KEGG   ORTHOLOGY: K18684
Entry
K18684                      KO                                     
Symbol
ALOXE3
Name
hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
Disease
H00734  Autosomal recessive congenital ichthyosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K18684  ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.152  hydroperoxy icosatetraenoate dehydratase
     K18684  ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.4  Transferring hydroxy groups
    5.4.4.7  hydroperoxy icosatetraenoate isomerase
     K18684  ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase
Other DBs
RN: R07039 R07040 R10761 R10766 R13044 R13045
GO: 0106256 0106255
Genes
HSA: 59344(ALOXE3)
PTR: 455102(ALOXE3)
PPS: 100972484(ALOXE3)
GGO: 101143347(ALOXE3)
PON: 100451294(ALOXE3)
NLE: 100586195
MCC: 716840(ALOXE3)
MCF: 102115677(ALOXE3)
MTHB: 126939828
CSAB: 103242340(ALOXE3)
CATY: 105581968(ALOXE3)
PANU: 101015325(ALOXE3)
TGE: 112609608(ALOXE3)
RRO: 104661680(ALOXE3)
RBB: 108514454(ALOXE3)
TFN: 117067738(ALOXE3)
PTEH: 111527078(ALOXE3)
CANG: 105523640(ALOXE3)
CJC: 100410917(ALOXE3)
SBQ: 101049071(ALOXE3)
CSYR: 103263442(ALOXE3)
MMUR: 105877288(ALOXE3)
LCAT: 123650919(ALOXE3)
PCOQ: 105819408(ALOXE3)
OGA: 100958391(ALOXE3)
MMU: 23801(Aloxe3)
MCAL: 110305086(Aloxe3)
MPAH: 110332034(Aloxe3)
RNO: 287424(Aloxe3)
MCOC: 116078132(Aloxe3)
MUN: 110551722(Aloxe3)
CGE: 100754187(Aloxe3)
MAUA: 101838996(Aloxe3)
PLEU: 114693158(Aloxe3)
MORG: 121457114(Aloxe3)
MFOT: 126514115
AAMP: 119812707(Aloxe3)
NGI: 103752100(Aloxe3)
HGL: 101709560(Aloxe3)
CPOC: 100731721(Aloxe3)
CCAN: 109693886(Aloxe3)
DORD: 105983368(Aloxe3)
DSP: 122100410(Aloxe3)
NCAR: 124980809
OCU: 100342323
OPI: 101524657(ALOXE3)
TUP: 102493953(ALOXE3)
GVR: 103597843(ALOXE3)
CFA: 489487(ALOXE3)
CLUD: 112647409(ALOXE3)
VVP: 112924867(ALOXE3)
VLG: 121500136(ALOXE3)
AML: 100479842(ALOXE3)
UMR: 103660488(ALOXE3)
UAH: 113271146(ALOXE3)
UAR: 123792055(ALOXE3)
ELK: 111161151
LLV: 125088017
MPUF: 101671256(ALOXE3)
ORO: 101371570(ALOXE3)
EJU: 114225375(ALOXE3)
ZCA: 113939629(ALOXE3)
MLX: 118000045(ALOXE3)
NSU: 110584484(ALOXE3)
LWW: 102728543(ALOXE3)
FCA: 101101515(ALOXE3)
PYU: 121015957(ALOXE3)
PBG: 122484921(ALOXE3)
LRUF: 124519582
PPAD: 109245905(ALOXE3)
AJU: 106972447(ALOXE3)
HHV: 120231419(ALOXE3)
BTA: 517001(ALOXE3)
BOM: 102276466(ALOXE3)
BIU: 109573427(ALOXE3)
BBUB: 102408112(ALOXE3)
BBIS: 104990749(ALOXE3)
CHX: 102173227(ALOXE3)
OAS: 101121693(ALOXE3)
ODA: 120866020(ALOXE3)
CCAD: 122445980(ALOXE3)
SSC: 100511043(ALOXE3)
CFR: 102517831(ALOXE3)
CBAI: 105077530(ALOXE3)
CDK: 105103062
VPC: 102528339(ALOXE3)
BACU: 102998369(ALOXE3)
OOR: 101281475
DLE: 111185793(ALOXE3)
PCAD: 102992018
ECB: 100062351(ALOXE3)
EPZ: 103564279(ALOXE3)
EAI: 106844234(ALOXE3)
MYB: 102250064(ALOXE3)
MYD: 102763007(ALOXE3)
MMYO: 118672110(ALOXE3)
MLF: 102435376(ALOXE3)
MNA: 107544535(ALOXE3)
PKL: 118726788
HAI: 109395102(ALOXE3)
DRO: 112308514(ALOXE3)
SHON: 118974644
