KEGG   ORTHOLOGY: K16422
Entry
K16422                      KO                                     
Symbol
hmo, nocN
Name
4-hydroxymandelate oxidase [EC:1.1.3.46]
Pathway
map00261  Monobactam biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.46  4-hydroxymandelate oxidase
     K16422  hmo, nocN; 4-hydroxymandelate oxidase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K16422  hmo, nocN; 4-hydroxymandelate oxidase
Other DBs
RN: R06633
Genes
EBI: EbC_45010
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PSUW: WQ53_04950
XBA: C7S18_07265
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PFUW: KF707C_9130
PSET: THL1_1034
PALL: UYA_03960
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
AGU: AS4_05470
ABOU: ACBO_26740
SKH: STH12_02859(lldD)
PTU: PTUN_a4088(glcD)
LFA: LFA_1216(GLO)
LHA: LHA_0501
GAI: IMCC3135_25780(hmo)
HCH: HCH_01681
SALN: SALB1_1045
CGD: CR3_3245(glcD)
BGU: KS03_3471
AFQ: AFA_02405
ACRA: BSY15_3965
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
METR: BSY238_10
OTR: OTERR_15390(lldD)
AOA: dqs_0678
AELL: AELL_0874
ASUI: ASUIS_0518
ACLO: ACLO_0849
DVL: Dvul_0528
DFL: DFE_2112
DMA: DMR_21260
DGG: DGI_1415
DDE: Dde_0750
DAS: Daes_2493
DBA: Dbac_1976
DPS: DP0843
DALK: DSCA_14510
DLI: dnl_38430
SCL: sce7671
HOH: Hoch_0089
PLA: Plav_0378
NWI: Nwi_0702
AZC: AZC_1619
KRO: BVG79_01849(glcD)
SINL: DSM14862_02055(hmo)
PDE: Pden_4676
NAR: Saro_0774
SWI: Swit_4251
HTL: HPTL_0509
LAD: LA14_1588
LAF: SD55_1597
LAM: LA2_08960
LKE: WANG_0215
CPE: CPE1878
CPF: CPF_2132
CPR: CPR_1844
CLS: CXIVA_13840(LldD)
CSQ: CSCA_4771
CACE: CACET_c16820(lldD)
AOE: Clos_1159
HHW: NCTC503_02011(lldD)
CCE: Ccel_2344
FPR: FP2_21160
FPA: FPR_06650
CSCI: HDCHBGLK_02317(hmo)
EHL: EHLA_0737
PHX: KGNDJEFE_01524(hmo)
DRM: Dred_1257
CTHM: CFE_0998
ADG: Adeg_1075
TSH: Tsac_2535
TACI: TDSAC_1603
TOC: Toce_0633
KME: H0A61_01190(hmo)
MED: MELS_0352
PUF: UFO1_4337
STED: SPTER_33280(lldD)
AIN: Acin_0831
RHB: NY08_2291
TPR: Tpau_3076
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SMAL: SMALA_0360
SALU: DC74_564
SALL: SAZ_03315
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
SRJ: SRO_7148
SAUH: SU9_002085
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NCA: Noca_1980
NDK: I601_3731(lldD_2)
NAQU: ENKNEFLB_02043(hmo)
NCX: Nocox_13260(noc1)
FAL: FRAAL3814
NML: Namu_3188
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
KRA: Krad_2981
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
AMYY: YIM_21185
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ACTS: ACWT_2064
SNA: Snas_1502
BTP: D805_1170
RXY: Rxyl_2999
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
NSH: GXM_03321
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
CTHE: Chro_0042
DGE: Dgeo_2057
DFC: DFI_08470
