M_01895
SNANI6N98_02115
OSGBST96_16505
MICCAUP74_02724(caiD_2)
MIIBTJ40_09630
MICTFIU95_11175(caiD)
MICZGL2_32310(atuE)
MVBMJO52_09445
KIMG3T16_17330
AFUSEYZ66_13125
LANTTUM19329_30250
CYQQ91_1220
CZACYCME_1208
CYYCPC19_06505
HCHHCH_05751
HAHEENC22_05160
ABOABO_0987(ech2)
ALNAS19_10500
ADIB5T_01798(ech2)
AXEP40_08545
APACS7S_10300
KAKKalk_03350
TWANHUF19_01590
OAIOLEAN_C05750(ech)
BMARHF888_06875
BACZKFF03_16430
OMEOLMES_1767
SOKD0B54_13390 D0B54_21520 D0B54_21680
FCEJN531_011725
GPBHDN1F_10700
RPJN234_26495
REHH16_A2138(h16_A2138)
CNCCNE_1c27020
CUHBJN34_26635
REUReut_B4461
RMERmet_1723
CBWRR42_s2503
CCUPBKK81_27005
CUPBKK80_29315
CUUBKK79_35265
COXE0W60_00885
BPSBPSS2033
BPMBURPS1710b_A1151
BPLBURPS1106A_A2776
BPDBURPS668_A2931
BPSEBDL_5456
BPSMBBQ_4088
BPSUBBN_5508
BPSDBBX_4623
BPZBP1026B_II2188
BPQBPC006_II2741
BPKBBK_4784
BPSHDR55_5688
BPSABBU_3965
BPSOX996_5493
BUTX994_5050
BTEBTH_II0287
BTQBTQ_3582
BTJBTJ_4618
BTZBTL_5405
BTDBTI_4953
BTVBTHA_4797
BTHEBTN_5076
BTHMBTRA_5344
BTHADR62_5205
BTHLBG87_5412
BOKDM82_6352
BOCBG90_4322
BUUWS70_27685
BSAVWS86_29380
BHGI6G56_28270
BULBW21_4481
BUDAQ610_30715
BURKDM992_33055
PMEGFNZ07_28820
AXYAXYL_05147 AXYL_05905 AXYL_06695
AKATKWG_13775
RFRRfer_2816
RSBRS694_04405
RHGEXZ61_04955
RHOAHZ993_09220
ACKC380_03330
ACRABSY15_2085
ARADKI609_03520
VEIVeis_2207 Veis_4192
CTTCtCNB1_1720
CTESO987_10850
CODOLAD35_12085
ADNAlide_0006 Alide_0191
ADKAlide2_0011 Alide2_0180
LIHL63ED372_00597(paaF_2)
HYRBSY239_341
HYBQ5W_16945
HYLLPB072_13945
HPSEHPF_03620(paaF2)
HTNKI616_23290
HCZG9Q37_12945
DIHG7047_04265
SIMPC6571_17635
MELMC7H73_12860
RGERGE_32890
RBNRBXJA2T_12974
PKTAT984_14395
SHDSUTH_02875
NANNO0S08_37805
NIYFQ775_15165
PMOBHG718_07165
RVARvan_3071
RBMTEF_02215 TEF_19345
PSFPSE_4602
PZUPHZ_p0199
HDHG5B40_00900
GAKX907_0621
SECHB18_27410
SPHGAZE99_15810
SFLASPHFLASMR4Y_02318(caiD)
SPHYCHN51_05355
PARJJ4G78_10640
PHAOHF685_10675
SRFLHU95_03865
RCERC1_3532
TMOTMO_b0367
SNEANBZ79_16340
PMETG4Y79_18165
SCORJ3U87_30230
 » show all
Reference
1  [PMID:14339651]
  Authors
SEUBERT W, FASS E.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]
  Journal
Biochem Z 341:23-34 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.57
IUBMB Enzyme Nomenclature: 4.2.1.57
ExPASy - ENZYME nomenclature database: 4.2.1.57
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.57
BRENDA, the Enzyme Database: 4.2.1.57
CAS: 37290-84-9

KEGG   REACTION: R03493
Entry
R03493                      Reaction                               
Name
3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA hydro-lyase
Definition
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-Methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
Equation
Reaction class
RC00941  C01291_C04675
Enzyme
Pathway
rn00281  Geraniol degradation
rn01110  Biosynthesis of secondary metabolites
Orthology
K13779  isohexenylglutaconyl-CoA hydratase [EC:4.2.1.57]
Reference
1  [PMID:16820476]
  Authors
Forster-Fromme K, Hoschle B, Mack C, Bott M, Armbruster W, Jendrossek D
  Title
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
  Journal
Appl Environ Microbiol 72:4819-28 (2006)
DOI:10.1128/AEM.00853-06
Other DBs
RHEA: 24147

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