KEGG   ORTHOLOGY: K15315
Entry
K15315                      KO                                     
Symbol
sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10
Name
enediyne core biosynthesis thioesterase
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K15315  sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10; enediyne core biosynthesis thioesterase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15315  sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10; enediyne core biosynthesis thioesterase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Hydrolase
   K15315  sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10; enediyne core biosynthesis thioesterase
Other DBs
RN: R11436
Genes
MAH: MEALZ_1604
MBUR: EQU24_12395
MEIN: methR_P2300
TIG: THII_2901
HOH: Hoch_0692
NBR: O3I_023125
NTP: CRH09_15815
NOZ: DMB37_04405 DMB37_37230
NAH: F5544_22910
SGR: SGR_604(tebC)
SGB: WQO_33955
STRM: M444_38000
SRO: Sros_6998
AMD: AMED_6863
AMN: RAM_35215
AMM: AMES_6758
AMZ: B737_6758
AOI: AORI_1841(ybgC)
AMYY: YIM_40780
AORI: SD37_32005
AMI: Amir_4082
SESP: BN6_39310
ACTI: UA75_19070
ACAD: UA74_18580
MIL: ML5_5848
ACTN: L083_3211
CAI: Caci_6350
MAR: MAE_12770
MPK: VL20_1927
HAU: Haur_0865
AG: AAM78011(ncsE10) AAM94793(calE7) AAQ17111(mdpE10) AFV52146(kedE10)
 » show all
Reference
  Authors
Horsman GP, Chen Y, Thorson JS, Shen B
  Title
Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.
  Journal
Proc Natl Acad Sci U S A 107:11331-5 (2010)
DOI:10.1073/pnas.1003442107
Reference
  Authors
Horsman GP, Van Lanen SG, Shen B
  Title
Iterative type I polyketide synthases for enediyne core biosynthesis.
  Journal
Methods Enzymol 459:97-112 (2009)
DOI:10.1016/S0076-6879(09)04605-9
Reference
PMID:12183628 (sgcE10)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33955]
Reference
PMID:17918933 (mdpE10)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
PMID:15797213 (ncsE10)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE10)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
Reference
PMID:12183629 (calE7)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence

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