KEGG   ORTHOLOGY: K15373
Entry
K15373                      KO                                     
Symbol
isfD
Name
sulfoacetaldehyde reductase [EC:1.1.1.313]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K15373  isfD; sulfoacetaldehyde reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.313  sulfoacetaldehyde reductase
     K15373  isfD; sulfoacetaldehyde reductase
Other DBs
RN: R02600
Genes
ENR: H650_21530
ENF: AKI40_3718
KPN: KPN_00576
KPU: KP1_1516
KPM: KPHS_14060
KPP: A79E_3668
KPH: KPNIH24_21755
KPZ: KPNIH27_06510
KPV: KPNIH29_07210
KPW: KPNIH30_07240
KPT: VK055_1961(sdh)
KPR: KPR_3984
KPJ: N559_3751
KPX: PMK1_02903(isfD)
KPNU: LI86_19240
KPNK: BN49_1630
KVA: Kvar_3797
KPE: KPK_4008
KOX: KOX_13770
KOE: A225_1573
RTG: NCTC13098_05468(sdh)
REE: electrica_03726(isfD)
KIE: NCTC12125_02387(sdh)
PPSE: BN5_0584
PSA: PST_4121
PSTT: CH92_10795
PSES: PSCI_0298
PALL: UYA_03345
HAM: HALO0642
CDIZ: CEDIAZO_03401(isfD)
ODI: ODI_R0192
EBLA: JGUZn3_01220(isfD)
 » show all
Reference
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology 156:1547-55 (2010)
DOI:10.1099/mic.0.036699-0
  Sequence

KEGG   ENZYME: 1.1.1.313
Entry
EC 1.1.1.313                Enzyme                                 
Name
sulfoacetaldehyde reductase;
isfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isethionate:NADP+ oxidoreductase
Reaction(IUBMB)
isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+ [RN:R02600]
Reaction(KEGG)
R02600
Substrate
isethionate [CPD:C05123];
NADP+ [CPD:C00006]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells.
History
EC 1.1.1.313 created 2011
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K15373  sulfoacetaldehyde reductase
Genes
ENRH650_21530
ENFAKI40_3718
KPNKPN_00576
KPUKP1_1516
KPMKPHS_14060
KPPA79E_3668
KPHKPNIH24_21755
KPZKPNIH27_06510
KPVKPNIH29_07210
KPWKPNIH30_07240
KPYKPNIH31_07125
KPGKPNIH32_07345
KPCKPNIH10_07035
KPQKPR0928_06945
KPTVK055_1961(sdh)
KPOKPN2242_05720
KPRKPR_3984
KPJN559_3751
KPID364_02995
KPAKPNJ1_04010
KPXPMK1_02903(isfD)
KPBFH42_23905
KPNEKU54_019415
KPNULI86_19240
KPNKBN49_1630
KVAKvar_3797
KPEKPK_4008
KPKA593_17310
KVDKR75_14770
KVQSP68_21400
KOXKOX_13770
KOEA225_1573
KOYJ415_23770
KOMHR38_12515
KOKKONIH1_07720
KOCAB185_28375
KQUAVR78_11510
KLLBJF97_08105
KLWDA718_20615
KARLGL98_18440
KGRJJJ10_20430
RORRORB6_12190
RONTE10_08740
RPLNB1209_19890
RAODSD31_18740
RTGNCTC13098_05468(sdh)
REEelectrica_03726(isfD)
PGELG71_22100
KSAC813_08935
KORAWR26_18435
KRDA3780_05845
KPSEIP581_05955
KGOCEW81_17995
KIENCTC12125_02387(sdh)
KASKATP_32820
METYMRY16398_41760
KINAB182_18395
PDZHHA33_20875
EBCC2U52_29615
EBUCUC76_08560
SERASer39006_001610
SERQCWC46_01610
DAQDAQ1742_04400
DDADd703_0033
BGJAWC36_18995
BRBEH207_00165
BNGEH206_00325
LBQCKQ53_05475
LPOPI6N93_00125
VNAPN96_16100
VEJVEJY3_24206
VBRA6E01_10135
VCCFAZ90_18230
VASGT360_16430
VZIG5S32_21200
PGBH744_1c1567
PPSEBN5_0584
PFVPsefu_4080
PSAPST_4121
PSZPSTAB_4103
PSRPSTAA_4273
PSCA458_00540
PSJPSJM300_18885
PSHPsest_0101
PSTUUIB01_00490
PSTTCH92_10795
PCHLLLJ08_00490
PBMCL52_20375
PRHLT40_19355
PSESPSCI_0298
PSEDDM292_19735
PALLUYA_03345
PSEJHNQ25_20830
PKHJLK41_03575
PTYJWV26_14350
AVNAvin_16870 Avin_30890
AVLAvCA_16870 AvCA_30890
AVDAvCA6_16870 AvCA6_30890
ACXAchr_17360 Achr_26200
EMODM558_08540
HPEGEAO82_01580
HAESLO767_00655
MSRAU15_02960
TZOTHMIRHAT_10700
SSALSPISAL_03475
CSACsal_0161 Csal_2684
HCSFF32_03330
HAKKO116_00630
HAMHALO0642
HSIBOX17_12380
HALOBWR19_05090 BWR19_11015
HHHCLM76_08275
HALKCUU95_08810
HVNEI420_17320
HOLHORIV_63670
HSRHSBAA_60050
HTTHZS52_07980
HPIZGYM47_15200
HTXEKK97_11325
ZPLZBT109_2532
HAAA5892_16765
KUSB9G99_08575
KMAB9H00_06270
KUYFY550_02415 FY550_11870
CDIZCEDIAZO_03401(isfD)
BOJCBF45_06055
ODIODI_R0192
KGYEHF36_06485
MMYRMXMO3_02929
AUAM673_19980
EBLAJGUZn3_01220(isfD)
 » show all
Reference
1  [PMID:20133363]
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology 156:1547-55 (2010)
DOI:10.1099/mic.0.036699-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.313
IUBMB Enzyme Nomenclature: 1.1.1.313
ExPASy - ENZYME nomenclature database: 1.1.1.313
BRENDA, the Enzyme Database: 1.1.1.313

KEGG   REACTION: R02600
Entry
R02600                      Reaction                               
Name
isethionate:NADP+ oxidoreductase
Definition
Sulfoacetaldehyde + NADPH + H+ <=> 2-Hydroxyethanesulfonate + NADP+
Equation
Reaction class
RC00001  C00005_C00006
RC00087  C00593_C05123
Enzyme
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Orthology
K15373  sulfoacetaldehyde reductase [EC:1.1.1.313]
Other DBs
RHEA: 29594

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