KEGG   ORTHOLOGY: K18057
Entry
K18057                      KO                                     
Symbol
pntD, penD, ptlD
Name
pentalenolactone F synthase [EC:1.14.11.36]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K18057  pntD, penD, ptlD; pentalenolactone F synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.36  pentalenolactone F synthase
     K18057  pntD, penD, ptlD; pentalenolactone F synthase
Other DBs
RN: R10145
COG: COG2175
Genes
SMA: SAVERM_2995(ptlD)
SBH: SBI_09677
SCI: B446_29685
SCW: TU94_27395
SLE: sle_13180(sle_13180)
SSIA: A7J05_09250
SGJ: IAG43_27145
SHK: J2N69_35815
Reference
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence

KEGG   ENZYME: 1.14.11.36
Entry
EC 1.14.11.36               Enzyme                                 
Name
pentalenolactone F synthase;
penD (gene name);
pntD (gene name);
ptlD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction) [RN:R10145];
(1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O [RN:R10143];
(1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 [RN:R10144]
Reaction(KEGG)
Substrate
pentalenolactone D [CPD:C20399];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
pentalenolactone E [CPD:C20398]
Product
pentalenolactone F [CPD:C20397];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001];
pentalenolactone E [CPD:C20398]
Comment
Requires Fe(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway.
History
EC 1.14.11.36 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18057  pentalenolactone F synthase
Genes
SMASAVERM_2995(ptlD)
SBHSBI_09677
SCIB446_29685
SCWTU94_27395
SLEsle_13180(sle_13180)
SSIAA7J05_09250
SGJIAG43_27145
SHKJ2N69_35815
Reference
1  [PMID:21250661]
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.36
IUBMB Enzyme Nomenclature: 1.14.11.36
ExPASy - ENZYME nomenclature database: 1.14.11.36
BRENDA, the Enzyme Database: 1.14.11.36

KEGG   REACTION: R10145
Entry
R10145                      Reaction                               
Name
pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase
Definition
Pentalenolactone D + 2 2-Oxoglutarate + 2 Oxygen <=> Pentalenolactone F + 2 Succinate + 2 CO2 + H2O
Equation
C20399 + 2 C00026 + 2 C00007 <=> C20397 + 2 C00042 + 2 C00011 + C00001
Comment
two-step reaction (see R10143+R10144)
Reaction class
RC03061  C20397_C20399
Enzyme
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Orthology
K18057  pentalenolactone F synthase [EC:1.14.11.36]
Other DBs
RHEA: 34582

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