KEGG   ORTHOLOGY: K17648
Entry
K17648                      KO                                     
Symbol
ESTA
Name
versiconal hemiacetal acetate esterase [EC:3.1.1.94]
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17648  ESTA; versiconal hemiacetal acetate esterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.94  versiconal hemiacetal acetate esterase
     K17648  ESTA; versiconal hemiacetal acetate esterase
Other DBs
RN: R10398 R10401
COG: COG0657
GO: 0140397
Genes
PAN: PODANSg8561
MTM: MYCTH_54712
FGR: FGSG_09112
FVR: FVEG_03630 FVEG_07643
FOX: FOXG_04573 FOXG_05758
NHE: NECHADRAFT_44040
SAPO: SAPIO_CDS0298 SAPIO_CDS8256
SSL: SS1G_01703
BFU: BCIN_02g03480
MBE: MBM_02254
ANG: ANI_1_1088094(An11g08610)
PTE: PTT_13757
AG: AAS66011(estA)
 » show all
Reference
  Authors
Chang PK, Yabe K, Yu J
  Title
The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 70:3593-9 (2004)
DOI:10.1128/AEM.70.6.3593-3599.2004
  Sequence

KEGG   ENZYME: 3.1.1.94
Entry
EC 3.1.1.94                 Enzyme                                 
Name
versiconal hemiacetal acetate esterase;
VHA esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
versiconal-hemiacetal-acetate O-acetylhydrolase
Reaction(IUBMB)
(1) versiconal hemiacetal acetate + H2O = versiconal + acetate [RN:R10401];
(2) versiconol acetate + H2O = versiconol + acetate [RN:R10398]
Reaction(KEGG)
R10398 R10401
Substrate
versiconal hemiacetal acetate [CPD:C20505];
H2O [CPD:C00001];
versiconol acetate [CPD:C20506]
Product
versiconal [CPD:C20507];
acetate [CPD:C00033];
versiconol [CPD:C20508]
Comment
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
History
EC 3.1.1.94 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17648  versiconal hemiacetal acetate esterase
Genes
PANPODANSg8561
MTMMYCTH_54712
FGRFGSG_09112
FVRFVEG_03630 FVEG_07643
FOXFOXG_04573 FOXG_05758
NHENECHADRAFT_44040
SAPOSAPIO_CDS0298 SAPIO_CDS8256
SSLSS1G_01703
BFUBCIN_02g03480
MBEMBM_02254
PSCOLY89DRAFT_594986
GLZGLAREA_08109
ANIAN5565.2 AN7816.2
ACTACLA_062700
AORAO090026000017
ANGANI_1_1088094(An11g08610)
AFVAFLA_006302
APUUAPUU_10059S APUU_20047S
PCSPc22g19340
PNOSNOG_09866
PTEPTT_13757
BZECOCCADRAFT_3427
BSCCOCSADRAFT_131207
BORCOCMIDRAFT_32193
AALTCC77DRAFT_1033655
ZTRMYCGRDRAFT_77854
PFJMYCFIDRAFT_42424 MYCFIDRAFT_49459
FFUCLAFUR5_06057 CLAFUR5_14256
BCOMBAUCODRAFT_148152 BAUCODRAFT_307726
 » show all
Reference
1  [PMID:8776851]
  Authors
Kusumoto K, Hsieh DP
  Title
Purification and characterization of the esterases involved in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Can J Microbiol 42:804-10 (1996)
DOI:10.1139/m96-101
Reference
2  [PMID:15184162]
  Authors
Chang PK, Yabe K, Yu J
  Title
The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 70:3593-9 (2004)
DOI:10.1128/AEM.70.6.3593-3599.2004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.94
IUBMB Enzyme Nomenclature: 3.1.1.94
ExPASy - ENZYME nomenclature database: 3.1.1.94
BRENDA, the Enzyme Database: 3.1.1.94

KEGG   REACTION: R10398
Entry
R10398                      Reaction                               
Name
versiconol acetate O-acetylhydrolase
Definition
Versiconol acetate + H2O <=> Versiconol + Acetate
Equation
Reaction class
RC00020  C00033_C20506
RC00041  C20506_C20508
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K17648  versiconal hemiacetal acetate esterase [EC:3.1.1.94]
Other DBs
RHEA: 35722

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