KEGG   ORTHOLOGY: K16249
Entry
K16249                      KO                                     
Symbol
dmpK, poxA, tomA0
Name
phenol/toluene 2-monooxygenase (NADH) P0/A0
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
   00623 Toluene degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
Other DBs
RN: R03560 R03608 R10042 R10043
Genes
PSD: DSC_04440
RTH: LRK53_10135
RBD: ALSL_0901
PRE: PCA10_06960(dmpK)
PFUW: KF707C_6690(dmpK)
PCQ: PcP3B5_25300
PPG: PputGB1_3311
PPJ: RK21_04248
PVR: PverR02_14655
PKC: PKB_1741
PALL: UYA_20205
AVN: Avin_08860(dmpK) Avin_30760(lapK)
AVL: AvCA_08860(dmpK) AvCA_30760(lapK)
AVD: AvCA6_08860(dmpK) AvCA6_30760(lapK)
MAD: HP15_4024
MARJ: MARI_05330
ABAU: IX87_04535
ACC: BDGL_000476(mphK)
AGU: AS4_16460(dsoA)
NJP: NEJAP_0662(dmpK)
AJP: AMJAP_3011(dmpK)
TBN: TBH_C0905
RPI: Rpic_4631
REH: H16_B0539(poxA)
CNC: CNE_2c04850(poxA)
RME: Rmet_1331(tomA0) Rmet_1787
BCEN: DM39_4844
BCT: GEM_5413
BCED: DM42_5003
BCON: NL30_24650
BTEI: WS51_00510
BPSL: WS57_12215
AFQ: AFA_08515
AJS: Ajs_0206
VEI: Veis_2796
HPSE: HPF_01930
MPT: Mpe_A2285(dmpK) Mpe_A3309(dmpK)
LCH: Lcho_3363
DAR: Daro_3797
AZO: azo1845(lapK) azo2444(poxA)
ACIB: ACBT_0280(dmpK)
AFC: AFAEC_1858(dmpK)
AAQI: AAQM_0969(dmpK)
ACLO: ACLO_a0155(dmpK)
ADZ: ADFLV_2569(dmpK)
ARC: ABLL_2460
ALK: ALEK_0370(dmpK)
AANA: AANAER_1245(dmpK)
SJP: SJA_C1-11980(tomA0)
SINB: SIDU_08275
HTL: HPTL_0057
AG: BAA23330(dsoA)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ORTHOLOGY: K16243
Entry
K16243                      KO                                     
Symbol
dmpL, poxB, tomA1
Name
phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
   00623 Toluene degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
Other DBs
RN: R03560 R03608 R10042 R10043
Genes
PSD: DSC_04435
RTH: LRK53_10140
RBD: ALSL_0900
PRE: PCA10_06970(dmpL)
PFUW: KF707C_6700(dmpL)
PCQ: PcP3B5_25310(mphL)
PPG: PputGB1_3310
PPJ: RK21_04247
PVR: PverR02_14660
PKC: PKB_1742(dmpL)
PALL: UYA_20200
AVN: Avin_08850(dpmL) Avin_30750(lapL)
AVL: AvCA_08850(dpmL) AvCA_30750(lapL)
AVD: AvCA6_08850(dpmL) AvCA6_30750(lapL)
MAD: HP15_4025
MARJ: MARI_05340(mphL)
ABAU: IX87_04540
ACC: BDGL_000474(mphL)
AGU: AS4_16450(dsoB)
NJP: NEJAP_0663(dmpL)
AJP: AMJAP_3010(dmpL)
TBN: TBH_C0906
NZO: SAMEA4504057_0438(mphL)
NCI: NCTC10296_00923(mphL)
RPI: Rpic_4630
REH: H16_B0540(poxB)
CNC: CNE_2c04860(poxB)
RME: Rmet_1330(tomA1) Rmet_1786(phyA)
BCEN: DM39_4843(mphL)
BCT: GEM_5412
BCED: DM42_5002(phL)
BCON: NL30_24645
BTEI: WS51_00515
BPSL: WS57_12210
AFQ: AFA_08520
AJS: Ajs_0207
VEI: Veis_2795
HPSE: HPF_01925(mphL)
MPT: Mpe_A2284(dmpL) Mpe_A3308(dmpL)
LCH: Lcho_3362
DAR: Daro_3796
AZO: azo1846(lapL) azo2443(poxB)
ACIB: ACBT_0279(dmpL)
AFC: AFAEC_1857(dmpL)
AAQI: AAQM_0970(dmpL)
ACLO: ACLO_a0154(dmpL)
ADZ: ADFLV_2568(dmpL)
ARC: ABLL_2459
ALK: ALEK_0371(dmpL)
AANA: AANAER_1246(dmpL)
MTUN: MTUNDRAET4_3881(dmpL)
BVY: NCTC9239_03024(mphL)
SJP: SJA_C1-11990(tomA1)
SINB: SIDU_08270
ASOC: CB4_02441(mphL)
BTS: Btus_0959
SAY: TPY_0628
TCU: Tcur_0524
PDX: Psed_0770
PSUU: Psuf_068230(mphL)
AG: BAA23331(dsoB)
 » show all
Reference
  Authors
Dalvi S, Azetsu S, Patrauchan MA, Aktas DF, Fathepure BZ
  Title
Proteogenomic elucidation of the initial steps in the benzene degradation pathway of a novel halophile, Arhodomonas sp. strain Rozel, isolated from a hypersaline environment.
