KEGG   ORTHOLOGY: K18572
Entry
K18572                      KO                                     

Name
cmmT, thnT
Definition
putative pantetheine hydrolase [EC:3.5.1.-]
Pathway
ko00332  Carbapenem biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18572  cmmT, thnT; putative pantetheine hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     K18572  cmmT, thnT; putative pantetheine hydrolase
Other DBs
RN: R10752
Genes
SCT: SCAT_p0839(thnT)
SCY: SCATT_p08960
SFA: Sfla_0149
SBH: SBI_06476
STRP: F750_6873
Reference
  Authors
Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA
  Title
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:11128-33 (2008)
DOI:10.1073/pnas.0804500105
  Sequence
Reference
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319

KEGG   REACTION: R10752
Entry
R10752                      Reaction                               

Name
OA-6129-C amidohydrolase
Definition
OA-6129 C + H2O <=> Deacetylepithienamycin F + Pantothenate
Equation
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC00090  C00864_C20814
RC00096  C20814_C20816
Enzyme
3.5.1.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K18572  putative pantetheine hydrolase [EC:3.5.1.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319

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