KEGG   ORTHOLOGY: K16004
Entry
K16004            Tight     KO                                     

Name
desVII
Definition
narbonolide/10-deoxymethynolide desosaminyltransferase [EC:2.4.1.277]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.277  10-deoxymethynolide desosaminyltransferase
     K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
Other DBs
RN: R06460 R06461
COG: COG1819
CAZy: GT1
Genes
AG: AAC68677(desVII)
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence
Reference
  Authors
Borisova SA, Liu HW
  Title
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
  Journal
Biochemistry 49:8071-84 (2010)
DOI:10.1021/bi1007657
  Sequence

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