  Journal
Appl Environ Microbiol 78:7309-16 (2012)
DOI:10.1128/AEM.01327-12
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ORTHOLOGY: K16244
Entry
K16244                      KO                                     
Symbol
dmpM, poxC, tomA2
Name
phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
   00623 Toluene degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
Other DBs
RN: R03560 R03608 R10042 R10043
Genes
PSD: DSC_04430
RTH: LRK53_10145
RBD: ALSL_0899
PRE: PCA10_06980(dmpM)
PFUW: KF707C_6710(dmpM)
PCQ: PcP3B5_25320(dmpM)
PPG: PputGB1_3309
PPJ: RK21_04246
PVR: PverR02_14665
PKC: PKB_1743
PALL: UYA_20195
AVN: Avin_08840(dmpM) Avin_30740(lapM)
AVL: AvCA_08840(dmpM) AvCA_30740(lapM)
AVD: AvCA6_08840(dmpM) AvCA6_30740(lapM)
MAD: HP15_4026
MARJ: MARI_05350(dmpM)
ABAU: IX87_04545
ACC: BDGL_000473(mphM)
AGU: AS4_16440(dsoC)
NJP: NEJAP_0664(dmpM)
AJP: AMJAP_3009(dmpM)
TBN: TBH_C0907
NZO: SAMEA4504057_0439(dmpM)
NCI: NCTC10296_00922(dmpM)
RPI: Rpic_4629
REH: H16_B0541(poxC)
CNC: CNE_2c04870(poxC)
RME: Rmet_1329(tomA2) Rmet_1785(phyB)
BCEN: DM39_4842(dmpM)
BCT: GEM_5411
BCED: DM42_5001(dmpM)
BCON: NL30_24640
BTEI: WS51_00520
BPSL: WS57_12205
BYI: BYI23_C000550(mmoB_dmpM)
BUE: BRPE67_CCDS12520(mmoB_dmpM)
AFQ: AFA_08525
AJS: Ajs_0208
VEI: Veis_2794
HPSE: HPF_01920(dmpM)
MPT: Mpe_A2283(dmpM) Mpe_A3307(dmpM)
LCH: Lcho_3361
DAR: Daro_3795
AZO: azo1847(lapM) azo2442(poxC)
ACIB: ACBT_0278(dmpM)
AFC: AFAEC_1856(dmpM)
AAQI: AAQM_0971(dmpM)
ACLO: ACLO_a0153(dmpM)
ADZ: ADFLV_2567(dmpM)
ARC: ABLL_2458
ALK: ALEK_0372(dmpM)
AANA: AANAER_1247(dmpM)
MTUN: MTUNDRAET4_3882(dmpM)
BVY: NCTC9239_03025(dmpM)
SJP: SJA_C1-12000(tomA2)
SINB: SIDU_08265
ASOC: CB4_02442(dmpM)
BTS: Btus_0960
SAY: TPY_0629
MMAG: MMAD_31790
TCU: Tcur_0525
PDX: Psed_0769
AG: BAA23332(dsoC)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ORTHOLOGY: K16242
Entry
K16242                      KO                                     
Symbol
dmpN, poxD, tomA3
Name
phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
   00623 Toluene degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
Other DBs
RN: R03560 R03608 R10042 R10043
Genes
PSD: DSC_04425
RTH: LRK53_10150
RBD: ALSL_0898
PRE: PCA10_06990(dmpN)
PFUW: KF707C_6720(dmpN)
PCQ: PcP3B5_25330(tmoA)
PPG: PputGB1_3308
PPJ: RK21_04244 RK21_04245
PVR: PverR02_14670
PKC: PKB_1744(dmpN)
PALL: UYA_20190
AVN: Avin_08830(dmpN) Avin_30730(lapN)
AVL: AvCA_08830(dmpN) AvCA_30730(lapN)
AVD: AvCA6_08830(dmpN) AvCA6_30730(lapN)
MAD: HP15_4027
MARJ: MARI_05360(tmoA)
ABAU: IX87_04550
ACC: BDGL_000472(mphN)
AGU: AS4_16430(dsoD)
NJP: NEJAP_0665(dmpN)
AJP: AMJAP_3008(dmpN)
TBN: TBH_C0908
NZO: SAMEA4504057_0440(tmoA)
NCI: NCTC10296_00921(tmoA)
RPI: Rpic_4628
REH: H16_B0542(poxD)
CNC: CNE_2c04880(poxD)
RME: Rmet_1328(tomA3) Rmet_1784(phyC)
BCEN: DM39_4841(phN)
BCT: GEM_5410
BCED: DM42_5000(phN)
BCON: NL30_24635
BTEI: WS51_00525
BPSL: WS57_12200
AFQ: AFA_08530
AJS: Ajs_0209
VEI: Veis_2793
HPSE: HPF_01915(tmoA2)
MPT: Mpe_A2282(dmpN) Mpe_A3306(dmpN)
LCH: Lcho_3360
DAR: Daro_3794
AZO: azo1848(lapN) azo2441(poxD)
ACIB: ACBT_0277(dmpN)
AFC: AFAEC_1855(dmpN)
AAQI: AAQM_0972(dmpN)
ACLO: ACLO_a0152(dmpN)
ADZ: ADFLV_2566(dmpN)
ARC: ABLL_2457
ALK: ALEK_0373(dmpN)
AANA: AANAER_1248(dmpN)
BVY: NCTC9239_03026(tmoA)
SJP: SJA_C1-12010(tomA3)
SINB: SIDU_08260
ASOC: CB4_02443(tmoA)
BTS: Btus_0961
SAY: TPY_0630
MMAG: MMAD_31810(mphN)
TCU: Tcur_0526
PDX: Psed_0768
PSUU: Psuf_068250(mphN)
AG: BAA23333(dsoD)
 » show all
Reference
  Authors
Dalvi S, Azetsu S, Patrauchan MA, Aktas DF, Fathepure BZ
  Title
Proteogenomic elucidation of the initial steps in the benzene degradation pathway of a novel halophile, Arhodomonas sp. strain Rozel, isolated from a hypersaline environment.
