KEGG   ORTHOLOGY: K18108
Entry
K18108                      KO                                     

Name
E4.2.3.111
Definition
(-)-alpha-terpineol synthase [EC:4.2.3.111]
Pathway
ko00902  Monoterpenoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K18108  E4.2.3.111; (-)-alpha-terpineol synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.111  (-)-alpha-terpineol synthase
     K18108  E4.2.3.111; (-)-alpha-terpineol synthase
Other DBs
RN: R06421
Genes
VVI: 100232956 100854267 100855144
Reference
  Authors
Martin DM, Bohlmann J
  Title
Identification of Vitis vinifera (-)-alpha-terpineol synthase by in silico screening of full-length cDNA ESTs and functional characterization of recombinant terpene synthase.
  Journal
Phytochemistry 65:1223-9 (2004)
DOI:10.1016/j.phytochem.2004.03.018
  Sequence
[vvi:100232956]

KEGG   ENZYME: 4.2.3.111
Entry
EC 4.2.3.111                Enzyme                                 

Name
(-)-alpha-terpineol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-terpineol-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (-)-alpha-terpineol + diphosphate [RN:R06421]
Reaction(KEGG)
R06421
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(-)-alpha-terpineol [CPD:C11393];
diphosphate [CPD:C00013]
Comment
The enzyme has been characterized from Vitis vinifera (grape). Also forms some 1,8-cineole and traces of other monoterpenoids.
History
EC 4.2.3.111 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18108  (-)-alpha-terpineol synthase
Genes
VVI: 100232956 100854267 100855144
Reference
1  [PMID:15184006]
  Authors
Martin DM, Bohlmann J
  Title
Identification of Vitis vinifera (-)-alpha-terpineol synthase by in silico screening of full-length cDNA ESTs and functional characterization of recombinant terpene synthase.
  Journal
Phytochemistry 65:1223-9 (2004)
DOI:10.1016/j.phytochem.2004.03.018
  Sequence
[vvi:100232956]
Reference
2  [PMID:15464152]
  Authors
Lucker J, Bowen P, Bohlmann J
  Title
Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries.
  Journal
Phytochemistry 65:2649-59 (2004)
DOI:10.1016/j.phytochem.2004.08.017
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.111
IUBMB Enzyme Nomenclature: 4.2.3.111
ExPASy - ENZYME nomenclature database: 4.2.3.111
BRENDA, the Enzyme Database: 4.2.3.111

KEGG   REACTION: R06421
Entry
R06421                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-terpineol-forming]
Definition
Geranyl diphosphate + H2O <=> (-)-alpha-Terpineol + Diphosphate
Equation
Comment
subsequently R06422
Reaction class
RC02773  C00341_C11393
Enzyme
4.2.3.108       4.2.3.111
Pathway
rn00902  Monoterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K07385  1,8-cineole synthase [EC:4.2.3.108]
K18108  (-)-alpha-terpineol synthase [EC:4.2.3.111]
Other DBs
RHEA: 32554

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