KEGG   ORTHOLOGY: K14418
Entry
K14418            Tight     KO                                     
Symbol
fcbB
Name
4-chlorobenzoyl-CoA dehalogenase [EC:3.8.1.7]
Pathway
map00364  Fluorobenzoate degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00364 Fluorobenzoate degradation
    K14418  fcbB; 4-chlorobenzoyl-CoA dehalogenase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.8  Acting on halide bonds
   3.8.1  In carbon-halide compounds
    3.8.1.7  4-chlorobenzoyl-CoA dehalogenase
     K14418  fcbB; 4-chlorobenzoyl-CoA dehalogenase
Other DBs
RN: R04101 R08118
GO: 0018787
Genes
AG: ABQ44578(fcbB)
Reference
  Authors
Chae JC, Song B, Zylstra GJ
  Title
Identification of genes coding for hydrolytic dehalogenation in the metagenome derived from a denitrifying 4-chlorobenzoate degrading consortium.
  Journal
FEMS Microbiol Lett 281:203-9 (2008)
DOI:10.1111/j.1574-6968.2008.01106.x
Reference
PMID:7765837
  Authors
Dunaway-Mariano D, Babbitt PC
  Title
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
  Journal
Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464
Reference
PMID:1610806
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence

KEGG   ENZYME: 3.8.1.7
Entry
EC 3.8.1.7                  Enzyme                                 
Name
4-chlorobenzoyl-CoA dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
Sysname
4-chlorobenzoyl CoA chlorohydrolase
Reaction(IUBMB)
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride [RN:R04101]
Reaction(KEGG)
R04101;
(other) R08118
Substrate
4-chlorobenzoyl-CoA [CPD:C06387];
H2O [CPD:C00001]
Product
4-hydroxybenzoyl CoA;
chloride [CPD:C00698]
Comment
Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 3.8.1.7 created 1999
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14418  4-chlorobenzoyl-CoA dehalogenase
Reference
1  [PMID:1610806]
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence
Reference
2  [PMID:7918379]
  Authors
Crooks GP, Copley SD
  Title
Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1.
  Journal
Biochemistry 33:11645-9 (1994)
DOI:10.1021/bi00204a028
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.7
IUBMB Enzyme Nomenclature: 3.8.1.7
ExPASy - ENZYME nomenclature database: 3.8.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.7
BRENDA, the Enzyme Database: 3.8.1.7
CAS: 141583-18-8

KEGG   REACTION: R04101
Entry
R04101                      Reaction                               
Name
4-Chlorobenzoyl CoA chlorohydrolase
Definition
4-Chlorobenzoyl-CoA + H2O <=> 4-Hydroxybenzoyl-CoA + Cl- + H+
Equation
Reaction class
RC00492  C02949_C06387
Enzyme
Pathway
rn00364  Fluorobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K14418  4-chlorobenzoyl-CoA dehalogenase [EC:3.8.1.7]
Other DBs
RHEA: 14856

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