KEGG   ORTHOLOGY: K15086
Entry
K15086                      KO                                     

Name
TPS14
Definition
(3S)-linalool synthase [EC:4.2.3.25]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15086  TPS14; (3S)-linalool synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.25  S-linalool synthase
     K15086  TPS14; (3S)-linalool synthase
Other DBs
RN: R07631
GO: 0034007
Genes
ATH: AT1G61680(TPS14)
CSAT: 104705165
BNA: 106393947
BOE: 106314371
THJ: 104809528 104818931 104818943
CSV: 101204552
RCU: 8267425
VVI: 100244313 100852527
OSA: 4328124
DOSA: Os02t0121700-01(Os02g0121700)
BDI: 100823591
ATS: 109736851
ZMA: 103654934 732758(TPS2)
 » show all
Reference
  Authors
Chen F, Tholl D, D'Auria JC, Farooq A, Pichersky E, Gershenzon J
  Title
Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers.
  Journal
Plant Cell 15:481-94 (2003)
DOI:10.1105/tpc.007989
Reference
  Authors
Cseke L, Dudareva N, Pichersky E
  Title
Structure and evolution of linalool synthase.
  Journal
Mol Biol Evol 15:1491-8 (1998)
DOI:10.1093/oxfordjournals.molbev.a025876
Reference
  Authors
Aubourg S, Lecharny A, Bohlmann J
  Title
Genomic analysis of the terpenoid synthase ( AtTPS) gene family of Arabidopsis thaliana.
  Journal
Mol Genet Genomics 267:730-45 (2002)
DOI:10.1007/s00438-002-0709-y

KEGG   ORTHOLOGY: K22049
Entry
K22049            Tight     KO                                     

Name
LIS
Definition
S-linalool synthase [EC:4.2.3.25]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K22049  LIS; S-linalool synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.25  S-linalool synthase
     K22049  LIS; S-linalool synthase
Other DBs
RN: R07631
GO: 0034007
Genes
AG: AAC49395(LIS)
Reference
PMID:8768373
  Authors
Dudareva N, Cseke L, Blanc VM, Pichersky E
  Title
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower.
  Journal
Plant Cell 8:1137-48 (1996)
DOI:10.1105/tpc.8.7.1137
  Sequence

KEGG   ENZYME: 4.2.3.25
Entry
EC 4.2.3.25                 Enzyme                                 

Name
S-linalool synthase;
LIS;
Lis;
3S-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3S)-linalool + diphosphate [RN:R07631]
Reaction(KEGG)
R07631
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3S)-linalool [CPD:C11389];
diphosphate [CPD:C00013]
Comment
Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed.
History
EC 4.2.3.25 created 2006
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15086  (3S)-linalool synthase
K22049  S-linalool synthase
Genes
ATH: AT1G61680(TPS14)
CSAT: 104705165
BNA: 106393947
BOE: 106314371
THJ: 104809528 104818931 104818943
CSV: 101204552
RCU: 8267425
VVI: 100244313 100852527
OSA: 4328124
DOSA: Os02t0121700-01(Os02g0121700)
BDI: 100823591
ATS: 109736851
ZMA: 103654934 732758(TPS2)
 » show all
Reference
1  [PMID:7864636]
  Authors
Pichersky E, Lewinsohn E, Croteau R.
  Title
Purification and characterization of S-linalool synthase, an enzyme involved in the production of floral scent in Clarkia breweri.
  Journal
Arch Biochem Biophys 316:803-7 (1995)
DOI:10.1006/abbi.1995.1107
Reference
2  [PMID:11532177]
  Authors
Lucker J, Bouwmeester HJ, Schwab W, Blaas J, van der Plas LH, Verhoeven HA.
  Title
Expression of Clarkia S-linalool synthase in transgenic petunia plants results in the accumulation of S-linalyl-beta-D-glucopyranoside.
  Journal
Plant J 27:315-24 (2001)
DOI:10.1046/j.1365-313x.2001.01097.x
Reference
3  [PMID:8768373]
  Authors
Dudareva N, Cseke L, Blanc VM, Pichersky E
  Title
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower.
  Journal
Plant Cell 8:1137-48 (1996)
DOI:10.1105/tpc.8.7.1137
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.25
IUBMB Enzyme Nomenclature: 4.2.3.25
ExPASy - ENZYME nomenclature database: 4.2.3.25
BRENDA, the Enzyme Database: 4.2.3.25
CAS: 160477-81-6

KEGG   REACTION: R07631
Entry
R07631                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Definition
Geranyl diphosphate + H2O <=> (+)-Linalool + Diphosphate
Equation
Reaction class
RC01821  C00341_C11389
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15086  (3S)-linalool synthase [EC:4.2.3.25]
K22049  S-linalool synthase [EC:4.2.3.25]
Other DBs
RHEA: 24119

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