AJM: 119049055(ALOXE3)
PDIC: 114515164
PHAS: 123809290(ALOXE3)
MMF: 118634238(ALOXE3)
RFQ: 117013451(ALOXE3)
PALE: 102893198(ALOXE3)
PGIG: 120589697(ALOXE3)
PVP: 105291240(ALOXE3)
RAY: 107515646(ALOXE3)
MJV: 108409698(ALOXE3)
TOD: 119232234(ALOXE3)
SARA: 101554994(ALOXE3)
LAV: 100671875(ALOXE3)
TMU: 101348431
ETF: 101660496
DNM: 101433166(ALOXE3)
MDO: 100014706(ALOXE3)
GAS: 123243987(ALOXE3)
SHR: 100934620(ALOXE3)
PCW: 110194412
OAA: 100078389(ALOXE3)
GGA: 425997(ALOX15B)
CJO: 107314128
NMEL: 110401191
ACYG: 106049819
TGU: 115493074
SCAN: 103824640
PMOA: 120503612
OTC: 121337727
PRUF: 121357289
GFR: 102043765(ALOXE3)
FAB: 101818404(ALOXE3) 101820391
PMAJ: 107198965
CCAE: 111942155
CCW: 120412173
CBRC: 103625181
ETL: 114071482
ZAB: 102064963
NNI: 104022923
PLET: 104621328
PCRI: 104030873
TALA: 116963178
AGEN: 126037044
GCL: 127028893
CCRI: 104154924
LDI: 104350827
ACAR: 114818373
AVIT: 104280152
AAM: 106484843 106500300(ALOXE3)
SCAM: 104142868
AMJ: 102558959(ALOXE3) 102564354
PSS: 102450844
XTR: 100494252(alox15b) 100494678 100496875 116408939 548458(alox12b)
BGAR: 122924120
DRE: 794132(si:dkey-17e16.9)
SRX: 107756080
SGH: 107548144
CAUA: 113038569
MAMB: 125253227(si:dkey-17e16.9)
EEE: 113590746
NCC: 104945566 104965473(b3gntl1)
ECRA: 117961557(si:dkey-17e16.9)
ESP: 116705832
OML: 112158170
GAF: 122825686
CVG: 107086029
CTUL: 119795946
NFU: 107374447
KMR: 108228955(zgc:152891) 108240061
NWH: 119418224
POV: 109636209
LCF: 108880880(si:dkey-17e16.9) 108891324(zgc:152891)
XGL: 120788899(si:dkey-17e16.9) 120802480(zgc:152891)
HCQ: 109527797
MALB: 109955487
ONE: 115139270
CCLU: 121549254
SFM: 108925302
ARUT: 117396925
LCM: 102352103
PJA: 122248285
PCHN: 125029265
HAZT: 108675024
VDE: 111245717
VJA: 111262905
CRG: 105319482
MYI: 110442376
PMAX: 117321221
ATEN: 116292301
XEN: 124451873
SLY: 101244897
 » show all
Reference
  Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
  Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
  Journal
Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002
  Sequence
[hsa:59344] [mmu:23801]

KEGG   ENZYME: 5.4.4.7
Entry
EC 5.4.4.7                  Enzyme                                 
Name
hydroperoxy icosatetraenoate isomerase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)
Class
Isomerases;
Intramolecular transferases;
Transferring hydroxy groups
Sysname
hydroperoxyicosatetraenoate hydroxymutase
Reaction(IUBMB)
a hydroperoxyicosatetraenoate = a hydroxyepoxyicosatrienoate [RN:R10766]
Reaction(KEGG)
R10766 > R07039 R07040
Substrate
hydroperoxyicosatetraenoate [CPD:C20832]
Product
hydroxyepoxyicosatrienoate [CPD:C20837]
Comment
Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxyicosatetraenoates producing one or several different hydroxyepoxyicosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate [1]. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate [2]. The enzymes also have the activity of EC 4.2.1.152, hydroperoxy icosatetraenoate dehydratase.
