KEGG   ORTHOLOGY: K14519
Entry
K14519                      KO                                     
Symbol
aldH
Name
NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
Pathway
map00930  Caprolactam degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K14519  aldH; NADP-dependent aldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.4  aldehyde dehydrogenase (NADP+)
     K14519  aldH; NADP-dependent aldehyde dehydrogenase
Other DBs
RN: R05099
GO: 0033721
Genes
POL: Bpro_2298
AAV: Aave_0115
PDE: Pden_3264
HBA: Hbal_2501
MGO: AFA91_18385
MMAG: MMAD_17910
MTY: MTOK_16350
MMAT: MMAGJ_18140
CSUR: N24_0341(aldH)
CCYC: SCMU_32610
SCO: SCO1871(SCI39.18c)
SALB: XNR_4954
SGR: SGR_5625
SGB: WQO_07195
SHY: SHJG_3333
SMAL: SMALA_1828
SCT: SCAT_1069(aldH)
SFA: Sfla_4940
SBH: SBI_08125
SVE: SVEN_1516
STRP: F750_1741
SFI: SFUL_1445
SALU: DC74_2375
SALL: SAZ_13230
STRE: GZL_06632
STRM: M444_09735
SAMB: SAM23877_1946(aldH)
SRW: TUE45_02355(aldH)
SLE: sle_52630(sle_52630)
SRN: A4G23_01098(aldH)
STRD: NI25_29855
SALF: SMD44_02024(aldH)
SLX: SLAV_28055(aldH)
SFK: KY5_1790c
SGE: DWG14_06529(aldH)
SNF: JYK04_02543(aldH)
SHUN: DWB77_05847(aldH)
SCYG: S1361_10270(aldH)
SAUH: SU9_007405
CMI: CMM_0812
CMS: CMS0069
CMC: CMN_00768
ART: Arth_3335
ARR: ARUE_c34530(aldH)
ARM: ART_2596
AAU: AAur_3317(aldH)
ACH: Achl_3135
BCV: Bcav_0786
LMOI: VV02_11040
NCA: Noca_0086
KFL: Kfla_6632
TFU: Tfu_1706
NDA: Ndas_5346
NAL: B005_1809
SRO: Sros_1486
NCX: Nocox_10180(aldH)
GOB: Gobs_2395
BSD: BLASA_1682(aldH)
AMD: AMED_5971
AMN: RAM_30625
AMM: AMES_5887
AMZ: B737_5887
AOI: AORI_3623(aldH) AORI_4998(aldH)
AORI: SD37_24610
KAL: KALB_6874
ACTI: UA75_13535
ACAD: UA74_13450
CAI: Caci_7805
SNA: Snas_4113
CWO: Cwoe_3952
RBA: RB1887
 » show all
Reference
  Authors
Ahvazi B, Coulombe R, Delarge M, Vedadi M, Zhang L, Meighen E, Vrielink A
  Title
Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity.
  Journal
Biochem J 349 Pt 3:853-61 (2000)
DOI:10.1042/bj3490853

