KEGG   ORTHOLOGY: K18067
Entry
K18067                      KO                                     
Symbol
pht4
Name
phthalate 4,5-cis-dihydrodiol dehydrogenase [EC:1.3.1.64]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00623  Phthalate degradation, phthalate => protocatechuate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18067  pht4; phthalate 4,5-cis-dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.64  phthalate 4,5-cis-dihydrodiol dehydrogenase
     K18067  pht4; phthalate 4,5-cis-dihydrodiol dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18067
Other DBs
RN: R05275
GO: 0018517
Genes
PLUL: FOB45_02785
HAM: HALO0376
HSR: HSBAA_48110
HMD: CTT34_16675
HSX: HNO51_14910
MPRF: J8N69_04560
MGEO: CFI10_14940
CVI: CV_1407
CVC: BKX93_20060
CHRI: DK842_14610
CNC: CNE_2c21270(pht2)
BMJ: BMULJ_03711(ophB)
BMU: Bmul_4806
BMK: DM80_4021
BFN: OI25_3031
BPT: Bpet0249
BHZ: ACR54_04436(pht4)
POL: Bpro_1908
PNA: Pnap_4623
VEI: Veis_2924
CTES: O987_21845
LIM: L103DPR2_01699(pht4_1) L103DPR2_02575(pht4_2)
MMED: Mame_05094(pht4)
LABT: FIU93_07210(pht2)
CID: P73_2965
RID: RIdsm_00903(pht4)
ROT: FIV09_12215(pht3)
SPHR: BSY17_4183
MMC: Mmcs_5443
MGI: Mflv_0624
MGAD: MGAD_31770
AG: BAA02512(pht4)
 » show all
Reference
  Authors
Nomura Y, Nakagawa M, Ogawa N, Harashima S, Oshima Y
  Title
Genes in PHT plasmid encoding the initial degradation pathway of phthalate in Pseudomonas putida.
  Journal
J Ferment Bioeng 74:333-344 (1992)
DOI:10.1016/0922-338X(92)90028-S
  Sequence

KEGG   ENZYME: 1.3.1.64
Entry
EC 1.3.1.64                 Enzyme                                 
Name
phthalate 4,5-cis-dihydrodiol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+ [RN:R05275]
Reaction(KEGG)
R05275
Substrate
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]
Product
4,5-dihydroxyphthalate [CPD:C03233];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the phthalate degradation pathway in bacteria.
History
EC 1.3.1.64 created 2000
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18067  phthalate 4,5-cis-dihydrodiol dehydrogenase
Genes
PLULFOB45_02785
HAMHALO0376
HSRHSBAA_48110
HMDCTT34_16675
HSXHNO51_14910
MPRFJ8N69_04560
MGEOCFI10_14940
CVICV_1407
CVCBKX93_20060
CHRIDK842_14610
CHRBDK843_20170
RPFRpic12D_2780 Rpic12D_4959
CNCCNE_2c21270(pht2)
BVIBcep1808_4272
BMJBMULJ_03711(ophB)
BMUBmul_4806
BMKDM80_4021
BYIBYI23_B001660 BYI23_D008170
BUEBRPE67_BCDS04050 BRPE67_DCDS10090
BFNOI25_3031
BCAIK788_0000442
PHSC2L64_49420
BUOBRPE64_DCDS03570 BRPE64_DCDS07100
BPTBpet0249
BHZACR54_04436(pht4)
BBROBAU06_03765
BFZBAU07_15850
BPDZBBN53_00970
BOHAKI39_21315
PIGEGT29_25715
RHYRD110_25730
POLBpro_1908
PNAPnap_4623
POSDT070_20435
POOF7R28_10140
ACIDCBP33_05515
ACIPCBP36_05965 CBP36_20390
ACINCBP34_05350
ACISCBP35_12980
VEIVeis_2924
DELDelCs14_1659
CTTCtCNB1_1487
CTESO987_21845
OTKC6570_10600
LIML103DPR2_01699(pht4_1) L103DPR2_02575(pht4_2)
HYRBSY239_3462
HYNF9K07_27565
HTNKI616_03500 KI616_03540
MASWAM586_27435 AM586_27600 AM586_27665
ABAWD5400_03690 D5400_20245
BVVBHK69_01750
BOIBLM15_16150
LNEFZC33_27460
MOCBB934_42765
MIVC4E04_17825
RHZRHPLAN_09750 RHPLAN_11140
DSALK1X15_01470
MMEDMame_05094(pht4)
PSINCAK95_02255 CAK95_05905
LABTFIU93_07210(pht2)
CIDP73_2965
CEHCEW89_13895
TPROGa0080559_TMP5106
PABYGa0080574_TMP2100
RIDRIdsm_00903(pht4)
ROTFIV09_12215(pht3)
RMHLVO79_19205
HDHG5B40_16615
NORFA702_15520
NDRHT578_08885
SPHRBSY17_4183
SHYDCJD35_19415 CJD35_19640
SPHJBSL82_13975
CNAAB433_10230
POTE2E27_18195
RMTIAI58_16240
PPSCEHS13_03485
PRZGZH47_26560
MMCMmcs_5443
MKMMkms_5612 Mkms_5840
MYEAB431_15435
MGAUMGALJ_00490
MPAEK0O64_27355
MGIMflv_0624
MGADMGAD_31770
RKOJWS14_17115
AREAL755_04590
AAQAOC05_01465
PSNINIBR502771_04435
RMARGBA65_17505
 » show all
Reference
1  [PMID:3805038]
  Authors
Batie CJ, LaHaie E, Ballou DP.
  Title
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
  Journal
J Biol Chem 262:1510-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.64
IUBMB Enzyme Nomenclature: 1.3.1.64
ExPASy - ENZYME nomenclature database: 1.3.1.64
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.64
BRENDA, the Enzyme Database: 1.3.1.64

KEGG   REACTION: R05275
Entry
R05275                      Reaction                               
Name
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase
Definition
cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ <=> 4,5-Dihydroxyphthalate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00386  C03233_C04783
Enzyme
Pathway
rn00624  Polycyclic aromatic hydrocarbon degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00623  Phthalate degradation, phthalate => protocatechuate
Orthology
K18067  phthalate 4,5-cis-dihydrodiol dehydrogenase [EC:1.3.1.64]
Other DBs
RHEA: 13840

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