History
EC 5.4.4.7 created 2014
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K18684  hydroperoxy icosatetraenoate dehydratase/isomerase
Genes
HSA59344(ALOXE3)
PTR455102(ALOXE3)
PPS100972484(ALOXE3)
GGO101143347(ALOXE3)
PON100451294(ALOXE3)
NLE100586195
MCC716840(ALOXE3)
MCF102115677(ALOXE3)
MTHB126939828
CSAB103242340(ALOXE3)
CATY105581968(ALOXE3)
PANU101015325(ALOXE3)
TGE112609608(ALOXE3)
RRO104661680(ALOXE3)
RBB108514454(ALOXE3)
TFN117067738(ALOXE3)
PTEH111527078(ALOXE3)
CANG105523640(ALOXE3)
CJC100410917(ALOXE3)
SBQ101049071(ALOXE3)
CSYR103263442(ALOXE3)
MMUR105877288(ALOXE3)
LCAT123650919(ALOXE3)
PCOQ105819408(ALOXE3)
OGA100958391(ALOXE3)
MMU23801(Aloxe3)
MCAL110305086(Aloxe3)
MPAH110332034(Aloxe3)
RNO287424(Aloxe3)
MCOC116078132(Aloxe3)
MUN110551722(Aloxe3)
CGE100754187(Aloxe3)
MAUA101838996(Aloxe3)
PLEU114693158(Aloxe3)
MORG121457114(Aloxe3)
MFOT126514115
AAMP119812707(Aloxe3)
NGI103752100(Aloxe3)
HGL101709560(Aloxe3)
CPOC100731721(Aloxe3)
CCAN109693886(Aloxe3)
DORD105983368(Aloxe3)
DSP122100410(Aloxe3)
NCAR124980809
OCU100342323
OPI101524657(ALOXE3)
TUP102493953(ALOXE3)
GVR103597843(ALOXE3)
CFA489487(ALOXE3)
CLUD112647409(ALOXE3)
VVP112924867(ALOXE3)
VLG121500136(ALOXE3)
AML100479842(ALOXE3)
UMR103660488(ALOXE3)
UAH113271146(ALOXE3)
UAR123792055(ALOXE3)
ELK111161151
LLV125088017
MPUF101671256(ALOXE3)
ORO101371570(ALOXE3)
EJU114225375(ALOXE3)
ZCA113939629(ALOXE3)
MLX118000045(ALOXE3)
NSU110584484(ALOXE3)
LWW102728543(ALOXE3)
FCA101101515(ALOXE3)
PYU121015957(ALOXE3)
PBG122484921(ALOXE3)
LRUF124519582
PPAD109245905(ALOXE3)
AJU106972447(ALOXE3)
HHV120231419(ALOXE3)
BTA517001(ALOXE3)
BOM102276466(ALOXE3)
BIU109573427(ALOXE3)
BBUB102408112(ALOXE3)
BBIS104990749(ALOXE3)
CHX102173227(ALOXE3)
OAS101121693(ALOXE3)
ODA120866020(ALOXE3)
CCAD122445980(ALOXE3)
SSC100511043(ALOXE3)
CFR102517831(ALOXE3)
CBAI105077530(ALOXE3)
CDK105103062
VPC102528339(ALOXE3)
BACU102998369(ALOXE3)
OOR101281475
DLE111185793(ALOXE3)
PCAD102992018
ECB100062351(ALOXE3)
EPZ103564279(ALOXE3)
EAI106844234(ALOXE3)
MYB102250064(ALOXE3)
MYD102763007(ALOXE3)
MMYO118672110(ALOXE3)
MLF102435376(ALOXE3)
MNA107544535(ALOXE3)
PKL118726788
HAI109395102(ALOXE3)
DRO112308514(ALOXE3)
SHON118974644
AJM119049055(ALOXE3)
PDIC114515164
PHAS123809290(ALOXE3)
MMF118634238(ALOXE3)
RFQ117013451(ALOXE3)
PALE102893198(ALOXE3)
PGIG120589697(ALOXE3)
PVP105291240(ALOXE3)
RAY107515646(ALOXE3)
MJV108409698(ALOXE3)
TOD119232234(ALOXE3)
SARA101554994(ALOXE3)
LAV100671875(ALOXE3)
TMU101348431
ETF101660496
DNM101433166(ALOXE3)
MDO100014706(ALOXE3)
GAS123243987(ALOXE3)
SHR100934620(ALOXE3)
PCW110194412
OAA100078389(ALOXE3)
GGA425997(ALOX15B)
CJO107314128
NMEL110401191
ACYG106049819
TGU115493074
LSR110480955 110482566
SCAN103824640
PMOA120503612
OTC121337727
PRUF121357289