TRA: Trad_2342
BPW: WESB_0467
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
AG: AAT09795(nocN) CAA11762(hmo)
 » show all
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3228]
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012
  Sequence

KEGG   ENZYME: 1.1.3.46
Entry
EC 1.1.3.46                 Enzyme                                 
Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:R06633]
Reaction(KEGG)
R06633
Substrate
(S)-4-hydroxymandelate [CPD:C03198];
O2 [CPD:C00007]
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:C03590];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16422  4-hydroxymandelate oxidase
Genes
EBIEbC_45010
PAOPat9b_0059
KLNLH22_02000
PANSFCN45_00295
PSUWWQ53_04950
XBAC7S18_07265
PMYPmen_0804
PREPCA10_09820(lldD)
PPSEBN5_0696(glcD3)
PFUWKF707C_9130
PSETTHL1_1034
PALLUYA_03960
POJPtoMrB4_11440
PLALFXN65_04550
PKHJLK41_04285
PNNKEM63_07345
PWZJ7655_03835
AVNAvin_12350(lldD)
AVLAvCA_12350(lldD)
AVDAvCA6_12350(lldD)
ACXAchr_30250(lldD)
EMODM558_00105
HAESLO767_01930
PSYYDLE54_06755 DLE54_06980
ATTAMQ28_05560
AEIAOY20_01775
AJORZ95_14500
AHLAHTJS_02455
ASJAsACE_CH00433
AIDCTZ23_02310
ADVDJ533_16435
AWUBEN71_03430
ACUMC9E88_006515
AGUAS4_05470
ADSFPL17_16865
ABERBSR55_17750
ACHICDG60_15615
ASHAG8E00_02820
ATGJ4G44_00650
ABOUACBO_26740
SPOLFH971_10065
SKHSTH12_02859(lldD)
SDKKHX94_16705
PTUPTUN_a4088(glcD)
PMESFX988_00687
ZALAZF00_16215
LFALFA_1216(GLO)
LHALHA_0501
CYYCPC19_11350
TXAHQN79_00810
THISHZT40_14725
GAIIMCC3135_25780(hmo)
HCHHCH_01681
HAHEENC22_22225
HHHCLM76_06065
KAKKalk_08620
MARSA8C75_03950
NCUF0U83_13850
GSNYC6258_04793
SINIGT972_11345
SALNSALB1_1045
VFFVITFI_CDS3216
VITADP71_31350
VSTLVJ81_12130
AQLBXU06_07955
VOGLCH97_08320
CGDCR3_3245(glcD)
CPAUEHF44_23235
BGUKS03_3471
BPLAbpln_1g26350
PMEGFNZ07_25555
PUSCKA81_03480
PUDG9Q38_09430
AFAUZ73_08085
AFQAFA_02405
AAMMFE795_02370
OURCEQ07_08655
OUEI6G29_10405
PIGEGT29_20715
PACRFXN63_21860
RHYRD110_19630
ACKC380_14255
ACRABSY15_3965
ACIDCBP33_11150
ACIPCBP36_11075
ACINCBP34_10980
ACISCBP35_07855
ACIOEAG14_07140
AMONH9L24_02175
AANTHUK68_11660
ARADKI609_10130
DTSBI380_00615
DHKBO996_20975
DLAI6G47_01340
CKEB5M06_07315
CSERCCO03_11830
COFFOZ74_09250
CAQTKAQ61_14740
CODOLAD35_07210
OTKC6570_07945
LIHL63ED372_01067(lldD_1)
HYRBSY239_2087
HYBQ5W_00125
HYLLPB072_15815
HYCE5678_07245
HPSEHPF_09820
HYNF9K07_18330
HTNKI616_14805
DPYBA022_12275
DIHG7047_00230
DAERH9K75_17485
DRGH9K76_18230
SIMPC6571_16290
MELMC7H73_03560
MELAC6568_06065
MJELVC68_02580
STHMIS481_00890
KIAG8A07_26140
MASSCR152_05310
MANCIV454_11370
RGERGE_43910
PKTAT984_17325
AONDEH84_01955
SNNEWH46_04875
TTWLCC91_03490
ATERMW290_15185
BBAYA4V04_09650
NSTNstercoris_01156
METRBSY238_10
MEUACJ67_12165
SNIVSFSGTM_20120
AIQAzoinq_10760
