KEGG   ORTHOLOGY: K17683
Entry
K17683            Tight     KO                                     

Name
CYP2A6
Definition
cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Pathway
ko00232  Caffeine metabolism
ko00830  Retinol metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis - DNA adducts
ko05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-  
     K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Other DBs
RN: R07000 R07001 R07945 R08225 R08324 R08325 R08326 R08327 R08390 R08391 R08392 R09408 R09421 R09423 R09424 R09425
Genes
HSA: 1548(CYP2A6) 1549(CYP2A7)
PTR: 107966456
GGO: 101146638
PON: 100457048
Reference
PMID:2726448 (CYP2A6)
  Authors
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR
  Title
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
  Journal
Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907
  Sequence
[hsa:1548]
Reference
PMID:7668294 (CYP2A7)
  Authors
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al.
  Title
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
  Journal
Am J Hum Genet 57:651-60 (1995)
  Sequence
[hsa:1549]
Reference
  Authors
Xu C, Goodz S, Sellers EM, Tyndale RF
  Title
CYP2A6 genetic variation and potential consequences.
  Journal
Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0

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