GFR102043765(ALOXE3)
FAB101818404(ALOXE3) 101820391
PHI102104136 102111055
PMAJ107198965
CCAE111942155
CCW120412173
CBRC103625181
ETL114071482
ZAB102064963
NNI104022923
PLET104621328
PCRI104030873
TALA116963178
ACHC115337612 115337613
HLE104834235 104836076
AGEN126037044
GCL127028893
CCRI104154924
LDI104350827
ACAR114818373
AVIT104280152
AAM106484843 106500300(ALOXE3)
AROW112962918 112972483
SCAM104142868
ASN102375634 102379888
AMJ102558959(ALOXE3) 102564354
PSS102450844
CMY102946032 102946254 114018354 119564589 119564653
CPIC101934678 101943453 101947851 101948565 101952038(ALOX12B)
TST117869933 117869934 117869955 117870000 117870107
CABI116839650 116839651
MRV120381499 120381501 120381799 120381807 120381808 120381913
ACS100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626
PVT110071007 110071137 110071138 110087753 110088257 110088279 110088292
SUND121933934 121934888 121934889 121935423 121935497
PBI103062621 103064438 107326021 112540458(ALOXE3)
PMUR107297127 107297128 107297129 107297130 107297132
CTIG120305736 120305737 120305739 120305742
PGUT117657096 117660229 117671250 117671251 117671255
VKO123016598 123016642 123016652
PMUA114581886 114581887 114582384 114582617 114583620
ZVI118094283 118094804 118094805 118094999
GJA107115224 107120726 107120728
STOW125444427 125444768 125444782 125445316
XLA108707611 108707612(alox15b.L) 108707613 108708795 108708797 108708798 734312(alox12b.S)
XTR100494252(alox15b) 100494678 100496875 116408939 548458(alox12b)
NPR108796083 108796085 108796093 108799096
RTEM120928225 120929270 120929271 120929272
BGAR122924120
DRE794132(si:dkey-17e16.9)
SRX107756080
SANH107673846 107699996
SGH107548144
CCAR109063989 109113592
CAUA113038569
MAMB125253227(si:dkey-17e16.9)
EEE113590746
TRU101063080 101064929 101065403
TNGGSTEN00023059G001 GSTEN00033460G001
LCO104926147 104928887 104939860 109137379
NCC104945566 104965473(b3gntl1)
CGOB115003520 115003907 115003908
ELY117250386 117270324 117270482 117270947 117270948 117270949 117271028 117271031 117271148
EFO125896652 125896654 125896655 125896673 125897371 125897569 125897570 125897571
PLEP121955229 121955231 121955232
SLUC116066135 116066173
ECRA117961557(si:dkey-17e16.9)
ESP116705832
CUD121521149 121521554
ALAT119012490 119012492 119012534 119012535
MZE101465465 101468181 101476255 101480284 112429854 112434905
ONL100689972 100691581 100694795 100701198 100702747 100706043 100706304 109194246 109194292
OAU116309996(zgc:152891) 116310798(si:dkey-17e16.9) 116327369 116327377 116327379 116329960 116330064 116330065 116330066 116330067
OLA101165367 101168429
OML112158170
XMA102225361 102225623
XCO114144052 114158302
XHE116733716 116733717
PRET103457519 103457522 103457523
PFOR103134921 103134944
PLAI106958151 106959115
PMEI106928763 106928764