KEGG   ENZYME: 1.2.1.4
Entry
EC 1.2.1.4                  Enzyme                                 
Name
aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
aldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]
Reaction(KEGG)
R00634 > R00711 R05099
Substrate
aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.4 created 1961
Pathway
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14519  NADP-dependent aldehyde dehydrogenase
Genes
POLBpro_2298
AAVAave_0115
PDEPden_3264
HBAHbal_2501
MGOAFA91_18385
MMAGMMAD_17910
MTYMTOK_16350
MMATMMAGJ_18140
CSURN24_0341(aldH)
CCYCSCMU_32610
NBRO3I_014410
NOZDMB37_12025
NAHF5544_03970 F5544_18980
NIEKV110_32105
RHARHA1_ro02898 RHA1_ro08151
REBXU06_29340
ROPROP_04960 ROP_33690
ROAPd630_LPD01864 Pd630_LPD07647
RPYY013_12795
RKOJWS14_15360 JWS14_29370
GPOGPOL_c08310
GAMGII34_11230
SCOSCO1871(SCI39.18c)
SALBXNR_4954
SMASAVERM_6389
SGRSGR_5625
SGBWQO_07195
SCBSCAB_70651
SSXSACTE_1304
SVLStrvi_6068 Strvi_6961
SHYSHJG_3333
SHOSHJGH_3098
SRCM271_36920 M271_42100
SMALSMALA_1828
SSOII1A49_12290
SCTSCAT_1069(aldH)
SCYSCATT_10640
SFASfla_4940
SBHSBI_08125
SVESVEN_1516
SDVBN159_6637
SALSSLNWT_3889 SLNWT_5169
STRPF750_1741
SFISFUL_1445
SCIB446_09735
SALUDC74_2375
SALLSAZ_13230
SLVSLIV_28360
SGUSGLAU_08360
SVTSVTN_09040
STREGZL_06632
SCWTU94_07955
SXISXIM_08460
STRMM444_09735
STRCAA958_05410
SAMBSAM23877_1946(aldH)
SPRISPRI_5639 SPRI_6598
SCZABE83_05080 ABE83_28580
SCXAS200_33840
SRWTUE45_02355(aldH)
STRFASR50_09120
SLEsle_52630(sle_52630)
SRNA4G23_01098(aldH)
SPAVSpa2297_07475
STRTA8713_06920
SGSAVL59_36200
STSIA4E84_09445
SKYD0C37_26780
SALWCP975_07930
SGMGCM10017557_63870
SCADDN051_29150
SLSSLINC_2143
SNRSNOUR_30860
SPLULK06_006345
STRDNI25_29855
SNWBBN63_27130
SAUOBV401_12610
SSIAA7J05_27570
SPUNBFF78_31920
SALFSMD44_02024(aldH)
SLXSLAV_28055(aldH)
SFKKY5_1790c
SNZDC008_07595
SGEDWG14_06529(aldH)
SLKSLUN_09055
SDXC4B68_30950
SGDELQ87_30185
SCYAEJ357_10760
SASTCD934_26295
SNQCP978_09035
SKACP970_33710
SGZC0216_22605
SVNCP980_25430
SNKCP967_26925
SHAWCEB94_09900
SFICEIZ62_25730
SGALCP966_08010
SPADDVK44_05385
SFYGFH48_30745
SAQUEJC51_12510
SGFHEP81_07415
SCAVCVT27_06070
SSEOD0Z67_06320
SBYH7H31_27955
SRIMCP984_31595
SSUBCP968_25250
SPHVF9278_09390 F9278_41905
SCINCP977_08425
SFUGCNQ36_08105
SPACB1H29_28125
SCHACP983_33330
SGXH4W23_09490
SCOECP976_10630
SBATG4Z16_27200 G4Z16_31395
SSPBCP982_11050
SNFJYK04_02543(aldH)
SPLACP981_09390
SBROGQF42_12225
STUIGCM10017668_14690
SATAC5746_10310
SCHFIPT68_08685
SHUNDWB77_05847(aldH)
SHARHUT13_04790
SCYGS1361_10270(aldH)
SFEUIM697_12885
SLIAHA039_26585
SDWK7C20_08905
SVDCP969_10400 CP969_21185
SAUHSU9_007405
SFBCP974_05695
SPRACP972_08485
SROIIAG44_31050
SXNIAG42_27470
SGJIAG43_06880
SHKJ2N69_07750
SANUK7396_27430
SDDD9753_27385
SACTDMT42_08595
SMAOCAG99_10430 CAG99_23505
SINEKI385_12000
SLFJEQ17_35575
KABB7C62_06205
YIALO772_29230
LEIFHF024_03025 HF024_15475 HF024_15560
LSEF1C12_02900
CMICMM_0812
CMSCMS0069
CMCCMN_00768
CMHVO01_12315
CZHH9X71_03675
MCWA8L33_01720
MPALBO218_08130 BO218_12285
MPRTET475_03200
MCHNHCR76_14865
MICSC1N74_02830 C1N74_14770
AGYATC03_04975 ATC03_15645
AARCG127AT_04820
AMAUDSM26151_06040 DSM26151_17850(aldH)
ASOIMTP13_01615
LEBG7066_05385
LDNH9L06_03900
LVIG7068_14510 G7068_14680
LLUTK1X41_04820
HEAHL652_16540 HL652_20135
GLNF1C58_00235
GSDM3M28_01495
ARTArth_3335
ARRARUE_c34530(aldH)
ARMART_2596
AREAL755_00525
AAQAOC05_16125
ARWMB46_17645
ARZAUT26_15885
ARIUM93_13775
AAUAAur_3317(aldH)
PUEFV140_17450
PNVJMY29_15825
ACHAchl_3135
APNAsphe3_32640
PSULAU252_14625
RSARSal33209_1814
BCVBcav_0786
LMOIVV02_11040
HALTIM660_17765
NCANoca_0086
MUZH4N58_00735
KFLKfla_6632
KQIF1D05_17890
TFUTfu_1706
THAONI17_003845
TALXFOF52_07935
NDANdas_5346
NALB005_1809
NFEHUT17_01055
SAIUJ4H86_15000
SROSros_1486
NCXNocox_10180(aldH)
NGNLCN96_11480
TBITbis_1086 Tbis_1743
FREFranean1_4676
GOBGobs_2395
BSDBLASA_1682(aldH)
SENSACE_1997 SACE_2783
SACGFDZ84_03090
AMDAMED_5971
AMNRAM_30625
AMMAMES_5887
AMZB737_5887
AOIAORI_3623(aldH) AORI_4998(aldH)
AJAAJAP_14530 AJAP_21020
AMQAMETH_6878
AORISD37_24610
AACDLWP59_12210 LWP59_13140 LWP59_13260
PHHAFB00_20980
AMIAmir_1484 Amir_4721
KALKALB_6874
KPHYAOZ06_14455
LEDBBK82_01545 BBK82_46985
AHMTL08_12515
ACTIUA75_13535
ACADUA74_13450
AMSAMIS_59920
AIHAiant_90370
ATLAthai_51790
ASERAsera_23020
PRYPrubr_70620
NHYJQS43_03115 JQS43_13575
CAICaci_7805
SNASnas_4113
NAVJQS30_15595
JTLM6D93_07025
CWOCwoe_3952
RBARB1887
 » show all
Reference
1
  Authors
Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.
  Title
Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.
  Journal
Agric Biol Chem 44:155-164 (1980)
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3
  Authors
Nakayama, T.
  Title
Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.
  Journal
J Biochem (Tokyo) 48:812-830 (1960)
Reference
4  [PMID:13061400]
  Authors
SEEGMILLER JE.
  Title
Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.
  Journal
J Biol Chem 201:629-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.4
IUBMB Enzyme Nomenclature: 1.2.1.4
ExPASy - ENZYME nomenclature database: 1.2.1.4
BRENDA, the Enzyme Database: 1.2.1.4
CAS: 9028-87-9

KEGG   REACTION: R05099
Entry
R05099                      Reaction                               
Name
6-oxohexanoate:NADP+ oxidoreductase
Definition
Adipate semialdehyde + NADP+ + H2O <=> Adipate + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00080  C06102_C06104
Enzyme
1.2.1.4         1.2.1.63
Pathway
rn00930  Caprolactam degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K14519  NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
K19962  6-oxohexanoate dehydrogenase [EC:1.2.1.63]
Other DBs
RHEA: 13400

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