KEGG   ORTHOLOGY: K16016
Entry
K16016                      KO                                     
Symbol
rifK, asm24, asm43
Name
3-amino-5-hydroxybenzoate synthase [EC:4.2.1.144 2.6.1.-]
Pathway
map01051  Biosynthesis of ansamycins
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01051 Biosynthesis of ansamycins
    K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.-
     K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.144  3-amino-5-hydroxybenzoate synthase
     K16016  rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase
Other DBs
RN: R06586 R06595
Genes
ROI: N4261_13590
AUB: LXB15_06500
PSON: JI735_17065
SINT: K5I26_02630
SVL: Strvi_5368
SRC: M271_45560
SMAL: SMALA_0450 SMALA_1356
SSOI: I1A49_05770 I1A49_10280(rifK)
SRW: TUE45_00080(rifK)
SLE: cxmK(cxmK)
SPAV: Spa2297_32585
SPHW: NFX46_22810
SAUO: BV401_06010 BV401_10595
SVU: B1H20_29920
SPUN: BFF78_27075
SPHV: F9278_17960
SCHA: CP983_04310
SSPB: CP982_35325 CP982_36640
SCYG: S1361_01090(rifK1) S1361_34015(rifK2)
SCAL: I6J39_29725
SDD: D9753_04175 D9753_04745
STAA: LDH80_10615
YIA: LO772_07395
FRA: Francci3_0429
FRE: Franean1_1659 Franean1_4841
FAL: FRAAL0914(gdnA)
SEN: SACE_2870(rifK)
AMD: AMED_0627(rifK)
AMN: RAM_03205
AMM: AMES_0625(rifK)
AMZ: B737_0626(rifK)
AAB: A4R43_38525
AMYY: YIM_39450(rifK)
AORI: SD37_10940 SD37_16800
APRE: CNX65_16265 CNX65_16520
AMI: Amir_3196 Amir_3287
ACTA: C1701_25910
SAQ: Sare_1255
MAU: Micau_2448
MIL: ML5_5914
MICB: MicB006_3068
MCAB: HXZ27_10305
MSAG: GCM10017556_49860(rifK)
ACTN: L083_2890 L083_5704
PLAB: C6361_34460
PLAT: C6W10_21740
PRY: Prubr_62820(rifK)
MCOS: GM418_28500
 » show all
Reference
PMID:9497318
  Authors
Kim CG, Yu TW, Fryhle CB, Handa S, Floss HG
  Title
3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.
  Journal
J Biol Chem 273:6030-40 (1998)
DOI:10.1074/jbc.273.11.6030
  Sequence
[amn:RAM_03205]
Reference
PMID:21081954
  Authors
Floss HG, Yu TW, Arakawa K
  Title
The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.
  Journal
J Antibiot (Tokyo) 64:35-44 (2011)
DOI:10.1038/ja.2010.139
Reference
PMID:12060743
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (3)   
Gene (61)   
   KEGG GENES (59)   
   RefGene (1)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (76)   

Download RDF
DBGET integrated database retrieval system