KEGG   ORTHOLOGY: K14039
Entry
K14039            Tight     KO                                     
Symbol
E1.14.14.176
Name
taxadiene 5alpha-hydroxylase [EC:1.14.14.176]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K14039  E1.14.14.176; taxadiene 5alpha-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.176  taxadiene 5alpha-hydroxylase
     K14039  E1.14.14.176; taxadiene 5alpha-hydroxylase
Other DBs
RN: R06306
GO: 0050604
Genes
AG: AAQ56240
Reference
  Authors
Jennewein S, Long RM, Williams RM, Croteau R
  Title
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.
  Journal
Chem Biol 11:379-87 (2004)
DOI:10.1016/j.chembiol.2004.02.022
  Sequence
Reference
PMID:8807878
  Authors
Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R
  Title
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis.
  Journal
Chem Biol 3:479-89 (1996)
DOI:10.1016/s1074-5521(96)90096-4

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