GAF122825686
CVG107086029
CTUL119795946
NFU107374447
KMR108228955(zgc:152891) 108240061
ALIM106517057 106519785
NWH119418224
AOCE111570537 111570984 111575944
MCEP124999076 124999077 124999078 124999079 124999091
CSEM103381087 103393539 103393540
POV109636209
SSEN122783964 122783965 122783967
HHIP117758044 117758046 117758047 117758048 117758050
HSP118099179 118099180 124851192 124851193 124851194
LCF108880880(si:dkey-17e16.9) 108891324(zgc:152891)
SDU111236613 111236740 111236750 111236756
SLAL111653009 111655584 111655591 111655606
XGL120788899(si:dkey-17e16.9) 120802480(zgc:152891)
HCQ109527797
BPEC110155993 110156036
MALB109955487
SASA100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332
STRU115179646 115179723 115206553
OTW112217364 112217711 112226389
OMY110491145 110497317 110514910 110517354 110521065 110522385 110534564 118941428 118941429
OGO123995239 123995544
ONE115139270
SALP111972916 111973191
SNH120019324 120019325
CCLU121549254
ELS105008072 105010254 105014517 105020997 105029908 114830628
SFM108925302
AANG118224951 118225212
LOC102692216 102697403
PSPA121319168 121319184
ARUT117396925
PSEX120525109 120526473
LCM102352103
PJA122248285
PCHN125029265
HAZT108675024
VDE111245717
VJA111262905
BGT106071023 106071096
CRG105319482
MYI110442376
PMAX117321221
MMER123534520 123541244 123550058 123551042 123551206 123551207 123553547
ATEN116292301
XEN124451873
CICCICLE_v10027295mg
SLY101244897
EHXEMIHUDRAFT_102763 EMIHUDRAFT_247361
 » show all
Reference
1  [PMID:12881489]
  Authors
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR
  Title
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
  Journal
Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100
  Sequence
[hsa:59344]
Reference
2  [PMID:17045234]
  Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
  Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
  Journal
Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002
  Sequence
[hsa:59344] [mmu:23801]
Reference
3  [PMID:20921226]
  Authors
Zheng Y, Brash AR
  Title
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
  Journal
J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374
  Sequence
[hsa:59344]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.4.7
IUBMB Enzyme Nomenclature: 5.4.4.7
ExPASy - ENZYME nomenclature database: 5.4.4.7
BRENDA, the Enzyme Database: 5.4.4.7

KEGG   REACTION: R07040
Entry
R07040                      Reaction                               
Name
12(S)-HPETE hydroxymutase
Definition
12(S)-HPETE <=> Hepoxilin B3
Equation
Reaction class
RC01724  C05965_C14810
Enzyme
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Orthology
K18684  hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7]

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