KEGG   ORTHOLOGY: K15932
Entry
K15932            Tight     KO                                     
Symbol
lndZ4, lanZ4
Name
reductase LndZ4/LanZ4
Pathway
map01057  Biosynthesis of type II polyketide products
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15932  lndZ4, lanZ4; reductase LndZ4/LanZ4
Other DBs
RN: R09357
COG: COG0431
Genes
SCYG: S1361_29990(azr3)
AG: AAD13563(lanZ4) AAR16419(lndZ4)
Reference
  Authors
Ostash B, Rix U, Rix LL, Liu T, Lombo F, Luzhetskyy A, Gromyko O, Wang C, Brana AF, Mendez C, Salas JA, Fedorenko V, Rohr J
  Title
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.
  Journal
Chem Biol 11:547-55 (2004)
DOI:10.1016/j.chembiol.2004.03.011
  Sequence
Reference
PMID:9933932
  Authors
Westrich L, Domann S, Faust B, Bedford D, Hopwood DA, Bechthold A
  Title
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.
  Journal
FEMS Microbiol Lett 170:381-7 (1999)
DOI:10.1111/j.1574-6968.1999.tb13398.x
  Sequence

KEGG   ORTHOLOGY: K15933
Entry
K15933            Tight     KO                                     
Symbol
lndZ5, lanZ5
Name
oxygenase LndZ5/LanZ5
Pathway
map01057  Biosynthesis of type II polyketide products
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15933  lndZ5, lanZ5; oxygenase LndZ5/LanZ5
Other DBs
RN: R09357
COG: COG1960
Genes
SCYG: S1361_29995(hsaA1)
AG: AAD13564(lanZ5) AAR16420(lndZ5)
Reference
  Authors
Ostash B, Rix U, Rix LL, Liu T, Lombo F, Luzhetskyy A, Gromyko O, Wang C, Brana AF, Mendez C, Salas JA, Fedorenko V, Rohr J
  Title
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.
  Journal
Chem Biol 11:547-55 (2004)
DOI:10.1016/j.chembiol.2004.03.011
  Sequence
Reference
PMID:9933932
  Authors
Westrich L, Domann S, Faust B, Bedford D, Hopwood DA, Bechthold A
  Title
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.
  Journal
FEMS Microbiol Lett 170:381-7 (1999)
DOI:10.1111/j.1574-6968.1999.tb13398.x
  Sequence

KEGG   REACTION: R09357
Entry
R09357                      Reaction                               
Definition
Landomycin H <=> 8-D-Olivosyl-landomycin
Equation
Comment
C11-hydroxylation, LndZ4/Z5
Reaction class
RC00046  C18683_C18778
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01110  Biosynthesis of secondary metabolites
Orthology
K15932  reductase LndZ4/LanZ4
K15933  oxygenase LndZ5/LanZ5

DBGET integrated database retrieval system