  Journal
Appl Environ Microbiol 78:7309-16 (2012)
DOI:10.1128/AEM.01327-12
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ORTHOLOGY: K16245
Entry
K16245                      KO                                     
Symbol
dmpO, poxE, tomA4
Name
phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
   00623 Toluene degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
Other DBs
RN: R03560 R03608 R10042 R10043
Genes
PSD: DSC_04420
RTH: LRK53_10155
RBD: ALSL_0897
PRE: PCA10_07000(dmpO)
PFUW: KF707C_6730(dmpO)
PCQ: PcP3B5_25340
PPG: PputGB1_3307
PPJ: RK21_04243
PVR: PverR02_14675
PKC: PKB_1745
PALL: UYA_20185
AVN: Avin_08820(dmpO) Avin_30720(lapO)
AVL: AvCA_08820(dmpO) AvCA_30720(lapO)
AVD: AvCA6_08820(dmpO) AvCA6_30720(lapO)
MAD: HP15_4028
MARJ: MARI_05370
ABAU: IX87_04555
ACC: BDGL_000471(mphO)
AGU: AS4_16420(dsoE)
NJP: NEJAP_0666(dmpO)
AJP: AMJAP_3007(dmpO)
TBN: TBH_C0909
RPI: Rpic_4627
REH: H16_B0543(poxE)
CNC: CNE_2c04890(poxE)
RME: Rmet_1327(tomA4) Rmet_1783(phyD)
BCEN: DM39_4840(phO)
BCT: GEM_5409
BCED: DM42_4999(phO)
BCON: NL30_24630
BTEI: WS51_00530
BPSL: WS57_12195
AFQ: AFA_08535
AJS: Ajs_0210
VEI: Veis_2792
HPSE: HPF_01910(tbuD)
MPT: Mpe_A2281(dmpO) Mpe_A3305(dmpO)
LCH: Lcho_3359
DAR: Daro_3793
AZO: azo1849(lapO) azo2440(poxE)
ACIB: ACBT_0276(dmpO)
AFC: AFAEC_1854(dmpO)
AAQI: AAQM_0973(dmpO)
ACLO: ACLO_a0151(dmpO)
ADZ: ADFLV_2565(dmpO)
ARC: ABLL_2456
ALK: ALEK_0374(dmpO)
AANA: AANAER_1249(dmpO)
SJP: SJA_C1-12020(tomA4)
SINB: SIDU_08255
SAY: TPY_0631
TCU: Tcur_0527
PDX: Psed_0767
AG: BAA23334(dsoE)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ORTHOLOGY: K16246
Entry
K16246                      KO                                     
Symbol
dmpP, poxF, tomA5
Name
phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
   00623 Toluene degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
Other DBs
RN: R03560 R03608 R10042 R10043
COG: COG0543 COG0633
Genes
PSD: DSC_04415
RTH: LRK53_10245
RBD: ALSL_0896
PRE: PCA10_07010(dmpP)
PFUW: KF707C_6740(dmpP)
PCQ: PcP3B5_25350(dmpP)
PPG: PputGB1_3306
PPJ: RK21_04242
PVR: PverR02_14680
PKC: PKB_1746(dmpP)
PALL: UYA_20180
AVN: Avin_08810(dmpP) Avin_30710(lapP)
AVL: AvCA_08810(dmpP) AvCA_30710(lapP)
AVD: AvCA6_08810(dmpP) AvCA6_30710(lapP)
MAD: HP15_4029
MARJ: MARI_05380(dmpP)
ABAU: IX87_04560
ACC: BDGL_000470(mphP)
AGU: AS4_16410(dsoF)
NJP: NEJAP_0667(dmpP)
AJP: AMJAP_3006(dmpP)
TBN: TBH_C0910
NZO: SAMEA4504057_0442(mphP)
NCI: NCTC10296_00919(mphP)
RPI: Rpic_4626
REH: H16_B0544(poxF)
CNC: CNE_2c04900(poxF)
RME: Rmet_1326(tomA5) Rmet_1782(phyE)
BCEN: DM39_4839(dmpP)
BCT: GEM_5408
BCED: DM42_4998(dmpP)
BCON: NL30_24625
BTEI: WS51_00535
BPSL: WS57_12190
AFQ: AFA_08540
AJS: Ajs_0211
VEI: Veis_2791
HPSE: HPF_01905(dmpP)
MPT: Mpe_A2280(dmpP)
LCH: Lcho_3358
DAR: Daro_3792
AZO: azo1850(lapP) azo2439(poxF)
ACIB: ACBT_0275(dmpP)
AFC: AFAEC_1853(dmpP)
AAQI: AAQM_0974(dmpP)
ACLO: ACLO_a0150(dmpP)
ADZ: ADFLV_2564(dmpP)
ARC: ABLL_2455
ALK: ALEK_0375(dmpP)
AANA: AANAER_1250(dmpP)
MTUN: MTUNDRAET4_3886(dmpP)
SJP: SJA_C1-12030(tomA5)
SINB: SIDU_08250
SAY: TPY_0634(benC)
MHIB: MHIB_39890(mphP)
CCYC: SCMU_04650(mphP)
TCU: Tcur_0530
PDX: Psed_0766
PSUU: Psuf_068280(mphP)
AG: BAA23335(dsoF)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
Reference
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence

KEGG   ENZYME: 1.14.13.244
Entry
EC 1.14.13.244              Enzyme                                 
Name
phenol 2-monooxygenase (NADH);
dmpLMNOP (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
phenol + NADH + H+ + O2 = catechol + NAD+ + H2O [RN:R10043]
Reaction(KEGG)
R10043;
(other) R10042
Substrate
phenol [CPD:C00146];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacteria Pseudomonas sp. CF600 and Acinetobacter radioresistens, consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The reductase component is responsible for transferring electrons from NADH to the dinuclear iron center.
