KEGG   ORTHOLOGY: K14250
Entry
K14250                      KO                                     

Symbol
oxyN, snoaM, dpsY, aknW, mtmY
Name
cyclase
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
   00253 Tetracycline biosynthesis
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Nonaketide PKS
     K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
    Decaketide PKS
     K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
Other DBs
RN: R09188 R09325 R09326 R09350
Genes
PAKH: B0X70_21795
NAH: F5544_10720 F5544_17035
SHY: SHJG_1191
SHO: SHJGH_1026
SFA: Sfla_5330
SBH: SBI_06843
STRP: F750_1293
SCI: B446_13310
SGS: AVL59_46195
SGM: GCM10017557_73870
SHUN: DWB77_05175(kynB)
AORI: SD37_34190
KAL: KALB_7821
MIL: ML5_4398
AG: AAC38443(dpsY) AAF01818(snoaM) AAF73459(aknW) AAZ78337(oxyN) CAK50782(mtmY)
 » show all
Reference
PMID:16597959 (oxyN)
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
  Authors
Zhang W, Watanabe K, Wang CC, Tang Y
  Title
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
  Journal
J Biol Chem 282:25717-25 (2007)
DOI:10.1074/jbc.M703437200
Reference
PMID:11683270 (snoaM)
  Authors
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
  Title
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
  Journal
Mol Genet Genomics 266:276-88 (2001)
DOI:10.1007/s004380100554
  Sequence
Reference
PMID:9573189 (dpsY)
  Authors
Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR
  Title
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.
  Journal
J Bacteriol 180:2379-86 (1998)
DOI:10.1128/JB.180.9.2379-2386.1998
  Sequence
Reference
PMID:10102355 (mtmY)
  Authors
Prado L, Lombo F, Brana AF, Mendez C, Rohr J, Salas JA
  Title
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.
  Journal
Mol Gen Genet 261:216-25 (1999)
DOI:10.1007/s004380050960
  Sequence

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