KEGG   ORTHOLOGY: K17754
Entry
K17754                      KO                                     
Symbol
cpnA
Name
cyclopentanol dehydrogenase [EC:1.1.1.163]
Pathway
map00930  Caprolactam degradation
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K17754  cpnA; cyclopentanol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.163  cyclopentanol dehydrogenase
     K17754  cpnA; cyclopentanol dehydrogenase
Other DBs
RN: R02229
GO: 0055041
Genes
SRHZ: FO014_11955
RBD: ALSL_0416
PPJ: RK21_02868
SNAN: I6N98_03905
POL: Bpro_5564
AJS: Ajs_2100
ADK: Alide2_4312
HPSE: HPF_13115(cpnA)
FLE: KI610_13570
NAF: GQ61_01095
PLA: Plav_1760
LABT: FIU93_30975(cpnA)
RUT: FIU92_22365(cpnA2)
SPSE: SULPSESMR1_04139(cpnA)
MALU: KU6B_59940
LVS: LOKVESSMR4R_03945(cpnA)
PMO: Pmob_0729
DTN: DTL3_0723(cpnA)
AG: BAC22653(cpnA)
 » show all
Reference
  Authors
Iwaki H, Hasegawa Y, Wang S, Kayser MM, Lau PC
  Title
Cloning and characterization of a gene cluster involved in cyclopentanol metabolism in Comamonas sp. strain NCIMB 9872 and biotransformations effected by Escherichia coli-expressed cyclopentanone 1,2-monooxygenase.
  Journal
Appl Environ Microbiol 68:5671-84 (2002)
DOI:10.1128/AEM.68.11.5671-5684.2002
  Sequence

KEGG   ENZYME: 1.1.1.163
Entry
EC 1.1.1.163                Enzyme                                 
Name
cyclopentanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cyclopentanol:NAD+ oxidoreductase
Reaction(IUBMB)
cyclopentanol + NAD+ = cyclopentanone + NADH + H+ [RN:R02553]
Reaction(KEGG)
R02553;
(other) R02229
Substrate
cyclopentanol [CPD:C02020];
NAD+ [CPD:C00003]
Product
cyclopentanone [CPD:C00557];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
4-Methylcyclohexanol and cyclohexanol can also act as substrates.
History
EC 1.1.1.163 created 1976
Pathway
ec00930  Caprolactam degradation
Orthology
K17754  cyclopentanol dehydrogenase
Genes
SRHZFO014_11955
RBDALSL_0416
PPJRK21_02868
SNANI6N98_03905
POLBpro_5564
AJSAjs_2100
ADKAlide2_4312
HPSEHPF_13115(cpnA)
FLEKI610_13570
NAFGQ61_01095
PLAPlav_1760
LABTFIU93_30975(cpnA)
CAULKCG34_11950
RUTFIU92_22365(cpnA2)
CONTQ29_18920
PABYGa0080574_TMP217
SUAMBOO69_22550
SULDB5M07_18390
SPSESULPSESMR1_04139(cpnA)
MALUKU6B_59940
LVSLOKVESSMR4R_03945(cpnA)
SBARH5V43_03335
SPOOJ3U78_20725
VCOPMM50RIKEN_16230
MSENK3U95_02715
GAMIIHQ52_01435
MHOSCXR34_00710
MSFIT882_15835
PBROHOP40_26490
TPAVHRQ91_01950
BHCJFL75_01600
SMISLDL76_09610
PMOPmob_0729
DTNDTL3_0723(cpnA)
 » show all
Reference
1  [PMID:4349113]
  Authors
Griffin M, Trudgill PW.
  Title
The metabolism of cyclopentanol by Pseudomonas N.C.I.B. 9872.
  Journal
Biochem J 129:595-603 (1972)
DOI:10.1042/bj1290595
Reference
2  [PMID:12406764]
  Authors
Iwaki H, Hasegawa Y, Wang S, Kayser MM, Lau PC
  Title
Cloning and characterization of a gene cluster involved in cyclopentanol metabolism in Comamonas sp. strain NCIMB 9872 and biotransformations effected by Escherichia coli-expressed cyclopentanone 1,2-monooxygenase.
  Journal
Appl Environ Microbiol 68:5671-84 (2002)
DOI:10.1128/AEM.68.11.5671-5684.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.163
IUBMB Enzyme Nomenclature: 1.1.1.163
ExPASy - ENZYME nomenclature database: 1.1.1.163
BRENDA, the Enzyme Database: 1.1.1.163
CAS: 37364-12-8

KEGG   REACTION: R02229
Entry
R02229                      Reaction                               
Name
cyclohexanol:NAD+ oxidoreductase
Definition
Cyclohexanone + NADH + H+ <=> Cyclohexanol + NAD+
Equation
Reaction class
RC00001  C00003_C00004
RC00144  C00414_C00854
Enzyme
1.1.1.163       1.1.1.245
Pathway
rn00930  Caprolactam degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K17754  cyclopentanol dehydrogenase [EC:1.1.1.163]
K19960  cyclohexanol dehydrogenase [EC:1.1.1.245]
Other DBs
RHEA: 10047

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