KEGG   ORTHOLOGY: K17754
Entry
K17754                      KO                                     
Symbol
cpnA
Name
cyclopentanol dehydrogenase [EC:1.1.1.163]
Pathway
map00930  Caprolactam degradation
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K17754  cpnA; cyclopentanol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.163  cyclopentanol dehydrogenase
     K17754  cpnA; cyclopentanol dehydrogenase
Other DBs
RN: R02229
GO: 0055041
Genes
SRHZ: FO014_11955
RBD: ALSL_0416
PPJ: RK21_02868
SNAN: I6N98_03905
POL: Bpro_5564
AJS: Ajs_2100
ATEM: PQV96_11850
ADK: Alide2_4312
HPSE: HPF_13115(cpnA)
HCZ: G9Q37_07260
FLE: KI610_13570
NAF: GQ61_01095
PLA: Plav_1760
LABT: FIU93_30975(cpnA)
CAUL: KCG34_11950
RUT: FIU92_22365(cpnA2)
CON: TQ29_18920
PABY: Ga0080574_TMP217
SUAM: BOO69_22550
SULD: B5M07_18390
SPSE: SULPSESMR1_04139(cpnA)
MALU: KU6B_59940
PVER: E3U25_08870
LVS: LOKVESSMR4R_03945(cpnA)
SBAR: H5V43_03335
VCOP: MM50RIKEN_16230
MSEN: K3U95_02715
GAMI: IHQ52_01435
MHOS: CXR34_00710
MSF: IT882_15835
BSPO: L1F31_01630
PBRO: HOP40_26490
TPAV: HRQ91_01950
BHC: JFL75_01600
PMO: Pmob_0729
DTN: DTL3_0723(cpnA)
AG: BAC22653(cpnA)
 » show all
Reference
PMID:12406764
  Authors
Iwaki H, Hasegawa Y, Wang S, Kayser MM, Lau PC
  Title
Cloning and characterization of a gene cluster involved in cyclopentanol metabolism in Comamonas sp. strain NCIMB 9872 and biotransformations effected by Escherichia coli-expressed cyclopentanone 1,2-monooxygenase.
  Journal
Appl Environ Microbiol 68:5671-84 (2002)
DOI:10.1128/AEM.68.11.5671-5684.2002
  Sequence
[ag:BAC22653]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (175)   
   KEGG GENES (37)   
   KEGG MGENES (136)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (186)   

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KEGG   ENZYME: 1.1.1.163
Entry
EC 1.1.1.163                Enzyme                                 
Name
cyclopentanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cyclopentanol:NAD+ oxidoreductase
Reaction(IUBMB)
cyclopentanol + NAD+ = cyclopentanone + NADH + H+ [RN:R02553]
Reaction(KEGG)
R02553;
(other) R02229
Substrate
cyclopentanol [CPD:C02020];
NAD+ [CPD:C00003]
Product
cyclopentanone [CPD:C00557];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
4-Methylcyclohexanol and cyclohexanol can also act as substrates.
History
EC 1.1.1.163 created 1976
Pathway
ec00930  Caprolactam degradation
Orthology
K17754  cyclopentanol dehydrogenase
Genes
SRHZ: FO014_11955
RBD: ALSL_0416
PPJ: RK21_02868
SNAN: I6N98_03905
POL: Bpro_5564
AJS: Ajs_2100
ATEM: PQV96_11850
ADK: Alide2_4312
HPSE: HPF_13115(cpnA)
HCZ: G9Q37_07260
FLE: KI610_13570
NAF: GQ61_01095
PLA: Plav_1760
LABT: FIU93_30975(cpnA)
CAUL: KCG34_11950
RUT: FIU92_22365(cpnA2)
CON: TQ29_18920
PABY: Ga0080574_TMP217
SUAM: BOO69_22550
SULD: B5M07_18390
SPSE: SULPSESMR1_04139(cpnA)
MALU: KU6B_59940
PVER: E3U25_08870
LVS: LOKVESSMR4R_03945(cpnA)
SBAR: H5V43_03335
VCOP: MM50RIKEN_16230
MSEN: K3U95_02715
GAMI: IHQ52_01435
MHOS: CXR34_00710
MSF: IT882_15835
BSPO: L1F31_01630
PBRO: HOP40_26490
TPAV: HRQ91_01950
BHC: JFL75_01600
PMO: Pmob_0729
DTN: DTL3_0723(cpnA)
 » show all
Reference
1  [PMID:4349113]
  Authors
Griffin M, Trudgill PW.
  Title
The metabolism of cyclopentanol by Pseudomonas N.C.I.B. 9872.
  Journal
Biochem J 129:595-603 (1972)
DOI:10.1042/bj1290595
Reference
2  [PMID:12406764]
  Authors
Iwaki H, Hasegawa Y, Wang S, Kayser MM, Lau PC
  Title
Cloning and characterization of a gene cluster involved in cyclopentanol metabolism in Comamonas sp. strain NCIMB 9872 and biotransformations effected by Escherichia coli-expressed cyclopentanone 1,2-monooxygenase.
  Journal
Appl Environ Microbiol 68:5671-84 (2002)
DOI:10.1128/AEM.68.11.5671-5684.2002
  Sequence
[ag:BAC22653]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.163
IUBMB Enzyme Nomenclature: 1.1.1.163
ExPASy - ENZYME nomenclature database: 1.1.1.163
BRENDA, the Enzyme Database: 1.1.1.163
CAS: 37364-12-8

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (174)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (37)   
   KEGG MGENES (136)   
Protein sequence (985)   
   UniProt (983)   
   SWISS-PROT (2)   
DNA sequence (1380)   
   GenBank (718)   
   EMBL (662)   
Protein domain (2)   
   InterPro (2)   
All databases (2553)   

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KEGG   REACTION: R02229
Entry
R02229                      Reaction                               
Name
cyclohexanol:NAD+ oxidoreductase
Definition
Cyclohexanone + NADH + H+ <=> Cyclohexanol + NAD+
Equation
C00414 + C00004 + C00080 <=> C00854 + C00003
Reaction class
RC00001  C00003_C00004
RC00144  C00414_C00854
Enzyme
1.1.1.163       1.1.1.245
Pathway
rn00930  Caprolactam degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K17754  cyclopentanol dehydrogenase [EC:1.1.1.163]
K19960  cyclohexanol dehydrogenase [EC:1.1.1.245]
Other DBs
RHEA: 10047

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
   UMBBD-RN (1)   
Gene (40)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (38)   
All databases (58)   

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