KEGG   ORTHOLOGY: K18565
Entry
K18565                      KO                                     

Name
thnG, cmmG
Definition
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
ko00332  Carbapenem biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18565  thnG, cmmG; 2-oxoglutarate-dependent dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.-  
     K18565  thnG, cmmG; 2-oxoglutarate-dependent dioxygenase
Other DBs
RN: R10740 R10741 R10742
Genes
SCT: SCAT_p0826(thnG)
SCY: SCATT_p09090
SFA: Sfla_0162
STRP: F750_6859
Reference
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319

KEGG   REACTION: R10742
Entry
R10742                      Reaction                               

Name
epithienamycin-E,2-oxoglutarate:oxygen oxidoreductase (sulfoxidation)
Definition
Epithienamycin E + 2-Oxoglutarate + Oxygen <=> MM 4550 + Succinate + CO2
Equation
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC03269  C11755_C20815
Enzyme
1.14.20.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K18565  2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319

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