KEGG   ORTHOLOGY: K14633
Entry
K14633                      KO                                     

Symbol
gra6, RED2
Name
ketoreductase RED2 [EC:1.1.1.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14633  gra6, RED2; ketoreductase RED2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14633  gra6, RED2; ketoreductase RED2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K14633  gra6, RED2; ketoreductase RED2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K14633  gra6, RED2; ketoreductase RED2
Other DBs
RN: R09309 R09310
Genes
IDC: LRM40_19980
SCIB: HUG20_02160
MBRD: MBRA_56680
SVE: SVEN_1543
SDV: BN159_2510
SVT: SVTN_09180 SVTN_18790
STRE: GZL_p00221
SPRI: SPRI_0261
SGS: AVL59_18640
SALJ: SMD11_1158
SFK: KY5_1829c
SHUN: DWB77_05833(fabG_8)
CAI: Caci_6492
AG: BAD51477(gra-orf6)
 » show all
Reference
  Authors
Ichinose K, Taguchi T, Bedford DJ, Ebizuka Y, Hopwood DA
  Title
Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.
  Journal
J Bacteriol 183:3247-50 (2001)
DOI:10.1128/JB.183.10.3247-3250.2001
Reference
  Authors
Taguchi T, Ebizuka Y, Hopwood DA, Ichinose K
  Title
A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22.
  Journal
J Am Chem Soc 123:11376-80 (2001)
DOI:10.1021/ja015981+
Reference
  Authors
Taguchi T, Kunieda K, Takeda-Shitaka M, Takaya D, Kawano N, Kimberley MR, Booker-Milburn KI, Stephenson GR, Umeyama H, Ebizuka Y, Ichinose K
  Title
Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.
  Journal
Bioorg Med Chem 12:5917-27 (2004)
DOI:10.1016/j.bmc.2004.08.026
  Sequence

KEGG   REACTION: R09310
Entry
R09310                      Reaction                               

Definition
(R)-Chiral alcohol <=> (R)-Hemiketal
Equation
Reaction class
RC02484  C18355_C18357
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01110  Biosynthesis of secondary metabolites
Orthology
K14633  ketoreductase RED2 [EC:1.1.1.-]

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