KEGG   ORTHOLOGY: K14041
Entry
K14041            Tight     KO                                     
Symbol
TPS-LAS, LPS
Name
levopimaradiene/copalyl diphosphate synthase [EC:4.2.3.32 5.5.1.12]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K14041  TPS-LAS, LPS; levopimaradiene/copalyl diphosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.32  levopimaradiene synthase
     K14041  TPS-LAS, LPS; levopimaradiene/copalyl diphosphate synthase
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.12  copalyl diphosphate synthase
     K14041  TPS-LAS, LPS; levopimaradiene/copalyl diphosphate synthase
Other DBs
RN: R06298 R06302 R06304
GO: 0052678 0050559
Genes
AG: AAL09965(LPS)
Reference
  Authors
Schepmann HG, Pang J, Matsuda SP
  Title
Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis.
  Journal
Arch Biochem Biophys 392:263-9 (2001)
DOI:10.1006/abbi.2001.2438
  Sequence
Reference
  Authors
Keeling CI, Weisshaar S, Lin RP, Bohlmann J
  Title
Functional plasticity of paralogous diterpene synthases involved in conifer defense.
  Journal
Proc Natl Acad Sci U S A 105:1085-90 (2008)
DOI:10.1073/pnas.0709466105
Reference
  Authors
Martin DM, Faldt J, Bohlmann J
  Title
Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily.
  Journal
Plant Physiol 135:1908-27 (2004)
DOI:10.1104/pp.104.042028

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