KEGG   ORTHOLOGY: K15087
Entry
K15087            Tight     KO                                     

Name
E4.2.3.26
Definition
(3R)-linalool synthase [EC:4.2.3.26]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15087  E4.2.3.26; (3R)-linalool synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.26  R-linalool synthase
     K15087  E4.2.3.26; (3R)-linalool synthase
Other DBs
RN: R07632
GO: 0034008
Genes
AG: AAF13356(QH5) AAF13357(QH1) AAL99381
Reference
  Authors
Crowell AL, Williams DC, Davis EM, Wildung MR, Croteau R
  Title
Molecular cloning and characterization of a new linalool synthase.
  Journal
Arch Biochem Biophys 405:112-21 (2002)
DOI:10.1016/S0003-9861(02)00348-X
  Sequence

KEGG   ENZYME: 4.2.3.26
Entry
EC 4.2.3.26                 Enzyme                                 

Name
R-linalool synthase;
(3R)-linalool synthase;
(-)-3R-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3R)-linalool + diphosphate [RN:R07632]
Reaction(KEGG)
R07632
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3R)-linalool [CPD:C11388];
diphosphate [CPD:C00013]
Comment
Geranyl diphosphate cannot be replaced by isopentenyl diphosphate, dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate [1]. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed.
History
EC 4.2.3.26 created 2006
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15087  (3R)-linalool synthase
Reference
1  [PMID:10562427]
  Authors
Jia JW, Crock J, Lu S, Croteau R, Chen XY
  Title
(3R)-Linalool synthase from Artemisia annua L.: cDNA isolation, characterization, and wound induction.
  Journal
Arch Biochem Biophys 372:143-9 (1999)
DOI:10.1006/abbi.1999.1466
  Sequence
Reference
2  [PMID:12176064]
  Authors
Crowell AL, Williams DC, Davis EM, Wildung MR, Croteau R
  Title
Molecular cloning and characterization of a new linalool synthase.
  Journal
Arch Biochem Biophys 405:112-21 (2002)
DOI:10.1016/S0003-9861(02)00348-X
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.26
IUBMB Enzyme Nomenclature: 4.2.3.26
ExPASy - ENZYME nomenclature database: 4.2.3.26
BRENDA, the Enzyme Database: 4.2.3.26
CAS: 254993-26-5

KEGG   REACTION: R07632
Entry
R07632                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming]
Definition
Geranyl diphosphate + H2O <=> (-)-Linalool + Diphosphate
Equation
Reaction class
RC01821  C00341_C11388
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15087  (3R)-linalool synthase [EC:4.2.3.26]
Other DBs
RHEA: 15812

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