History
EC 1.14.13.244 created 2019
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5
Genes
PSDDSC_04415 DSC_04420 DSC_04425 DSC_04430 DSC_04435
RTHLRK53_10140 LRK53_10145 LRK53_10150 LRK53_10155 LRK53_10245
RBDALSL_0896 ALSL_0897 ALSL_0898 ALSL_0899 ALSL_0900
PREPCA10_06970(dmpL) PCA10_06980(dmpM) PCA10_06990(dmpN) PCA10_07000(dmpO) PCA10_07010(dmpP)
PFUWKF707C_6700(dmpL) KF707C_6710(dmpM) KF707C_6720(dmpN) KF707C_6730(dmpO) KF707C_6740(dmpP)
PCQPcP3B5_25310(mphL) PcP3B5_25320(dmpM) PcP3B5_25330(tmoA) PcP3B5_25340 PcP3B5_25350(dmpP)
PPGPputGB1_3306 PputGB1_3307 PputGB1_3308 PputGB1_3309 PputGB1_3310
PPJRK21_04242 RK21_04243 RK21_04244 RK21_04245 RK21_04246 RK21_04247
PVRPverR02_14660 PverR02_14665 PverR02_14670 PverR02_14675 PverR02_14680
PKCPKB_1742(dmpL) PKB_1743 PKB_1744(dmpN) PKB_1745 PKB_1746(dmpP)
PALKPSAKL28_05880 PSAKL28_05890 PSAKL28_05900 PSAKL28_05910 PSAKL28_05920
PALLUYA_20180 UYA_20185 UYA_20190 UYA_20195 UYA_20200
PUMHGP31_14970 HGP31_14975 HGP31_14980 HGP31_14985 HGP31_14990
PLALFXN65_03415 FXN65_03420 FXN65_03425 FXN65_03430 FXN65_03435
PPHABVH74_06110 BVH74_06115 BVH74_06120 BVH74_06125 BVH74_06130
AVNAvin_08810(dmpP) Avin_08820(dmpO) Avin_08830(dmpN) Avin_08840(dmpM) Avin_08850(dpmL) Avin_30710(lapP) Avin_30720(lapO) Avin_30730(lapN) Avin_30740(lapM) Avin_30750(lapL)
AVLAvCA_08810(dmpP) AvCA_08820(dmpO) AvCA_08830(dmpN) AvCA_08840(dmpM) AvCA_08850(dpmL) AvCA_30710(lapP) AvCA_30720(lapO) AvCA_30730(lapN) AvCA_30740(lapM) AvCA_30750(lapL)
AVDAvCA6_08810(dmpP) AvCA6_08820(dmpO) AvCA6_08830(dmpN) AvCA6_08840(dmpM) AvCA6_08850(dpmL) AvCA6_30710(lapP) AvCA6_30720(lapO) AvCA6_30730(lapN) AvCA6_30740(lapM) AvCA6_30750(lapL)
HPEGEAO82_09380 EAO82_09385 EAO82_09390 EAO82_09395 EAO82_09400
HAESLO767_17625 LO767_17630 LO767_17635 LO767_17640 LO767_17645
MADHP15_4025 HP15_4026 HP15_4027 HP15_4028 HP15_4029
MSRAU15_09285 AU15_09290 AU15_09305 AU15_20690 AU15_20695 AU15_20705 AU15_20710
MLQASQ50_09240 ASQ50_09245 ASQ50_09250 ASQ50_09255 ASQ50_09260
MSQBKP64_13875 BKP64_13880 BKP64_13885 BKP64_13890 BKP64_13895
MARJMARI_05340(mphL) MARI_05350(dmpM) MARI_05360(tmoA) MARI_05370 MARI_05380(dmpP)
PSPGAK823_07300 AK823_07305 AK823_07310 AK823_07315 AK823_07320
PSYGAK825_07395 AK825_07400 AK825_07405 AK825_07410 AK825_07415
ABKLX00_05865 LX00_05870 LX00_05875 LX00_05880 LX00_05885
ABAUIX87_04540 IX87_04545 IX87_04550 IX87_04555 IX87_04560
ACCBDGL_000470(mphP) BDGL_000471(mphO) BDGL_000472(mphN) BDGL_000473(mphM) BDGL_000474(mphL)
ALCOTEC02_12945 OTEC02_12950 OTEC02_12955 OTEC02_12960 OTEC02_12965
ASEII8T81_12960 I8T81_12965 I8T81_12970 I8T81_12975 I8T81_12980
ACDAOLE_13300 AOLE_13305 AOLE_13310 AOLE_13315 AOLE_13320
AJORZ95_18640 RZ95_18645 RZ95_18650 RZ95_18655 RZ95_18660
ACWA0J50_11600 A0J50_11605 A0J50_11610 A0J50_11615 A0J50_11620
ALABFG52_11000 BFG52_11005 BFG52_11010 BFG52_11015 BFG52_11020
ADVDJ533_01815 DJ533_01820 DJ533_01825 DJ533_01830 DJ533_01835 DJ533_10995 DJ533_11000 DJ533_11005 DJ533_11010 DJ533_11015
AWUBEN71_12685 BEN71_12690 BEN71_12695 BEN71_12700 BEN71_12705
AGUAS4_16410(dsoF) AS4_16420(dsoE) AS4_16430(dsoD) AS4_16440(dsoC) AS4_16450(dsoB)