RBUPG1C_09700
OTROTERR_15390(lldD)
DDENKI615_16175
QAUKI612_03440
FLEKI610_05585
AOAdqs_0678
ACOMCEW83_18180
THUAC731_012105
THKCCZ27_15025
AZQG3580_15095
ZPAC3497_07680
AELLAELL_0874
ASUIASUIS_0518
ACLOACLO_0849
AVPAVENP_0617
DVLDvul_0528
DVGDeval_2571
DFIAXF13_09095
DPGDESPIGER_1501
DFLDFE_2112
DSDGD606_16625
DMADMR_21260
DCBC3Y92_10185
DGGDGI_1415
DDEDde_0750
DMSE8L03_10940
DSADesal_1465
DHYDESAM_22812
DASDaes_2493
DEJAWY79_15335
PSELGM415_08775 GM415_17505
DSXGD604_14390
DBADbac_1976
DPSDP0843
DPRDespr_0716
DEOCAY53_04955
DOGHP555_00960
DATHRM2_41110
DALKDSCA_14510
DLIdnl_38430
AGEAA314_00340
AVMJQX13_15815 JQX13_32715
MBDMEBOL_001680
CFUSCYFUS_002912 CYFUS_008761
SCLsce7671
SCUSCE1572_44330
PAUUE8A73_024105
LLUAKJ09_10055
MRMA7982_09601
HOHHoch_0089
HOEIMCC20628_00688
PLAPlav_0378
NWINwi_0702
TRBHB776_09700
BOPAXW83_15230
AZCAZC_1619
ANCGBB76_07300
APRAG3A50_03145
HNIW911_04290
RHZRHPLAN_58200 RHPLAN_67990
YTIFNA67_17300
MPARF7D14_11785
NOHG5V57_17935
KROBVG79_01849(glcD)
PABYGa0080574_TMP356
SULDB5M07_08410
SPOTG6548_05240
SINLDSM14862_02055(hmo)
SAGUCDO87_26325
LSALKBK07_09835
PDEPden_4676
PPANESD82_02735
PSHQF3W81_12270
NARSaro_0774
NREBES08_00445
NOVTQ38_005445
SWISwit_4251
SPANAWL63_11515
SPHAD3Y57_07445
RGIRGI145_05600
ROSCTJ15_11790
RMUCFOB66_07430
RMTIAI58_21860
SVCSTVA_32270
ALIAZOLI_p20485
ABSAZOBR_p1110093
ABQABAZ39_15315
ABFAMK58_20855
ATIAL072_18250
AZTTSH58p_26095
AZMDM194_19930
SMUCJL100_019020
SROEJL101_017820
HTLHPTL_0509
LADLA14_1588
LAFSD55_1597
LAMLA2_08960
LAILAC30SC_08600
LAYLAB52_07995
LKEWANG_0215
LJEBUE77_00305
CPECPE1878
CPFCPF_2132
CPRCPR_1844
CLJCLJU_c34360
CLSCXIVA_13840(LldD)
CAHCAETHG_1336
CSQCSCA_4771
CACECACET_c16820(lldD)
CCKCcar_17325
CARGRSJ17_08045
CDRKB9W14_21015
CFERD4Z93_04370
AOEClos_1159
GFEGferi_07105
HHWNCTC503_02011(lldD)
CALEFDN13_03910
CRSFQB35_00670
SARJHH195_07595 HH195_11630
CCLClocl_0919
RBPB6259_09280
CCECcel_2344
RHEREHE19_004325
RALRumal_2056
FPRFP2_21160
FPAFPR_06650
FPRACG447_04040
CCOMI6K69_07045
CSCIHDCHBGLK_02317(hmo)
ACACEYQ97_08425
EHLEHLA_0737
RGNRGna_01260
PDCCDIF630_01416 CDIF630_02628
CDCCD196_1125 CD196_2228
CDLCDR20291_1103 CDR20291_2274
PDFCD630DERM_12630 CD630DERM_23870
CSTCLOST_1147
PSORRSJ16_14275
ROCHF520_09305
PHXKGNDJEFE_01524(hmo)
DORDesor_5480
DAIDesaci_4587
DMIDesmer_4518
DEDDHBDCA_p1237
DECDCF50_p1303
DCADesca_1949
DRMDred_1257
DRUDesru_2825
DFGB0537_05970
DKUDesku_2803
TFRBR63_01350
HCVFTV88_0031
AWOAwo_c03770
ACAEHYG86_06340
CTHMCFE_0998
MDVC5Q96_08410
EUUADJ67_06690
CHYCHY_0269 CHY_1319
ADGAdeg_1075
GEKkuro4_13110
COBCOB47_2205
CKNCalkro_0254
CCHAELD05_12315
TSHTsac_2535
TNRThena_1632
TACITDSAC_1603
TEPTepRe1_1797
TAETepiRe1_1937
TOCToce_0633
NTHNther_2031
KMEH0A61_01190(hmo)
KPARJL105_01275
MEDMELS_0352
