KEGG   ORTHOLOGY: K15097
Entry
K15097            Tight     KO                                     

Name
E4.2.3.10
Definition
(-)-endo-fenchol synthase [EC:4.2.3.10]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15097  E4.2.3.10; (-)-endo-fenchol synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.10  (-)-endo-fenchol synthase
     K15097  E4.2.3.10; (-)-endo-fenchol synthase
Other DBs
RN: R02004
GO: 0050437
Genes
AG: AAV63790(FES)
Reference
  Authors
Iijima Y, Davidovich-Rikanati R, Fridman E, Gang DR, Bar E, Lewinsohn E, Pichersky E
  Title
The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basil.
  Journal
Plant Physiol 136:3724-36 (2004)
DOI:10.1104/pp.104.051318
  Sequence

KEGG   ENZYME: 4.2.3.10
Entry
EC 4.2.3.10                 Enzyme                                 

Name
(-)-endo-fenchol synthase;
(-)-endo-fenchol cyclase;
geranyl pyrophosphate:(-)-endo-fenchol cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate [RN:R02004]
Reaction(KEGG)
R02004
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(-)-endo-fenchol [CPD:C02344];
diphosphate [CPD:C00013]
Comment
(3R)-Linalyl diphosphate is an intermediate in the reaction
History
EC 4.2.3.10 created 1992 as EC 4.6.1.8, transferred 2000 to EC 4.2.3.10
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15097  (-)-endo-fenchol synthase
Reference
1  [PMID:2919880]
  Authors
Croteau R, Miyazaki JH, Wheeler CJ.
  Title
Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare).
  Journal
Arch Biochem Biophys 269:507-16 (1989)
DOI:10.1016/0003-9861(89)90134-3
Reference
2  [PMID:3170591]
  Authors
Croteau R, Satterwhite DM, Wheeler CJ, Felton NM.
  Title
Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol.
  Journal
J Biol Chem 263:15449-53 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.10
IUBMB Enzyme Nomenclature: 4.2.3.10
ExPASy - ENZYME nomenclature database: 4.2.3.10
BRENDA, the Enzyme Database: 4.2.3.10
CAS: 117758-41-5

KEGG   REACTION: R02004
Entry
R02004                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Definition
Geranyl diphosphate + H2O <=> (-)-endo-Fenchol + Diphosphate
Equation
Reaction class
RC00634  C00341_C02344
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15097  (-)-endo-fenchol synthase [EC:4.2.3.10]
Other DBs
RHEA: 20568

DBGET integrated database retrieval system