ABERBSR55_16090 BSR55_16095 BSR55_16100 BSR55_16105 BSR55_16110
ACHICDG60_14300 CDG60_14305 CDG60_14310 CDG60_14315 CDG60_14320
ATGJ4G44_06365 J4G44_06370 J4G44_06375 J4G44_06380 J4G44_06385
ACIUA3K93_13810
AFUSEYZ66_02625 EYZ66_02630 EYZ66_02635 EYZ66_02640 EYZ66_02645
CZACYCME_2107 CYCME_2108 CYCME_2109 CYCME_2110 CYCME_2111
BLEPAL038_01325 AL038_01330 AL038_01335
THISHZT40_13275 HZT40_13280 HZT40_13285 HZT40_13290 HZT40_13300
MARSA8C75_10395 A8C75_10400 A8C75_10405 A8C75_10410 A8C75_10415
MGEOCFI10_13960 CFI10_13965 CFI10_13970 CFI10_13975 CFI10_13980
MSECLN244_11600 LN244_11605 LN244_11610 LN244_11615 LN244_11620
NCUF0U83_03005 F0U83_03010 F0U83_03015 F0U83_03020 F0U83_03025
NJPNEJAP_0663(dmpL) NEJAP_0664(dmpM) NEJAP_0665(dmpN) NEJAP_0666(dmpO) NEJAP_0667(dmpP)
NIKF5I99_10130 F5I99_10135 F5I99_10140 F5I99_10145 F5I99_10150
AJPAMJAP_3006(dmpP) AMJAP_3007(dmpO) AMJAP_3008(dmpN) AMJAP_3009(dmpM) AMJAP_3010(dmpL)
SINIGT972_13680 GT972_13685 GT972_13690 GT972_13695 GT972_13700
TBNTBH_C0906 TBH_C0907 TBH_C0908 TBH_C0909 TBH_C0910
NZOSAMEA4504057_0438(mphL) SAMEA4504057_0439(dmpM) SAMEA4504057_0440(tmoA) SAMEA4504057_0441 SAMEA4504057_0442(mphP)
NCINCTC10296_00919(mphP) NCTC10296_00920 NCTC10296_00921(tmoA) NCTC10296_00922(dmpM) NCTC10296_00923(mphL)
NWDH3L96_04785 H3L96_04790 H3L96_04795 H3L96_04800 H3L96_04805
NDULVJ88_00550 LVJ88_00555 LVJ88_00560 LVJ88_00565 LVJ88_00570
VFFVITFI_CDS1382 VITFI_CDS1383 VITFI_CDS1384 VITFI_CDS1385 VITFI_CDS1386
PTESJQU52_04820 JQU52_04825 JQU52_04830 JQU52_04835 JQU52_04840
USULVJ78_03620 LVJ78_03625 LVJ78_03630 LVJ78_03635 LVJ78_03640
AQLBXU06_12755 BXU06_12760 BXU06_12765 BXU06_12770 BXU06_12775 BXU06_16820 BXU06_16825 BXU06_16830 BXU06_16835 BXU06_16840
RPIRpic_4626 Rpic_4627 Rpic_4628 Rpic_4629 Rpic_4630
RPFRpic12D_3550 Rpic12D_3551 Rpic12D_3552 Rpic12D_3553 Rpic12D_3554
RPJN234_08110 N234_08115 N234_08120 N234_08125 N234_08130
REHH16_B0540(poxB) H16_B0541(poxC) H16_B0542(poxD) H16_B0543(poxE) H16_B0544(poxF)
CNCCNE_2c04860(poxB) CNE_2c04870(poxC) CNE_2c04880(poxD) CNE_2c04890(poxE) CNE_2c04900(poxF)
REUReut_A1700 Reut_A1701 Reut_A1702 Reut_A1703 Reut_A1704 Reut_B5681 Reut_B5682 Reut_B5683 Reut_B5684 Reut_B5685
RMERmet_1326(tomA5) Rmet_1327(tomA4) Rmet_1328(tomA3) Rmet_1329(tomA2) Rmet_1330(tomA1) Rmet_1782(phyE) Rmet_1783(phyD) Rmet_1784(phyC) Rmet_1785(phyB) Rmet_1786(phyA)
CBWRR42_s2488 RR42_s2489 RR42_s2490 RR42_s2491 RR42_s2492
CCUPBKK81_27050 BKK81_27055 BKK81_27060 BKK81_27065 BKK81_27070
CUPBKK80_29250 BKK80_29255 BKK80_29260 BKK80_29265 BKK80_29270
CUUBKK79_35200 BKK79_35205 BKK79_35210 BKK79_35215 BKK79_35220
COXE0W60_07735 E0W60_07740 E0W60_07745 E0W60_07750 E0W60_07755
BVIBcep1808_7594 Bcep1808_7595 Bcep1808_7596 Bcep1808_7597 Bcep1808_7598
BURBcep18194_B2966 Bcep18194_B2967 Bcep18194_B2968 Bcep18194_B2969 Bcep18194_B2970
BCENDM39_4839(dmpP) DM39_4840(phO) DM39_4841(phN) DM39_4842(dmpM) DM39_4843(mphL)
BCTGEM_5408 GEM_5409 GEM_5410 GEM_5411 GEM_5412
BCEDDM42_4998(dmpP) DM42_4999(phO) DM42_5000(phN) DM42_5001(dmpM) DM42_5002(phL)
BCONNL30_24625 NL30_24630 NL30_24635 NL30_24640 NL30_24645