MEGDKB62_02690
PUFUFO1_4337
STEDSPTER_33280(lldD)
AINAcin_0831
AARGAargi30884_12510
ABSIA9CBEGH2_13410
CIUG4D55_06025
LCGL3BBH23_07350
ERBA4V01_07355
NBRO3I_010580
NTPCRH09_30885
NOZDMB37_31330
NAHF5544_09030 F5544_26845
RHBNY08_2291
TPRTpau_3076
TSMASU32_06245
TPULTPB0596_35140
SCOSCO3228(SCE63.05)
SGBWQO_12235
SVLStrvi_5274 Strvi_8790
SHYSHJG_8441
SHOSHJGH_8202
SRCM271_09165 M271_27675 M271_46055
SMALSMALA_0360
SSOII1A49_05315
SBHSBI_01125 SBI_04778
SALUDC74_564
SALLSAZ_03315
SLVSLIV_21550
STREGZL_08686
SLCSL103_26565
STRCAA958_31845
SAMBSAM23877_5651
SRWTUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
STRFASR50_31315
SPAVSpa2297_02910 Spa2297_26640 Spa2297_32980
STRTA8713_31370
SKYD0C37_28255
SALWCP975_03175 CP975_31960 CP975_31975 CP975_34475
SGMGCM10017557_81720
SNRSNOUR_39380 SNOUR_40635
SPLULK06_031590
SAUOBV401_05560
SSIAA7J05_00250 A7J05_04110 A7J05_36485
SVUB1H20_11470
SLAUSLA_6885
SALFSMD44_00061(glcD)
STROSTRMOE7_29125
SFKKY5_6264c KY5_6713 KY5_7436c
SRJSRO_7148
SCYAEJ357_01685
SKACP970_03000 CP970_03015 CP970_07080 CP970_09765
SVRCP971_02375 CP971_08180
SFYGFH48_02895 GFH48_36330
SGFHEP81_07478
SBYH7H31_03485
SRIMCP984_06505 CP984_27455 CP984_39205
SFUGCNQ36_25595
STSUB7R87_00115
SCHACP983_01450 CP983_10835
SGXH4W23_38360
SSPBCP982_05960 CP982_06170
STUIGCM10017668_03330
SCYGS1361_20500
SFEUIM697_27410
SCALI6J39_11675
SAUHSU9_002085
SANUK7396_35160
SINEKI385_01580
KSKKSE_65170 KSE_67420
KABB7C62_11140
KAUB6264_28340
KITCFP65_1219
RFSC1I64_00520
FRPAX769_15450
LMOIVV02_16505
YIMJ5M86_08715
ALXLVQ62_10700
XYAET471_17455
CFLCfla_2130
SERJSGUI_0332
NCANoca_1980
NDKI601_3731(lldD_2)
NOYEXE57_04390
NOOFE634_08345
NANOG5V58_08260
NAQUENKNEFLB_02043(hmo)
NPSKRR39_10975
AERAERYTH_16755
AEZC3E78_17710
AEFGEV26_17485
KFLKfla_6052 Kfla_6167
KQIF1D05_14905 F1D05_15510
AGRAAGRA3207_000911
NOABKM31_54210
NOWGBF35_33890
NCXNocox_13260(noc1)
NGNLCN96_07785
FRAFrancci3_2463
FREFranean1_3511
FRIFraEuI1c_3200
FALFRAAL3814
NMLNamu_3188
BSDBLASA_0395(Hao) BLASA_2148(hao2)
MMARMODMU_3504(Hao)
KRAKrad_2981
AMDAMED_0893
AMNRAM_04555
AMMAMES_0890
AMZB737_0891
AOIAORI_1496(glcD)
AJAAJAP_32035
AMYCCU254_03020
AMYBBKN51_41525
AMYYYIM_21185
AORISD37_16615 SD37_33640
AACDLWP59_10735
APRECNX65_20200
AMIAmir_4034 Amir_4598
SSYIEKG83_30070 EKG83_30930
KALKALB_6131
KPHYAOZ06_37045
ACTIUA75_15340
ACADUA74_14770
ACTAC1701_23445
STPStrop_2478
SAQSare_0496 Sare_2661
MAUMicau_3468
MILML5_4923
MICBMicB006_2522 MicB006_2968
MTUACSH63_07705 CSH63_12375
MICHFJK98_14210 FJK98_16505
MTEMGCE86_13310
MCABHXZ27_13965 HXZ27_18275
MSAGGCM10017556_53930
VMAVAB18032_22225 VAB18032_24785
ACTNL083_5468 L083_7109
AFSAFR_01595 AFR_37575
ACTSACWT_2064
ACTRAsp14428_12750 Asp14428_15790
PFLAPflav_007660
PSUUPsuf_064700 Psuf_086480
