KEGG   ORTHOLOGY: K14417
Entry
K14417            Tight     KO                                     
Symbol
fcbA
Name
4-chlorobenzoate-CoA ligase [EC:6.2.1.33]
Pathway
map00364  Fluorobenzoate degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00364 Fluorobenzoate degradation
    K14417  fcbA; 4-chlorobenzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.33  4-chlorobenzoate---CoA ligase
     K14417  fcbA; 4-chlorobenzoate-CoA ligase
Other DBs
RN: R03932 R08117
GO: 0018861
Genes
AG: ABQ44579(fcbA)
Reference
PMID:1610806
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence
Reference
  Authors
Chae JC, Song B, Zylstra GJ
  Title
Identification of genes coding for hydrolytic dehalogenation in the metagenome derived from a denitrifying 4-chlorobenzoate degrading consortium.
  Journal
FEMS Microbiol Lett 281:203-9 (2008)
DOI:10.1111/j.1574-6968.2008.01106.x
Reference
PMID:7765837
  Authors
Dunaway-Mariano D, Babbitt PC
  Title
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
  Journal
Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464

KEGG   ENZYME: 6.2.1.33
Entry
EC 6.2.1.33                 Enzyme                                 
Name
4-chlorobenzoate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-chlorobenzoate:CoA ligase
Reaction(IUBMB)
4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate [RN:R03932]
Reaction(KEGG)
R03932;
(other) R08117
Substrate
4-chlorobenzoate [CPD:C02370];
CoA [CPD:C00010];
ATP [CPD:C00002]
Product
4-chlorobenzoyl-CoA [CPD:C06387];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 6.2.1.33 created 1999
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14417  4-chlorobenzoate-CoA ligase
Reference
1  [PMID:7765837]
  Authors
Dunaway-Mariano D, Babbitt PC
  Title
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
  Journal
Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464
Reference
2  [PMID:1418673]
  Authors
Loffler F, Muller R, Lingens F.
  Title
Purification and properties of 4-halobenzoate-coenzyme A ligase from Pseudomonas sp. CBS3.
  Journal
Biol Chem Hoppe Seyler 373:1001-7 (1992)
DOI:10.1515/bchm3.1992.373.2.1001
Reference
3  [PMID:1610806]
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.33
IUBMB Enzyme Nomenclature: 6.2.1.33
ExPASy - ENZYME nomenclature database: 6.2.1.33
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.33
BRENDA, the Enzyme Database: 6.2.1.33
CAS: 141583-20-2

KEGG   REACTION: R08117
Entry
R08117                      Reaction                               
Name
4-fluorobenzoate:CoA ligase
Definition
4-Fluorobenzoate + CoA + ATP <=> 4-Fluorobenzoyl-CoA + AMP + Diphosphate
Equation
Reaction class
RC00004  C00010_C02802
RC00174  C02371_C02802
Enzyme
Pathway
rn00364  Fluorobenzoate degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K14417  4-chlorobenzoate-CoA ligase [EC:6.2.1.33]

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