BDFWI26_15940 WI26_15945 WI26_15950 WI26_15955 WI26_15960
BTEIWS51_00515 WS51_00520 WS51_00525 WS51_00530 WS51_00535
BPSLWS57_12190 WS57_12195 WS57_12200 WS57_12205 WS57_12210
BSTLBBJ41_10465 BBJ41_10470 BBJ41_10475 BBJ41_10480 BBJ41_10485
BANNJFN94_19080 JFN94_19085 JFN94_19090 JFN94_19095 JFN94_19100
BYIBYI23_C000520 BYI23_C000530 BYI23_C000540 BYI23_C000550(mmoB_dmpM) BYI23_C000560
BUEBRPE67_CCDS12510 BRPE67_CCDS12520(mmoB_dmpM) BRPE67_CCDS12530 BRPE67_CCDS12540 BRPE67_CCDS12550
BUZAYM40_16195 AYM40_16200 AYM40_16205 AYM40_16210 AYM40_16215
PARBCJU94_38070 CJU94_38075 CJU94_38080 CJU94_38085 CJU94_38090
PTERC2L65_07810 C2L65_07815 C2L65_07820 C2L65_07825 C2L65_07830
PPKU875_01925 U875_01930 U875_01935 U875_01940 U875_01945
PRBX636_07525 X636_07530 X636_07535 X636_07540 X636_07545
LIMNHKT17_03880 HKT17_03885 HKT17_03890 HKT17_03895 HKT17_03900
BOJCBF45_04540 CBF45_04545 CBF45_04550 CBF45_04555 CBF45_04560
CDNBN940_04341 BN940_04346 BN940_04351 BN940_04356 BN940_04361
AFAUZ73_17835 UZ73_17840 UZ73_17845 UZ73_17850 UZ73_17855
AFQAFA_08520 AFA_08525 AFA_08530 AFA_08535 AFA_08540
AAQUD3M96_09740 D3M96_09745 D3M96_09750 D3M96_09755 D3M96_09760
AAMMFE795_07735 FE795_07740 FE795_07745 FE795_07750 FE795_07755
PIGEGT29_26535 EGT29_26540 EGT29_26545 EGT29_26550 EGT29_26555
KGYEHF36_04925 EHF36_04930 EHF36_04935 EHF36_04940 EHF36_04945
AJSAjs_0207 Ajs_0208 Ajs_0209 Ajs_0210 Ajs_0211
ACIDCBP33_01035 CBP33_01055 CBP33_01060
ACIPCBP36_01140 CBP36_01145 CBP36_01150 CBP36_01155 CBP36_01160
ACINCBP34_01050 CBP34_01055 CBP34_01060 CBP34_01065 CBP34_01070
ACISCBP35_17790 CBP35_17795 CBP35_17800 CBP35_17805 CBP35_17810
AMONH9L24_14235 H9L24_14240 H9L24_14245 H9L24_14250 H9L24_14255
VEIVeis_2791 Veis_2792 Veis_2793 Veis_2794 Veis_2795
VBOCKY39_28530 CKY39_28540 CKY39_28545 CKY39_28550
CTTCtCNB1_3157 CtCNB1_3158 CtCNB1_3159 CtCNB1_3160 CtCNB1_3161
COFFOZ74_08255 FOZ74_08260 FOZ74_08265 FOZ74_08270 FOZ74_08275
ADNAlide_0324 Alide_0325 Alide_0326 Alide_0327 Alide_0328
ADKAlide2_0271 Alide2_0272 Alide2_0273 Alide2_0274 Alide2_0275
OTDJ1M35_00080 J1M35_00085 J1M35_00090 J1M35_00095 J1M35_00100
HYLLPB072_18130 LPB072_18135 LPB072_18140 LPB072_18145 LPB072_18150
HPSEHPF_01905(dmpP) HPF_01910(tbuD) HPF_01915(tmoA2) HPF_01920(dmpM) HPF_01925(mphL)
HYNF9K07_02700 F9K07_02705 F9K07_02710 F9K07_02715 F9K07_02720
HTNKI616_01995 KI616_02000 KI616_02005 KI616_02010 KI616_02015
DIHG7047_01705 G7047_01710 G7047_01715 G7047_01720 G7047_01725
DRGH9K76_11590 H9K76_11595 H9K76_11600 H9K76_11605 H9K76_11610
SIMPC6571_13570 C6571_13575 C6571_13580 C6571_13585 C6571_13590
MELAC6568_07885 C6568_07890 C6568_07895 C6568_07900 C6568_07905
MJELVC68_00955 LVC68_00960 LVC68_00965 LVC68_00970 LVC68_00975
STHMIS481_10480 IS481_10485 IS481_10490 IS481_10495 IS481_10500
MPTMpe_A2280(dmpP) Mpe_A2281(dmpO) Mpe_A2282(dmpN) Mpe_A2283(dmpM) Mpe_A2284(dmpL) Mpe_A3305(dmpO) Mpe_A3306(dmpN) Mpe_A3307(dmpM) Mpe_A3308(dmpL)
METPC1M51_06255 C1M51_06260 C1M51_06265 C1M51_06275 C1M51_06280 C1M51_06285 C1M51_06290 C1M51_06295 C1M51_15440 C1M51_15445 C1M51_15450 C1M51_15455
SNNEWH46_19245 EWH46_19250 EWH46_19255 EWH46_19260 EWH46_19265
