KEGG   ORTHOLOGY: K16016
Entry
K16016                      KO                                     

Symbol
rifK, asm24, asm43
Name
3-amino-5-hydroxybenzoate synthase [EC:4.2.1.144 2.6.1.-]
Pathway
map01051  Biosynthesis of ansamycins
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01051 Biosynthesis of ansamycins
    K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.-  
     K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.144  3-amino-5-hydroxybenzoate synthase
     K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
Other DBs
RN: R06586 R06595
Genes
AUB: LXB15_06500
PSON: JI735_17065
SVL: Strvi_5368
SRC: M271_45560
SMAL: SMALA_0450 SMALA_1356
SSOI: I1A49_05770 I1A49_10280(rifK)
SRW: TUE45_00080(rifK)
SLE: cxmK(cxmK)
SPAV: Spa2297_32585
SAUO: BV401_06010 BV401_10595
SCYG: S1361_01090(rifK1) S1361_34015(rifK2)
FAL: FRAAL0914(gdnA)
SEN: SACE_2870(rifK)
AMD: AMED_0627(rifK)
AMN: RAM_03205
AMM: AMES_0625(rifK)
AMZ: B737_0626(rifK)
AMYY: YIM_39450(rifK)
SAQ: Sare_1255
MIL: ML5_5914
MSAG: GCM10017556_49860(rifK)
PRY: Prubr_62820(rifK)
 » show all
Reference
PMID:9497318
  Authors
Kim CG, Yu TW, Fryhle CB, Handa S, Floss HG
  Title
3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.
  Journal
J Biol Chem 273:6030-40 (1998)
DOI:10.1074/jbc.273.11.6030
  Sequence
[amn:RAM_03205]
Reference
  Authors
Floss HG, Yu TW, Arakawa K
  Title
The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.
  Journal
J Antibiot (Tokyo) 64:35-44 (2011)
DOI:10.1038/ja.2010.139
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

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