KEGG   ORTHOLOGY: K18275
Entry
K18275                      KO                                     
Symbol
phdK
Name
2-formylbenzoate dehydrogenase [EC:1.2.1.78]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18275  phdK; 2-formylbenzoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.78  2-formylbenzoate dehydrogenase
     K18275  phdK; 2-formylbenzoate dehydrogenase
Other DBs
RN: R05643
Genes
SENP: KHA73_20375
SLIG: GTU79_17835
HSX: HNO51_14960
NKI: KW403_13540
MMAN: MMAN_42220(gbsA)
MMC: Mmcs_1663
MKM: Mkms_1687 Mkms_5636
MJL: Mjls_1636
MYE: AB431_15525
MGAU: MGALJ_00300
MVA: Mvan_0522
MGI: Mflv_0643
MTY: MTOK_55630(dhaS)
MGAD: MGAD_31960(betB)
AG: BAA23265(phdK)
 » show all
Reference
PMID:9335300
  Authors
Iwabuchi T, Harayama S
  Title
Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7.
  Journal
J Bacteriol 179:6488-94 (1997)
DOI:10.1128/JB.179.20.6488-6494.1997
  Sequence

KEGG   ENZYME: 1.2.1.78
Entry
EC 1.2.1.78                 Enzyme                                 
Name
2-formylbenzoate dehydrogenase;
2-carboxybenzaldehyde dehydrogenase;
2CBAL dehydrogenase;
PhdK
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-formylbenzoate:NAD+ oxidoreductase
Reaction(IUBMB)
2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ [RN:R05643]
Reaction(KEGG)
R05643
Substrate
2-formylbenzoate [CPD:C03057];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
o-phthalic acid [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is involved in phenanthrene degradation.
History
EC 1.2.1.78 created 2010
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K18275  2-formylbenzoate dehydrogenase
Genes
SENPKHA73_20375
SLIGGTU79_17835
HSXHNO51_14960
NKIKW403_13540
MMANMMAN_42220(gbsA)
MMCMmcs_1663
MKMMkms_1687 Mkms_5636
MJLMjls_1636
MYEAB431_15525
MGAUMGALJ_00300
MPAEK0O64_27450
MCROMI149_00805
MVAMvan_0522
MGIMflv_0643
MSPMspyr1_01810
MRHMycrhN_3178
MTYMTOK_55630(dhaS)
MGADMGAD_31960(betB)
SBATG4Z16_01300
MSEDE3O41_13870
ASUFMNQ99_01420
APNAsphe3_40220
AGRAAGRA3207_001969
DROSDrose_13945
RMARGBA65_17430
 » show all
Reference
1  [PMID:9335300]
  Authors
Iwabuchi T, Harayama S
  Title
Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7.
  Journal
J Bacteriol 179:6488-94 (1997)
DOI:10.1128/JB.179.20.6488-6494.1997
  Sequence
Reference
2
  Authors
Kiyohara, H., Nagao, K. and Yano, K.
  Title
Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene.
  Journal
J Gen Appl Microbiol 27:443-455 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.78
IUBMB Enzyme Nomenclature: 1.2.1.78
ExPASy - ENZYME nomenclature database: 1.2.1.78
BRENDA, the Enzyme Database: 1.2.1.78

KEGG   REACTION: R05643
Entry
R05643                      Reaction                               
Name
2-formylbenzoate:NAD+ oxidoreductase
Definition
2-Carboxybenzaldehyde + NAD+ + H2O <=> Phthalate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00075  C01606_C03057
Enzyme
Pathway
rn00624  Polycyclic aromatic hydrocarbon degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K18275  2-formylbenzoate dehydrogenase [EC:1.2.1.78]
Other DBs
RHEA: 27301

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