KEGG   ORTHOLOGY: K16421
Entry
K16421                      KO                                     

Symbol
hmaS, nocF
Name
4-hydroxymandelate synthase [EC:1.13.11.46]
Pathway
map00261  Monobactam biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.46  4-hydroxymandelate synthase
     K16421  hmaS, nocF; 4-hydroxymandelate synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K16421  hmaS, nocF; 4-hydroxymandelate synthase
Other DBs
RN: R06632
GO: 0050585
Genes
MSD: MYSTI_03600
MFB: MFUL124B02_19465
AGE: AA314_04078
CFUS: CYFUS_002913
THAA: CFI11_12525
NTP: CRH09_30890(hppD)
NHU: H0264_30685(hppD)
SCO: SCO3229(SCE63.04)
SVL: Strvi_8789
SRC: M271_09160 M271_27680
SBH: SBI_01126
SALU: DC74_563
SALL: SAZ_03310
STRE: GZL_08687
SKY: D0C37_28235(hppD)
SALW: CP975_31965(hppD)
SLAU: SLA_6884
SCYA: EJ357_01680(hppD)
SKA: CP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD)
SRK: FGW37_00515(hppD)
SVR: CP971_02370(hppD) CP971_08110(hppD)
SFY: GFH48_02890(hppD) GFH48_36325(hppD)
SBY: H7H31_03515(hppD)
SRIM: CP984_06500(hppD)
SFUG: CNQ36_25575(hppD)
SCHA: CP983_01445(hppD) CP983_10855(hppD)
SGX: H4W23_38355(hppD)
SATA: C5746_00990(hppD) C5746_42245(hppD)
SAUH: SU9_002080(hppD)
KFL: Kfla_6066
SRO: Sros_6970
NCX: Nocox_13265(noc2)
NGN: LCN96_07790(hppD) LCN96_24325(hppD)
AOI: AORI_1495(hppD)
AMI: Amir_4590
SSYI: EKG83_29580(hppD) EKG83_30955(hppD)
KAL: KALB_6132
ACTI: UA75_15380
ACAD: UA74_14810
ACTA: C1701_23410(hppD)
SAQ: Sare_2673
MIL: ML5_4909
MTUA: CSH63_07635(hppD)
MICH: FJK98_16440(hppD)
MTEM: GCE86_13405(hppD)
MCAB: HXZ27_18210(hppD)
DVC: Dvina_13810(hppD) Dvina_18685(hppD)
CAI: Caci_3256
HAU: Haur_1888
AG: AAT09803(nocF) CAA11761(hmaS)
 » show all
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3229]
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012
  Sequence

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