VERHUT12_12305
ATLAthai_14010 Athai_22660
ASERAsera_47800 Asera_52290
PRYPrubr_36980 Prubr_65040
CATICS0771_77030
DVCDvina_13750 Dvina_17890 Dvina_20420 Dvina_38790
NHYJQS43_15560
CCAZCOUCH_38130
CAICaci_3265 Caci_4107
SNASnas_1502
BTPD805_1170
JTLM6D93_03240
ABAIIMCC26256_11496
RXYRxyl_2999
PARNNBH00_16110 NBH00_19215
ERZER308_09970
HHGXM38_038450(hmo)
PSERABRG53_a068 ABRG53_a072
CYTcce_1717
CYJCyan7822_5209
TERTery_2398
MICMic7113_4887
MPROBJP34_25760
CEPCri9333_3045
ANAall0170
NPUNpun_R5717
NOSNos7107_4571
NOPNos7524_4202
NONNOS3756_46730
NFLCOO91_03705
NOECLI64_13360
NSHGXM_03321
NEDHUN01_27595
AVAAva_1430
ANBANA_C12655
ANNEH233_27075
CSGCylst_0380
RSINB6N60_01287
CALOCal7507_4047
CALHIJ00_16930
DOUBMF77_03099(hmo)
DFSHGD76_08665
AFLOHEQ12_14100
TOQHCG51_14550
NCNBZZ01_30295
CTHEChro_0042
PLPPle7327_3868
STANSTA3757_22630
HAUHaur_0229 Haur_1871
PBFCFX0092_A1841
KBSEPA93_04875 EPA93_25295 EPA93_37090
DGEDgeo_2057
DDRDeide_15560
DCHSY84_09605
DABAUC44_00610
DPUSU48_02005
DWUDVJ83_02750
DFCDFI_08470
DEINDAAJ005_04280
DGADEGR_01180
TRATrad_2342
VBHCMV30_13800
OBTOPIT5_09870
LUOHHL09_02440
LAMBKBB96_19135
TIMGMBLW1_07500
TPITREPR_3177
TRIDYE50_00095
SSMSpirs_1471
TAZTREAZ_3083
BPOBP951000_1638
BPJB2904_orf2334
BPIPBPP43_07045
BPWWESB_0467
BHPBHAMNSH16_10970
ABASACPOL_6814
SUSAcid_1641 Acid_1779 Acid_7243
ABACLuPra_01597(lldD_1) LuPra_02070(lldD_2)
SCORJ3U87_21565
FVAFV113G1_10750
FGOC4N16_05810 C4N16_06435
FNFBSQ88_05685
IPOIlyop_0744
AMOAnamo_1914
GAUGAU_0248
GPHGEMMAAP_10810 GEMMAAP_16695
GGRHKW67_03885
GBAJ421_0641 J421_1218
PMZHMPREF0659_A6324
PFUSADJ77_07250
PJECRM71_07770
PHISJ5A62_00620
SPIKEXU85_15990
SPIBG8759_31000
RUNDR864_23485
TYETHEYE_A0075
TCMHL41_07275
THETF1847_08305
 » show all
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2  [PMID:12240298]
  Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
  Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
  Journal
Chem Commun (Camb) 1752-3 (2001)
DOI:10.1039/b103548g
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.46
IUBMB Enzyme Nomenclature: 1.1.3.46
ExPASy - ENZYME nomenclature database: 1.1.3.46
BRENDA, the Enzyme Database: 1.1.3.46

KEGG   REACTION: R06633
Entry
R06633                      Reaction                               
Name
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Definition
(S)-4-Hydroxymandelate + Oxygen <=> 4-Hydroxyphenylglyoxylate + Hydrogen peroxide
Equation
Reaction class
RC00240  C03198_C03590
RC02755  C00007_C00027
Enzyme
Pathway
rn00261  Monobactam biosynthesis
rn01055  Biosynthesis of vancomycin group antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16422  4-hydroxymandelate oxidase [EC:1.1.3.46]
Other DBs
RHEA: 41230

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