IDCLRM40_19515 LRM40_19520 LRM40_19525 LRM40_19530 LRM40_19535
MASWAM586_18610 AM586_18615 AM586_18620 AM586_18625 AM586_18630
LCHLcho_3358 Lcho_3359 Lcho_3360 Lcho_3361 Lcho_3362
RBUPG1C_06885 PG1C_06890 PG1C_06895 PG1C_06900 PG1C_06905
DARDaro_3792 Daro_3793 Daro_3794 Daro_3795 Daro_3796
DEYHYN24_14140 HYN24_14145 HYN24_14150 HYN24_14155 HYN24_14250 HYN24_14255 HYN24_14260 HYN24_14265 HYN24_14270
DDENKI615_16920 KI615_16925 KI615_16930 KI615_16935 KI615_16940
QAUKI612_13860 KI612_13865 KI612_13870 KI612_13875 KI612_13880
FLEKI610_15390 KI610_15395 KI610_15400 KI610_15405 KI610_15500 KI610_15505 KI610_15510 KI610_15515 KI610_15520
AZOazo1846(lapL) azo1847(lapM) azo1848(lapN) azo1849(lapO) azo1850(lapP) azo2439(poxF) azo2440(poxE) azo2441(poxD) azo2442(poxC) azo2443(poxB)
AOAdqs_1996 dqs_1997 dqs_1998 dqs_1999 dqs_2000 dqs_2583 dqs_2584 dqs_2585 dqs_2586 dqs_2587
AZDCDA09_10255 CDA09_10260 CDA09_10265 CDA09_10270 CDA09_10275 CDA09_10410 CDA09_10415 CDA09_10420 CDA09_10425 CDA09_10430
AZRCJ010_12195 CJ010_12200 CJ010_12205 CJ010_12210 CJ010_12215 CJ010_15245 CJ010_15250 CJ010_15255 CJ010_15260 CJ010_15265
TMZTmz1t_3111 Tmz1t_3112 Tmz1t_3113 Tmz1t_3114 Tmz1t_3115
THUAC731_001765 AC731_001770 AC731_001775 AC731_001780 AC731_001785
THKCCZ27_04535 CCZ27_04540 CCZ27_04545 CCZ27_04555 CCZ27_10665 CCZ27_10670 CCZ27_10675 CCZ27_10680 CCZ27_10685 CCZ27_10780 CCZ27_10785 CCZ27_10790 CCZ27_10795 CCZ27_10800
AZQG3580_00470 G3580_00475 G3580_00480 G3580_00485 G3580_00490 G3580_01295 G3580_01300 G3580_01305 G3580_01310 G3580_08210 G3580_08215 G3580_08220 G3580_08225 G3580_08230
ACIBACBT_0275(dmpP) ACBT_0276(dmpO) ACBT_0277(dmpN) ACBT_0278(dmpM) ACBT_0279(dmpL)
AFCAFAEC_1853(dmpP) AFAEC_1854(dmpO) AFAEC_1855(dmpN) AFAEC_1856(dmpM) AFAEC_1857(dmpL)
AAQIAAQM_0970(dmpL) AAQM_0971(dmpM) AAQM_0972(dmpN) AAQM_0973(dmpO) AAQM_0974(dmpP)
ACLOACLO_a0150(dmpP) ACLO_a0151(dmpO) ACLO_a0152(dmpN) ACLO_a0153(dmpM) ACLO_a0154(dmpL)
ADZADFLV_2564(dmpP) ADFLV_2565(dmpO) ADFLV_2566(dmpN) ADFLV_2567(dmpM) ADFLV_2568(dmpL)
ARCABLL_2455 ABLL_2456 ABLL_2457 ABLL_2458 ABLL_2459
ALKALEK_0371(dmpL) ALEK_0372(dmpM) ALEK_0373(dmpN) ALEK_0374(dmpO) ALEK_0375(dmpP)
AANAAANAER_1246(dmpL) AANAER_1247(dmpM) AANAER_1248(dmpN) AANAER_1249(dmpO) AANAER_1250(dmpP)
MTUNMTUNDRAET4_3881(dmpL) MTUNDRAET4_3882(dmpM) MTUNDRAET4_3883 MTUNDRAET4_3885 MTUNDRAET4_3886(dmpP)
MAADAZF01_11200 AZF01_11205 AZF01_11210 AZF01_11215 AZF01_11220
MLUTJET14_11645 JET14_11650 JET14_11655 JET14_11660 JET14_11665
BVYNCTC9239_03024(mphL) NCTC9239_03025(dmpM) NCTC9239_03026(tmoA)
SMYBJP26_18670 BJP26_18675 BJP26_18680 BJP26_18685 BJP26_18690
SJPSJA_C1-11990(tomA1) SJA_C1-12000(tomA2) SJA_C1-12010(tomA3) SJA_C1-12020(tomA4) SJA_C1-12030(tomA5)
SINBSIDU_08250 SIDU_08255 SIDU_08260 SIDU_08265 SIDU_08270
SYBTZ53_09070 TZ53_09075 TZ53_09080 TZ53_09085 TZ53_09090
SUFLFIL70_18925 FIL70_18930 FIL70_18935 FIL70_18940 FIL70_18945
SBARH5V43_20575 H5V43_20580 H5V43_20585 H5V43_20590 H5V43_20595
BACIB1NLA3E_08455 B1NLA3E_08460 B1NLA3E_08465
ASOCCB4_02441(mphL) CB4_02442(dmpM) CB4_02443(tmoA)
BTSBtus_0959 Btus_0960 Btus_0961
KYRCVV65_10610 CVV65_10615 CVV65_10620 CVV65_11330 CVV65_11335 CVV65_11340
