KEGG   ORTHOLOGY: K15998
Entry
K15998            Tight     KO                                     
Symbol
megDI
Name
TDP-megosamine glycosyltransferase
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15998  megDI; TDP-megosamine glycosyltransferase
Other DBs
RN: R06506
Genes
AG: AAG13908(megDI)
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x
  Sequence

KEGG   ORTHOLOGY: K19698
Entry
K19698            Tight     KO                                     
Symbol
megDVI
Name
TDP-megosamine glycosyltransferase auxiliary protein
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K19698  megDVI; TDP-megosamine glycosyltransferase auxiliary protein
Other DBs
RN: R06506
Genes
AG: AAG13907(megDVI)
Reference
  Authors
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H
  Title
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
  Journal
Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x
  Sequence

KEGG   REACTION: R06506
Entry
R06506                      Reaction                               
Definition
Erythromycin C + dTDP-L-megosamine <=> Megalomicin A + dTDP
Equation
Comment
TDP-megosamine glycosyltransferase,MegD1
Reaction class
RC00005  C00363_C11919
RC00028  C06616_C11985
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01110  Biosynthesis of secondary metabolites
Orthology
K15998  TDP-megosamine glycosyltransferase
K19698  TDP-megosamine glycosyltransferase auxiliary protein

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