KEGG   ORTHOLOGY: K14334
Entry
K14334                      KO                                     
Symbol
CMLE
Name
carboxy-cis,cis-muconate cyclase [EC:5.5.1.5]
Pathway
map00362  Benzoate degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K14334  CMLE; carboxy-cis,cis-muconate cyclase
Enzymes [BR:ko01000]
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.5  carboxy-cis,cis-muconate cyclase
     K14334  CMLE; carboxy-cis,cis-muconate cyclase
Other DBs
RN: R03308
GO: 0047768
Genes
QSU: 111989910 112002592
NCR: NCU04071(cmc)
NTE: NEUTE1DRAFT69050(NEUTE1DRAFT_69050)
SMP: SMAC_00654
PAN: PODANSg3147
TTT: THITE_2109649
MTM: MYCTH_102792
CTHR: CTHT_0043430
MGR: MGG_01335
TMN: UCRPA7_4619
SSCK: SPSK_01165
CMT: CCM_05099
MBE: MBM_04706
ANI: AN1151.2
ANG: ANI_1_1578014(An01g11680)
PTE: PTT_18720
 » show all
Reference
  Authors
Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW, Goldman A
  Title
The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase.
  Journal
Structure 10:483-92 (2002)
DOI:10.1016/S0969-2126(02)00744-X
  Sequence
[ncr:NCU04071]

KEGG   ENZYME: 5.5.1.5
Entry
EC 5.5.1.5                  Enzyme                                 
Name
carboxy-cis,cis-muconate cyclase;
3-carboxymuconate cyclase;
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Reaction(IUBMB)
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate [RN:R03308]
Reaction(KEGG)
R03308
Substrate
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04553]
Product
3-carboxy-cis,cis-muconate [CPD:C01163]
History
EC 5.5.1.5 created 1972
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K14334  carboxy-cis,cis-muconate cyclase
Genes
QSU111989910 112002592
NCRNCU04071(cmc)
NTENEUTE1DRAFT69050(NEUTE1DRAFT_69050)
SMPSMAC_00654
PANPODANSg3147
TTTTHITE_2109649
MTMMYCTH_102792
CTHRCTHT_0043430
MGRMGG_01335
TMNUCRPA7_4619
SSCKSPSK_01165
FGRFGSG_01797 FGSG_09485
FPUFPSE_10485 FPSE_11356
FVRFVEG_13026 FVEG_13891 FVEG_15389
FOXFOXG_13515 FOXG_17141 FOXG_17757
NHENECHADRAFT_34285 NECHADRAFT_95122
TRETRIREDRAFT_4875
TRRM419DRAFT_83874
MAWMAC_02676 MAC_03669
MAJMAA_02127 MAA_02523 MAA_07740
CMTCCM_05099
PLJVFPFJ_03962
VALVDBG_08102
VDAVDAG_01598
CFJCFIO01_06351 CFIO01_08166 CFIO01_13719
CLUPCLUP02_00342 CLUP02_15378 CLUP02_15569
CHIGCH63R_05008 CH63R_08134
SAPOSAPIO_CDS4774
ELAUCREL1_3619 UCREL1_4578 UCREL1_8893 UCREL1_9455
PFYPFICI_05544 PFICI_10416 PFICI_11298 PFICI_11300 PFICI_14718
SSLSS1G_02777
BFUBCIN_06g04470
MBEMBM_04706
PSCOLY89DRAFT_576208 LY89DRAFT_579583 LY89DRAFT_743822
GLZGLAREA_06984 GLAREA_09387
ANIAN1151.2
AFMAFUA_6G11580
ACTACLA_085230
NFINFIA_057270
AORAO090005000349 AO090023000419
ANGANI_1_1578014(An01g11680)
AFVAFLA_003133 AFLA_006766
ALUCAKAW2_10446A
ACHEACHE_60039A
APUUAPUU_50606S
PCSPc20g02010
PDPPDIP_05030
TMFPMAA_014680
TRGTRUGW13939_04691
PBLPAAG_02873
PBNPADG_01898
AJEHCAG_03387
BGHBDBG_05986
PNOSNOG_03242
PTEPTT_18720
BZECOCCADRAFT_25253 COCCADRAFT_6173
BSCCOCSADRAFT_165269 COCSADRAFT_35109
BORCOCMIDRAFT_270 COCMIDRAFT_79696
AALTCC77DRAFT_1023877 CC77DRAFT_1025708
ZTRMYCGRDRAFT_74026 MYCGRDRAFT_99485(MLE)
PFJMYCFIDRAFT_210932 MYCFIDRAFT_80983
FFUCLAFUR5_12243
BCOMBAUCODRAFT_389389 BAUCODRAFT_80070
NPAUCRNP2_3006 UCRNP2_5709
SHSSTEHIDRAFT_116697 STEHIDRAFT_161496
HIRHETIRDRAFT_327492
LBCLACBIDRAFT_318272
CCICC1G_09812
MRRMoror_14232
MOREE1B28_006009
UMAUMAG_02142
PGRPGTG_10167
MLRMELLADRAFT_93461
 » show all
Reference
1  [PMID:13319299]
  Authors
GROSS SR, GAFFORD RD, TATUM EL.
  Title
The metabolism of protocatechuic acid by Neurospora.
  Journal
J Biol Chem 219:781-96 (1956)
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.5
IUBMB Enzyme Nomenclature: 5.5.1.5
ExPASy - ENZYME nomenclature database: 5.5.1.5
BRENDA, the Enzyme Database: 5.5.1.5
CAS: 37318-55-1

KEGG   REACTION: R03308
Entry
R03308                      Reaction                               
Name
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
Definition
3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-Carboxy-cis,cis-muconate
Equation
Reaction class
RC00903  C01163_C04553
Enzyme
Pathway
rn00362  Benzoate degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K14334  carboxy-cis,cis-muconate cyclase [EC:5.5.1.5]
Other DBs
RHEA: 14980

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