SAYTPY_0628 TPY_0629 TPY_0630 TPY_0631 TPY_0634(benC)
SAPSulac_3005 Sulac_3008 Sulac_3009 Sulac_3010 Sulac_3011
MSAMycsm_01964 Mycsm_01965 Mycsm_01966 Mycsm_01967 Mycsm_01968
MCROMI149_22720 MI149_22730
MLLB1R94_25100 B1R94_25110 B1R94_25115
MMAGMMAD_31790 MMAD_31810(mphN)
MHIBMHIB_39890(mphP)
CCYCSCMU_04650(mphP)
ROZCBI38_31750 CBI38_32160 CBI38_32255
GOQACH46_03525 ACH46_03530 ACH46_03535 ACH46_03540 ACH46_03545
GOCCXX93_06730 CXX93_06735 CXX93_06740 CXX93_06745 CXX93_06750
GAMGII34_22040 GII34_22045 GII34_22050 GII34_22055 GII34_22060
TOYFO059_13965 FO059_13970 FO059_13975 FO059_13980 FO059_13985
JTEASJ30_00060 ASJ30_00065 ASJ30_00070 ASJ30_00075 ASJ30_00080
JLIEXU32_15385 EXU32_15390 EXU32_15395 EXU32_15400 EXU32_15405
JMEEEW87_015365 EEW87_015370 EEW87_015375 EEW87_015380 EEW87_015385
PHWG7075_13205 G7075_13210 G7075_13215 G7075_13225
AUSIPK37_11610 IPK37_11620 IPK37_11625 IPK37_11640
RAINRai3103_07175 Rai3103_07185 Rai3103_07190 Rai3103_07195
NMESH9L09_04340
TCUTcur_0524 Tcur_0525 Tcur_0526 Tcur_0527 Tcur_0530
AACDLWP59_26105 LWP59_26110 LWP59_26115 LWP59_26120 LWP59_26125 LWP59_38095 LWP59_38100 LWP59_38105 LWP59_38110 LWP59_38115
PDXPsed_0766 Psed_0767 Psed_0768 Psed_0769 Psed_0770
PSUUPsuf_068230(mphL) Psuf_068240 Psuf_068250(mphN) Psuf_068280(mphP)
COYHF329_27145
CFILMYF79_02125
NKFNkreftii_004063
 » show all
Reference
1  [PMID:2254258]
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
Reference
2  [PMID:2254259]
  Authors
Powlowski J, Shingler V
  Title
In vitro analysis of polypeptide requirements of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6834-40 (1990)
DOI:10.1128/jb.172.12.6834-6840.1990
Reference
3  [PMID:8995386]
  Authors
Powlowski J, Sealy J, Shingler V, Cadieux E
  Title
On the role of DmpK, an auxiliary protein associated with multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Biol Chem 272:945-51 (1997)
DOI:10.1074/jbc.272.2.945
Reference
4  [PMID:9012665]
  Authors
Qian H, Edlund U, Powlowski J, Shingler V, Sethson I
  Title
Solution structure of phenol hydroxylase protein component P2 determined by NMR spectroscopy.
  Journal
Biochemistry 36:495-504 (1997)
DOI:10.1021/bi9619233
Reference
5  [PMID:12186554]
  Authors
Cadieux E, Vrajmasu V, Achim C, Powlowski J, Munck E
  Title
Biochemical, Mossbauer, and EPR studies of the diiron cluster of phenol hydroxylase from Pseudomonas sp. strain CF 600.
  Journal
Biochemistry 41:10680-91 (2002)
DOI:10.1021/bi025901u
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.244
IUBMB Enzyme Nomenclature: 1.14.13.244
ExPASy - ENZYME nomenclature database: 1.14.13.244
BRENDA, the Enzyme Database: 1.14.13.244

KEGG   REACTION: R10042
Entry
R10042                      Reaction                               
Name
benzene,NADH:oxygen oxidoreductase
Definition
Benzene + Oxygen + NADH + H+ <=> Phenol + NAD+ + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC00490  C00146_C01407
Enzyme
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Orthology
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0

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