KEGG   ORTHOLOGY: K18562
Entry
K18562                      KO                                     

Name
thnQ, cmmQ
Definition
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18562  thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.-  
     K18562  thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase
Other DBs
RN: R10415 R10735
Genes
SCT: SCAT_p0836(thnQ)
SCY: SCATT_p08990
SFA: Sfla_0152
STRP: F750_6869
Reference
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319

KEGG   REACTION: R10415
Entry
R10415                      Reaction                               

Name
(3S,5S)-carbapenam-3-carboxylate,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
Definition
(3S,5S)-Carbapenam-3-carboxylic acid + 2-Oxoglutarate + Oxygen <=> (5R)-Carbapen-2-em-3-carboxylate + Succinate + CO2 + H2O
Equation
Reaction class
RC03174  C06669_C17367
Enzyme
1.14.20.3       1.14.20.-
Pathway
rn00332  Carbapenem biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Orthology
K18315  (5R)-carbapenem-3-carboxylate synthase [EC:1.14.20.3]
K18562  2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Other DBs
RHEA: 36614

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