KEGG   ORTHOLOGY: K14130
Entry
K14130                      KO                                     
Symbol
FGAPT2
Name
tryptophan 4-dimethylallyltransferase [EC:2.5.1.34]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K14130  FGAPT2; tryptophan 4-dimethylallyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K14130  FGAPT2; tryptophan 4-dimethylallyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.34  4-dimethylallyltryptophan synthase
     K14130  FGAPT2; tryptophan 4-dimethylallyltransferase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  Indole prenyltransferase
   K14130  FGAPT2; tryptophan 4-dimethylallyltransferase
Other DBs
RN: R01657
GO: 0050364
Genes
MAW: MAC_06989
MAJ: MAA_06736
GLZ: GLAREA_05930
AFM: AFUA_2G18040
ACT: ACLA_031240
AOR: AO090005001079
AFV: AFLA_003907
ACHE: ACHE_61019A ACHE_61023A
ABE: ARB_04649
TVE: TRV_01863
 » show all
Reference
  Authors
Metzger U, Schall C, Zocher G, Unsold I, Stec E, Li SM, Heide L, Stehle T
  Title
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria.
  Journal
Proc Natl Acad Sci U S A 106:14309-14 (2009)
DOI:10.1073/pnas.0904897106
  Sequence

KEGG   ENZYME: 2.5.1.34
Entry
EC 2.5.1.34                 Enzyme                                 
Name
4-dimethylallyltryptophan synthase;
dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase;
dimethylallyltryptophan synthetase;
dimethylallylpyrophosphate:tryptophan dimethylallyl transferase;
DMAT synthetase;
4-(gamma,gamma-dimethylallyl)tryptophan synthase;
tryptophan dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase
Reaction(IUBMB)
dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan [RN:R01657]
Reaction(KEGG)
R01657;
(other) R02943
Substrate
dimethylallyl diphosphate [CPD:C00235];
L-tryptophan [CPD:C00078]
Product
diphosphate [CPD:C00013];
4-(3-methylbut-2-enyl)-L-tryptophan [CPD:C04290]
History
EC 2.5.1.34 created 1984, modified 2010
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14130  tryptophan 4-dimethylallyltransferase
Genes
MAWMAC_06989
MAJMAA_06736
GLZGLAREA_05930
AFMAFUA_2G18040
ACTACLA_031240
AORAO090005001079
AFVAFLA_003907
ACHEACHE_61019A ACHE_61023A
ABEARB_04649
TVETRV_01863
BSCCOCSADRAFT_185949
 » show all
Reference
1  [PMID:999297]
  Authors
Lee SL, Floss HG, Heinstein P.
  Title
Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58.
  Journal
Arch Biochem Biophys 177:84-94 (1976)
DOI:10.1016/0003-9861(76)90418-5
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.34
IUBMB Enzyme Nomenclature: 2.5.1.34
ExPASy - ENZYME nomenclature database: 2.5.1.34
BRENDA, the Enzyme Database: 2.5.1.34
CAS: 55127-01-0

KEGG   REACTION: R01657
Entry
R01657                      Reaction                               
Name
Dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase
Definition
Dimethylallyl diphosphate + L-Tryptophan <=> Diphosphate + 4-(3-Methylbut-2-enyl)-L-tryptophan
Equation
Reaction class
RC00209  C00078_C04290
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Orthology
K14130  tryptophan 4-dimethylallyltransferase [EC:2.5.1.34]
Other DBs
RHEA: 14176

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